1. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
Career Vision Statement
To invest the entire breadth of my training and experience toward improving the human
condition through the understanding of the diverse factors which affect human health.
Education
M.P.H. Biostatistics, 2010, Department of Biostatistics, University of North Carolina at Chapel Hill,
Chapel Hill, NC.
M.S., Environmental Analytical Chemistry, 1974, University of North Carolina at Chapel Hill, Chapel
Hill, NC.
B.S., Chemistry (graduated cum laude), 1972, Moravian College, Bethlehem, PA.
Undergraduate Research Program, National Science Foundation, 1971, Muhlenberg College,
Allentown, PA.
Continuing Education
Continuing Statistical Training: Non-Detects and Data Analysis, Atlanta, GA; Structural Equation
Modeling, Instructor: Dr. Ken Bollen, UNC-CH; R programming, Johns Hopkins University
online.
Formal SAS training: Advanced Programming, Advanced Macros, Graphics, SAS/Internet,
Intermediate Statistics, SQL, Applied Clustering Techniques. SAS Institute, Cary, NC.
Professional Summary
Research Scientist (biostatistician) in the Technology for Industry and the Environment Division at
RTI International; Focused research efforts toward the understanding of adverse health outcomes
resulting from environmental chemical exposure; Experience gained from significant leadership
contributions to more than 60 research contracts and grants; Early career, instrumental in developing
analytical chemistry methodologies for measuring both organic and inorganic species in a broad array of
environmental and biological media, as well as developing the sample collection strategies needed for the
field studies that acquired these diverse media.
Drawing directly from experience in analytical chemistry to broaden quantitative technical expertise
into environmental and health data management and statistical data analysis through formal training in
biostatistics; Supporting complex data analysis requirements, designed and constructed nearly all of the
data processing applications used to support RTI’s chemical exposure assessment programs for more than
25 years, primarily using SAS; Data analysis and statistics experience encompasses the breadth of
classical stochastic, descriptive, and inferential parametric and non-parametric processes, including data
summaries (quantitative and graphical), correlations, linear and logistic regressions, Monte Carlo
simulations, longitudinal analyses, multivariate analyses, and cluster analyses; Working closely with
exposure epidemiologists, demonstrated extensive experience with incorporation and analysis of
questionnaire data into complex data structures.
Career Experience
RTI International, Research Triangle Park, NC; (1976-2014)
2000-2014: Research Scientist/Biostatistician, Exposure Assessment Research Program, Discovery-
Science-Technology. Design, construction, and management of complex SAS datasets for exposure
assessment programs. Transport complex environmental and biological file structures from diverse
and specialized data formats. Construct SAS programs to support statistical data analysis, applying
advanced SAS macro techniques. Design and develop manual and automated SAS-based processing
algorithms for computational processing of analytical and clinical chemistry results. Perform
intermediate and advanced statistical analyses on environmental and biological data compiled from
observational and experimental studies. Create publication-ready graphics and reports from SAS for

2. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
presentations, project reports and peer-reviewed publications. Perform multivariate principal
components and cluster analyses on metabolomics data using SAS and SIMCA.
1976-2000: Research Analytical Chemist,
University of North Carolina at Chapel Hill, Chapel Hill, NC (1974-1976).
Advanced methods development, sampling and analysis for
hazardous organic and inorganic substances in environmental and biological media incorporating gas
chromatography (GC/MS) and liquid chromatography. Develop and apply capabilities in liquid
chromatography with electrochemical detection. Perform electrochemical analyses for metals using
anodic-stripping voltammetry. Serve as System Administrator for VAX/VMS, later Microsoft
Windows NT and 2000, chromatography data systems.
Research Technician 3
Moravian College, Bethlehem, PA (1970-1972).
, Department of Environmental Sciences and Engineering. Develop
electroanalytical methodologies for the study of metal–organic interactions in aquatic and marine
waters using anodic-stripping voltammetry, cyclic voltammetry, and rotated ring-disk techniques.
Laboratory Instructor, Chemistry Department. Prepared and instructed undergraduate general and
organic chemistry laboratories.
