The document describes sterilization and medical device packaging services located in Moscow, Russia. The facility has 3M Steri-Vac sterilizers, a clean room classified as ISO 7, and equipment for tray sealing, thermoforming, and medical device assembly. Validation, sterility testing, and other services are also provided to ensure sterility of packaged products. Over 15 medical device producers utilize these services for single-use medical devices.
This document discusses quality control and evaluation tests for pharmaceutical aerosols. It describes tests for various components of aerosols including propellants, valves, containers, and spray characteristics. Specific tests are outlined to check properties such as weight, leaks, spray pattern, and dosage uniformity. Biological tests include evaluating therapeutic activity through particle size and determining toxicity by exposing test animals. A variety of methods are provided to analyze the flammability, physical/chemical traits, performance, and safety of pharmaceutical aerosol products.
Quality control & evaluation test of aerosalPritom Sinha
The document discusses quality control and evaluation tests for pharmaceutical aerosols. It defines aerosols as pressurized dosage forms that emit fine dispersions of materials upon actuation. Quality control tests evaluate properties of propellants, containers, valves, and product concentrates. Tests include vapor pressure determination, leak testing, and spray pattern analysis. Evaluation tests assess physicochemical characteristics, performance, and biological activity to ensure safety, efficacy, and consistency of pharmaceutical aerosols.
This document discusses the manufacturing and quality control of pharmaceutical aerosols. It begins by defining aerosols and their classification. It then describes the key components of an aerosol system, including propellants, containers, valves, and actuators. The two main manufacturing methods - cold filling and pressure filling - are outlined. Finally, the document details various quality control tests performed on the propellants, components, containers, and finished aerosol products to ensure quality. These include tests for leaks, spray pattern, weight, delivery rate and more.
This article introduces an oxygen transmission rate test method to test the pudding cup, i.e. the coulometric method. The test principle, instrument features, specifications, and testing procedures are all included in this article, which may provide reference for oxygen permeability test of packaging containers
Same as human being food, pet food conforms to strict standards to ensure the safety of pets. Pet food must keep their original flavor and nutrition during maintenance, transportation and shelf life, which rely heavily on the pet food packages. In the keen competitions, prolonging pet food shelf life attracts more and more manufacturers and suppliers attentions. In this article, I will talk about the factors that affect pet food shelf life and related solutions to prolong shelf life in terms of pet food packaging.
This document describes a study assessing the compatibility of a model monoclonal antibody formulation stored in glass vials and Blow-Fill-Seal (BFS) plastic vials. Several analytical tests were conducted to evaluate the stability, particle formation, aggregation, and leachables of the antibody formulation when stored in the two container types. The results showed no differences in potency, size exclusion chromatography profiles, or subvisible particle levels between the glass and plastic vial formats after 9 months of storage. Additionally, no significant leachables were detected from the BFS plastic container. Therefore, the study demonstrated comparable stability and compatibility of the monoclonal antibody formulation when stored in glass or BFS plastic vials.
The document describes sterilization and medical device packaging services located in Moscow, Russia. The facility has 3M Steri-Vac sterilizers, a clean room classified as ISO 7, and equipment for tray sealing, thermoforming, and medical device assembly. Validation, sterility testing, and other services are also provided to ensure sterility of packaged products. Over 15 medical device producers utilize these services for single-use medical devices.
This document discusses quality control and evaluation tests for pharmaceutical aerosols. It describes tests for various components of aerosols including propellants, valves, containers, and spray characteristics. Specific tests are outlined to check properties such as weight, leaks, spray pattern, and dosage uniformity. Biological tests include evaluating therapeutic activity through particle size and determining toxicity by exposing test animals. A variety of methods are provided to analyze the flammability, physical/chemical traits, performance, and safety of pharmaceutical aerosol products.
Quality control & evaluation test of aerosalPritom Sinha
The document discusses quality control and evaluation tests for pharmaceutical aerosols. It defines aerosols as pressurized dosage forms that emit fine dispersions of materials upon actuation. Quality control tests evaluate properties of propellants, containers, valves, and product concentrates. Tests include vapor pressure determination, leak testing, and spray pattern analysis. Evaluation tests assess physicochemical characteristics, performance, and biological activity to ensure safety, efficacy, and consistency of pharmaceutical aerosols.
