BMDSys Optical GmbH has developed a new diagnostic system called APOLLO CXS that allows cardiologists to estimate the risk of sudden cardiac death within five minutes by analyzing the heart's magnetic signals. The previous system required expensive liquid helium cooling, but APOLLO CXS uses a new optical technology that eliminates this cost. Clinical tests of the prototype were successful. The company plans to begin series production and international marketing of APOLLO CXS over the next 1-2 years to address the large market potential for reliable, affordable cardiac risk assessment systems.
Investment in medical diagnostic system for sudden cardiac death (SCD) (English)De Micco & Friends Group
In the industrialized countries heart diseases are cause of death number one!
Worldwide approx. 9 mio. people die per year because of sudden cardiac death (SCD). In Germany there are 100,000 cases per year.
In approximately 80 % of all cases high frequent heart arrhythmias are responsible. In principle every person can be in danger.
Sudden cardiac death (SCD) is in approx. 50 % of all cases the first manifestation of a heart disease. The affected persons did not know about their heart problem and thus could not take any preventive action.
The BMDSys Optical GmbH offers with a unique technical innovation a solution for this problem!
The diagnostic system developed by BMDSys Optical GmbH allows a cardiologist to estimate the risk for sudden cardiac death within five minutes based on the heart‘s magnetic signals.
The team of BMDSys Optical GmbH and the physicians accompanying the clinical studies developed a technology that allows an individual risk stratification, which saves many lives.
Thus, this innovation is not only a highly interesting investment, but of high medical, clinical, sociological and economical relevance.
Investors can participate actively in the company and profit from the future prospects.
More information at http://www.demicco.ch/investment_opps.html
mHealth Israel_Rhon klinikum overview_Oct 2015_Digital Health and Network Med...Levi Shapiro
Rhon Klinikum CFO and CTO presenting at mHealth Israel meetup event in Tel Aviv, Oct, 2015. Peter Neumann, CFO and Board Members, Martin Scherer, Head of IT Operations, as well as the Head of Rhon Klinikum's €50 million venture capital fund
With regards to we.CONECT's international event, the 2nd MES & Process Minds (30th September – 1st October 2013, Berlin) we highly recommend you to check out our Media Center with TOP-presentations from last year´s edition (including interviews + speaker presentations related to strategic approaches and challenges of collaboration tools, platforms and their management).
Going into this situation, what were Thaldorf�s major strengths and .pdfaucmistry
Going into this situation, what were Thaldorfs major strengths and weaknesses as a
representative of Mediquip?
Identify each member of Lohmann Hospitals decision-making unit (DMU).
What were the needs, concerns, and motivation of each DMU member?
What was the relative power position of each DMU member? On December 18, Kurt Thaldorf, a
sales engineer for can diagnose cancer of the pancreas in less than two the German sales
subsidiary of Mediquip, S.A., was weeks after it develops. This was not possible before informed
by Lohmann University Hospital in Stuttgart CT scanners." that it had decided to place an order
with Sigma, a Mediquip was a subsidiary of Technologie UniDutch competitor, for a CT
scanner. The hospital's verselle, a French conglomerate. The company's proddecision came as
disappointing news to Thaldorf, who uct line included, in addition to CT scanners, X-ray, had
worked for nearly eight months on the account. ultrasonic, and nuclear diagnostic equipment.
Mediquip The order, if obtained, would have meant a sale of enjoyed a worldwide reputation for
advanced technol(Euro) 2,370,000 for the sales engineer. 1 He was con- ogy and competent
after-sales service. vinced that Mediquip's CTscanner was technologically "Our competitors are
mostly from other European superior to Sigma's and, overall, a better product. countries,"
commented Mediquip's Sales Director for Thaldorf began a review of his call reports in order
Europe. "In some markets they have been there longer to better understand the factors that had
led to Lohmann than we have, and they know the decision-makers betUniversity Hospital's
decision. He wanted to apply the ter than we do. But we are learning fast." Sigma, the lessons
from this experience to future sales situations. subsidiary of a diversified Dutch company under
the same name, was the company's most serious competiBACKGROUND tor. Other major
contenders in the CT scanner market were FNC, Eldora, Magna, and Piper. At the time, the
computer tomography (CT) scanner Mediquip executives estimated the European marwas a
relatively recent product in the field of diagnostic ket for CT scanners to be around 200 units per
year. imaging. This medical device, used for diagnostic pur- They pointed out that prices ranged
from 1.5 to 3.0 poses, allowed examination of cross sections of the million per unit. The
company's CT scanner sold in the human body through display of images. CT scanners upper
end of the price range. "Our equipment is at least combined sophisticated X-ray equipment with
a com- two years ahead of our most advanced competition," puter to collect the necessary data
and translate them explained a sales executive. "And our price reflects this into visual images.
