PRESENTATION IS COMPACT AND INFORMATIVE. HAS FLOWCHARTS AND DIAGRAMS. REFERENCE IS FROM LATEST ARTICLES AND STANDARD TEXTBOOKS. SERVES A GREAT DEAL TO BRUSH UP THE THEORETICAL KNOWLEDGE .

1. Photo Album
by USER1

113. PSVT
ADENOSINE
BB /VERAPAMIL( RECURRENCE)
VENT
1B—LIGNOCAINE
ATRIA
ADENOSINE/DIGOXIN/VERAPAMIL
WPW
FLECAINIDE

114. PLZ CHECK PFT LFT TFT
• PIGMENTATION
• PHOTOSENSITIVITY
• CORNEAL DEPOSIT (WHORLING)
• PULM FIBROSIS
• PERIPHERLA NEUROPATHY
• PSEUDOALCOHOLIC LIVER INJURY
• HYPOTHYROIDISM /HYPERTHYROIDISM

116. PURE AS GOLD

121. CUT --PYRIMIDINE

122. CYTARABINE

124. 5 FLURO URACIL

125. capacitabine

128. Neutrophil chemotactic
factors:
C - C5a
I - IL-8
L - Leukotriene B4

129. Oncogenes. Gain of function
mutation in one allele -->
cancer.
K-ras: Kolon, panKreatic
H-ras: (Hematuria) - bladder
and kidney tumors
N-ras: melaNomas

130. Tumor suppressor genes:
DPC - Deleted in Pancreatic Cancer
DCC - Deleted in Colon Cancer

131. Psammoma bodies - laminated,
concentric, "rings on a tree"
spherical calcifications:
P - Papillary (adenocarcinoma of
thyroid)
S - Serous (cystadenoma of ovary)
M - Meningioma
M - Mesothelioma (asbestos
exposure)

132. Metastases to brain (# metastases = #
primary brain tumors):
Lung, Breast, Skin (melanoma), Kidney
(RCC), GI
Typically, multiple well-circumcribed
tumors at gray-white border

133. Metastases to liver (metastases
>> primary liver tumors):
Colon, Stomach, Pancreas,
Breast, Lung.
*Think breast & lung, plus what
is drained by portal venous
system to liver.

134. Metastases to bone (metastases >>
primary):
Prostate, Thyroid, Breast, Lung,
Kidney
Lung = Lytic (IL-1)
Prostate = blastic

135. Drugs with zero order elimination
P - Phenytoin
E - Ethanol
A - Aspirin (at high or toxic
concentrations)

136. • Therapeutic Index equation:
TI = LD50 / ED50
Safer drugs have higher TI's

137. • G-protein linked 2nd messengers:
q - alpha 1 - vasoconstriction --> inc BP
i - alpha 2 - dec sympathetic outflow
s - beta 1 - inc HR, contractility, renin, lipolysis
s - beta 2 - vaso-/bronchodilation, inc HR
q - M1 - CNS, ENS
i - M2 - dec HR, dec contractility of atria
q - M3 - peristalsis, gastric acid,
bronchoconstriction, miosis, accommodation

138. • G-protein linked 2nd messengers:
s - D1 - relaxes renal vascular sm muscle
i - D2 - modulates NT release, esp in brain
q - H1 - (nasal, bronchial mucus production)
s - H2 (gastric acid secretion)
q - V1 - vasopressin (sm m contraction)
s - V2 - vasopressin (inc H2O permeability

139. • Receptors that use the Gq pathway:
H1, alpha-1, V1, M1, M3
Gq -> phospholipase C -> -> IP3 (-> Ca++ from
ER) + DAG (-> Protein Kinase C)

140. • Receptors that use the Gi pathway:
M2, alpha-2, D2
Gi --> inhibition of Adenylate cyclase --> dec
cAMP --> dec protein kinase A

141. OP
• Hot as a hare (inc body temp)
Dry as a bone (dry mouth, skin)
Red as a beet (flushed skin)
Blind as a bat (cycloplegia, mydriasis)
Mad as a hatter (delirium)
Bloated as a toad (constipation, urinary
retention)

142. • low doses of epinephrine are selective for
beta-1 receptors -->