This document describes educational modules and problem sets developed by Rowan University in collaboration with the National Science Foundation funded Engineering Research Center for Structured Organic Particulate Systems (C-SOPS). The goal is to introduce students to engineering concepts in particle and powder technology for pharmaceutical processing and drug delivery systems. Rowan University developed hands-on teaching modules including a pneumatic transport mobile unit for fluid mechanics courses and K-12 outreach. Problem sets were also developed that integrate pharmaceutical technology topics into chemical engineering courses covering material and energy balances. Initial results of student experiments using the modules to investigate powder mixing are presented.
2014.09.30. Bioavailability Enhancement Webinar Series: Optimizing Technology Choice to Enhance Bioavailability
Capsugel (Bend Research)
Abstract:
An increasing number of active compounds in pipelines today have properties that require functional formulation to enable exposure and efficacy. Despite many new technology choices, it is often difficult to match the right drug-delivery technology to a given molecule and problem statement. This problem is exacerbated by the need to save time and valuable drug in early development. This webinar describes an efficient strategy for mating enabling drug-delivery technologies with problem statements based on challenging compound properties and product concepts, building on an understanding of gut physiology, key molecule physicochemical properties, and the target product profile.
Company Summary:
Capsugel Dosage Form Solutions designs, develops and manufactures innovative dosage forms addressing bioavailability and other pressing product development challenges, including bioavailability enhancement, modified release, abuse deterrence, biotherapeutic processing, and inhalation formulation.
Speakers Bio:
Dr. David Vodak
Vice President Bend Research Moderator
Dr. Vodak's areas of expertise are research and development of novel pharmaceutical drug-delivery systems. Dr. Vodak holds a PhD in materials chemistry from the University of Michigan and a B.A. in chemistry from Willamette University.
Dr. David Lyon
Senior Vice President Bend Research
Dr. Lyon is the Senior Vice President at Bend Research. He leads development activities for new technologies, oversees the development of predictive biomodels, and provides technical leadership to the research groups for new and applied technologies.
This document summarizes recent developments in the design and application of advanced polymeric systems for precision agriculture. It discusses how smart polymeric systems have contributed to sustainable agriculture by facilitating controlled release of agrochemicals like pesticides and fertilizers, allowing for lower doses to be used more efficiently. The document reviews the various polymer structures and properties used for applications like controlled chemical delivery, superabsorbent polymers for water management, and polymers used inside plants. It identifies future directions for functional polymers to further advance sustainable agriculture.
The importance of education quality can never be over emphasized. The objective of this research is to introduce how to set up scientific and reasonable curriculum system in the training of chemical engineering ideas and abilities of students who majored in chemistry and other related specialties. According to the many years practice, the system is built and optimized, and it includes the following courses in the order of “Elementary Chemical Industry”, “Chemical Engineering Experiment”, “Chemical Industry Charting”, “Industry Chemistry” or “Chemical Technology”, “Chemical Process Simulation Experiment”, “Chemical Process and Plant Design”, “Chemical Practice”. Teaching practices have testified that students cultivated by this curriculum system presented well comprehensive quality of innovative talents, and the employment capability is obviously enhanced.
Este documento presenta un ejercicio para estudiantes de guionismo audiovisual que involucra buscar imágenes en Internet relacionadas con diferentes sentidos y describir las sensaciones que evocan. El objetivo es estimular los sentidos de los estudiantes y generar ideas y sensaciones que puedan usarse como material para la creación de textos. Los sentidos a explorar son la vista, el olfato, el gusto, el tacto y el oído, y cada uno se asocia con una palabra clave como "origen" para la vista o "música" para el o
2014.09.30. Bioavailability Enhancement Webinar Series: Optimizing Technology Choice to Enhance Bioavailability
Capsugel (Bend Research)
Abstract:
An increasing number of active compounds in pipelines today have properties that require functional formulation to enable exposure and efficacy. Despite many new technology choices, it is often difficult to match the right drug-delivery technology to a given molecule and problem statement. This problem is exacerbated by the need to save time and valuable drug in early development. This webinar describes an efficient strategy for mating enabling drug-delivery technologies with problem statements based on challenging compound properties and product concepts, building on an understanding of gut physiology, key molecule physicochemical properties, and the target product profile.
Company Summary:
Capsugel Dosage Form Solutions designs, develops and manufactures innovative dosage forms addressing bioavailability and other pressing product development challenges, including bioavailability enhancement, modified release, abuse deterrence, biotherapeutic processing, and inhalation formulation.
Speakers Bio:
Dr. David Vodak
Vice President Bend Research Moderator
Dr. Vodak's areas of expertise are research and development of novel pharmaceutical drug-delivery systems. Dr. Vodak holds a PhD in materials chemistry from the University of Michigan and a B.A. in chemistry from Willamette University.
Dr. David Lyon
Senior Vice President Bend Research
Dr. Lyon is the Senior Vice President at Bend Research. He leads development activities for new technologies, oversees the development of predictive biomodels, and provides technical leadership to the research groups for new and applied technologies.
This document summarizes recent developments in the design and application of advanced polymeric systems for precision agriculture. It discusses how smart polymeric systems have contributed to sustainable agriculture by facilitating controlled release of agrochemicals like pesticides and fertilizers, allowing for lower doses to be used more efficiently. The document reviews the various polymer structures and properties used for applications like controlled chemical delivery, superabsorbent polymers for water management, and polymers used inside plants. It identifies future directions for functional polymers to further advance sustainable agriculture.
The importance of education quality can never be over emphasized. The objective of this research is to introduce how to set up scientific and reasonable curriculum system in the training of chemical engineering ideas and abilities of students who majored in chemistry and other related specialties. According to the many years practice, the system is built and optimized, and it includes the following courses in the order of “Elementary Chemical Industry”, “Chemical Engineering Experiment”, “Chemical Industry Charting”, “Industry Chemistry” or “Chemical Technology”, “Chemical Process Simulation Experiment”, “Chemical Process and Plant Design”, “Chemical Practice”. Teaching practices have testified that students cultivated by this curriculum system presented well comprehensive quality of innovative talents, and the employment capability is obviously enhanced.