When computer tomography was first introduced in Mediquip's sales organization in Europe
included the late 1960s, radiologists had hailed it as a major tech- eight country sales
subsidiaries, each headed by a mannologiqal breakthrough. Commenting on the adva.
Investment in medical diagnostic system for sudden cardiac death (SCD) (English)De Micco & Friends Group
In the industrialized countries heart diseases are cause of death number one!
Worldwide approx. 9 mio. people die per year because of sudden cardiac death (SCD). In Germany there are 100,000 cases per year.
In approximately 80 % of all cases high frequent heart arrhythmias are responsible. In principle every person can be in danger.
Sudden cardiac death (SCD) is in approx. 50 % of all cases the first manifestation of a heart disease. The affected persons did not know about their heart problem and thus could not take any preventive action.
The BMDSys Optical GmbH offers with a unique technical innovation a solution for this problem!
The diagnostic system developed by BMDSys Optical GmbH allows a cardiologist to estimate the risk for sudden cardiac death within five minutes based on the heart‘s magnetic signals.
The team of BMDSys Optical GmbH and the physicians accompanying the clinical studies developed a technology that allows an individual risk stratification, which saves many lives.
Thus, this innovation is not only a highly interesting investment, but of high medical, clinical, sociological and economical relevance.
Investors can participate actively in the company and profit from the future prospects.
More information at http://www.demicco.ch/investment_opps.html
mHealth Israel_Rhon klinikum overview_Oct 2015_Digital Health and Network Med...Levi Shapiro
Rhon Klinikum CFO and CTO presenting at mHealth Israel meetup event in Tel Aviv, Oct, 2015. Peter Neumann, CFO and Board Members, Martin Scherer, Head of IT Operations, as well as the Head of Rhon Klinikum's €50 million venture capital fund
With regards to we.CONECT's international event, the 2nd MES & Process Minds (30th September – 1st October 2013, Berlin) we highly recommend you to check out our Media Center with TOP-presentations from last year´s edition (including interviews + speaker presentations related to strategic approaches and challenges of collaboration tools, platforms and their management).
Going into this situation, what were Thaldorf�s major strengths and .pdfaucmistry
Going into this situation, what were Thaldorfs major strengths and weaknesses as a
representative of Mediquip?
Identify each member of Lohmann Hospitals decision-making unit (DMU).
What were the needs, concerns, and motivation of each DMU member?
What was the relative power position of each DMU member? On December 18, Kurt Thaldorf, a
sales engineer for can diagnose cancer of the pancreas in less than two the German sales
subsidiary of Mediquip, S.A., was weeks after it develops. This was not possible before informed
by Lohmann University Hospital in Stuttgart CT scanners." that it had decided to place an order
with Sigma, a Mediquip was a subsidiary of Technologie UniDutch competitor, for a CT
scanner. The hospital's verselle, a French conglomerate. The company's proddecision came as
disappointing news to Thaldorf, who uct line included, in addition to CT scanners, X-ray, had
worked for nearly eight months on the account. ultrasonic, and nuclear diagnostic equipment.
Mediquip The order, if obtained, would have meant a sale of enjoyed a worldwide reputation for
advanced technol(Euro) 2,370,000 for the sales engineer. 1 He was con- ogy and competent
after-sales service. vinced that Mediquip's CTscanner was technologically "Our competitors are
mostly from other European superior to Sigma's and, overall, a better product. countries,"
commented Mediquip's Sales Director for Thaldorf began a review of his call reports in order
Europe. "In some markets they have been there longer to better understand the factors that had
led to Lohmann than we have, and they know the decision-makers betUniversity Hospital's
decision. He wanted to apply the ter than we do. But we are learning fast." Sigma, the lessons
from this experience to future sales situations. subsidiary of a diversified Dutch company under
the same name, was the company's most serious competiBACKGROUND tor. Other major
contenders in the CT scanner market were FNC, Eldora, Magna, and Piper. At the time, the
computer tomography (CT) scanner Mediquip executives estimated the European marwas a
relatively recent product in the field of diagnostic ket for CT scanners to be around 200 units per
year. imaging. This medical device, used for diagnostic pur- They pointed out that prices ranged
from 1.5 to 3.0 poses, allowed examination of cross sections of the million per unit. The
company's CT scanner sold in the human body through display of images. CT scanners upper
end of the price range. "Our equipment is at least combined sophisticated X-ray equipment with
a com- two years ahead of our most advanced competition," puter to collect the necessary data
and translate them explained a sales executive. "And our price reflects this into visual images.
