The document discusses 5 hormonal blocks that can cause weight loss resistance: 1) issues with thyroid hormones which slow metabolism, 2) high cortisol levels from chronic stress which shut down metabolism, 3) high insulin levels from a diet high in sugar/carbs which signals fat storage, 4) low sex hormones which slow metabolism, and 5) high inflammation in the body from food sensitivities which disrupts hormones. Fixing these 5 hormonal blocks through natural methods helped the author lose 34 pounds and regain her health and confidence.
With a 30 second “snack” that eliminates food cravingsArathiRamanujam
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix unclogged my hormones and had me dropping pound-after-pound in under a week.
My husband John and I never used to fight…
But ever since I realized that virtually all of my weight problems were due to my hormones…
And lost 34lbs in just under 90 days.
He’s constantly complaining that I shop too much.
He’s not wrong…
But literally, NONE of my clothes fit me anymore…
So what am I supposed to do?
Should I walk around wearing clothes that fit like a poncho?
Or better yet…
Should I just walk around naked?
My husband might say “yes” to the naked part
But seriously…
When you fix your broken hormones (there are 5 total btw)…
And drop the pounds as fast as I have…
You pretty much need to update your entire wardrobe.
And besides, it’s not like I’m buying a bunch of designer clothes anyways…
I mean sure, a few times…
But that’s only because it’s just so fun going into those fancy boutiques…
The same ones that I used to avoid like the plague because their clothes weren’t made for people like “me”…
Trying on outfit-after-outfit…
And every single one seems to mold perfectly to my newfound, slim physique.
It’s a total confidence rush…
So, of course, I’m going to do that sometimes…
But that’s beside the point…
Because I try on way more stuff from those stores than I buy…
And most of the new clothing I’m getting is coming from Goodwill and is very cheap…
So seriously, what’s my husband’s deal!
Lose Weight with A 30-Second “Snack” That Eliminates Food Cravings
& Burns 34 Pounds In Less Than 60 Days!
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix that unclogged my hormones and had me dropping pound-after-pound in under a week.
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix that unclogged my hormones and had me dropping pound-after-pound in under a week.
Do you want to unlock your hormones and start burning fat today?tasiml
The 5 Hormonal Blockages that make it impossible to lose weight...
Plus, 30 Second Fix which unclogged my hormones and dropped me pound after pound in less than a week.
With a 30 second “snack” that eliminates food cravingsArathiRamanujam
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix unclogged my hormones and had me dropping pound-after-pound in under a week.
My husband John and I never used to fight…
But ever since I realized that virtually all of my weight problems were due to my hormones…
And lost 34lbs in just under 90 days.
He’s constantly complaining that I shop too much.
He’s not wrong…
But literally, NONE of my clothes fit me anymore…
So what am I supposed to do?
Should I walk around wearing clothes that fit like a poncho?
Or better yet…
Should I just walk around naked?
My husband might say “yes” to the naked part
But seriously…
When you fix your broken hormones (there are 5 total btw)…
And drop the pounds as fast as I have…
You pretty much need to update your entire wardrobe.
And besides, it’s not like I’m buying a bunch of designer clothes anyways…
I mean sure, a few times…
But that’s only because it’s just so fun going into those fancy boutiques…
The same ones that I used to avoid like the plague because their clothes weren’t made for people like “me”…
Trying on outfit-after-outfit…
And every single one seems to mold perfectly to my newfound, slim physique.
It’s a total confidence rush…
So, of course, I’m going to do that sometimes…
But that’s beside the point…
Because I try on way more stuff from those stores than I buy…
And most of the new clothing I’m getting is coming from Goodwill and is very cheap…
So seriously, what’s my husband’s deal!
Lose Weight with A 30-Second “Snack” That Eliminates Food Cravings
& Burns 34 Pounds In Less Than 60 Days!
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix that unclogged my hormones and had me dropping pound-after-pound in under a week.
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix that unclogged my hormones and had me dropping pound-after-pound in under a week.
Do you want to unlock your hormones and start burning fat today?tasiml
The 5 Hormonal Blockages that make it impossible to lose weight...
Plus, 30 Second Fix which unclogged my hormones and dropped me pound after pound in less than a week.
Another Killer Fat Loss Masterpiece Geared Towards Women
With A 30-Second “Snack” That Eliminates Food Cravings
& Burns Away 34 Pounds Of Ugly Fat In Record Time!
Because this breakthrough is designed to support the balance of 5 crucial hormones in your body…
Thyroid Hormones, Cortisol, Estrogen, Insulin, and Leptin.