Este documento presenta un ejercicio para estudiantes de guionismo audiovisual que involucra buscar imágenes en Internet relacionadas con diferentes sentidos y describir las sensaciones que evocan. El objetivo es estimular los sentidos de los estudiantes y generar ideas y sensaciones que puedan usarse como material para la creación de textos. Los sentidos a explorar son la vista, el olfato, el gusto, el tacto y el oído, y cada uno se asocia con una palabra clave como "origen" para la vista o "música" para el o
Laporan 1 uji boraks pada sampel bahan panganMuhammad Ridlo
Laporan praktikum ini menguji keberadaan boraks dalam bakso dengan uji kualitatif secara fisik dan kimia. Uji fisik melihat warna, bau, dan kekenyalan bakso, sedangkan uji kimia membakar bakso dan melihat warna nyala apinya. Hasilnya menunjukkan sampel A positif mengandung boraks karena nyala hijau, sedangkan sampel B negatif tidak mengandung boraks karena nyala kuning.
This document discusses seepage forces and their effect on soil stability. It defines seepage forces as the viscous drag of water flowing through soil pores, which increases intergranular pressure and reduces effective stresses. Seepage forces are higher in more permeable soils like sand versus less permeable soils like clay. Two case studies of dam failures are presented: Nanak Sagar Dam in 1962 failed due to internal erosion from seepage forces, while Fontenelle Dam in 1965 also failed due to piping caused by seepage. The conclusion is that seepage forces can be strong enough to cause liquefaction, erosion, and failures of dams and retaining walls if not properly addressed.
Overview of Real estate market in Vietnam.
http://realestate1.vn
Vietnam Real Estate 1 - the largest properties listing website in Vietnam. We enable user to sell house, buy house, search for property in Vietnam, Our site has house for sale, apartment for sale, land for sale, business for sale, factory for sale, warehouse for sale in Vietnam. You can also lease house or property in Vietnam or locate a realestate agent in Vietnam.
Las células madre son aquellas capaces de sostener ciclos de división ilimitados y además tienen con capacidad para diferenciarse, dejar de ser una stem cell y convertirse en una de las 200 variedades celulares (1).
Auto-renovación: la habilidad de pasar a través de numerosos ciclos de división celular (mitosis) mientras mantiene un estado sin diferenciar.
Potencia: la capacidad de diferenciarse en células especializadas.
This document describes a cooperative team-based approach used to teach an introductory chemical engineering course at Bucknell University. Key points:
1. The course replaces traditional lectures with problem-based learning projects completed in teams of 4 students over 2 weeks each.
2. Projects cover material and energy balances, phase equilibria, and process simulation. Labs and plant trips are also included.
3. Students learn technical problem-solving as well as teamwork, communication, and professional skills.
4. Assessment shows benefits of this active learning approach over traditional lectures in better preparing students for chemical engineering careers.
Inquiry-based study can enhance long term retention and improve application and synthesis of knowledge. In this research, we provide a student-driven, inquiry-based teaching mode that trains undergraduate as researcher, who can raise questions, design and perform hypothesis-driven experiments, analyze data and discuss results. Before students design their research projects, they should know well and answer a series questions related experiment principle, condition and error control, data detection and processing, which guide them to familiarize with project principles, operations and data processing. Continuous distillation is an ideal choice for the training in an undergraduate lab due to it synthesizing the fluid flow, heat transfer and mass transfer. Students actively participate in the project, because their doubts can be removed through designing and implementing experiments, such as: How to evaluate the separation capacity of the distillation operation? How to implement the experiment and get the component concentration in simple way? How to evaluate the separation capacity of packing column? Students use their acquired research skills to design, execute and analyze experiments independently. While, the instructors only make some adjustments to ensure that the experimenter completes the design goal within the limited experimental time. Results show that distillation experiment builds an open, inquiry-based platform for students, which significantly enhances the ability to apply and integrate knowledge. The scientific research ability and teamwork awareness have also been nurtured.
Micro-scale Chemistry Laboratory Techniques at Senior Secondary School Level ...ijsrd.com
This document discusses a study that assessed the effectiveness of using micro-scale chemistry laboratory techniques at the senior secondary school level in India. The study found that students who performed experiments using micro-scale techniques, which require only small amounts of chemicals, performed better on a chemistry achievement test than students who learned with traditional techniques. Micro-scale techniques reduce costs, waste, and health hazards compared to traditional experiments. The document concludes that micro-scale techniques are an effective and economical way to teach chemistry labs in schools.
In 2006, the Commission on Higher Education (CHED)
released CHED Memorandum Order (CMO) no. 14 which changed the
duration of internship training program to six months as opposed to
the previous memorandum order, CMO no. 27 s. 1998 which required
a one-year internship schedule for Medical Laboratory Science (MLS)
students. Thirty-eight graduates of CMO No. 14 s. 2006 from Lyceum of
the Philippines University-Batangas and 13 chief medical technologists
(CMT) or senior medical laboratory staff from identified affiliate-
hospitals were surveyed about their perception on the attainment of the
objectives, as well as the strengths and weaknesses of the said program.
Results show that objectives were achieved even if the duration of the
training period was shortened. The graduate-respondents favored the 6-month internship training program while the CMT preferred the
one year timetable. This study can be used as a pilot study for other
higher education institutions implementing the same CMO and can
be used as a basis for a curricular reform by assessing the different
parameters that were identified in order to enhance further the six-
month internship training program in producing globally competitive
medical laboratory scientists.
This document summarizes applied research projects at TAFE institutes in Victoria, Australia. It discusses how TAFEs have partnered with local industries to solve problems through applied research projects integrated into teaching. Specific examples discussed include Melbourne Polytechnic developing prototypes with industry partners, GOTAFE introducing new boatbuilding materials and techniques to local enterprises through apprentice training, and The Gordon implementing its BlendED strategy to expand e-learning capabilities.
The document discusses two case studies of integrating entrepreneurship into a biomedical engineering program through an external business plan competition. In the first case study, biomedical engineering students developed a low-cost camera system to track movement of people with disabilities. In the second case study, students proposed a bone fixation system that could locally deliver antibiotics. The competition helped foster collaboration between the biomedical engineering and entrepreneurship programs, exposing students to entrepreneurial aspects and encouraging engineering innovation.
Larry Charles Michael provides a resume summarizing his career experience and qualifications. He has over 40 years of experience in environmental health research focusing on understanding health outcomes from chemical exposure. He has a background in analytical chemistry and biostatistics. For the past 15 years at RTI International, he has led over 60 research projects performing statistical analysis and developing databases to analyze exposure and health data. His expertise includes statistical analysis, data management, exposure measurement, and study design.
