This document summarizes strategies used by a primary care trust in England to influence prescribing in primary care. Key factors for success included strategic coordination through prescribing committees, tailored implementation with pharmacist support tailored to each practice, and clinical engagement at all levels. An example statin switch program demonstrated how evidence-based review, consensus-building, comprehensive support materials, and regular reinforcement of messages can successfully implement a prescribing change. Current issues include structural NHS reforms and maintaining initiatives amid new priorities around waste reduction and improving quality and productivity.