From the moment I began using HB5, I could feel things changing in my body…
I started having more energy in the morning…
That energy was lasting through the day, without any spikes and crashes…
Plus I was sleeping through the night and actually waking up feeling rested
Hormonal Harmony HB5 is a dietary complement in the structure of small tablets created by means of Dr. Eric J. Wood, that guarantees assist with hormonal issues such as weight loss resistance, exhaustion, intelligence fog, and anxiety.
HB5 is a diet pill that works on hormones to help you lose weight. HB5, also known as hormone block 5, targets hormonal problems that interfere with weight loss. The creators of HB5 claim that you can burn 34 pounds in 60 days if you take the supplement.
My name is Felicia & I'm an ambassador behind the brand Wealthy Woman – one of the fastest growing online communities of ambitious women and female entrepreneurs.
If you're looking to grow as an entrepreneur then you’ve landed in the right place. We’ve supported thousands of women to build financial stability through starting up their own business that they can run from the comfort of their own home and we’d love to work with you next!
We want to uplift each others voices, we want you to have confidence back in your life and nobody stifling your growth or potential and muddying the waters of your dreams.
If you want to take your life into your own hands, join our tribe of 'Wealthy Women' today!
My Husband Says I’m Addicted To Shopping… But After Losing 34lbs None Of My O...Cruz Rafael Ramos Marquez
And I’ve got to be honest…
It’s hilarious to me that my husband I are even having these arguments.
Just a few short months ago…
It never would have happened…
Because at that point, I’d been overweight for over a decade…
Anywhere between 30lbs to 50lbs too heavy on average…
And I had a whole section of my closet filled with outfits from my early
twenties...
That I was pretty sure I was never going to be able to wear again.
It seemed like “skinny Sam” was just some dusty relic of my past…
Not a person I could be in my early forties, like I am today…
And this probably would have been true…
While there are endless diets, supplements, and meal replacement plans claiming to ensure rapid weight loss, most lack any scientific evidence. There are, however, some strategies backed by science that do have an impact on weight management
Achieving healthy weight loss isn’t about a “diet” or “program” but a lifestyle with healthy eating patterns, regular physical activity, and stress management. Medications taken for other conditions may also make it harder to lose weight. If you are concerned about your weight or have questions about your medications, talk with your health care provider.
When you’re trying to lose weight, it’s natural to want it to happen very quickly. But people with gradual and steady weight loss (about 1 to 2 pounds per week) are more likely to keep the weight off.
So I made an appointment with my doctor…
And during the visit, I asked him to test my hormones.
I was expecting him to say “sure Sam, whatever you want!”…
So I felt CRUSHED when instead of doing that…
He let out this arrogant little smirk…
Then literally rolled his eyes!
My dear old doctor told me that hormone testing is expensive and unnecessary…
Then he proceeded repeat the same tired advice he’d been giving me for nearly two decades:
“If you want to lose weight, you just need to burn more calories than you put in.”
My doctor said it was all simple math…
Then he asked me if I belonged to a gym…
And by the time he was done talking…
Oh my God. I wanted to explode…
My face must have been beet-red as I walked out of his office…
It was so humiliating and embarrassing how he lectured me…
He was always just assuming that everything was MY fault…
And yet when I - the patient - asked him to do a hormone test…
He pretty much said “NOPE”…
And that really ticked me off.
“I’m done with him” I thought…
And I wasn’t lying…
I haven’t been back to that doc since.
But even though I got the thrill of
dumping my doc that day…
I still felt lost…
And I needed help.
I wasn’t sure where to turn…
I did look for other doctors in my town…
But I was scared they’d just have the same reaction my doctor did…
And I was afraid to go through that humiliation and embarrassment again.
So I thought about just giving up…
Just “letting go” and accepting that I’d never feel normal again…
And that might have been where the story ended…
If I hadn’t gotten a call from an old friend.
It was a Thursday night and I was standing exhaustedly in the kitchen…
When my cell rang.
It was my girlfriend Jen…
She’d been overseas with her husband for the past year…
But now she was back in the U.S. and she was calling to say hi.
So at first we just chit-chatted and caught up…
But then, as we were talking…
I remembered something important.
Jen had struggled with estrogen problems a while back…
But then she’d seen some hormone expert that she’d really liked…
And I remembered how she’d felt a lot better after…
Plus she’d lost a ton of weight too.
I’d always assumed that Jen just did estrogen replacement therapy or something like that…
But when I asked her during our conversation…
She let out this huge, belly-splitting laugh…
Then said that I had it all wrong.
“No way!” Jenn told me.
“Estrogen therapy is expensive and scary as heck.
Seriously you don’t even want to know about the side effects.
I did fix my estrogen, but it was entirely natural.
And it just wasn’t just my estrogen either…
It was all my hormones.
And really I owe it all to Dr. Wood...
He’s the hormone expert I saw…
Seriously the guy’s the best.”
Well that was all I needed to hear…
I got Dr. Wood’s information from Jen…
And three days later…
I was sitting in his office…
Trying hard not to show my nervousness or excitement.
