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Pharmacology of swedan
- 1. Pharmacology Of Swedan Dr Swapnil Shinde Ayush Ayurveda LLP Nigdi Pune 411044 9272857797 ayurvedaremedies@gmail.com www.mruja.in 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 2. Swedan Karma • Swedana is the Karma less discussed and taken care amongst Panchkarmas. • But I say it’s the main karma giving maximum repute to Vaidya fraternity. • As a Swedana - Less • But by its Modified versions • Have a big repute to their names. 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 3. Swedan Karma • This is one of the karmas mention which actually felicitated the drug absorption • Gunas of Swedan dravya • {YNaM taIXNaM sarM isnagQaM r]XaM saUXmaM d`vaM isqarma | • d`vyaM gaur] ca yatpa`ayasqaiQd svaodnamaucyatao || ca.saU. 22ó16 • Due to this following gunas the swedan falicitate the absorption of drug into the body.5/4/2020 Dr Swapnil Shinde www.mruja.in
- 4. Swedan Karma • Swedan Types • According to Vagbhat, Shushrut and Ashtang Sangraha. There are four main types of swedan. 1. Tapsweda 2. Upnahasweda 3. Ushna sweda 4. Drava sweda • But charak explained 13 types of swedas. • saMkxrpa`starao naaDI pairYaokxaovagaaGnama • jaoMtaakxao#SmaGana: kxYau- kuxTI BaU:kuMxiBakOxva ca || • kuxpaao haolaakx [tyaotao svaodyaMita ~ayaaodSa || ca.saU. 14ó39 • All the 13 types can be included in above main types. 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 5. Advantages Swedan • SaItaSaulavyauparmao staMBagaaOrvainaga`ho | saMjaatao maad-vao svaodo svaodnaaiWritama-taa || ca.saU. 41ó13 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 6. Indications • Shodhan for Dosha Vishyandan and Shlathanam. • Shamanam in : • Bronchial asthma (swasa), cough (kasa), sinusitis ( Pratishyaya), hiccough (Hikka), flatulence ( Atopa), hoarseness of voice (Swarabheda and Galagraha), hemiplegia (Pakshavadh), low backache (Katishoola and Graha), sciatica (Grudhrasi), dysuria(Mutrakruch6), Tumours (Arbuda) etc 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 7. Contraindications • Excess of Rakta and Pitta conditions • Obesity, diarrhea, jaundice, anemia, • Diabetes, abscess, coma, trauma, pregnancy, ascites, • Poisoning, alcoholic abuse, • cataract, certain skin lesions, • Edema, thirst, hunger. 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 10. COMPONENTS COMPONENTS 1. Stimulus - Changes in the temperature of our external environment can cause core body temperature to rise or fall 2. Receptors - Nerve endings in the skin and brain (hypothalamus) sense the external and internal body temperature respectively. 3. Control Centre - The hypothalamus (part of our brain) processes signals from the thermoreceptors and signals various effectors that are used to restore the core temperature to its set point (approximately 37°C). 4. Effectors - The following components are used to adjust our core temperature, compensating for the external environment and restoring our core temperature to its set point. •Skeletal Muscles •Smooth Muscle Surrounding Blood Vessels •Thyroid Hormones •Adrenaline •Piloerector Muscles •Sweat Glands 5. Effect - Our core body temperature is raised / lowered back to it's set point of approximately 37°C 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 11. Effects Of Swedan On Human Body • Intense short-term heat exposure elevates skin temperature and core body temperature and activates thermoregulatory pathways via the hypothalamus and CNS (central nervous system) leading to activation of the autonomic nervous system. The activation of the sympathetic nervous system, hypothalamus-pituitary-adrenal hormonal axis, and the renin-angiotensin-aldosterone system leads to well-documented cardiovascular effects with increased heart rate, skin blood flow, cardiac output, and sweating 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 12. Effect On Tissue • Relaxes Muscule • Relive Pain • Vasodilatation • Increase Tissue Permeability • Reduce BP • Reduce Stress 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 13. At cellular level • On a cellular level, acute whole-body thermotherapy (both wet and dry forms) induces discrete metabolic changes that include production of heat shock proteins, reduction of reactive oxygenated species, reduced oxidative stress and inflammation pathway activities, increased NO (nitric oxide) bioavailability, increased insulin sensitivity, and alterations in various endothelial- dependent vasodilatation metabolic pathways 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 14. Heat shock proteins • Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic up regulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor(HSF) 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 16. chaperones • Several heat shock proteins function as intra- cellular chaperones for other proteins. They play an important role in protein–protein interactions such as folding and assisting in the establishment of proper protein conformation (shape) and prevention of unwanted protein aggregation. By helping to stabilize partially unfolded proteins, HSPs aid in transporting proteins across membranes within the cell 5/4/2020 Dr Swapnil Shinde www.mruja.in
- 18. Thank S 5/4/2020 Dr Swapnil Shinde www.mruja.in