When computer tomography was first introduced in Mediquip's sales organization in Europe
included the late 1960s, radiologists had hailed it as a major tech- eight country sales
subsidiaries, each headed by a mannologiqal breakthrough. Commenting on the adva.
Pharma Maintenance2Reliability minds 2013 - MAIN PRMaria Willamowius
One of Europe´s most important conferences for strategic approaches and challenges in the field of plant asset- maintenance and reliability management in the Pharma & Life Science industries More information regarding speakers, keynotes, main topics and program on : http://pharma-maintenance2013.we-conect.com/
How well did Thaldorf interact with each member of the DMUOn what.pdfallystraders
How well did Thaldorf interact with each member of the DMU?
On what date did Thaldorf effectively lose the sale to Lohmann University? On December 18,
Kurt Thaldorf, a sales engineer for can diagnose cancer of the pancreas in less than two the
German sales subsidiary of Mediquip, S.A., was weeks after it develops. This was not possible
before informed by Lohmann University Hospital in Stuttgart CT scanners." that it had decided
to place an order with Sigma, a Mediquip was a subsidiary of Technologie UniDutch competitor,
for a CT scanner. The hospital's verselle, a French conglomerate. The company's proddecision
came as disappointing news to Thaldorf, who uct line included, in addition to CT scanners, X-
ray, had worked for nearly eight months on the account. ultrasonic, and nuclear diagnostic
equipment. Mediquip The order, if obtained, would have meant a sale of enjoyed a worldwide
reputation for advanced technol(Euro) 2,370,000 for the sales engineer. 1 He was con- ogy and
competent after-sales service. vinced that Mediquip's CTscanner was technologically "Our
competitors are mostly from other European superior to Sigma's and, overall, a better product.
countries," commented Mediquip's Sales Director for Thaldorf began a review of his call reports
in order Europe. "In some markets they have been there longer to better understand the factors
that had led to Lohmann than we have, and they know the decision-makers betUniversity
Hospital's decision. He wanted to apply the ter than we do. But we are learning fast." Sigma, the
lessons from this experience to future sales situations. subsidiary of a diversified Dutch company
under the same name, was the company's most serious competiBACKGROUND tor. Other
major contenders in the CT scanner market were FNC, Eldora, Magna, and Piper. At the time,
the computer tomography (CT) scanner Mediquip executives estimated the European marwas a
relatively recent product in the field of diagnostic ket for CT scanners to be around 200 units per
year. imaging. This medical device, used for diagnostic pur- They pointed out that prices ranged
from 1.5 to 3.0 poses, allowed examination of cross sections of the million per unit. The
company's CT scanner sold in the human body through display of images. CT scanners upper
end of the price range. "Our equipment is at least combined sophisticated X-ray equipment with
a com- two years ahead of our most advanced competition," puter to collect the necessary data
and translate them explained a sales executive. "And our price reflects this into visual images.
When computer tomography was first introduced in Mediquip's sales organization in Europe
included the late 1960s, radiologists had hailed it as a major tech- eight country sales
subsidiaries, each headed by a mannologiqal breakthrough. Commenting on the advantages
aging director. Within each country, sales engineers of CT scanners, a product specialist with
Mediquip said, reported to regional sales managers who, in turn, ".
Revolutionary Consumer Products: Company presentation by Katharina Wild, CMO of Smartfrog at the NOAH Conference London 2019, 30-31 October, Old Billingsgate.
This report presents a strategic analysis of the Germany Dental Care Market and a forecast for its development in the medium and long term. It provides a broad overview of the market dynamics, trends and insights, growth drivers and restraints, segmentation, competitive landscape, healthcare policies, regulatory framework, reimbursement scenario, challenges, and future outlook. This is one of the most comprehensive reports about the Germany Dental Care Market, offering unmatched value, accuracy, and expert insights.
