COX 1 and COX 2 enzymes have different physiological roles, with COX 1 involved in normal physiological functions and COX 2 primarily mediating inflammatory responses. Drugs that selectively inhibit COX 2 can provide analgesic and anti-inflammatory effects without disrupting normal physiological functions mediated by COX 1. The document discusses the mechanisms of action of COX 1 and COX 2 enzymes and how drugs work by selectively targeting COX 2.

1. Prepared by : Ms. Uditi Handa
(Assistant Professor)
Pharmaceutics (Ph.D.)

4. COX 1: Physiological action
COX 2: Inflammatory action
General mechanism

8. Drug: MOA