This study evaluated the impact of blended learning incorporating video feedback on student performance in a medical laboratory science program. Students were randomly assigned to a video group, who received video recordings of their laboratory skills with expert feedback, or a control group. Results showed that students in the video group had statistically higher practical examination scores and final grades than the control group. The findings suggest students are engaged and motivated by blended learning incorporating video recordings and feedback on hands-on techniques. For academics, developing blended learning programs including virtual materials, videos, and online activities provides an effective way to teach technical skills.
This document contains abstracts from poster presentations given at the 2014 American Society for Clinical Laboratory Science Clinical Laboratory Educators' Conference. The posters covered topics such as improving student capstone projects, student perceptions of clinical experiences, curriculum revisions to incorporate competency-based education, using RStudio to teach biostatistics, predicting student success, the impact of mobile devices on clinical laboratory data, incorporating a laboratory information system in simulated laboratories, using videos to enhance lectures, flipping an immunology course, and quality improvement projects using evidence-based practice research.
Attitudes Of Nigerian Secondary School Chemistry Students Towards Concept Map...Robin Beregovska
The document discusses a study that examined the effect of different concept mapping strategies (hierarchical, flowchart, and spider) used as advance organizers on Nigerian secondary school chemistry students' learning of the mole concept. The study found that (1) using any of the concept mapping strategies as advance organizers produced similar effects on students' problem solving abilities, and (2) students had similar attitudes towards the different concept mapping strategies. The study concluded that the various types of concept maps were effective learning tools and students viewed them similarly.
Applying Experimental Designs To Large-Scale Program Evaluation. Research Pap...Sheila Sinclair
This document discusses the application of an experimental design to evaluate five National Science Foundation comprehensive projects. It describes how the evaluation team made decisions around sampling and data collection for the evaluation, including defining the school as the experimental unit, using a factorial design stratified by subject matter and rural/urban variables, selecting similar geographic control regions, and determining sample sizes despite uncertainty around dependent variables. The goal was to apply an experimental framework to assess the success of the projects in achieving their goal of helping schools improve science and math education, while addressing real-world challenges in implementing such a large-scale evaluation.
Theory-practice interaction in engineering teaching: Pedagogical experience i...IJAEMSJORNAL
The document describes a pedagogical experience integrating theory and practice in a chemical engineering course on effluent management and treatment. Students visited local industries to observe wastewater treatment in practice. They then developed a water treatment plant project in groups. A survey found students found the project engaging and that it helped apply concepts from class. Integrating theory, visits, and projects gave students a more holistic learning experience and better prepared them for their future careers.
This document summarizes the experience and qualifications of Steven Brown, including over 7 years of experience in petrochemical and biopharmaceutical industries as a research scientist and project manager. He has strong technical skills in fermentation science, experimental design, automation, and analytical techniques. Brown is currently pursuing his PhD researching engineering carbon metabolism in yeast. He aims to develop an industrial yeast that can increase the product portfolio of cellulosic ethanol plants.
Laporan 1 uji boraks pada sampel bahan panganMuhammad Ridlo
Laporan praktikum ini menguji keberadaan boraks dalam bakso dengan uji kualitatif secara fisik dan kimia. Uji fisik melihat warna, bau, dan kekenyalan bakso, sedangkan uji kimia membakar bakso dan melihat warna nyala apinya. Hasilnya menunjukkan sampel A positif mengandung boraks karena nyala hijau, sedangkan sampel B negatif tidak mengandung boraks karena nyala kuning.
This document discusses seepage forces and their effect on soil stability. It defines seepage forces as the viscous drag of water flowing through soil pores, which increases intergranular pressure and reduces effective stresses. Seepage forces are higher in more permeable soils like sand versus less permeable soils like clay. Two case studies of dam failures are presented: Nanak Sagar Dam in 1962 failed due to internal erosion from seepage forces, while Fontenelle Dam in 1965 also failed due to piping caused by seepage. The conclusion is that seepage forces can be strong enough to cause liquefaction, erosion, and failures of dams and retaining walls if not properly addressed.
Overview of Real estate market in Vietnam.
http://realestate1.vn
Vietnam Real Estate 1 - the largest properties listing website in Vietnam. We enable user to sell house, buy house, search for property in Vietnam, Our site has house for sale, apartment for sale, land for sale, business for sale, factory for sale, warehouse for sale in Vietnam. You can also lease house or property in Vietnam or locate a realestate agent in Vietnam.
Las células madre son aquellas capaces de sostener ciclos de división ilimitados y además tienen con capacidad para diferenciarse, dejar de ser una stem cell y convertirse en una de las 200 variedades celulares (1).
Auto-renovación: la habilidad de pasar a través de numerosos ciclos de división celular (mitosis) mientras mantiene un estado sin diferenciar.
Potencia: la capacidad de diferenciarse en células especializadas.
This document describes a cooperative team-based approach used to teach an introductory chemical engineering course at Bucknell University. Key points:
1. The course replaces traditional lectures with problem-based learning projects completed in teams of 4 students over 2 weeks each.
2. Projects cover material and energy balances, phase equilibria, and process simulation. Labs and plant trips are also included.
3. Students learn technical problem-solving as well as teamwork, communication, and professional skills.
4. Assessment shows benefits of this active learning approach over traditional lectures in better preparing students for chemical engineering careers.
Inquiry-based study can enhance long term retention and improve application and synthesis of knowledge. In this research, we provide a student-driven, inquiry-based teaching mode that trains undergraduate as researcher, who can raise questions, design and perform hypothesis-driven experiments, analyze data and discuss results. Before students design their research projects, they should know well and answer a series questions related experiment principle, condition and error control, data detection and processing, which guide them to familiarize with project principles, operations and data processing. Continuous distillation is an ideal choice for the training in an undergraduate lab due to it synthesizing the fluid flow, heat transfer and mass transfer. Students actively participate in the project, because their doubts can be removed through designing and implementing experiments, such as: How to evaluate the separation capacity of the distillation operation? How to implement the experiment and get the component concentration in simple way? How to evaluate the separation capacity of packing column? Students use their acquired research skills to design, execute and analyze experiments independently. While, the instructors only make some adjustments to ensure that the experimenter completes the design goal within the limited experimental time. Results show that distillation experiment builds an open, inquiry-based platform for students, which significantly enhances the ability to apply and integrate knowledge. The scientific research ability and teamwork awareness have also been nurtured.