Top stories of the 2nd pharma maintenance2 reliability minds conference 2013Maria Willamowius
From Maintenance to Reliability
Dates: 14th & 15th November 2013, Berlin / Germany
Website: http://pharma-maintenance2013.we-conect.com/en/
TOP Stories 2013:
- Dr. Ernst Keck from Roche Diagnostics GmbH in Germany will comment on how to implement a sustainable Asset Life-Cycle-Management (LCM).
- Christian Bugl from Baxter BioScience in Austria will illustrate the value of products and highlights the importance of optimizing the equipment life-cycle costs since overall equipment effectiveness specifies just a direction.
- Sergio Steffenoni from Sandoz GmbH in Germany will report on preventive, predictive and corrective maintenance and illuminate the challenges for planning and implementation of a robust and sustainable PM framework.
Find more information here: http://pharma-maintenance2013.we-conect.com/en/
Digital Health & Wellness: Company Presentation by Rainer Kasan, Co-Founder & CTO of Telepaxx at the NOAH Conference 2018 in London, Old Billingsgate 30-31 October 2018.
Op 15 maart waren er 130 mensen in MediaPlaza uit de shipping oliebusiness. Ik hield een verhaal over innovatie en samenwerking maar vooral hoe elektrisch rijden het leven gaat veranderen
De Micco & Friends protects your private and
commercial assets around the world from
unsafe, compromised or blocked locations.
Political and economic situations in some world regions compel wealthy individuals and companies to protect their assets.
Moving or totally relocating far from home is not always desirable. But many of our clients want to minimise risk and increase security by diversifying asset locations.
In some especially troubling situations, this is not about gaining security but about preventing total loss of assets.
DE MICCO & FRIENDS DESIGNS AND
STRUCTURES ALL KINDS OF ASSET TRANSFERS AND IMPLEMENTS THESE WORLDWIDE.
Private Placement Program Trading
STRUCTURING, SETUP, DUE DILIGENCE AND FRAUD PROTECTION
As an experienced team of economists, lawyers and bankers specialized in the financial sector, De Micco & Friends is one of a small number of law firms which provide qualified assistance and consulting in Private Placement Programs (PPP). More than twenty years of experience in private and public financial transactions makes the group a good partner for investors, institutions and banks.
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Similar to New business summary of BMDSys Optical investment
Pharma Maintenance2Reliability minds 2013 - MAIN PRMaria Willamowius
One of Europe´s most important conferences for strategic approaches and challenges in the field of plant asset- maintenance and reliability management in the Pharma & Life Science industries More information regarding speakers, keynotes, main topics and program on : http://pharma-maintenance2013.we-conect.com/
How well did Thaldorf interact with each member of the DMUOn what.pdfallystraders
How well did Thaldorf interact with each member of the DMU?
On what date did Thaldorf effectively lose the sale to Lohmann University? On December 18,
Kurt Thaldorf, a sales engineer for can diagnose cancer of the pancreas in less than two the
German sales subsidiary of Mediquip, S.A., was weeks after it develops. This was not possible
before informed by Lohmann University Hospital in Stuttgart CT scanners." that it had decided
to place an order with Sigma, a Mediquip was a subsidiary of Technologie UniDutch competitor,
for a CT scanner. The hospital's verselle, a French conglomerate. The company's proddecision
came as disappointing news to Thaldorf, who uct line included, in addition to CT scanners, X-
ray, had worked for nearly eight months on the account. ultrasonic, and nuclear diagnostic
equipment. Mediquip The order, if obtained, would have meant a sale of enjoyed a worldwide
reputation for advanced technol(Euro) 2,370,000 for the sales engineer. 1 He was con- ogy and
competent after-sales service. vinced that Mediquip's CTscanner was technologically "Our
competitors are mostly from other European superior to Sigma's and, overall, a better product.
countries," commented Mediquip's Sales Director for Thaldorf began a review of his call reports
in order Europe. "In some markets they have been there longer to better understand the factors
that had led to Lohmann than we have, and they know the decision-makers betUniversity
Hospital's decision. He wanted to apply the ter than we do. But we are learning fast." Sigma, the
lessons from this experience to future sales situations. subsidiary of a diversified Dutch company
under the same name, was the company's most serious competiBACKGROUND tor. Other
major contenders in the CT scanner market were FNC, Eldora, Magna, and Piper. At the time,
the computer tomography (CT) scanner Mediquip executives estimated the European marwas a
relatively recent product in the field of diagnostic ket for CT scanners to be around 200 units per
year. imaging. This medical device, used for diagnostic pur- They pointed out that prices ranged
from 1.5 to 3.0 poses, allowed examination of cross sections of the million per unit. The
company's CT scanner sold in the human body through display of images. CT scanners upper
end of the price range. "Our equipment is at least combined sophisticated X-ray equipment with
a com- two years ahead of our most advanced competition," puter to collect the necessary data
and translate them explained a sales executive. "And our price reflects this into visual images.
