PHARMACY AND THERAPEUTIC COMMITTEE

1. SUBMITTED BY UNDER THE GUIDANCE OF
PYDALA SAI PRASANNA Dr. G. RAMESH PHARM. D
15AB1T0021 DEPARTMENT OF
IV PHARM. D PHARMACY PRACTICE
VIGNAN PHARMACY COLLEGE
(Approved by AICTE & PCI Affiliated to JNTU KAKINADA)
VADLAMUDI, GUNTUR DIST, ANDHRA PRADESH, INDIA, PIN: 522 213

2. DEFINITION:
The pharmacy and therapeutics committee is a
policy faming and recommending body to the
medical staff and the administration of hospital on
matters related to therapeutic use of drugs.

3. OBJECTIVE OF PHARMACYAND
THERAPEUTICS COMMITTEE
The pharmacy and therapeutics have three major
rules to play. These
are:
ADVISORY
EDUCATIONAL
DRUG SAFETY AND ADVERSE DRUG
MONITORING

4. COMPOSITION OF PHARMACY AND
THERAPEUTIC COMMITTEE:
 Composition of pharmacy and therapeutics committee (PTC) might
vary from hospital to hospital.
The following scheme is suggested for general adoption: The PTC may
be composed of:
At least three physicians from the medical staff
A pharmacist
A representative of the nursing staff
An hospital administrator with his/her designated an ex-officio member
of the committee one of the physicians may be appointed as the
chairman of PTC.

5. CONTINUE…..
 MEDICAL STAFF HOSPITAL PHARMACIST (CHAIRMAN)
 ADMINISTRATORS (SECRETARY) (DIRECTOR)
 PHARMACY AND TERAPEUTICS COMMITTEE
 SUB-COMMITTEES
 SUB-COMMITTEE -1
 Neo-plastics
 SUB-COMMITTEE-2
 Anti-infectives

6. CONTINUE……
 SUB-COMMITTEE-3
 Cardio-vascular dugs
 Diuretics
 Cardiac glycosides
 Hypotensives
 Vasodilators
 Anti-coagulants
 SUB-COMMITTEE-4
 Gastro-intestinal drugs
 Autonomic

7. CONTINUE…...
 SUB-COMMITTEE-5
 CNS agents
 Analgesics
 Psychotherapeutics
 Respiratory & Cerebral Stimulants
 Sedatives & Hypnotics
 SUB-COMMITTEE-6
 Endocrine agents
 Anti diabetic agents
 Anti-inflammatory agents
 Hormones
 Thyroid Preparations.

8. OPERATION OF PHARMACY AND
THERAPEUTICS COMMITTEE:
 This committee should meet regularly at least six times in An year and
also when necessary.
 The agenda and the supplementary materials should be prepared by the
secretary and furnished to the committee Members well in advance so that
the members can study them properly before meeting.
 A typical Agenda may consists of following:
 Minutes of the previous meeting
 Review of the contents of the Hospital Formulary for the purpose of
bringing it up to date, and deleting of products not considered for use
 Information regarding new drugs which may have become commercially
available.

9. ROLE OF PHARMACYAND THERAPEUTICS
COMMITTEE (PTC) IN DRUG SAFETY:
 Drug safety is the moral, legal and professional obligation of pharmacist in
western countries.
 It includes responsibility from dispensing of drugs to drug administration.
 Following guidelines may sub serve the committee in ascertaining the adequate
safety factor of hospital pharmacy:
 The hospital must employ a qualified, at least, a registered pharmacist with at least
B.Pharm degree as ‘Chief Pharmacist’ and the rest are may be At least Diploma
holders in pharmacist.
 Should not permit non-pharmacist personnel to dispense drugs and allied
materials.
 Must employ a sufficient members of qualified considering the work load of a
pharmacist and allow for adequate coverage(7days/week).
 Must provide adequate safe, work space, and storage facilities

10. CONTINUE…….
 Should have equipment necessary to safely and adequately carry out the modern
practice of pharmacy.
 Must have an automatic stop order regulation for dangerous drugs. E.g: narcotics,
anticoagulants etc.
 Should have a drug formulary which periodically revised and kept up to date.
 The poisonous materials are separated from non-poisonous materials in the
pharmacy.
 The external used preparations should be separated from internal used
medications.
 Must have adequate quality control measures and follow good manufacturing
practices.