It was pretty crazy though…
My Husband Says I’m Addicted To Shopping… But After Losing 34lbs None Of My O...Cruz Rafael Ramos Marquez
The 5 Hormonal Blocks that make it impossible to
lose weight…
Plus, the 30 Second Fix that unclogged my
hormones and had me dropping pound-afterpound in under a week.
My husband John and I never used to fight…
But ever since I realized that virtually all of my weight problems were due to
my hormones…
And lost 34lbs in a few short months…
He’s constantly complaining that I shop too much.
He’s not wrong…
But literally NONE of my clothes fit me anymore…
So what am I supposed to do?
Should I walk around wearing clothes that fit like a poncho?
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
More Related Content
Similar to Once I fixed these 5 Hormonal Blocks, I lost 34lbs lost in just under 180 days…
Another Killer Fat Loss Masterpiece Geared Towards Women
With A 30-Second “Snack” That Eliminates Food Cravings
& Burns Away 34 Pounds Of Ugly Fat In Record Time!
Because this breakthrough is designed to support the balance of 5 crucial hormones in your body…
Thyroid Hormones, Cortisol, Estrogen, Insulin, and Leptin.
From the moment I began using HB5, I could feel things changing in my body…
I started having more energy in the morning…
That energy was lasting through the day, without any spikes and crashes…
Plus I was sleeping through the night and actually waking up feeling rested
Hormonal Harmony HB5 is a dietary complement in the structure of small tablets created by means of Dr. Eric J. Wood, that guarantees assist with hormonal issues such as weight loss resistance, exhaustion, intelligence fog, and anxiety.
HB5 is a diet pill that works on hormones to help you lose weight. HB5, also known as hormone block 5, targets hormonal problems that interfere with weight loss. The creators of HB5 claim that you can burn 34 pounds in 60 days if you take the supplement.
My name is Felicia & I'm an ambassador behind the brand Wealthy Woman – one of the fastest growing online communities of ambitious women and female entrepreneurs.
If you're looking to grow as an entrepreneur then you’ve landed in the right place. We’ve supported thousands of women to build financial stability through starting up their own business that they can run from the comfort of their own home and we’d love to work with you next!
We want to uplift each others voices, we want you to have confidence back in your life and nobody stifling your growth or potential and muddying the waters of your dreams.
If you want to take your life into your own hands, join our tribe of 'Wealthy Women' today!
My Husband Says I’m Addicted To Shopping… But After Losing 34lbs None Of My O...Cruz Rafael Ramos Marquez
And I’ve got to be honest…
It’s hilarious to me that my husband I are even having these arguments.
Just a few short months ago…
It never would have happened…
Because at that point, I’d been overweight for over a decade…
Anywhere between 30lbs to 50lbs too heavy on average…
And I had a whole section of my closet filled with outfits from my early
twenties...
That I was pretty sure I was never going to be able to wear again.
It seemed like “skinny Sam” was just some dusty relic of my past…
Not a person I could be in my early forties, like I am today…
And this probably would have been true…
While there are endless diets, supplements, and meal replacement plans claiming to ensure rapid weight loss, most lack any scientific evidence. There are, however, some strategies backed by science that do have an impact on weight management
Achieving healthy weight loss isn’t about a “diet” or “program” but a lifestyle with healthy eating patterns, regular physical activity, and stress management. Medications taken for other conditions may also make it harder to lose weight. If you are concerned about your weight or have questions about your medications, talk with your health care provider.
When you’re trying to lose weight, it’s natural to want it to happen very quickly. But people with gradual and steady weight loss (about 1 to 2 pounds per week) are more likely to keep the weight off.
So I made an appointment with my doctor…
And during the visit, I asked him to test my hormones.
I was expecting him to say “sure Sam, whatever you want!”…
So I felt CRUSHED when instead of doing that…
He let out this arrogant little smirk…
Then literally rolled his eyes!
My dear old doctor told me that hormone testing is expensive and unnecessary…
Then he proceeded repeat the same tired advice he’d been giving me for nearly two decades:
“If you want to lose weight, you just need to burn more calories than you put in.”
My doctor said it was all simple math…
Then he asked me if I belonged to a gym…
And by the time he was done talking…
Oh my God. I wanted to explode…
My face must have been beet-red as I walked out of his office…
It was so humiliating and embarrassing how he lectured me…
He was always just assuming that everything was MY fault…
And yet when I - the patient - asked him to do a hormone test…
He pretty much said “NOPE”…
And that really ticked me off.
“I’m done with him” I thought…
And I wasn’t lying…
I haven’t been back to that doc since.
But even though I got the thrill of
dumping my doc that day…
I still felt lost…
And I needed help.