When computer tomography was first introduced in Mediquip's sales organization in Europe
included the late 1960s, radiologists had hailed it as a major tech- eight country sales
subsidiaries, each headed by a mannologiqal breakthrough. Commenting on the advantages
aging director. Within each country, sales engineers of CT scanners, a product specialist with
Mediquip said, reported to regional sales managers who, in turn, ".
Revolutionary Consumer Products: Company presentation by Katharina Wild, CMO of Smartfrog at the NOAH Conference London 2019, 30-31 October, Old Billingsgate.
This report presents a strategic analysis of the Germany Dental Care Market and a forecast for its development in the medium and long term. It provides a broad overview of the market dynamics, trends and insights, growth drivers and restraints, segmentation, competitive landscape, healthcare policies, regulatory framework, reimbursement scenario, challenges, and future outlook. This is one of the most comprehensive reports about the Germany Dental Care Market, offering unmatched value, accuracy, and expert insights.
Top stories of the 2nd pharma maintenance2 reliability minds conference 2013Maria Willamowius
From Maintenance to Reliability
Dates: 14th & 15th November 2013, Berlin / Germany
Website: http://pharma-maintenance2013.we-conect.com/en/
TOP Stories 2013:
- Dr. Ernst Keck from Roche Diagnostics GmbH in Germany will comment on how to implement a sustainable Asset Life-Cycle-Management (LCM).
- Christian Bugl from Baxter BioScience in Austria will illustrate the value of products and highlights the importance of optimizing the equipment life-cycle costs since overall equipment effectiveness specifies just a direction.
- Sergio Steffenoni from Sandoz GmbH in Germany will report on preventive, predictive and corrective maintenance and illuminate the challenges for planning and implementation of a robust and sustainable PM framework.
Find more information here: http://pharma-maintenance2013.we-conect.com/en/
Digital Health & Wellness: Company Presentation by Rainer Kasan, Co-Founder & CTO of Telepaxx at the NOAH Conference 2018 in London, Old Billingsgate 30-31 October 2018.
Op 15 maart waren er 130 mensen in MediaPlaza uit de shipping oliebusiness. Ik hield een verhaal over innovatie en samenwerking maar vooral hoe elektrisch rijden het leven gaat veranderen
De Micco & Friends protects your private and
commercial assets around the world from
unsafe, compromised or blocked locations.
Political and economic situations in some world regions compel wealthy individuals and companies to protect their assets.
Moving or totally relocating far from home is not always desirable. But many of our clients want to minimise risk and increase security by diversifying asset locations.
In some especially troubling situations, this is not about gaining security but about preventing total loss of assets.
DE MICCO & FRIENDS DESIGNS AND
STRUCTURES ALL KINDS OF ASSET TRANSFERS AND IMPLEMENTS THESE WORLDWIDE.
Private Placement Program Trading
STRUCTURING, SETUP, DUE DILIGENCE AND FRAUD PROTECTION
As an experienced team of economists, lawyers and bankers specialized in the financial sector, De Micco & Friends is one of a small number of law firms which provide qualified assistance and consulting in Private Placement Programs (PPP). More than twenty years of experience in private and public financial transactions makes the group a good partner for investors, institutions and banks.
خدمات مهاجرت به سراسر جهان
دفتر دومیکو و دوستان به افراد با سرمایه بالا، خانواده ها و سرمایه گذاران کمک میکند تا ”تابعیت جهانی“ داشته باشند و کمک میکند تا از طریق ارایه خدمات و راهکارهای مختص به ان فرد، بتوانند برنامه های زندگی شان را محقق سازند.
سرمایه گذاری اموال، اوراق قرضه دولتی و یا شرکت ها، این پتانسیل را برای برای شخصیت های با سرمایه بالا فعال میکند تا اقامت جهانی کسب کنند. شرکت دومیکو و دوستان، مسیر را برای بالاترین انعطاف پذیری برای صدها فرد و خانواده در 15 سال گذشته هموار کرده است. ما بعنوان یک شرکت حقوقی بین المللی از اهمیت استراتژیک پشت فلسفه اقامت جهانی آگاهیم و مفاهیم، دانش و شبکه بین المللی مان را در اختیار افراد با سرمایه بالا قرار می دهیم تا بتوانند از این فرصت استفاده کنند.