Micro-scale Chemistry Laboratory Techniques at Senior Secondary School Level ...ijsrd.com
This document discusses a study that assessed the effectiveness of using micro-scale chemistry laboratory techniques at the senior secondary school level in India. The study found that students who performed experiments using micro-scale techniques, which require only small amounts of chemicals, performed better on a chemistry achievement test than students who learned with traditional techniques. Micro-scale techniques reduce costs, waste, and health hazards compared to traditional experiments. The document concludes that micro-scale techniques are an effective and economical way to teach chemistry labs in schools.
In 2006, the Commission on Higher Education (CHED)
released CHED Memorandum Order (CMO) no. 14 which changed the
duration of internship training program to six months as opposed to
the previous memorandum order, CMO no. 27 s. 1998 which required
a one-year internship schedule for Medical Laboratory Science (MLS)
students. Thirty-eight graduates of CMO No. 14 s. 2006 from Lyceum of
the Philippines University-Batangas and 13 chief medical technologists
(CMT) or senior medical laboratory staff from identified affiliate-
hospitals were surveyed about their perception on the attainment of the
objectives, as well as the strengths and weaknesses of the said program.
Results show that objectives were achieved even if the duration of the
training period was shortened. The graduate-respondents favored the 6-month internship training program while the CMT preferred the
one year timetable. This study can be used as a pilot study for other
higher education institutions implementing the same CMO and can
be used as a basis for a curricular reform by assessing the different
parameters that were identified in order to enhance further the six-
month internship training program in producing globally competitive
medical laboratory scientists.
This document summarizes applied research projects at TAFE institutes in Victoria, Australia. It discusses how TAFEs have partnered with local industries to solve problems through applied research projects integrated into teaching. Specific examples discussed include Melbourne Polytechnic developing prototypes with industry partners, GOTAFE introducing new boatbuilding materials and techniques to local enterprises through apprentice training, and The Gordon implementing its BlendED strategy to expand e-learning capabilities.
The document discusses two case studies of integrating entrepreneurship into a biomedical engineering program through an external business plan competition. In the first case study, biomedical engineering students developed a low-cost camera system to track movement of people with disabilities. In the second case study, students proposed a bone fixation system that could locally deliver antibiotics. The competition helped foster collaboration between the biomedical engineering and entrepreneurship programs, exposing students to entrepreneurial aspects and encouraging engineering innovation.
Larry Charles Michael provides a resume summarizing his career experience and qualifications. He has over 40 years of experience in environmental health research focusing on understanding health outcomes from chemical exposure. He has a background in analytical chemistry and biostatistics. For the past 15 years at RTI International, he has led over 60 research projects performing statistical analysis and developing databases to analyze exposure and health data. His expertise includes statistical analysis, data management, exposure measurement, and study design.
This study evaluated the impact of blended learning incorporating video feedback on student performance in a medical laboratory science program. Students were randomly assigned to a video group, who received video recordings of their laboratory skills with expert feedback, or a control group. Results showed that students in the video group had statistically higher practical examination scores and final grades than the control group. The findings suggest students are engaged and motivated by blended learning incorporating video recordings and feedback on hands-on techniques. For academics, developing blended learning programs including virtual materials, videos, and online activities provides an effective way to teach technical skills.
This document contains abstracts from poster presentations given at the 2014 American Society for Clinical Laboratory Science Clinical Laboratory Educators' Conference. The posters covered topics such as improving student capstone projects, student perceptions of clinical experiences, curriculum revisions to incorporate competency-based education, using RStudio to teach biostatistics, predicting student success, the impact of mobile devices on clinical laboratory data, incorporating a laboratory information system in simulated laboratories, using videos to enhance lectures, flipping an immunology course, and quality improvement projects using evidence-based practice research.
Attitudes Of Nigerian Secondary School Chemistry Students Towards Concept Map...Robin Beregovska
The document discusses a study that examined the effect of different concept mapping strategies (hierarchical, flowchart, and spider) used as advance organizers on Nigerian secondary school chemistry students' learning of the mole concept. The study found that (1) using any of the concept mapping strategies as advance organizers produced similar effects on students' problem solving abilities, and (2) students had similar attitudes towards the different concept mapping strategies. The study concluded that the various types of concept maps were effective learning tools and students viewed them similarly.
Applying Experimental Designs To Large-Scale Program Evaluation. Research Pap...Sheila Sinclair
This document discusses the application of an experimental design to evaluate five National Science Foundation comprehensive projects. It describes how the evaluation team made decisions around sampling and data collection for the evaluation, including defining the school as the experimental unit, using a factorial design stratified by subject matter and rural/urban variables, selecting similar geographic control regions, and determining sample sizes despite uncertainty around dependent variables. The goal was to apply an experimental framework to assess the success of the projects in achieving their goal of helping schools improve science and math education, while addressing real-world challenges in implementing such a large-scale evaluation.
Theory-practice interaction in engineering teaching: Pedagogical experience i...IJAEMSJORNAL
The document describes a pedagogical experience integrating theory and practice in a chemical engineering course on effluent management and treatment. Students visited local industries to observe wastewater treatment in practice. They then developed a water treatment plant project in groups. A survey found students found the project engaging and that it helped apply concepts from class. Integrating theory, visits, and projects gave students a more holistic learning experience and better prepared them for their future careers.
This document summarizes the experience and qualifications of Steven Brown, including over 7 years of experience in petrochemical and biopharmaceutical industries as a research scientist and project manager. He has strong technical skills in fermentation science, experimental design, automation, and analytical techniques. Brown is currently pursuing his PhD researching engineering carbon metabolism in yeast. He aims to develop an industrial yeast that can increase the product portfolio of cellulosic ethanol plants.
Social, Economic and Political Contexts for Chemistry Through SustainabilityKatherine Haxton
This document outlines a curriculum for a chemistry through sustainability module. It includes the following key points:
- The module is delivered over 6 years and incorporates students from chemistry and environmental science backgrounds.
- Learning outcomes are designed to develop graduate attributes and skills related to sustainability.
- Assessments include a magazine article assignment, portfolio with short tasks applying skills, and evaluations to monitor the module's effectiveness in teaching sustainability.