I wasn’t sure where to turn…
I did look for other doctors in my town…
But I was scared they’d just have the same reaction my doctor did…
And I was afraid to go through that humiliation and embarrassment again.
So I thought about just giving up…
Just “letting go” and accepting that I’d never feel normal again…
And that might have been where the story ended…
If I hadn’t gotten a call from an old friend.
It was a Thursday night and I was standing exhaustedly in the kitchen…
When my cell rang.
It was my girlfriend Jen…
She’d been overseas with her husband for the past year…
But now she was back in the U.S. and she was calling to say hi.
So at first we just chit-chatted and caught up…
But then, as we were talking…
I remembered something important.
Jen had struggled with estrogen problems a while back…
But then she’d seen some hormone expert that she’d really liked…
And I remembered how she’d felt a lot better after…
Plus she’d lost a ton of weight too.
I’d always assumed that Jen just did estrogen replacement therapy or something like that…
But when I asked her during our conversation…
She let out this huge, belly-splitting laugh…
Then said that I had it all wrong.
“No way!” Jenn told me.
“Estrogen therapy is expensive and scary as heck.
Seriously you don’t even want to know about the side effects.
I did fix my estrogen, but it was entirely natural.
And it just wasn’t just my estrogen either…
It was all my hormones.
And really I owe it all to Dr. Wood...
He’s the hormone expert I saw…
Seriously the guy’s the best.”
Well that was all I needed to hear…
I got Dr. Wood’s information from Jen…
And three days later…
I was sitting in his office…
Trying hard not to show my nervousness or excitement.
It was pretty crazy though…
My Husband Says I’m Addicted To Shopping… But After Losing 34lbs None Of My O...Cruz Rafael Ramos Marquez
The 5 Hormonal Blocks that make it impossible to
lose weight…
Plus, the 30 Second Fix that unclogged my
hormones and had me dropping pound-afterpound in under a week.
My husband John and I never used to fight…
But ever since I realized that virtually all of my weight problems were due to
my hormones…
And lost 34lbs in a few short months…
He’s constantly complaining that I shop too much.
He’s not wrong…
But literally NONE of my clothes fit me anymore…
So what am I supposed to do?
Should I walk around wearing clothes that fit like a poncho?
Similar to Once I fixed these 5 Hormonal Blocks, I lost 34lbs lost in just under 180 days… (15)
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Maxilla, Mandible & Hyoid Bone & Clinical Correlations by Dr. RIG.pptx
Once I fixed these 5 Hormonal Blocks, I lost 34lbs lost in just under 180 days…
1. My Husband Says I’m Addicted To Shopping…
But After Losing 34lbs
None Of My Old Clothes Fit!
Inside:
The 5 Hormonal Blocks that make it impossible to lose weight…
Plus, the 30 Second Fix that unclogged my hormones and had me dropping pound-
after-pound in under a week.
My husband John and I never used to fight…
But ever since I realized that virtually all of my weight
problems were due to my hormones…
And lost 34lbs in a few short months…
He’s constantly complaining that I shop too much.
He’s not wrong…
But literally NONE of my clothes fit me anymore…
So what am I supposed to do?
Should I walk around wearing clothes that fit like a
poncho?
Or better yet…
Should I just walk around naked?
My husband might say “yes” to the naked part
But seriously…
When you fix your broken hormones (there are 5 total
btw)…
And drop the pounds as fast as I have…
You pretty much need to update your entire wardrobe.
And besides, it’s not like I’m buying a bunch of designer
clothes anyways…
I mean sure, a few times…
But that’s only because it’s just so fun going into those
fancy boutiques…
2. Hi I’m Sam by the way…
And I’ve got to be honest…
It’s hilarious to me that my husband I are even having
these arguments.
Just a few short months ago…
It never would have happened…
Because at that point, I’d been overweight for over a
decade…
Anywhere between 30lbs to 50lbs too heavy on average…
And I had a whole section of my closet filled with outfits
from my early twenties...
That I was pretty sure I was never going to be able to wear
again.
It seemed like “skinny Sam” was just some dusty relic
of my past…
Not a person I could be in my early forties, like I am today…
And this probably would have been true…
The same ones that I used to avoid like the plague,
because their clothes weren’t made for people like “me”…
Trying on outfit-after-outfit…
And every single one seems to mold perfectly to my
newfound, slim physique.
It’s a total confidence rush…
So of course I’m going to do that sometimes…
But that’s besides the point…
Because I try on way more stuff from those stores than I
actually buy…
And most of the new clothing I’m getting is coming from
Goodwill and is very cheap…
So seriously, what’s my husband’s deal!
3. If it wasn’t for the help of one of the nation’s top hormone
experts…
A man named Dr. Eric J. Wood.