11. ROLE OF PTC IN ADVERSE DRUG
REACTION MONITORING PROGRAMME:
 An adverse drug reaction is defined as any usual of unexpected
harmful reaction including acute poisonings by narcotics,
barbiturates, and amphetemines as well as industrial poisonings.
 There is a proportionate increase in the drug reactions. In order to
gain an understanding of these problems and to formulate competent
opinions as to the best type of prevention and treatment, the PTC
must assume the responsibility for the developing and instituting a
procedure for the purpose of committee.

12. AUTOMATIC ORDERS FOR DANGEROUS
DRUGS:
 “All Drug orders for narcotics, sedatives, hypnotic
anticoagulants, and antibiotics (adminstered orally or
parenterally) shall be automatically discontinued after 48
hours unless the order indicates an exact number of doses
to be adminstered, or the attending physician, re-orders the
medication”.
 All orders for narcotics, sedatives and hypnotics must be
rewritten every 24 hours.

13. ROLE OF PTC IN “EMERGENCY DRUG
LISTS ”
 The Time Factor is necessary for the Pharmacy and Therapeutics
Committee of a hospital to get prepared boxes containing emergency
drugs which should be always available readily for use at the bed-
side. List of such drugs and other supplies should compiled by
Committee, and it should find their place in “Emergency Kits”
 After the emergency boxes have been placed in the wards, it is very
essential and compulsory that a system is developed whereby they
are checked daily either by the hospital pharmacists or by nursing
supervisor responsible for the ward. Following is the list of
suggested drugs and other articles maintained in Emergency Box:

14. SUPPLLIES TO BE MAINTAINED IN
EMERGENCY BOX:
 Syringes of various range
 Needles
 Files for breaking the ampoule
 Airway equipment DRUGS FOR EMERGENCY BOX: These may be selected in
consultation with the physician.
 Atropine sulphate 0.4 mg/ml
 Digoxin 0.25 mg/ml
 Heparin 10.000 units/ml
 Neostigmine methyl sulphate 0.25 mg/ml
 Mannitol injection 25%
 Saline for injection 09% 30 ml
 Water for injection 20 ml.

15. SUPPLIES FOR CABINET UTILITY ROOM:
Oxygen catheters
Razor with blades
Resuscitation tube.

16. OTHER EMERGENCY SUPPLIES:
Burn sheets
Dextran and tubing
Resuscitation carts.

17. ROLE OF PHARMACY AND THERAPEUTIC
COMMITTEE IN DRUG PRODUCT DEFECT
REPORTING PROGRAMME:
The drugs purchased by hospital may be defective in
quality.
It is for the committee to get information about the
defective drug products and to inform it first to the
manufacturer for appropriate action.
If satisfactory answer is not obtained from the
manufacturer , it should be reported to the Food and Drug
Control Adminstration.

18. ROLE OF PHARMACY AND THERAPEUTICS
COMMITTEE IN DRUG UTILISATION REVIEW:
 Drug utilisation includes prescribing, dispensing, adminstering and
ingesting of prescription of drugs.
 Hospital pharmacist should take medication history that should include
following information:
 Medication being taken at the time of admission, during admission,
home remedies (OTC drugs).
 Drug allergies and idiosyncrosy towards food products etc. Patent
medication profile to be maintained for each patient. This will serve the
following purposes:
 To help improved drug prescribing practices by
 promoting the safe and rational use of drugs.

19. CONTINUE…..
To detect and prevent adverse drug reactions in sensitive
patients.
To detect and prevents IV additive incompatibilities.
To detect drug-induced diseases.
To help detect and potentiaTo detect and help prevent
drug-interactions.
l drug-toxicities.