Brendan McKeogh is seeking a position in chemical engineering. He received his Master's and Bachelor's degrees in chemical engineering from Worcester Polytechnic Institute, maintaining high GPAs. For his master's thesis, he prepared and tested hydrothermal carbon to characterize chemical changes over time using various analytical techniques. As an undergraduate, he conducted a study examining chemical changes to hydrothermal carbon using spectroscopy. He also has work experience interning at an energy research company and as a teaching assistant for a process controls course.
This report summarizes the activities and accomplishments of the first year of the Ufolio eportfolio project at the University of Oregon. The project involved faculty and programs from the Lundquist College of Business, Arts and Administration Program, and School of Architecture. In the first year, the group selected an open-source WordPress platform to use, piloted eportfolios in seven courses, and provided preliminary findings and recommendations based on student and faculty feedback. Going forward, the group aims to further operationalize support structures and expand eportfolio use across additional programs in the coming academic year.
This document summarizes an action research project conducted by Dr. Sanjay Narhar Karmarkar on organizing organic chemistry reactions alphabetically. The project aims to help higher secondary students better remember and apply various organic reactions and reagents through collecting them in alphabetical order. It involved compiling organic chemistry reactions from the new syllabus across 9 units in an alphabetical list with short explanations. The research hopes this methodology will benefit students in recalling information and applying principles to different molecules near exams. It was conducted with 16 students from Vidya Bhavan Junior College to examine memorization difficulties and develop analytical skills.
1. AC 2011-1427: INTEGRATION OF PARTICLE TECHNOLOGY WITH
PHARMACEUTICAL INDUSTRY APPLICATIONS IN THE CHEMICAL
ENGINEERING UNDERGRADUATE CURRICULUM AND K-12 EDUCA-
TION
Zenaida Otero Gephardt, Rowan University
Stephanie Farrell, Rowan University
Stephanie Farrell is an Associate Professor in Chemical Engineering at Rowan University. Prior to joining
Rowan in 1998, she was an assistant professor in Chemical Engineering and adjunct professor in Biomed-
ical Engineering at Louisiana Tech University. She received her Bachelor’s, MS, and PhD degrees in
Chemical Engineering from the University of Pennsylvania, Stevens Institute of Technology, and New
Jersey Institute of Technology, respectively. Stephanie’s educational interests are in laboratory develop-
ment and experiential learning, particularly in the areas of biomedical and sustainable engineering.
Mariano Javier Savelski, Rowan University
C. Stewart Slater, Rowan University
Maryfaith Rodgers, Rowan University
Pavlo Kostetskyy, Rowan University
Coauthor as a 4th year undergraduate student at Rowan University
Keith McIver
Haddy Diallo
kaitlyn jean zienowicz
Jason J. Giacomelli, Rowan University
Vladimir de Delva
c American Society for Engineering Education, 2011
2. Integration of Particle Technology with Pharmaceutical Industry
Applications in the Chemical Engineering Undergraduate Curriculum
and K-12 Education
Abstract
Rowan University, in collaboration with the National Science Foundation (NSF) funded
Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), is
developing teaching modules and problem sets to introduce students to engineering concepts in
the particle and powder technology of pharmaceutical processing and drug delivery systems. The
Center is hosted by Rutgers University and also includes Purdue University, the New Jersey
Institute of Technology, and the University of Puerto Rico in Mayagüez. The goal of the Center
is to become a national focal point for developing structured organic particulate systems used in
pharmaceuticals and their manufacturing processes. Rowan University has partnered as an
outreach/education member institution to develop teaching modules for K-12 and college level
students. The Rowan University efforts have focused on mobile, hands-on teaching modules
and problem sets for use in engineering courses. A pneumatic transport mobile experimental unit
has been designed and constructed for use in fluid mechanics courses and for K-12 outreach
activities, workshops and summer camps. The unit can be used for demonstrations and for
laboratory experiments. Students can apply energy balance principles to calculate velocities and
drag forces. The use of this unit in the Rowan Engineers-on-Wheels Program will be
highlighted. The problem sets developed as part of this work focus on the integration of
pharmaceutical technology into introductory-level chemical engineering courses. These problem
set modules include topics covering terminology, formulation and manufacturing techniques for
personal care products, over the counter medicines and prescription drugs. The problems are
organized for use in a material and energy balance course, and cover a wide range of subjects
from simple mass balances to heats of formation. The completed educational materials will be
incorporated into the C-SOPS website for use by Center members and faculty at other schools.
This work will serve to expand and strengthen the educational impact of the Center in the region
and throughout the country.
Introduction
The NSF-sponsored Center for Structured Organic Particulate Systems (C-SOPS) is striving to
become a focal point in pharmaceutical processing. The overall goals of the Engineering
Research Center are coordinated through carefully planned thrust areas. The thrust areas include
the major research initiatives of the Center: manufacturing science; composites structuring and
characterization; and particle formation and functionalization. Three test beds based on
programs developed from the thrust areas have been created at the Center. Development
Program I concentrates on the continuous manufacturing of pharmaceutical tablets. Continuous
tablet manufacturing processes offer significant advantages over batch processes. These
advantages include an increase in tablet uniformity and stability, reduced production and labor
costs and simplified scale up from experimental testing to full scale manufacturing1
.
Development Programs II and III focus on novel methods for drug delivery. Development
Program II focuses on the stabilization of API (active pharmaceutical ingredient) nano-particles
3. in edible substrates1, 2
. The higher surface areas of nano-particles results in higher material
bioavailability. Finally, Development Program III includes a drop-on-demand system to layer
API’s on an edible substrate1, 2
. The system could be portable and compact for use in third world
countries and military applications. Rowan University partnered with the ERC-SOPS Center in
2008 to provide outreach and training components to support the educational mission of the
Center. During the first year of the project, Rowan University worked with various constituency
groups to implement certain projects that directly impact the Center’s goals. This work has been
expanded during the subsequent two years and additional modules and course materials have
been developed.
This paper describes the progress to date. Our long term goals are to:
• train students who will be effective engineers and leaders in the manufacturing and
research operations of the pharmaceutical and allied industries of the center.
• train students for roles in education and in the agencies involved in regulating food
and drug manufacturing operations.
• integrate the Center´s research discoveries in engineered organic composite systems to
enrich the existing engineering curriculum at both the undergraduate and graduate levels
• develop educational programs for industrial practitioners and foster alliances with industry in
the education and outreach activities of the center.