Dr. Wood showed me that the real reason I could never
lose weight…
And the real reason why fat seemed to be continuously
migrating to my belly and my thighs…
Had nothing to do with my eating habits…
Or even how much time I spent in the gym…
But with 5 Hormonal Blocks…
Blocks that are affecting millions of women, and men,
right now…
And leading to something called “weight loss resistance”…
Where it can feel impossible to drop even a single pound.
Discovering these 5 Hormonal Blocks
changed my life…
Especially once Dr. Wood showed me how to fix each of
these blocks…
And because I’m sure you’re asking…
YES!
Of course I’m going to share all 5 hormonal blocks with
you inside this letter…
Plus, I’m going to show you how to fix them too…
Which is something that Dr. Wood normally charges
people over $1,000 for…
So let’s keep this between us ;)
Once I fixed these 5 Hormonal Blocks,
I lost 34lbs lost in just under 180 days…
4. And what’s even better…
Is that the weight has stayed off too…
Even though I didn’t change my diet…
Or have to cut out a whole bunch of my favorite foods.
Now I know what you’re thinking too…
“She’s saying I can lose weight without having to give
up all my favorite snacks, this must be B.S.!”
RED FLAG ALERT
If that’s what just went through your mind…
I totally get it…
Because for decades, I was conditioned to think the
same thing too.
You can’t lose weight without slaving away at the gym
and eating rabbit food right?
That’s what I was always told…
But THAT’S B.S…
And here’s why:
These 5 Hormonal Blocks I’m about to share with you…
They keep your body in fat storage mode all the time…
And they keep your metabolism feeling like it’s stuck in
a puddle of glue.
When that stuff is going on behind the scenes…
It doesn’t matter what you’re eating…
You can eat a juicy bacon cheeseburger…
Or be Keto Karen who’s allergic to carbs…
And the weight still just isn’t going to come off.
I’ll explain more in just a second…
But first, let me go ahead and share exactly how I came
to meet Dr. Wood in the first place…
Then we’ll jump right into the 5 Hormonal Blocks he
showed me…
And right after…
I’ll give you the simple, at-home-fix he created…
5. So about me.
I used to feel trapped in a body I didn’t love.
Okay, so as I mentioned my name is Sam.
And while today I’m finding any excuse possible to slip on
a bikini and run to the beach…
For most of my adult life…
I felt trapped inside a body I didn’t love.
It started in my late twenties…
At first, I just noticed that I wasn’t losing weight as easily
as before…
And even though I was pretty active and tried to eat
healthy…
Each year a little more unwelcomed fat would show up
on my body…
Mostly around my butt, face, arms, and neck…
And because this fat didn’t ever want to leave…
I started joking that my fat was like some awful house
guest who overstays their welcome.
I’d later learn that what I was dealing with…
Is something called weight loss resistance…
Which is the term for what happens when your body
refuses to burn fat…
But at the time I just felt frustrated…
And thought maybe this weight gain was my fault…
Or that there was something wrong with me.
Which is something you can start using today…
And that can finally end your weight loss resistance for
good.
So I worked out even harder, and ate even cleaner…
6. Yet by the time I hit my mid-thirties…
Things had gone from bad to worst…
Because not only was I starting to gain more fat around
my tummy and my thighs…
Suddenly there was a lot of other weird stuff
happening in my body too.
I started experiencing these waves anxiety that would hit
me out of nowhere…
My energy felt ZAPPED all of the time…
Plus my sleep was getting worse and worse:
I’d wake up in the middle of the night covered in
sweat…
Or I’d get into bed exhausted…
Then suddenly get these booming adrenaline rushes.
The cherry on top was the brain fog though…
It felt like my brain was shutting off on me…
I had the hardest time focusing at my job…
And even little things…
Like trying to help my children with their homework…
Became very hard because I just couldn’t focus.
I started feeling scared…
Because what had started as a little weight gain…
Was now me fluctuating between 30lbs and 50lbs
overweight all the time…
And not only did I no longer feel sexy…
Or have any confidence in myself…
But I was worried about the long-term effects of the
weight on my health too.
I thought about my mom…
How she’d gotten bigger and rounder as she got older…
Until she became pretty seriously overweight…
And ended up having a fatal heart attack in her sixties…
7. Which was far too young.
When my mom died…
I’d promised myself that I wouldn’t ever follow in her
footsteps…
Yet here I was…
The weight piling on…
My blood sugar becoming more erratic…
My energy levels at an all-time low…
And I just didn’t know what to do.
As all of this was going on…
I’d tried countless diets…
Yet those certainly didn’t seem to be working.
The most recent failure had been Keto…
Which had started off so promising (I’d lost 5lbs in the first
few week!)…
But then ended in disappointment…
As I quickly plateaued…
Became fatigued and moody 24/7..
Then gained back all the weight back…
Plus a little extra for good measure.
