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FACULTY OF PHARMACEUTICAL SCIENCE
PHARMACOTHERAPEUTICS ER20-24T
Chapter 2.1: Cardiovascular System
Topic 2.1.3. Myocardial Infraction
Presented by- Ms. ALKA
Assistant Professor
FACULTY OF PHARMACEUTICAL SCIENCE
RAMA UNIVERSITY UTTAR PRADESH
KANPUR, INDIA
2023-2024
1
FACULTY OF PHARMACEUTICAL SCIENCE
 Myocardial Infraction (MI): It consists of two words “Myocardial” which means Muscles
of the heart and the word “Infraction” means tissue death.
 MI is defined as the irreversible death (necrosis)of heart muscles secondary to the prolonged
lack of oxygen supply (ischemia).
 It is a type of acute coronary syndrome, which describes a sudden or short-term change in
symptoms related to blood flow to the heart.
Myocardial Infraction
FACULTY OF PHARMACEUTICAL SCIENCE
3
Types of Myocardial Infraction
 Unstable angina
 ST- elevation myocardial infarction (STEMI)
 Non-ST- elevation myocardial infarction (NSTEMI)
FACULTY OF PHARMACEUTICAL SCIENCE
4
Note:
• NSTEMI= It is usually the result of a blockage in one or more of the coronary arteries. A
blockage can develop due to a buildup of plaque, a substance mostly made of fat,
cholesterol, and cellular waste products.
• The phrase heart attack is often used non-specifically to refer to a myocardial infraction
and to sudden cardiac death.
• MI is different from cardiac arrest, but MI can cause cardiac arrest, where the heart is not
contracting at all or so poorly that all vital organs can’t function properly, thus causing
death. It is also distinct from heart failure, in which the heart’s pumping action is
impaired. However, an MI can lead to heart failure.
FACULTY OF PHARMACEUTICAL SCIENCE
5
 Clinical manifestations
a) Fatigue
b) Dyspnoea (Shortness of Breath)
c) Chest Pain/ Chest Discomfort
d) Increase sweating
e) Weakness
f) Vomiting
g) Light headedness
h) Palpitation
Age, Gender
Hypertension
Chronic Kidney disease
Obesity
Drug Abuse
Tobacco smoking, alcohol
Diabetes
Stress
 Etiology of Myocardial Infraction
FACULTY OF PHARMACEUTICAL SCIENCE
6
 Pathophysiology of MI
FACULTY OF PHARMACEUTICAL SCIENCE
7
 Non-Pharmacological management
Non-Pharmacological
management
Avoid Alcohol
intake
Diet and
nutrition
Self resistance
Lifestyle
measures
Smoking
cessation
Counselling
and education
of patients
FACULTY OF PHARMACEUTICAL SCIENCE
8
 Pharmacological management
FACULTY OF PHARMACEUTICAL SCIENCE
9

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Pharmacotherapeutics chapter 2 (c) Myocardial I nfraction.pptx

  • 1. FACULTY OF PHARMACEUTICAL SCIENCE PHARMACOTHERAPEUTICS ER20-24T Chapter 2.1: Cardiovascular System Topic 2.1.3. Myocardial Infraction Presented by- Ms. ALKA Assistant Professor FACULTY OF PHARMACEUTICAL SCIENCE RAMA UNIVERSITY UTTAR PRADESH KANPUR, INDIA 2023-2024 1
  • 2. FACULTY OF PHARMACEUTICAL SCIENCE  Myocardial Infraction (MI): It consists of two words “Myocardial” which means Muscles of the heart and the word “Infraction” means tissue death.  MI is defined as the irreversible death (necrosis)of heart muscles secondary to the prolonged lack of oxygen supply (ischemia).  It is a type of acute coronary syndrome, which describes a sudden or short-term change in symptoms related to blood flow to the heart. Myocardial Infraction
  • 3. FACULTY OF PHARMACEUTICAL SCIENCE 3 Types of Myocardial Infraction  Unstable angina  ST- elevation myocardial infarction (STEMI)  Non-ST- elevation myocardial infarction (NSTEMI)
  • 4. FACULTY OF PHARMACEUTICAL SCIENCE 4 Note: • NSTEMI= It is usually the result of a blockage in one or more of the coronary arteries. A blockage can develop due to a buildup of plaque, a substance mostly made of fat, cholesterol, and cellular waste products. • The phrase heart attack is often used non-specifically to refer to a myocardial infraction and to sudden cardiac death. • MI is different from cardiac arrest, but MI can cause cardiac arrest, where the heart is not contracting at all or so poorly that all vital organs can’t function properly, thus causing death. It is also distinct from heart failure, in which the heart’s pumping action is impaired. However, an MI can lead to heart failure.
  • 5. FACULTY OF PHARMACEUTICAL SCIENCE 5  Clinical manifestations a) Fatigue b) Dyspnoea (Shortness of Breath) c) Chest Pain/ Chest Discomfort d) Increase sweating e) Weakness f) Vomiting g) Light headedness h) Palpitation Age, Gender Hypertension Chronic Kidney disease Obesity Drug Abuse Tobacco smoking, alcohol Diabetes Stress  Etiology of Myocardial Infraction
  • 6. FACULTY OF PHARMACEUTICAL SCIENCE 6  Pathophysiology of MI
  • 7. FACULTY OF PHARMACEUTICAL SCIENCE 7  Non-Pharmacological management Non-Pharmacological management Avoid Alcohol intake Diet and nutrition Self resistance Lifestyle measures Smoking cessation Counselling and education of patients
  • 8. FACULTY OF PHARMACEUTICAL SCIENCE 8  Pharmacological management