Technical Expertise and Competencies
 Statistical Data Analysis.
▫ Qualitative and quantitative inferential statistical analyses and tests of hypotheses
▫ Statistical determination of analytical method detection limits, method precision, and accuracy
▫ Application of linear and logistic regression analyses using simple and repeated measures models.
▫ Monte Carlo simulations and sensitivity analysis to estimate analytical method uncertainties
▫ Qualitative graphical analyses and custom reports to support presentations and peer-reviewed
publications.
▫ Application of principal components and cluster analysis techniques
 Data Management/Database Development.
▫ Design, construction, and management of large, complex SAS databases from a diversity of file
types and structures
▫ Creation of SAS programs to support complex statistical data analysis using advanced macro
procedures
▫ Application of SQL to database construction and query
▫ Appointed Data Manager on numerous small and large public- and private-sponsored projects
▫ Preparation of reports and data summaries
▫ Analytical chemistry data system administration employing HP Basic, Digital VMS, Windows
NT, and Windows 2000 operating systems
 Environmental Databases.
▫ Extract, summarize, and analyze human exposure measurements and demographic information
from publicly accessible databases, including AQS and NHANES.
 Study Design.
▫ Design of human exposure studies, including formulation of project strategies to accomplish study
objectives and test study hypotheses.
 Quality Assurance
▫ Preparation of quality control documents, including quality systems implementation plans, Quality
Assurance Project Plans, validation plans, and validation reports.
▫ Design and implemented of hardware and software validation efforts in support of U.S. Food and
Drug Administration and EPA regulations.
▫ Directed studies within compliance guidelines established by GLP regulations.
 Ecological and Human Exposure Measurement and Monitoring.
▫ Design and execution of field methods for the collection of air, water, soil, wastewater, dust,
vegetation, food, beverage, blood, urine, and breath.

3. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
▫ Extensive array of organic (from volatile organic compounds to polychlorinated biphenyls) and
inorganic moieties.
▫ Direct field efforts in many geographic and climatologic domains.
▫ Human exposure monitoring
▫ Developed analytical methods for organic and inorganic species in environmental and biological
matrices. Created and validated numerous analytical methods to determine VOCs, pesticides,
polycyclic aromatic hydrocarbons, in ambient and personal air and in water.
Selected Project Experience
 Children’s Health After the Storm (CHATS, Centers for Disease Control and Prevention).
Laboratory Data Manager and principal liaison to all medical, chemistry and microbiology
laboratories. Compile and evaluate extensive laboratory-based environmental and biological sample
analysis results using statistical approaches. Perform inferential statistical analyses to investigate
relationships between environmental and biological measurements.
 Various Office of Air Quality Planning and Standards Project Work Assignments, (U.S. EPA
Office of Air Quality Planning and Standards). Technical and fiscal Work Assignment Leader and
Lead Statistician on numerous projects.
 Environmental Conditions and Child Outcomes. (National Institutes of Health). Perform
explorations of the AQS and NHANES databases. Conduct statistical modeling of cognitive
outcomes with metals exposures and psycho-social factors. Spatial integration of ambient air
monitoring data into cognitive outcome models.
 Children’s Dietary Intake Models. (U.S.EPA Office of Research and Development) Technical and
fiscal Work Assignment Leader and Statistician. Perform summary and inferential statistical analyses
of dietary pesticide data extracted from publically-accessible databases. Conduct modeling of
pesticide measurements to predict distribution of exposures in children.
 Epidemiologic Evaluation of Perfluorooctyl Compounds as Endocrine Disruptors in Males.
(National Institute of Environmental Health Sciences) Data management and statistical modeling.
Compile perfluorcarbon measurements in biological fluids, hormones measurements and
questionnaire data. Conduct statistical model development and application, leading toward successful
publication.
Selected Publications
Melnyk, L.J., J. Xue, G.G. Brown, M.S. McCombs, M. Nishioka, and L.C. Michael. 2014. Dietary intakes
of pesticides based on community duplicate diet samples. Sci. Total Environ. 468-469:785–790.