I’d later discover that the reason Keto didn’t work for
me…
And this is the same reason it doesn’t work for a lot of
women…
Has to do with those 5 Hormonal Blocks we’re going to
talk about in a second…
But at the time…
I just felt frustrated and depressed…
Like I wanted to crawl into my bed and never come out.
It was like…
8. What the hell happened?
I’d gone from being a fun-loving, energized woman…
To someone who felt shocked that her friends had the
energy to go out and do anything at all.
When I had to go out…
Like to a birthday party or a work dinner…
It took me two days to recover…
And it got to a point where I realized that this just
wasn’t normal…
Something had to give.
So I did what everyone does…
I started Googling all the stuff I was dealing with (LOL).
And while most of what I found was ridiculous…
I did find one article that caught my eye.
It was an interview with New York Times Bestselling
Author Dr. Sara Gottfried…
And in the interview…
Dr. Gottf ried said something that really grabbed my
attention…
She said that…
“After digging into the research, I learned that 99 percent
of weight loss resistance is hormonal” she said…
And then later she added that…
“It amazes me how easy weight loss becomes once
hormones are back in their sweet spots.”
Now this really made the hair on my neck stand tall…
Because, like any woman who is honest…
I’d blamed my hormones for stuff before…
But I’d never really thought that they could be the reason
why I was having so much trouble losing weight.
So I made an appointment with my doctor…
9. And during the visit, I asked him to test my hormones.
I was expecting him to say “sure Sam, whatever you
want!”…
So I felt CRUSHED when instead of doing that…
He let out this arrogant little smirk…
Then literally rolled his eyes!
My dear old doctor told me that hormone testing is
expensive and unnecessary…
Then he proceeded repeat the same tired advice he’d been
giving me for nearly two decades:
“If you want to lose weight, you just need to burn more
calories than you put in.”
My doctor said it was all simple math…
Then he asked me if I belonged to a gym…
And by the time he was done talking…
Oh my God. I wanted to explode…
My face must have been beet-red as I walked out of his
office…
It was so humiliating and embarrassing how he lectured
me…
He was always just assuming that everything was MY
fault…
And yet when I - the patient - asked him to do a hormone
test…
He pretty much said “NOPE”…
And that really ticked me off.
“I’m done with him” I thought…
And I wasn’t lying…
I haven’t been back to that doc since.
But even though I got the thrill of
dumping my doc that day…
10. It was my girlfriend Jen…
She’d been overseas with her husband for the past year…
But now she was back in the U.S. and she was calling to
say hi.
So at first we just chit-chatted and caught up…
But then, as we were talking…
I remembered something important.
Jen had struggled with estrogen problems a while back…
But then she’d seen some hormone expert that she’d
really liked…
And I remembered how she’d felt a lot better after…
Plus she’d lost a ton of weight too.
I still felt lost…
And I needed help.
I wasn’t sure where to turn…
I did look for other doctors in my town…
But I was scared they’d just have the same reaction my
doctor did…
And I was afraid to go through that humiliation and
embarrassment again.
So I thought about just giving up…
Just “letting go” and accepting that I’d never feel
normal again…
And that might have been where the story ended…
If I hadn’t gotten a call f rom an old f riend.
It was a Thursday night and I was standing exhaustedly
in the kitchen…
When my cell rang.
11. I’d always assumed that Jen just did estrogen replacement therapy or something like that…
But when I asked her during our conversation…
She let out this huge, belly-splitting laugh…
Then said that I had it all wrong.
“No way!” Jenn told me.
“Estrogen therapy is expensive and scary as heck.
Seriously you don’t even want to know about the side effects.
I did fix my estrogen, but it was entirely natural.
And it just wasn’t just my estrogen either…
It was all my hormones.
And really I owe it all to Dr. Wood...
He’s the hormone expert I saw…
Seriously the guy’s the best.”
Well that was all I needed to hear…
I got Dr. Wood’s information from Jen…
And three days later…
I was sitting in his office…
Trying hard not to show my nervousness or excitement.
It was pretty crazy though…
We’d barely even shook hands…
But Dr. Wood was already describing everything I’d been dealing with in amazing detail…
The weight loss resistance, the exhaustion, the brain fog, the anxiety…
It was like he’d been living inside my head this whole time.
Seriously, he knew EVERYTHING…
And when I asked him how this was possible…
He said it was because even though we’re always being told that weight loss is some mysterious black-box…
That’s simply not the case…
“The vast majority of our weight challenges
are hormonal…
12. And they almost always come down to
5 Hormonal Blocks”…
That’s what he said…
And he told me that these 5 Hormonal blocks can all happen in our body simultaneously…
Resulting in a sluggish metabolism…
Cells that are pumped full of fat…
And brains, moods, and emotions entirely out of whack.