This document discusses the manufacturing and quality control of pharmaceutical aerosols. It begins by defining aerosols and their classification. It then describes the key components of an aerosol system, including propellants, containers, valves, and actuators. The two main manufacturing methods - cold filling and pressure filling - are outlined. Finally, the document details various quality control tests performed on the propellants, components, containers, and finished aerosol products to ensure quality. These include tests for leaks, spray pattern, weight, delivery rate and more.
This article introduces an oxygen transmission rate test method to test the pudding cup, i.e. the coulometric method. The test principle, instrument features, specifications, and testing procedures are all included in this article, which may provide reference for oxygen permeability test of packaging containers
Same as human being food, pet food conforms to strict standards to ensure the safety of pets. Pet food must keep their original flavor and nutrition during maintenance, transportation and shelf life, which rely heavily on the pet food packages. In the keen competitions, prolonging pet food shelf life attracts more and more manufacturers and suppliers attentions. In this article, I will talk about the factors that affect pet food shelf life and related solutions to prolong shelf life in terms of pet food packaging.
This document describes a study assessing the compatibility of a model monoclonal antibody formulation stored in glass vials and Blow-Fill-Seal (BFS) plastic vials. Several analytical tests were conducted to evaluate the stability, particle formation, aggregation, and leachables of the antibody formulation when stored in the two container types. The results showed no differences in potency, size exclusion chromatography profiles, or subvisible particle levels between the glass and plastic vial formats after 9 months of storage. Additionally, no significant leachables were detected from the BFS plastic container. Therefore, the study demonstrated comparable stability and compatibility of the monoclonal antibody formulation when stored in glass or BFS plastic vials.
The document is a project report on detecting the presence of basic radicals in different chocolate samples found in the market. The student conducted experiments on Dairy Milk, KitKat, Milky Bar, OneBar, and Snickers chocolate bars using cobalt nitrate solution. Grey ash was observed in all samples, indicating the presence of calcium. The conclusion is that while chocolate provides some health benefits, it also contains sugars and fats, so moderation is important. References are provided from Wikipedia and research websites.
Pharmaceutical packaging serves several important functions:
1) It protects drugs from external environmental factors like light, moisture, and contamination.
2) Packaging identifies drug products, provides instructions for proper use, and ensures safety and efficacy.
3) Packaging types include bottles, blister packs, vials, and other containers/closures that are evaluated through testing to ensure sterility, integrity, and that they do not interact with drug contents.
The document discusses ventilator breathing circuits and their sterilization process. Breathing circuits create an artificial atmosphere between the patient and ventilator. They are produced via plastic injection and extrusion methods using various plastics. Circuits are packaged in Tyvek and sterilized using ethylene oxide which is the preferred method as it is effective and heat is not suitable. The sterilization process involves conditioning, exposure to ethylene oxide gas, and aeration to remove residues over 12-14 hours. Biological and chemical indicators are used to validate the sterilization process was effective.
Complete Information and knowledge about the selection criteria for packaging material and different test used for them .
All this material data is , Collected for seminar in QA SEM 2 , in the Subject of Pharmaceutical Manufacturing Technology .
Which also explain the How Quality control for Filling an pharmaceutical equipment is done.
Optimization of Antimony Leaching From Food Packaging Covers Made Of Low Dens...IRJET Journal
This document describes a study that used response surface methodology to optimize conditions for leaching antimony from food packaging made of low density polyethylene. The study investigated the individual and interactive effects of pH, temperature, and retention time on antimony leaching efficiency. A central composite experimental design evaluated 20 experiments to derive a second-order model relating the response (antimony leachability) to the three variables. Analysis of variance showed the model had a high coefficient of determination. The maximum antimony leaching occurred under alkaline pH conditions, high temperature, and short retention time.
This document discusses several instruments and techniques used in microbiology laboratories, including:
1. The Polystainer 5300, an automated system that can stain up to 20 slides in 5-10 minutes to aid rapid diagnosis.
2. The BACTEC 9240, an automated blood culture system that can detect bacteria in blood samples within days using sensors to detect changes in oxygen and carbon dioxide levels in culture vials.
3. The Vitek 2, an automated system that uses test cards containing 64 wells with metabolic substrates to identify microbes based on their reactions over 24-48 hours.