Melnyk, L.J., M.S. McCombs, G.G. Brown, J.H. Raymer, M. Nishioka, S. Buehler, N. Freeman, and L.C.
Michael. 2012. Community duplicate diet methodology: A new tool for estimating dietary exposures
to pesticides. Journal of Environmental Monitoring 14:85–93.
Melnyk, L.J., M. Byron, G. Brown, A. Clayton, and L. Michael. 2011. Pesticides on household surfaces
may influence dietary intake of children. Environmental Science & Technology, 45, 4594–4601
Raymer, J.H., L.C. Michael, W.S. Studabaker, G.W. Olsen, C.S. Sloan, T. Wilcosky, and D. K. Walmer.
2011. Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their
associations with human semen quality measurements. Reproductive Toxicology. June 29. Epub ahead
of print.
Raymer, J.H., and L.C. Michael. 2010. Uptake of water disinfection by-products into food. RTI Press
Publication No. MR-0016-1008. Research Triangle Park, NC: RTI International.
Raymer, J.H., G. Akland, T.R. Johnson, T. Long, L. Michael, L. Cauble, and M. McCombs. 2009.
Microenvironmental characteristics important for personal exposures to aldehydes in Sacramento, CA,
and Milwaukee, WI. Atmospheric Environment 43:3910–3917.

4. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
Helburn, R., J. Albritton, G. Howe, L. Michael, and D. Franke. 2008. Henry’s law constants for fragrance
and organic solvent compounds in aqueous industrial surfactants. Journal of Chemical & Engineering
Data 53:1071–1079.
Flanagan, J.B., L.C. Michael, R. Jayanty, K. Baumann, and P.A. Solomon. 2008. Intercomparison of PMF
receptor modeling results using data from collocated IMPROVE and CSN PM2.5 chemical speciation
sites. Pp. 264–265 in the Air and Waste Management Association’s (A&WMA’s) 101st Annual
Conference & Exhibition—Abstract Book (No. 539). Portland, OR. June 24–26.
Whitmore, R.W., E.D. Pellizzari, H.S. Zelon, L.C. Michael, and J.J. Quackenboss. 2005. Cost/variance
optimization for human exposure assessment studies. Journal of Exposure Analysis And
Environmental Epidemiology 15(6):464–472.
Raymer, J.H., G. Akland, T.R. Johnson, T.R. Long, L.C. Michael, and L. Cauble. 2002. Factors
associated with personal exposure to aldehydes and other pollutants in Sacramento and Milwaukee.
Epidemiology 13(4):145.
Pellizzari, E.D., D.J. Smith, C.A. Clayton, L.C. Michael, and J.J. Quackenboss. 2001. An assessment of
the data quality for NHEXAS–Part I: Exposure to metals and volatile organic chemicals in Region 5.
Journal of Exposure Analysis And Environmental Epidemiology 11(2):140–154.
Pellizzari, E.D., L.C. Michael, K.W. Thomas, P.G. Shields, and C. Harris. 1995. Identification of
1,3-butadiene, benzene, and other volatile organics from wok oil emissions. Journal of Exposure
Analysis And Environmental Epidemiology 5(1):77–87.
Lindstrom, A.B., V.R. Highsmith, T.J. Buckley, W.J. Pate, and L.C. Michael. 1994. Gasoline-
contaminated ground water as a source of residential benzene exposure–A case study. Journal of
Exposure Analysis And Environmental Epidemiology 4(2):183–195.
Hartwell, T.D., R.L. Perritt, E.D. Pellizzari, and L.C. Michael. 1992. Results from the 1987 Total
Exposure Assessment Methodology (TEAM) Study in southern California. Atmospheric Environment.
Part A. General Topics 26(8):1519–1527.
Lindstrom, A.B., R.M. Taft, L.C. Michael, and M.C. Oberg. 1991. Bake-out of a portion of a new high-
rise office building. In Proceedings of the 84th A&WMA Annual Meeting, Vancouver, BC. June.
Michael, L.C., E.D. Pellizzari, and D.L. Norwood. 1991. Application of the master analytical scheme to
the determination of volatile organics in wastewater influents and effluents. Environmental Science &
Technology 25(1):150–155.