Then Dr. Wood proceeded to share
what these 5 Hormonal Blocks Are…
And I’m going to share them with you right now too…
So make sure you pay close attention…
Because this is going to remove so much confusion from your life…
And it will finally make sense why you haven’t been able to lose your excess weight.
The first hormonal block Dr. Wood told
me about has to do with your Thyroid.
You’ve probably heard of your thyroid before…
It’s a small, tiny gland located in the front of
your neck…
And your thyroid’s role is to take iodine, which is
found in a variety of foods…
And convert it into two thyroid hormones…
Which are known as T3 and T4.
These thyroid hormones are then released into
the bloodstream…
Where they control your metabolism.
When your metabolism is functioning
normally…
It turns calories and fat into energy…
Then sends this energy to your cells…
Where it’s used to perform all kinds of essential
functions that keep you healthy.
13. But when your thyroid hormones are NOT functioning
properly…
It means that your metabolism doesn’t function properly
either…
And instead of burning calories like it should…
Your metabolism stores those calories as fat.
This is why, if you have issues with your thyroid
hormones…
You can starve yourself and workout all day…
But you’re STILL going to encounter weight loss resistance
and feel frustrated…
Because even though you’re doing activities that normally
WOULD burn calories…
When your thyroid hormones are out of whack…
They tell your metabolism to keep storing those calories as
fat.
This can leave you feeling exhausted, by the way…
Because over the course of the day…
You’re doing all of these things that require
energy…
Yet your body isn’t releasing that energy…
It’s holding onto it…
And if you f requently suffer f rom brain fog…
Your thyroid hormones could be to blame for
that as well…
Because your brain uses up a lot of energy…
But if your metabolism is broken and there’s no
energy available…
Your brain is starved of fuel.
Pretty crazy, right?
And your thyroid is just one of FIVE different
hormonal blocks you may be facing…
Imagine what it would be like to fix all 5
hormonal blocks at once?
It could seriously be like the difference between
being blind…
And having perfect 20/20 vision…
The difference is that dramatic.
14. The second hormonal block that Dr. Wood
told me about has to do with Cortisol
You have two adrenal glands that sit above your kidneys…
And they produce a hormone called cortisol…
Which is often referred to as a “stress hormone”…
Because it’s released when you experience stress.
Cortisol is very important to your survival…
But when your cortisol levels are always high…
Which can happen due to everyday stressors like:
A demanding job
Arguments on social media
A rocky relationship
Sitting in bad traffic
A challenging child
Plus anything else…
15. Your brain thinks you’re in survival mode…
So it shuts down your metabolism…
Your digestion…
And even parts of your brain.
Why does it do this?
Because even though your stress might be due to something
“harmless”…
Like your boss nonstop texting on a weekend…
Your brain can’t differentiate between “harmless” stress…
And a real threat…
So it takes energy f rom anywhere in the body that it views as “non-essential”…
Which includes your metabolism, your digestive system, and even parts of your brain…
And sends this energy to places like your muscles and your heart…
Which your brain considers essential to your survival.
Think of it like this:
But you know what’s NOT essential to fighting or running away?
If you need to fight, your muscles better work…
And if you need to run for your life, your heart better be able to pump blood…
Your metabolism raging and burning fat…
Your digestion operating smoothly so you don’t experience irregular bowel movements…
Or your brain being able to solve math equations or complex problems.
So the fact that those places get robbed of energy makes
sense…
In fact, it’s actually smart of your brain to do this.
The problem though…
Is that if your stress isn’t coming from a real threat…
But from your 24/7 job…
Or family commitments…
Then your metabolism, digestion, and brain always
remain robbed of energy…
It’s impossible to burn fat…
And you constantly feel like your brain is in a fog.
Pretty crazy, right?
16. And we’ve still got three more hormonal blocks left…
So let’s keep things going.
The third hormonal block Dr. Wood told
me about has to do with Estrogen.
Estrogen is what’s referred to as a “sex hormone”…
And when estrogen levels are too high, or too low…
And aren't in balance with progesterone...
Which is another important female reproductive
hormone….
It can very easily lead to weight loss resistance.
One of the tell-tale signs of erratic estrogen levels…
Is that you’ll notice more fat getting stored in your belly
and hips…
And you’ll notice that this fat is visceral and clingy…
To the point where it feels like it’s impossible to get rid of
it…
No matter how much dieting or exercising you do.
For many women…
Erratic estrogen problems start in their mid-thirties…
Then continue before, during, and after menopause.
The reason why…
Is because as a woman exits her prime reproductive
years…
Which normally happens between the ages of 30 and 35…
The balance between estrogen and progesterone can
grow increasingly out of whack…
And her estrogen levels will start to peak…
While her progesterone levels begin to free-fall.
And as women enter their 40s…
This imbalance between estrogen and progesterone only becomes worse..