A CNT-based artificial nose for food spoilage detectionIRJET Journal
This document proposes a CNT-based artificial nose for detecting food spoilage. It would consist of a storage box with a carbon nanotube sensor on the cover that detects waste gases produced by bacteria as food spoils. When the CNT sensor detects spoilage-level gases, a light on the box would turn on to warn the user not to eat the food. The CNTs would act as a chemiresistor, changing resistance when exposed to waste gases. This would allow the sensor to quantify gas concentration and determine if the food is still safe to consume, helping prevent food poisoning. The CNTs would be deposited on the cover via spray technique to form the sensing layer.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
The document is a final report for a project selecting a polymer material for a beverage bottle. It includes sections on materials selection, statistical analysis, material properties testing, sustainability analysis, physical tests, impact testing, and economic feasibility. Three polymers were chosen for testing: polyethylene terephthalate (PET), polypropylene (PP), and polyvinylchloride (PVC). A variety of tests will be conducted on the materials to determine which polymer best meets the requirements of withstanding drops, being manufacturable at scale, and having the best combination of material properties, sustainability, and cost.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
Pharmaceutical packaging components must be rigorously depyrogenated to remove bacterial endotoxins which can cause fever and pose safety risks. Two common depyrogenation methods are dry heat in an oven and intensive rinsing with purified water. Glass packaging is typically depyrogenated in ovens at 250°C for 30 minutes, while rubber stoppers are depyrogenated through rinsing with purified water and drying in sterile conditions. Proper validation of depyrogenation processes is necessary to safely reduce endotoxins to acceptable levels for patient safety.
This document describes procedures for determining biochemical oxygen demand (BOD) in a water sample. It defines BOD as a measure of the amount of oxygen used by aerobic bacteria to break down organic matter in water. The document outlines the objective, introduces BOD and the 5-day BOD test, discusses total and carbonaceous BOD, and lists safety procedures for handling wastewater samples.
Ch 1 Introduction to Chemistry Form 4 KSSM.pptxanishumaira15
This document provides an introduction to chemistry for Form 4 students in Malaysia. It discusses the meaning of chemistry and examples of chemicals used in daily life. It also summarizes the contributions of chemistry to technology and careers related to the field. The document outlines the scientific method and provides an example experiment to study the effect of temperature on salt solubility. It describes personal protective equipment and safety procedures in the laboratory, including handling apparatus, storing and disposing of chemicals, and emergency response. Test questions are provided to assess comprehension.
Decon7 Crushes Glutex in Study (Salmonella on Wood and Concrete Carriers)Casey Latto
Lab test results for Decon7 vs Glutex...
Average reduction on WOOD carriers after TEN minutes:
Decon7 1:1 - 5.07 log reduction (99.9991% kill rate)
Glutex 1:256 - 0.30 log reduction (50.13% kill rate)
Average reduction on CONCRETE carriers after TEN minutes:
Decon7 1:1 - 7.82 log reduction (99.999998% kill rate)
Glutex 1:256 - 7.82 log reduction (99.999998% kill rate)
Re-entry time after fogging Decon7 is 8 hours... Glutex is 72 hours.
D7 is nontoxic, nonhazardous, and nonflammable!
IRJET- Dairy Waste Water Treatment using Coconut Shell Activated Carbon and L...IRJET Journal
This document presents research on using low-cost adsorbents like coconut shell activated carbon and laterite to treat dairy wastewater. Column chromatography experiments were conducted with the adsorbents in different ratios and contact times to evaluate their effectiveness in reducing various water quality parameters. The results showed that increasing the contact time and using a 2:1 ratio of activated carbon to laterite improved removal efficiencies of parameters like biochemical oxygen demand and chemical oxygen demand the most, with over 60% reduction achieved in some cases. The study demonstrated the potential of these natural materials to treat dairy wastewater in a cost-effective manner.
The document is a project report on detecting the presence of basic radicals in different chocolate samples found in the market. The student conducted experiments on Dairy Milk, KitKat, Milky Bar, OneBar, and Snickers chocolate bars using cobalt nitrate solution. Grey ash was observed in all samples, indicating the presence of calcium. The conclusion is that while chocolate provides some health benefits, it also contains sugars and fats, so moderation is important. References are provided from Wikipedia and research websites.
Pharmaceutical packaging serves several important functions:
1) It protects drugs from external environmental factors like light, moisture, and contamination.
2) Packaging identifies drug products, provides instructions for proper use, and ensures safety and efficacy.
3) Packaging types include bottles, blister packs, vials, and other containers/closures that are evaluated through testing to ensure sterility, integrity, and that they do not interact with drug contents.