• design and promote experiential programs and pedagogical material for K-12 outreach
recognizing diverse student and teacher backgrounds.
• develop a suite of modular educational units for use by the various center constituents
in formats that allow for efficient web-based dissemination.
These goals are important components of the overall center vision and are an integral part of its
mission to bring together cutting-edge research, technology transfer and next-generation training
of the technical workforce. The outreach modules3
and educational materials have been
developed by a highly qualified College of Engineering faculty team working with
undergraduate and graduate students. The following sections provide a summary of the ongoing
activities in the various projects under the Rowan University / ERC-SOPS Center partnership
umbrella. There are two major sections in this paper. The first section highlights the educational
laboratory modules and outreach experiences, and the second section highlights the textbook
problems developed as part of this work. More detailed examples of the outreach/educational
materials and problems will be presented in the final poster presentation.
Educational laboratory modules and outreach experiences
Particle properties and powder mixing experiments throughout the curriculum:
A V-mixing laboratory experience4, 5
was designed last year for students to investigate the effect
of mixing time, particle size and loading configuration in a statistical design. The experiments
and data analysis can be conducted over multiple class periods, and students were exposed to
experimental design strategies. A 5 L constant frequency V-mixer was used for laboratory
experiences in courses, projects and research. Figures 1a and b show the mixer and the loading
operation for a mixing experiment.
4. Figures 1 a) 5 L V-mixer b) Loading mixer for experiment
Factorial and response surface Box-Behnken experimental designs are used and students assess
the efficacy of experimental design strategies. Variables studied include particle size and particle
size difference, mixing time and loading configuration. Figures 2 a and b are qualitative
illustrations of three variable factorial and Box-Benhken experimental designs used in this work.
The three variables illustrated in Figures 2 a and b are mixing time, particle size difference and
loading configuration. The circles indicate experimental conditions and the vertices are the
minimum and maximum values of the variables investigated. In the case of loading
configuration, the experimental conditions refer to specific configurations (i.e. top/down, side by
side).
particle size difference
mixing time loading configuration
Figures 2 a) Factorial Design b) Box-Behnken Design
A spectrophotometric technique was developed to measure mixing quality for these
experiments5
. Different color silica particles were used so that students could easily distinguish
among different mixtures and hexane was used to dissolve a dye and carry out the
spectrophotometric measurements. One color was tracked to simplify the spectrophotometric
statistical analyses using variance and the Poole Index to measure mixing quality.
The V- Mixer laboratory was expanded this year to include the use of conductivity to measure
mixing quality. Salt (NaCl) particles were mixed with silica particles. At the conclusion of the
mixing experiment, samples were taken and placed in 25 ml of distilled deionized water. The
sampling method was previously developed5
. The conductivity of the water was measured and
from a calibration curve, the sample salt content was obtained. Figure 3 shows the calibration
curve obtained for this work. It compares well with literature values for the conductivity of
5. Figure 3: Conductivity meter calibration – NaCl in water
NaCl. Preliminary results were obtained by mixing equal amounts of NaCl and silica in the V-
mixer for five minutes at 60Hz. At the conclusion of the experiment, the NaCl mass percent in
the sample ranged from 48% to 50%. The variance of the measurements was less than
3%indicating good repeatability among measurements.
Particle density and size can impact the quality of mixing in a V- mixer. Particle
characterization is an important component of overall mixing quality determination. The Stoke’s
terminal velocity, given by Equation 1, was used to characterize particles in this work6
. Stoke’s
Law applies for Reynolds Numbers <1.
Where ρs and ρ = the density of the particle and fluid in which it falls respectively
g = the acceleration of gravity
dp = particle diameter
μ = fluid viscosity
This particle characterization allows for a single parameter to be used as a variable in the
experimental design illustrated in Figures 2. The particle size difference shown in the figure is
replaced by the particle Stoke’s Law terminal velocity. Particle size was measured as part of this
work using a shaker. Φ50 values were used as estimates of average particle sizes.
Pneumatic Transport Demonstration:
A pneumatic transport demonstration was designed and constructed. This unit will be used in a
process fluids transport course, and to demonstrate energy balances in a fluid mechanics course.
y = 0.070x - 0.208
R² = 0.991
0
1
2
3
4
5
6
0 10 20 30 40 50 60 70 80
MassPercentNaCl
Conductivity(mS)
Conductivity Calibration
(1)
6. Figure 4 shows the unit. A more portable unit was also designed for outreach applications.
Figure 4: Pneumatic transport unit
The pneumatic transport unit can be constructed from a variety of materials. The part inventory
for the unit depicted in Figure 4 is listed below.
Table 1: Part Inventory For Pneumatic Transport Apparatus
ITEM QTY. SPECIFATION DESCRIPTION
1 6 ft 2" ID - 2.5" OD Tygon®
PVC Tubing (0.25" wall)
2 2 ft 1.75" OD 1.5" ID Poly-Carbonate Round Tube (clear - 0.125" wall)
3 2 1.0" NPT Brass Ball Valve - Female Connections
4 2 1.0" Medium-Pressure Cast Brass Threaded Pipe Fitting, TEE
5 2 1" Male X 1/2" Female Medium-Pressure Cast Brass Threaded Pipe Fitting, Hex Bushing
6 400 0.125" DIA. Nylon Spheres
7 4 0.5" NPTF Std. Brass Compression Tube Fitting Adapter Male Pipe
8 1 0.5" TUBE OD
Brass Ball Valve w/ YOR-LOK Fittings Diverting 3-port Ultra High
Pressure
9
6" x
6"
0.125" spacing Std. Screen/Mesh Air Distributor
10 1 1/2" class 150 Bronze Globe Valve 1" NPT Female - Throttling Valve
11 N/A 0.5" TUBE OD Unspecified length (can vary)
12 4 1"
Thick-wall Brass Threaded Pipe Nipple, Sch 80,11/16" Thread
Length
13 1 10-60 SCFM @ STP Rotameter/Flowmeter
The unit allowed for the
transport of particles from
one side to the other.
Different shape and size
particles can be used. Also,
different color particles add
visual appeal to the
demonstration. This is
especially valuable for
demonstrations with younger
students.
7. Hands-on demonstrations of particle properties:
A series of demonstrations were developed last year.5
Figures 5 through 8 show the
demonstrations illustrating arching in hopper flow, the effect of particle size on segregation,
compression forces generated during particle flow and the rise of a large particle in a bed of
smaller particles.