Which can negatively affect your thyroid hormones …
And lead to you putting on more and more pounds of fat.
17. It’s for this reason that so many women are being pushed towards hormone therapies once they enter their 40s and
50s…
But wouldn’t it be better if you could just keep estrogen levels balanced naturally…
Without continuously packing on more pounds of fresh belly fat?
Well the good news…
Is that this is absolutely possible.
I’ll show you exactly how to do it…
Plus give you four more proven hormonal fixes…
In just a few moments.
The 4th Hormonal Block Dr. Wood told
me about has to do with Insulin.
Insulin is a hormone that’s produced in your pancreas…
And you’ve almost certainly heard of insulin before…
Especially in in relation to diabetes.
The thing is though…
You don’t need to be a diabetic to have insulin
challenges…
Because as world renowned health expert
Dr. Mark
Hyman puts it:
“No contest: The monster hormone that causes weight
gain is excess insulin.”
Well with respect to Dr. Hyman…
There is a contest…
And it’s happening between all five of the hormones
we’re talking about today.
But while Dr. Hyman may be oversimplifying things a
little bit here…
There’s also a lot of truth to what he’s saying...
Because high insulin levels definitely are one of the
major reasons behind your weight loss resistance.
Insulin helps your body convert the carbohydrates
you eat into sugar (glucose)…
And then tells your body to store this sugar as glycogen
in your muscles.
The problem though is that your muscles can only store a small amount of glycogen at any given time…
And once your muscles’ about to store glycogen is maxed it…
18. The fifth hormonal block Dr. Wood told me
about has to do with Leptin.
Leptin’s job is to tell your brain when you’ve had enough to
eat.
This is why Leptin is often referred to as your “fullness
hormone”…
Because when Leptin is functioning normally…
You feel satisfied after each meal…
You don’t overeat…
And you don’t suffer from those gnawing cravings that
can strike out of nowhere.
That’s how Leptin is supposed to function…
Your body has no choice but to store additional glycogen as fat.
Obviously, that’s not good if you’re trying to lose weight…
And it’s especially brutal when you combine high insulin…
With the other hormonal blocks we’ve looked at so far.
Think about it…
Insulin and estrogen are BOTH telling your body to store more fat…
While your thyroid hormones and cortisol are BOTH telling your body not to burn fat.
So is it any wonder that you’ve been struggling to lose weight?
And all of this is before we add in the the last hormonal block too…
Which we’re going to go over right now.
19. But when you start putting on excess weight…
And you can’t burn fat no matter how hard you try…
(Which both happen due to the other four hormonal
blocks we’ve covered today)…
Your fat cells start producing more-and-more leptin…
And your brain becomes bombarded with leptin signals
non-stop…
Until it starts to ignore these signals entirely.
This is called leptin-resistance…
And as your brain becomes increasingly resistant to
leptin…
You can guess what happens:
You stop feeling full…
You start overeating the wrong foods…
You get almost addict-like-cravings for salty, sweet, or crispy junk foods…
And it results in you putting on even MORE weight…
Which in turn makes your leptin resistance even worse…
Until ultimately…
You spend very day feeling hungry, angry, and
depressed…
Because it seems like you can’t stop overeating no matter
how hard you try…
And you feel MAD at yourself…
Because you can’t understand why don’t have any self-
control.
If that’s you right now…
Trust me, I get it.
That’s where I was at too…
And I’ve had all of those same thoughts….
Which is why I was so surprised when…
Dr. Wood looked me in the eyes and told me
something I’ll never forget…
Something I’m going to repeat to you right now:
20. It’s really, truly, not your fault.
None of this is.
Your weight struggles aren’t due to a lack of willpower…
It’s not because you don’t “want to be skinny” bad enough…
The weight gain that’s been accelerating…
The increased weight loss resistance…
Those things aren’t being caused by you…
They’re being caused by your hormones…
And particularly those 5 hormonal blocks we’ve been going over
today.
Think about it like this...
What good is two hours on the treadmill…
Or going Keto…
If your metabolism refuses to burn fat for energy?
And what good are drugs that target your thyroid…
Or risky estrogen therapies…
When each of those things only targets one specific
hormonal block…
Out of a total of 5?
So you see…
You’ve Been Set Up!
You’ve been BLAMED for your weight loss resistance by the folks in the diet industry…
You’ve been NAMED as lazy by workout-addicts in the fitness industry…
And you’ve been SHAMED for your anxiety and exhaustion by pill-pushing health professionals…
When the truth is…
The vast majority of the time…
Your inability to lose weight…
Your low-energy…
Your poor nights of sleep…
Your brain fog…
Your mood swings…
And so much else...
They are all caused by something that’s out of your control…
The 5 Hormonal Blocks we’ve been looking at today.