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Olives provide many health benefits. They help eliminate excess cholesterol from the blood and control blood pressure. Olives are a good source of dietary fiber and vitamin E. They act as antioxidants, protecting cells, veins, and cavities. Olives can reduce the effects of degenerative diseases like Alzheimer's and tumors. However, for some people with low blood pressure, olives may cause dizziness due to their blood pressure lowering effects. Very strong olives can also cause stomach irritation or diarrhea in rare cases.
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- Antioxidants that prevent cellular damage and may reduce disease risk
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- Fiber intake helps digestive and heart health but average intake is too low
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
It includes regulation of combination products and medical devices. FDA and industry liaisons.
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
TEST BANK For Community and Public Health Nursing: Evidence for Practice, 3rd...
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Olive
- 3. OLIVE
- 5. OLIVE Olives eliminate excess cholesterol in the blood. - Olives control blood pressure. - Olives are a source of dietary fibre as an alternative to fruits and vegetables. - Olives are a great source of Vitamin E - Olives act as an antioxidant, protecting cells veins and cavities - Olives reduce the effects of degenerative diseases like ALZIMER’S, benign and malignant tumors, including less serious varicose
- 6. OLIVE -Olives help prevent blood clots that could lead to a myocardial infarction or deep vein thrombosis (DVT) - Olives protect cell membranes against diseases like CANCER - Olives are a great protection against anaemia - Olives enhances fertility and reproductive system - Olives play an important role in maintaining a healthy immune system, especially during oxidative stress and chronic viral diseases - And just in case these benefits weren’t enough, they are also a great aphrodisiac.
- 8. OLIVE - In some chronic cases, there may be an adverse reaction due to the liver, kidneys, and other organs becoming overburdened as the body begins to deal with dead microbes. - People with low blood pressure can face dizziness due to the natural blood pressure reducing capabilities of olives, olive oil and olive leaf extracts.
- 9. OLIVE -Very strong olives can cause stomach irritation or diarrhea, even candida in extreme cases. These are few of the risks of eating olives that can be alleviated by dilution or maintaining a healthy intake of water.