The document discusses ventilator breathing circuits and their sterilization process. Breathing circuits create an artificial atmosphere between the patient and ventilator. They are produced via plastic injection and extrusion methods using various plastics. Circuits are packaged in Tyvek and sterilized using ethylene oxide which is the preferred method as it is effective and heat is not suitable. The sterilization process involves conditioning, exposure to ethylene oxide gas, and aeration to remove residues over 12-14 hours. Biological and chemical indicators are used to validate the sterilization process was effective.
Complete Information and knowledge about the selection criteria for packaging material and different test used for them .
All this material data is , Collected for seminar in QA SEM 2 , in the Subject of Pharmaceutical Manufacturing Technology .
Which also explain the How Quality control for Filling an pharmaceutical equipment is done.
Optimization of Antimony Leaching From Food Packaging Covers Made Of Low Dens...IRJET Journal
This document describes a study that used response surface methodology to optimize conditions for leaching antimony from food packaging made of low density polyethylene. The study investigated the individual and interactive effects of pH, temperature, and retention time on antimony leaching efficiency. A central composite experimental design evaluated 20 experiments to derive a second-order model relating the response (antimony leachability) to the three variables. Analysis of variance showed the model had a high coefficient of determination. The maximum antimony leaching occurred under alkaline pH conditions, high temperature, and short retention time.
This document discusses several instruments and techniques used in microbiology laboratories, including:
1. The Polystainer 5300, an automated system that can stain up to 20 slides in 5-10 minutes to aid rapid diagnosis.
2. The BACTEC 9240, an automated blood culture system that can detect bacteria in blood samples within days using sensors to detect changes in oxygen and carbon dioxide levels in culture vials.
3. The Vitek 2, an automated system that uses test cards containing 64 wells with metabolic substrates to identify microbes based on their reactions over 24-48 hours.
A CNT-based artificial nose for food spoilage detectionIRJET Journal
This document proposes a CNT-based artificial nose for detecting food spoilage. It would consist of a storage box with a carbon nanotube sensor on the cover that detects waste gases produced by bacteria as food spoils. When the CNT sensor detects spoilage-level gases, a light on the box would turn on to warn the user not to eat the food. The CNTs would act as a chemiresistor, changing resistance when exposed to waste gases. This would allow the sensor to quantify gas concentration and determine if the food is still safe to consume, helping prevent food poisoning. The CNTs would be deposited on the cover via spray technique to form the sensing layer.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
G2/130 is based on differential pressure method, and can be used to measure gas transmission rate of flexible containers, including various bottles of carbonated drinks, juice, tea and packages of edible oil, dairy products, washing supplies and metal containers.
The document is a final report for a project selecting a polymer material for a beverage bottle. It includes sections on materials selection, statistical analysis, material properties testing, sustainability analysis, physical tests, impact testing, and economic feasibility. Three polymers were chosen for testing: polyethylene terephthalate (PET), polypropylene (PP), and polyvinylchloride (PVC). A variety of tests will be conducted on the materials to determine which polymer best meets the requirements of withstanding drops, being manufacturable at scale, and having the best combination of material properties, sustainability, and cost.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
Pharmaceutical packaging components must be rigorously depyrogenated to remove bacterial endotoxins which can cause fever and pose safety risks. Two common depyrogenation methods are dry heat in an oven and intensive rinsing with purified water. Glass packaging is typically depyrogenated in ovens at 250°C for 30 minutes, while rubber stoppers are depyrogenated through rinsing with purified water and drying in sterile conditions. Proper validation of depyrogenation processes is necessary to safely reduce endotoxins to acceptable levels for patient safety.
This document describes procedures for determining biochemical oxygen demand (BOD) in a water sample. It defines BOD as a measure of the amount of oxygen used by aerobic bacteria to break down organic matter in water. The document outlines the objective, introduces BOD and the 5-day BOD test, discusses total and carbonaceous BOD, and lists safety procedures for handling wastewater samples.
Ch 1 Introduction to Chemistry Form 4 KSSM.pptxanishumaira15
This document provides an introduction to chemistry for Form 4 students in Malaysia. It discusses the meaning of chemistry and examples of chemicals used in daily life. It also summarizes the contributions of chemistry to technology and careers related to the field. The document outlines the scientific method and provides an example experiment to study the effect of temperature on salt solubility. It describes personal protective equipment and safety procedures in the laboratory, including handling apparatus, storing and disposing of chemicals, and emergency response. Test questions are provided to assess comprehension.
Decon7 Crushes Glutex in Study (Salmonella on Wood and Concrete Carriers)Casey Latto
Lab test results for Decon7 vs Glutex...