Michael, L.C., E.D. Pellizzari, R.L. Perritt, T.D. Hartwell, D. Westerdahl, and W.C. Nelson. 1990.
Comparison of indoor, backyard and central air monitoring strategies for assessing personal exposure
to volatile organic compounds. Environmental Science & Technology 24(7):996–1003.
Wallace, L.A., E.D. Pellizzari, T.D. Hartwell, V. Davis, L.C. Michael, and R.W. Whitmore. 1989. The
influence of personal activities on exposure to volatile organic compounds. Environmental Research
50:37–55.
Selected Presentations
Melnyk, L.J., G.G. Brown, and L.C. Michael. 2012. Inadvertent Ingestion Exposure to Permethrin
Pesticides. Poster presented at the Joint Annual Conference of the International Society for
Environmental Epidemiology and International Society for Exposure Analysis, Seattle, WA.
Raymer, J.H., W. Studabaker, M. McCombs, L. Michael, S.H. Cho, and D. Wagener. 2012. The Impact of
Pre-Deployment Badge Storage on Formaldehyde Measurements in the CHATS Study. Poster
presented at the Joint Annual Conference of the International Society for Environmental Epidemiology
and International Society for Exposure Analysis, Seattle, WA.
Brown, G.G., L.C. Michael, and L.J. Melnyk. 2011. Regression Modeling of Pesticide Intakes from
Composited Food Samples. Poster presented at the Joint Annual Conference of the International
Society for Environmental Epidemiology and International Society for Exposure Analysis, Baltimore,
MD.
Melnyk, L.J., M.S. McCombs, G.G. Brown, M. Nishioka, and L.C. Michael. 2010. Dietary Intakes of
Pesticides from the Collection of Community Duplicate Diet Samples. Presented at the Joint Annual

5. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
Conference of the International Society for Environmental Epidemiology and International Society for
Exposure Analysis, Seoul, Korea.
Michael, L.C., L.J. Melnyk, G.G. Brown, M.S. McCombs, J.H. Raymer, and M. Nishioka. 2009.
Feasibility of the Community Duplicate Diet Methodology—Part 2: Statistical Simulations to Inform
Sample Compositing and Study Design. Poster presented at the 2009 Joint Annual Conference of the
International Society for Environmental Epidemiology and International Society for Exposure
Analysis, Minneapolis, MN.
Flanagan, J.B., L. Michael, R.M. Jayanty, K. Baumann, and P.A. Solomon. 2008. Intercomparison of
PMF Receptor Modeling Results Using Data From Collocated IMPROVE and CSN PM2.5 Chemical
Speciation Sites. Presented at the 101st A&WMA Annual Conference and Exhibition, Portland, OR.
June.
Flanagan, J.B., M.R. Peterson, R. Jayanty, and L.C. Michael. 2008. Intercomparison of OC/EC Data at
Two PM2.5 Monitoring Networks in the U.S. Poster presented at the American Association for Aerosol
Research’s (AAAR’s) 27th National Conference [American Association for Aerosol Research],
Orlando, FL. October.
Jayanty, R., L.C. Michael, and J.B. Flanagan. 2008. Intercomparison of Two PM2.5 Monitoring Networks
in the U.S. Presented at 2008 European Aerosol Conference (EAC2008), Thessaloniki, Greece.
August.
Raymer, J.H., B.M. Marriott, L. Olso, L.C. Michael, T.R. Fennell, J. Busby-Whitehead, N. Tulve, and
K.W. Thomas. 2008. Factors Important to Defining Susceptibility of the Aging Population to the
Effects of Environmental Exposures. Poster presented at the Joint Annual Conference of the
International Society for Environmental Epidemiology and International Society for Exposure
Analysis, Pasadena, CA. October.
Raymer, J.H., W. Studabaker, L.C. Michael, A.Murtha, C. Emond, and L. Birnbaum. 2007. Potential
Media for Monitoring In Utero Exposure to 2,2’,4,4’-Tetrabromodiphenyl Ether. Presented at the 17th
Annual Meeting of the International Society of Exposure Analysis (ISEA), Durham, NC. October 15–
18.
