Pakistan's relations with the US deteriorated after the 2016 US presidential election due to several factors. The new US policy in South Asia blamed Pakistan for failures in Afghanistan and demanded that Pakistan stop providing safe havens to terrorists. This policy was rejected by Pakistan and China but welcomed by India and Afghanistan. The Afghan factor also negatively impacted Pakistan-US relations as Afghanistan tilted more towards India with Indian influence growing in the country. The conclusion recommends that Pakistan reorganize its regional policies, improve civil-military relations, pursue diplomatic engagement, focus on its own interests above aid, and seek reliable alliances to manage deteriorating relations with the US.