https://www.cofttek.com/nicotinamide-mononucleotide/ Nicotinamide Mononucleotide(NMN)

1. The Best Anti-Aging Supplement of Nicotinamide
Mononucleotide(NMN) in 2020
1. Why We Need Nicotinamide Mononucleotide(NMN)
Aging is time-related and time-assisted retrogression of human bodily
functions. Though aging is inevitable and unavoidable, scientists have devoted
years to understanding how this process can be delayed and controlled.
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2. This continued research has led to the discovery of several substances and
compounds with anti-aging properties that can be converted into anti-aging
supplements. One such compound with significant anti-aging properties that
has scientists feeling fascinated is NMN or Nicotinamide Mononucleotide. In
this article, we discuss everything there is to know about NMN as well as the
best anti-aging supplement of nicotinamide mononucleotide in 2020.
2. What is Nicotinamide Mononucleotide(NMN)?
Nicotinamide Mononucleotide(1094-61-7) or NMN is a nucleotide that exists
naturally within most of the foods we eat. It is found in avocado, broccoli,
cucumber, cabbage, edamame, and tomatoes. However, the quantity of NMN
supplied by these foods is not enough to sustain key bodily functions and thus,
people are often advised to take NMN supplements. But, why is NMN so
crucial for the body?
Nicotinamide Mononucleotide or NMN is a precursor to Nicotinamide
Adenine Dinucleotide or NAD+. In simple words, NMN is the compound that
converts into NAD+ through a series of chemical reactions that happen inside
the cells. NAD+, on the other hand, is considered crucial for the body as it
performs several key tasks, including balancing the body's circadian rhythm,
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3. breaking down nutrients to release cellular energy, and facilitating key
enzymatic reactions, some of which delay aging. Unfortunately, though NAD+
is found within every cell of the body, its production decreases with age. More
importantly, there are no foods that a person can consume to increase the
production of NAD+ within the body. It is, thus, that the body requires an
NAD+ precursor that transforms into NAD+ within the cell, thereby balancing
out its decline within the body. This is where the use of NMN supplements
comes into play.
3. Nicotinamide Mononucleotide(NMN) Uses
Until a few years ago, all studies related to NMN uses were performed on
animals and while these studies showed promising results, these results were
not enough to establish the advantages of NMN use in human beings. In 2016,
a study was conducted to analyze the safety of NMN consumption and its time
course in human blood. The study delivered promising results. Post that,
another study was conducted in 2016 to study the effect of NMN
consumption in 50 older women suffering from high BMI, blood glucose, and
blood triglycerides. The study was successful. However, since the study
ground was restricted to women of a certain age, scientists believed that
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4. more proof was required to establish whether NMN consumption was safe for
human beings.
Therefore, more recently, in 2019, a study was conducted at the Clinical Trial
Unit of the Keio University School of Medicine. The subject of the study were
10 men aged between 40 and 60. These men were administered doses
ranging from 100 mg to 500 mg. The study concluded that NMN is
well-tolerated by human beings and is safe to consume as long as its
consumption is well-regulated. This study was crucial as it was the first NMN
study conducted on humans to study the effect of NMN on overall human
health. As soon as it was established that NMN consumption is safe,
manufacturers started bombarding the market with NMN supplements, which
have become quite common these days.
4. Nicotinamide Mononucleotide (NMN)Dosage
While studies have established that Nicotinamide Mononucleotide or NMN is
safe for human use, research is still being conducted to figure out the most
effective dosage and frequency of NMN dosage in humans. However, studies
that have been conducted so far have established that a dosage of up to 500
mg per day is safe for men. These days, Nicotinamide Mononucleotide is
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5. available in different forms, including pills and powder. NMN supplement
suppliers claim that oral supplements are quite effective at boosting NAD+
production in the body. These claims are based on the fact that Slc12a8, a
nicotinamide nucleotide transporter, helps with the absorption of NMN in the
gut.
5.Nicotinamide Mononucleotide (NMN) Benefits
In this section, we discuss the potential benefits linked with Nicotinamide
Mononucleotide or NMN benefits.
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6. ●NMN Slows Down Aging
One of the biggest advantages of NMN is that it slows down the aging process.
A few years ago David Sinclair, the popular Australian Biologist and professor
of Genetics, provided proof that NAD+ slows down aging as well as the onset
of age-related diseases in humans. However, the production of NAD+ reduces
with age. Thus, as people age, the need for an NAD+ precursor increases
within their bodies. This is where NMN comes into play: NMN enters the cells
and undergoes several chemical transformations before it turns into NAD+
and slows down age-induced processes.
●People Suffering from Diabetes Can Benefit from Its Consumption
A study was conducted to study how NMN oral supplementation helped with
diet and age-related diabetes in mice. The study revealed that the mice given
oral NMN supplementation exhibited increased sensitivity to insulin as well as
its increased secretion. This study provided some indication that Nicotinamide
Mononucleotide or NMN oral supplementation can help people suffering from
diabetes.