Michael, L.C., J.H. Raymer, W. Studabaker, M. McCombs, and Y.A. Hu. 2007 Assessment of Differential
Exposures of Adults and Children to Pyrethroid Pesticides in Residential Environments. Presented at
the 17th Annual ISEA Meeting, Durham, NC. October 15–18.
Studabaker, W.B., J.H. Raymer, Y.A. Hu., L.C. Michael, M. Spruill-McCombs, and D.B. Barr 2007.
Pyrethroid Hydrolysis Products as Potential Confounders of the Assessment of Exposure to Pyrethroid
Pesticides. Poster presentation at the 17th Annual ISEA Meeting, Durham, NC. October 15–18.
Michael, L.C., J.B. Flanagan, M.R. Peterson, and R.K.M. Jayanty. 2007. Analysis of PM2.5 Speciation
Network Carbon Blank Data. Poster presented at RTI Fellow Symposium, RTI International, Research
Triangle Park, NC.
Flanagan, J.B., R.K.M. Jayanty, L.C. Michael, E.E. Rickman, P.A. Solomon, J.J. Lantz, and C. McDade.
2007. Multi-year Intercomparison of Collocated STN (CSN) and IMPROVE Monitors. Presented at
AAAR’s 26th Annual Conference, Reno, NV. September 24–28.
Melnyk, L., M. Byron, G. Brown, A. Clayton, and L.C. Michael. 2006. Modeling Excess Dietary
Exposure. Poster presented at the Annual ISEA Meeting, Paris, France. September.
Thomas, K., S. Buehler, N. Wilson, S. Gordon, J.H. Raymer, L. Michael, and W. Studabaker. 2006.
Environmental Stressor and Exposure Information for Older Adults. Poster presented at ISEA’s
Annual Meeting, Paris, France. September.
Raymer, J.H., Y. Hu, L. Michael, W. Studabaker, M. McCombs, L. Ellis, J. Deese-Spruill, and J. Knight.
2005. Longitudinal Study of Children’s Exposures to Pyrethroid Pesticides. Presented at ISEA’s 15th
Annual Meeting, Tucson, AZ. October.
Raymer, J.H., W. Studabaker, L. Michael, B. Childs, K. Briggs, C.E. Garner, and A.C. Licata. 2005. In
Utero Exposures to Polybrominated Diphenyl Ethers: The Development of a Physiologically Based
Pharmocokinetic Model. Poster presented at ISEA’s 15th Annual Meeting, Tucson, AZ. October.

6. LARRY CHARLES MICHAEL, MS, MPH
216 VALLEY PARK DR., CHAPEL HILL, NC 27514 919-357-2080 LCMICH813@GMAIL.COM
July 2015
Raymer, J.H., G. Akland, T.R. Johnson, T. Long, L. Michael, L. Cauble, M. Spruill, and B. Childs. 2003.
Factors Associated with Personal Exposure to Aldehydes and Other Pollutants in Sacramento and
Milwaukee. Poster presented at ISEA’s 13th Annual Conference, Stresa, Italy. September 21–25.
Raymer, J.H., J. Rench, M. Spruill, L. Thalji, L. Michael, G. Akland, and R. Fortmann. 2003. Evaluation
of a Remote Exposure Monitoring Strategy for Use in Longitudinal Cohort Studies. Poster presented at
ISEA’s 13th Annual Conference, Stresa, Italy. September 21–25.
Raymer, J.H., G. Akland, T.R. Johnson, T. Long, L. Michael, L. Cauble, M. Spruill, and B. Childs. 2002.
Factors Associated with Personal Exposure to Aldehydes and Other Pollutants in Sacramento and
Milwaukee. Presented at ISEA’s 12th Annual Conference, Vancouver, British Columbia, Canada.
August 11–15.
Raymer, J.H., G. Akland, T.R. Johnson, T. Long, J. Bruce, B. Childs, and L. Michael. 2001. Human
Exposure to Aldehydes in the Urban Environment: Influence of Microenvironment and Activity.
Presented at ISEA’s Annual Meeting, Charleston, SC. November.