The document outlines the etiologic factors and risk factors that can lead to gallstone formation, which can cause abdominal pain and other issues. It shows that calcification of cholesterol in the gallbladder can lead to stone formation, which can then cause gallbladder spasms, obstruction, and pain as stones pass or cause distention of bile ducts. This impaired drainage can further lead to localized irritation, inflammation, and other symptoms.

1. Risk Factor Etiologic factors
Calcification of
choleterol
Stones formation Passage of Abdominal
(gallstone) stones colic
Abdominal
Gallbladder
pain obstruction
spasm
Distention of bile
Venous and Bacterial Localized cellular Decreased bile is
ducts
lymphatic Proliferation irritation secreted
drainage is
impaired
Antigen-
Impulse to Decreased
antibodies meet
vomiting emulsification of
center Decreased blood fats
supply Inflammatory
response
Decreased fat Intolerance
Nausea soluble
Ischemia of the of Fatty
and vitamins
tissues foods
vomiting absorption
Fever
Chills
necrosis Murphy’s
Sign