●NMN Consumption Is Also Linked with Improved Heart Health
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7. Another study was performed to study how NMN supplementation affected
heart health in mice The study revealed that NMN not only reversed
age-related blood vessel and capillary damage in mice but also led to
improved blood flow. What was most surprising was the fact that in mice
given NMN oral supplementation, the eruption of new blood vessels was
observed. More recently, another study was conducted to study the effect of
NMN on hearth health in mice and this study too revealed similar results.
These studies have provided enough proof to researchers to believe that NMN
consumption also promotes heart health in human beings.
●People with Alzheimer's Can Benefit from NMN Use
In people suffering from Alzheimer's disease, the NAD levels go
down significantly. Thus, when people suffering from Alzheimer's consume
NMN, the body reacts by increasing the amount of NAD+, which in turn, leads
to increased motor control, increased SIRT3 gene activity, improved memory,
and reduced neuroinflammation. Thus, people suffering from Alzheimer's can
benefit from consuming NMN.
●NMN Also Improves Kidney Function
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8. Oral NMN supplementation is linked with improved kidney function. This is
because NMN increases the production of NAD+ and SIRT1, both of which are
linked with enhanced kidney function.
6.Is Nicotinamide Mononucleotide(NMN) Safe?
Over the years, several studies have been conducted to study whether NMN
consumption in humans is safe or not. These studies have, time and again,
revelated that Nicotinamide Mononucleotide consumption is absolutely safe
when its dosage is restricted. In general, men are advised to stick to a daily
dose of less than 500 mg. However, it must be highlighted that the FDA has
not yet approved NMN as a safe drug. Thus, if you have any allergies or
medical issues, it's best you consult with your doctor before starting any NMN
supplements.
7.The Best Anti-Aging Supplement of Nicotinamide
Mononucleotide
After a 2019-study concluded that Nicotinamide Mononucleotide is safe for
human consumption if its consumption is restricted to the prescribed limit,
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9. several manufacturing companies have entered the market with their
offerings. This overabundance of choice has left buyers confused about which
Nictonimade Mononucleotide(NMN) supplement is best for them. In our
opinion, the best anti-aging supplement of Nicotinamide Mononucleotide
(NMN) in 2020 is the Cofttek company.
Cofttek is an A+ rated company that has been in the market for almost 12
years and has developed a loyal follower base during this time. The NMN
powder supplied by the company is triple lab-tested, pharmaceutical-grade
NMN sourced from the same companies that had supplied NMN for the
various significant human clinical trials that have taken place over the years.
The NMN powder supplied by Cofttek facilitates its easy absorption into the
body, thereby increasing the bioavailability of the product as well as its
physiological functions. More importantly, this powder comes in bulk and you
can store it for three months. All in all, this is one of the best supplements
currently available in the market with high user rating and it comes from a
company that has delivered reliable and effective products year after year.
8. Where to Buy Nicotinamide Mononucleotide(NMN) Powder in
Bulk?
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10. If you are looking to buy Nicotinamide Mononucleotide(NMN) powder in bulk,
the best place to buy NMN powder is https://www.cofttek.com/. Cofttek is a
high-tech pharmaceutical enterprise that has been providing innovative and
high-quality products since 2008. The company boasts of an impressive R&D
team with experienced individuals committed to the development of
competitive products. Cofttek has partners and supplies its products to
pharmaceutical companies in China, Europe, India, and North America. The
β-Nicotinamide Mononucleotide supplied by Cofttek is of very high-quality
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11. and completely safe for human consumption. More importantly, the company
supplies this powder in bulk, i.e. in units of 25kgs. Thus, if you are looking to
buy this powder in bulk, Cofttek is the company you should contact -- they are
the best Nicotinamide Mononucleotide (NMN) powder supplier in the market.
References:
(1) Yao, Z., et al. (2017). Nicotinamide Mononucleotide Inhibits JNK Activation to
Reverse Alzheimer Disease.
(2) Yoshino, J., et al. (2011). Nicotinamide Mononucleotide, a Key NAD(+)
Intermediate, Treats the Pathophysiology of Diet and Age-Induced Diabetes in Mice.
Cell Metabolism.
(3) Yamamoto, T., et al. (2014). Nicotinamide Mononucleotide, an Intermediate of
NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion.
(4) Wang, Y., et al. (2018). NAD+ Supplementation Normalizes Key Alzheimer’s
Features and DNA Damage Responses in a New AD Mouse Model with Introduced
DNA Repair Deficiency.
(5) Keisuke, O., et al. (2019). Implications of Altered NAD Metabolism in Metabolic
Disorders. Journal of Biomedical Sciences.
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