Frankenstein swings between hope and despair in the following ways:
1) Victor Frankenstein initially feels hopeful when creating life through science but then despairs at the monster's horrible appearance.
2) The monster finds hope in helping others unknown to them but Victor feels despair upon discovering the monster.
3) The monster causes further despair through a series of murders while wanting to create a female monster gives hope to him but despair to Victor.
4) Both Victor and the monster ultimately meet a despairing end through death, leaving interpretations of the novel's themes open-ended.