Figure 5: Arching in hopper flow Figure 6: Tumbler apparatus for segregation demonstration
Figure 7: Compression forces generated during particle flow Figure 8: Rise of large particle in bed of smaller particles
These demonstrations were refined this year and used in several outreach programs including
summer workshops for teachers and Science, Math and Related Technology programs at
Delaware Girls Inc. The demonstrations are presently being included in the Rowan Engineers on
Wheels program. The demonstrations will continue to be expanded and used in courses and
outreach programs.
Problem Modules for Introductory Chemical Engineering Courses
Problem sets have been developed on pharmaceutical technology for integration into
introductory-level chemical engineering courses. These modules include topics covering
terminology, formulation and manufacturing techniques for personal care products, over the
counter (OTC) medicines and prescription drugs. The problems are organized for use in a
material and energy balance course and cover a wide range of subjects from simple mass
balances to heats of formation.
8. This component of the ERC outreach effort is the development of problem sets for use as in-class
examples and homework problems for chemical engineering courses. The goal of this work is to
translate organic particulate systems manufacturing concepts and research being done the Center
into educational materials that can be used at various levels5,7,8
. The problem sets are curriculum
modules tailored to specific age levels by varying the technical content level of the problems.
Each curriculum module consists of a multi-part problem statement with a link to an ERC area,
relevant literature references, and fully executed solution.
During the last several years, the focus was on problem sets for introductory chemical
engineering courses such as material and energy balances7,8
. Concepts in drug formulation,
manufacturing and delivery were integrated with the educational objectives of the course in a
way that makes it easy for a professor to use. Problem sets consisting of a problem statement
and fully executed solution are presented in the module organized to follow the logical sequence
in an introductory course. These include problems in basic concepts in pharmaceutical
technology related to unit conversions and engineering calculations. Mass and energy balance
calculation problems focus on pharmaceutical engineering operations such as blenders, dryers,
tablet presses, etc. Problems related to stoichiometry focus on API synthesis. Various OTC drug
and consumer products are used as the basis for example problems related to single and multi-
phase equilibria, heats of mixing, heat or formation and degradation.
The problems are being designed for inclusion in the next edition of the textbook Elementary
Principles of Chemical Processes by Felder, Rousseau, and Newell9
. Therefore, each problem
has a designated concept/chapter/section mapping. The successful framework and concepts
already started by students last year was used to produce modules that are of significant quality
and suitable for inclusion into textbooks, journal papers/proceedings and web-based media.
Problems are posted on the PharmaHUB (www.PharmaHUB.org) under the ERC Educational
Modules resources section7,8
. The students at Rowan who develop these problems have a close
interaction with graduate student liaisons from the ERC schools for background material on
research activities of the Center as well as feedback on the technical content of the educational
materials.
The following examples illustrate the type of problems developed for the various topical areas.
Complete problem sets can be obtained through the PharmaHUB.
Cholesterol Drug Manufacturing Process10
:
Topics covered: Material balance; Multiple unit process; Pharmaceutical manufacturing unit
operations
Problem Statement:
About one in five Americans has a cholesterol level of above 200 mg/dL, this is considered to be
very unhealthy11
. A pharmaceutical company sets up a batch process in order to manufacture
1000 Cholesterol tablets used to lower the LDL and raise the HDL cholesterol12
.
The process of creating these tablets13
is initiated by adding equal amounts of two active
ingredients and 50.16 g of a filler to a kneading mixer. Once this is done another stream of
9. excipients consisting of 90.7% liquid by mass is added to the kneader. The resulting liquid
mixture consists of two parts water and one part ethanol.
The kneading mixer produces a wet mass called a cake, which is spread over trays and kept in an
oven at 45°C for eight hours. During the course of this time 17.3 wt% of the mass of the cake is
evaporated. This dry substance is blended with a lubricant and a binder, it is then finally sent to
be compressed into 100 mg tablets. The end product (tablets) has the following composition (%
wt): 20% API, 51.7% excipients, 27.5% binder and the remaining lubricant. How much of each
liquid is added to the kneader?
Problem Solution:
It is a good practice to draw the diagram with the given description.
Mixer
Crusher
Dryer
Kneader
50.16 g Excipient
API
xliquid = 0.907
100 mg/tablet
X API = 0.2
X ex = 0.517
X binder = 0.275
Lubricant
Binder
It is known that each tablet weighs 100 mg and the process produces 1000 tablets. Based on the
finished tablet formulation a calculation of the weight of 1000 tablets and its contents can be
performed.
100 mg
tablet
x
1 g
1000 mg
x 1000 tablets = 100 g for 1000 tablets
𝑚Binder = 100g 0.275 = 27.5 g Binder
𝑚Lubricant = 100g 0.008 = 0.8 g Lubricant
𝑚APIs = 100 g 0.20 = 20 g API for two APIs
𝑚excipients = 100 g 0.517 = 51.7 g
Mass exiting from the dryer
Mass leaving the dryer is equal to the mass of API and excipients
Mass exiting the dryer = 𝑚API + 𝑚ex = 20 g + 51.7 g = 71.7 g
10. The dryer evaporates 17.3 wt% of the mass entering, so 82.7 wt% of the mass is still left in the
dryer which is the mass that’s exiting the dryer.
Mass balance on the dryer:
𝑚in = 𝑚evap + 𝑚out
𝑚evap = 0.173𝑚in
𝑚in = 0.173𝑚in + 𝑚out → 0.827𝑚in = 𝑚out → 𝑚in =
71.7g
0.827
= 86.7
𝑚evap = 𝑚in − 𝑚out = 86.7 g − 71.7 g = 15.0 g
Mass entering the dryer is the same mass exiting the kneader. There are two streams entering the
kneader, one with the API and excipients and the other with excipients containing 90.7 wt%
liquid. It is also known that the 90.7 wt% liquid contains water and 95% ethanol, and there is
twice as much water as ethanol.
The mass of the API is found to be 20.0 g in the initial steps and the problem statement gives the
weight of the excipient in the stream with the API. A mass balance around the kneader can now
be performed to find the contents of each stream.
