Obesity induces changes to the gut microbiota and its metabolites that promote cellular senescence and a senescence-associated secretory phenotype (SASP) in hepatic stellate cells. This SASP facilitates the development of hepatocellular carcinoma (HCC) in mice. Specifically, a high-fat diet alters the gut microbiota to increase production of deoxycholic acid, which provokes SASP in hepatic stellate cells. This leads to proinflammatory cytokines and tumour-promoting factors that promote HCC upon exposure to a chemical carcinogen. Blocking deoxycholic acid production or depleting the gut microbiota reduced HCC development by decreasing senescent hepatic stellate cells.
Dr. Talita Resende - Organoids as an invitro model for enteric diseasesJohn Blue
Organoids as an invitro model for enteric diseases - Dr. Talita Resende, from the 2018 Allen D. Leman Swine Conference, September 15-18, 2018, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2018-leman-swine-conference-material
Dr. Talita Resende - Organoids as an invitro model for enteric diseasesJohn Blue
Organoids as an invitro model for enteric diseases - Dr. Talita Resende, from the 2018 Allen D. Leman Swine Conference, September 15-18, 2018, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2018-leman-swine-conference-material
In this webinar Dr Bailey explains the molecular mechanisms involved in colorectal cancer (CRC), initiation and progression and focus on dietary factors known to increase risk or offer protection against CRC development.
The colonic epithelium undergoes a constant and rapid renewal and intestinal homeostasis must therefore be tightly regulated to ensure continued homeostasis. Nowadays it is clear that lifestyle factors (mainly smoking, composition of the diet, and physical activity) play a role in the aetiology of colon inflammation and cancer initiation and progression. Among the dietary compounds known to significantly influence colonic health are various types of fatty acids originating from both dietary fat and fibre. In this webinar Dr Bailey explores the mechanisms by which fatty acids are thought to increase or decrease colorectal cancer risk. She also presents the science and evidence behind the growing interest of the omega-3 fatty acid EPA as an adjuvant in cancer prevention and treatment.
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomaeshaasini
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomasemualkaira
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC).
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomasemualkaira
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC).
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomadaranisaha
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC)
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaNainaAnon
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC). Using 16S rRNA sequencing analysis to compare the gut microbiome of patients with CRC, CRA and HC. The microbial diversity including alpha diversity, beta diversity and identified the microbial compositions among the three groups were characterized. Intestinal microbial composition and diversity were significantly decreased in the CRA group, whereas those were obviously increased in the CRC group. The fourth most predominant microbial compositions in the three groups were Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes at the phylum level. Moreover, the relative abundance of Fusobacteria at the phylum level behaved a general trend of decreasing in CRA group first and then increasing in CRC group. When exploring the Fusobacteria abundance in MetaCyc database signaling in different groups, it was indicated that Fusobacteria was also higher in CRC than CRA especially in the ICME2-PWY, Cobalsyn-PWY and Anaglycolysi signal pathways. Taken together, the observed intestinal microbial difference among the three groups provides a basis for understanding the potential role of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis.
A reading report for <Tumor microenvironment derived exosomes pleiotropically...星云 王
A reading report for <Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
>, only for private study use, please do not use it for profit or public.
In this webinar Dr Bailey explains the molecular mechanisms involved in colorectal cancer (CRC), initiation and progression and focus on dietary factors known to increase risk or offer protection against CRC development.
The colonic epithelium undergoes a constant and rapid renewal and intestinal homeostasis must therefore be tightly regulated to ensure continued homeostasis. Nowadays it is clear that lifestyle factors (mainly smoking, composition of the diet, and physical activity) play a role in the aetiology of colon inflammation and cancer initiation and progression. Among the dietary compounds known to significantly influence colonic health are various types of fatty acids originating from both dietary fat and fibre. In this webinar Dr Bailey explores the mechanisms by which fatty acids are thought to increase or decrease colorectal cancer risk. She also presents the science and evidence behind the growing interest of the omega-3 fatty acid EPA as an adjuvant in cancer prevention and treatment.
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomaeshaasini
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomasemualkaira
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC).
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomasemualkaira
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC).
Alterations of Gut Microbiota From Colorectal Adenoma to Carcinomadaranisaha
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC)
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaNainaAnon
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers. We analysed colorectal tissues (11 CRC, 11 CRA and 11 healthy volunteers (HC). Using 16S rRNA sequencing analysis to compare the gut microbiome of patients with CRC, CRA and HC. The microbial diversity including alpha diversity, beta diversity and identified the microbial compositions among the three groups were characterized. Intestinal microbial composition and diversity were significantly decreased in the CRA group, whereas those were obviously increased in the CRC group. The fourth most predominant microbial compositions in the three groups were Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes at the phylum level. Moreover, the relative abundance of Fusobacteria at the phylum level behaved a general trend of decreasing in CRA group first and then increasing in CRC group. When exploring the Fusobacteria abundance in MetaCyc database signaling in different groups, it was indicated that Fusobacteria was also higher in CRC than CRA especially in the ICME2-PWY, Cobalsyn-PWY and Anaglycolysi signal pathways. Taken together, the observed intestinal microbial difference among the three groups provides a basis for understanding the potential role of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis.
A reading report for <Tumor microenvironment derived exosomes pleiotropically...星云 王
A reading report for <Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
>, only for private study use, please do not use it for profit or public.
Moving into the Post-MetagenomicEra of Gut Microbiome ResearchJonathan Clarke
Julian Marchesi's presentation slides from our previous Microbiome R&D and Business Collaboration Forum. For information about this years event please visit http://www.globalengage.co.uk/microbiota.html