Average reduction on WOOD carriers after TEN minutes:
Decon7 1:1 - 5.07 log reduction (99.9991% kill rate)
Glutex 1:256 - 0.30 log reduction (50.13% kill rate)
Average reduction on CONCRETE carriers after TEN minutes:
Decon7 1:1 - 7.82 log reduction (99.999998% kill rate)
Glutex 1:256 - 7.82 log reduction (99.999998% kill rate)
Re-entry time after fogging Decon7 is 8 hours... Glutex is 72 hours.
D7 is nontoxic, nonhazardous, and nonflammable!
IRJET- Dairy Waste Water Treatment using Coconut Shell Activated Carbon and L...IRJET Journal
This document presents research on using low-cost adsorbents like coconut shell activated carbon and laterite to treat dairy wastewater. Column chromatography experiments were conducted with the adsorbents in different ratios and contact times to evaluate their effectiveness in reducing various water quality parameters. The results showed that increasing the contact time and using a 2:1 ratio of activated carbon to laterite improved removal efficiencies of parameters like biochemical oxygen demand and chemical oxygen demand the most, with over 60% reduction achieved in some cases. The study demonstrated the potential of these natural materials to treat dairy wastewater in a cost-effective manner.
Similar to Oxygen barrier property test of plastic bottles for dairy drinks (20)
Heritage Conservation.Strategies and Options for Preserving India HeritageJIT KUMAR GUPTA
Presentation looks at the role , relevance and importance of built and natural heritage, issues faced by heritage in the Indian context and options which can be leveraged to preserve and conserve the heritage.It also lists the challenges faced by the heritage due to rapid urbanisation, land speculation and commercialisation in the urban areas. In addition, ppt lays down the roadmap for the preservation, conservation and making value addition to the available heritage by making it integral part of the planning , designing and management of the human settlements.
Heritage Conservation.Strategies and Options for Preserving India Heritage
Oxygen barrier property test of plastic bottles for dairy drinks
1. Oxygen Barrier Property Test of Plastic Bottles for Dairy Drinks
Source: Labthink Instruments Co., Ltd
Dairy drinks are very common consumer products in people’s daily life. Peanut milk,
walnut milk and many other beverage containing milk are very popular. Dairy milk is
mainly made of fresh milk, which contains a large amount of protein, vitamin and fat.
Those nutrients are liable to be oxidized, which should be kept away from light. The
packaging materials used for dairy drinks should have sufficient oxygen barrier
property. Otherwise, those nutrients may be oxidized and the dairy drinks may get
deteriorated.
The packaging for dairy drinks include tetra pak, bottles or cans made of plastics or
metals. Different packaging materials may have distinct oxygen barrier property. In
this article, we take plastic bottle as an example to explain how to test the oxygen
barrier property of the packaging for dairy drinks. The testing instrument is
Labthink’s OX2/231 Oxygen Transmission Rate Tester.
In the tests, the pre-conditioned specimen is mounted between the upper and lower
chambers at ambient atmospheric pressure. One chamber contains oxygen and the
other chamber is slowly purged by a stream of nitrogen. Due to the concentration
difference between the two chambers, oxygen molecules permeate through the
specimen into the nitrogen side and are taken to the coulometric sensor where
proportional electrical signals are generated. The oxygen transmission rate is then
obtained by analyzing and calculating the signals. For package samples, high purity
nitrogen flows inside the package, and oxygen flows outside.
Figure 1 Common Packaging for Dairy Drinks
2. Figure 2. OX2/231 Oxygen Transmission Rate Tester
The tests shall be performed according to the following procedures.
(1) Condition the specimen in a desiccant container at 23℃ for 72 hours.
(2) Remove the specimen from the desiccant container and fix it on a sample support
with rapid transparent adhesive. Make sure the specimen is sealed tightly.
Figure 3. Seal the Specimen
(3) Place the specimen with sample support into the testing instrument and cover the
specimen with an aluminum foil bag.
(4) Set test temperature, test humidity and other test parameters. Click Start Test to
start the tests.
3. (5) The test results will be calculated and displayed automaticallyafter tests.
For more details about OX2/231 Oxygen Transmission Rate Tester, please visit
www.labthink.com
About Labthink Instruments Co., Ltd:
Labthink Instruments Co., Ltd is one leading supplier of packaging testing
instruments, which is headquartered in Jinan, China and operated in Boston, U.S.A.