Mass balance around the kneader:
𝑚1
stream with API
+
𝑚2
stream with liquid = 𝑚3 = 86.7 g
𝑚1 = 𝑚API + 𝑚ex = 20.0 g + 50.16 g = 70.16 g
𝑚2 = 𝑚3 − 𝑚1 = 86.7 g − 70.16 g = 16.54 g
𝑚liquid = 0.907𝑚2 = 0.907 16.54g = 15.0 g
Using ratios of 2 parts water to 1 part ethanol, the mass of each can be calculated.
15g = 3𝑥
𝑥 = 5.0 g ethanol
2𝑥 = 10.0 g water
This problem illustrates the following engineering principles: batch process calculations,
multiple unit processes, solid and liquid properties. It introduces the pharmaceutical concepts of
drug formulation terminology (API, binder, lubricant, etc), and pharmaceutical engineering
processes (mixers, kneaders, blenders, dryers).
Through this problem, the instructor can introduce the concept of drug formulation and the role
of the API and excipients. This is helpful in providing students with the terminology of the
pharmaceutical industry. It uses the example of a cholesterol lowering medication, since these
are among the most widely prescribed drugs on the market. Most problems in a material and
energy balance course introduce students to unit operations (distillation, extraction, continuous
stirred tank reactors, etc) which are prevalent in traditional chemical processing. This problem
provides student with examples of pharmaceutical engineering processes such as blenders,
kneading mixers, and cake dryers used in manufacturing.
11. Vapor Pressure of Surfactant in Medicinal Shampoo14
:
Topics covered: Multiphase Systems, Colligative Solution Properties, OTC Pharmaceutical
Formulations
Problem Statement:
Shampoos are composed principally of a surfactant (essentially soap), with various other
functional (plasticizers, binders, fillers) and decorative (lather enhancers, fragrances, colors)
ingredients added to suit specific regulation or marketing demands.15
Trichologic (hair/scalp)
complaints are frequently treated by the use of medicated shampoos, which contain some
effective ingredient for treating the condition.
Two popular surfactants (which you may have seen on the ingredient list of shampoo) are
sodium lauryl and sodium laureth sulfate. You are researching the feasibility of including
pyrithione zinc, a common anti-dandruff medication, in the new surfactant sodium super sulfate
(SSS). The solution of pyrithione zinc in SSS has a markedly lower vapor pressure than pure
SSS, which is fortunate since SSS boils at a low enough temperature (80 °F) already.
If the heat of vaporization of sodium super sulfate is 15 kJ/mol determine the lowest viable molar
fraction. Remember this is going to be used in hot showers as well as stored at room temperature.
Solution:
This is an exploration of colligative solution properties and an examination of possible
applications of this interaction.
By reading the problem statement, students can see that they need to determine boiling point
temperature as a function of composition of a solution of SSS and pyrithione zinc. A review of
Felder & Rousseau Section 6.5c (colligative solution properties) gives the equation below:
∆𝑇b = 𝑇bs − 𝑇b0 =
𝑅𝑇b0
2
∆𝐻v
𝑥
Since it is necessary to find what amount of pyrithione zinc in SSS will raise the boiling
temperature to a reasonable value, it makes sense to rearrange the equation:
𝑇bs =
𝑅𝑇b0
2
∆𝐻v
𝑥 + 𝑇b0
It should be obvious to students (possibly after a suggestion, if they don’t like or didn’t have
graphical algebra) that this is slope-intercept form:
𝑦 = 𝑚𝑥 + 𝑏
Because it looks complex and takes some time to calculate, it is worth simplifying the
coefficient:
12. 𝑅𝑇b0
2
∆𝐻v
= 8.314
J
mol ∙ K
× 80 + 459 °R 2
×
1
15
mol
kJ
×
1
1.8
K
R°
×
1
1000
kJ
J
= 89 R° = 89 F°
Note the necessity of converting to an absolute temperature scale (Rankine, as shown here, or
Kelvin) to match the absolute temperature scale of the gas constant. Also note the equivalency of
Rankine and Fahrenheit degrees.
Putting this into the equation:
𝑇bs = 89𝑥 + 80 °F
The students are now faced with a practical problem: What constitutes “viable” for the purposes
of this problem? What temperature range should be considered appropriate? OSHA stipulates
that water should not be less than 50°C at the showerhead to prevent incubation of Legionnaire’s
Disease16
, however this is scalding17
. Assuming that people won’t care if their shampoo boils
when they are already being scalded, take 50°C as the minimum temperature.
Converting to degrees F:
𝑇 °F = 1.8𝑇 °C + 32
𝑇 °F = 1.8 × 50 °C + 32
𝑇 °F = 122 °F
And now substituting:
122 − 80
89
= 𝑥
𝑥 = 0.47
It is left to the student to suggest that this is a rather high fraction for a solute in a solution.
This problem illustrates the following engineering principles: boiling point of solution as a
function of temperature, process design (temperature of water). It introduces the pharmaceutical
concepts of drug formulation terminology: surfactant, API, etc, and OTC solid-liquid solution
formulations.
Summary
The laboratory experiences and the textbook problems described here serve to educate students
on the research and technology associated with pharmaceutical processing. The modules will be
integrated into the CSOPS website for distribution to faculty within the Center and other schools.
The modules will also be used in college level courses and in outreach efforts for middle and
high school students and teachers. The laboratory modules illustrate a wide range of
pharmaceutical technologies and operations. They can be used to show how concepts of physics,
chemistry and engineering contribute to pharmaceutical manufacturing, research and
development. The problems developed as part of this work are intended for use in sophomore
level chemical engineering courses. Each problem introduces topics related to pharmaceutical
technology and is directly related to a process, tablet formulation, drug delivery, or
pharmaceutical equipment. All of the problem descriptions are based on realistic technology in
use or currently under development. Students must use principles of chemical engineering they
13. are learning in their courses to solve the problems. Detailed solutions are provided with each
problem. These solutions can be used by faculty to assist in the presentation of the problem, or
distributed directly to students. The problems have been reviewed by multiple team members and
faculty. They will be distributed to sophomore classes at Rowan University to obtain feedback
from students in the type of course where the problems could be used. Feedback on the
educational modules will be obtained as well in an effort to continuously enhance and improve
the material. The goal is for students to become familiar with pharmaceutical applications of
powder and particle technology, and to practice the material they are learning in class in a
realistic application of pharmaceutical technology. Students will become familiar with an
important technology in chemical engineering and the impact of the Center will be expanded
through increased student interest in pharmaceutical engineering.
Acknowledgements
ERC-SOPS is funded by NSF grant # 0540855
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