نحوه کار چگونه است
تعدادی از کشورهای اروپایی ویزا طلایی در قبال سرمایه گذاری در املاک و مستغلات، اوراق قرضه دولتی و یا شرکت ارائه می دهند. برجسته ترین برنامه های ویزای طلایی متعلق به اسپانیا، پرتغال، مالت، یونان و قبرس است.
بلغارستان و مجارستان، اقامت و شهروندی از طریق سرمایه گذاری در اوراق قرضه دولتی را ارائه می دهند.
در نتیجه رشد و تکثیر برنامه های ویزای سرمایه گذاری، در سال های اخیر مشتریان دفتر خانواده جهانی ما گزینه های زیادی برای اقامت و شهروندی در اروپا و کشورهای دیگر دارند.
بعلاوه، تعدادی از کشورهای کارائیب، یعنی، سنت کیتس، آنتیگوا، گرانادا و دومینیکا نیز شهروندی از طریق سرمایه گذاری و پاسپورت دوم به جهت امکان سفر به بسیاری از کشورهای با ویزای رایگان را ارائه می دهند.
FARKLI BIR KONSEPT
Klasik yatırım danışmanları ve çoklu family ofisleri hukuki, vergisel ve mali sorular için çoğu zaman harici danışmanlara başvurmak zorunda kalır iken, size De Micco & Friends Global Family Office şirketinin müvekkili olarak tüm hizmetler tek elden, tek çatı altından, küresel ve tabii ki tamamen gizli şekilde sunulur.
Benzersiz bir danışma ve hizmet konsepti geliştirdik. Çünkü Global Family Office müvekkillerinin, ticari işlemlerin ve varlık yönetiminin küreselleşmesi sonucu artan taleplerini dikkate almaktadır.
Kendine serbest Family Offices diyen veya bankaların Family Ofislerinin aksine müvekkillerimize varlıklarını veya yatırım hacimlerini sormayız, biz neye ihtiyaç duyduklarını sorarız. Ayrıca varlığınızı temel alarak prim hesabı yapmayız, biz sadece gerçekten verdiğimiz hizmetlerin ücretini talep ederiz.
Bir danışmanlık şirketinin danışmanlık kalitesi, danışmanlarının kalitesine bağlıdır.
Güven ve ihtiras, tecrübe ve hırs: Grubumuzun avukatlarından, ekonomistlerinden, bankerinden ve danışmanından beklentilerimiz çok yüksek.
De Micco & Friends şirketinin murahhas ortakları farklı konularda, olağanüstü uzmanlık bilgisine sahip, tecrübeli uzmanlardır. Danışmanlarımız uzun meslek hayatlarının tecrübesine sahiptirler.
Ekonomiye yakınlıklarının ve yüksek derecede hukuk ve vergi bilgilerinin kombinasyonu sonucunda De Micco & Friends uzmanları sizin için her branşta ve hukuki alanda, hem ulusal hem uluslararası arenada çok daha fazla fayda sağlayabilirler.
De Micco & Friends neredeyse dünyanın her ülkesinde şubeler ve ortakları ile hizmetinizdedir. Yine de yerel şubelerimiz dinamik ve esnek takımlara sahiptirler. Böylece siz hem bir uluslararası danışmanlık holdinginin uzmanlığından faydalanabiliyorsunuz, hem de yüksek derecede kişisel ve özel bir hizmet alabiliyorsunuz.
Mülke, devlet bonoları veya şirketlere yatırım yapmak öz sermayesi yüksek bireylerin Küresel ikamet sahibi olmasının önünü açar. De Micco & Friends, son 15 yıl içinde yüzlerce birey ve aileleri için esnekliği maksimuma çıkarmanın yolunu hazırladı. Uluslararası bir hukuk şirketi olarak, Küresel İkamet felsefesinin altında yatan stratejinin öneminin farkındayız ve öz sermayesi yüksek bireylerin bu fırsattan yararlanmasını sağlamak için kavramlarımızı, bilgimizi ve uluslararası ağımızı ortaya koyuyoruz.
Programlar, ilgili masraflara ilaveten 200.000 dolardan başlamaktadır.
Programların hepsi birbirinden farklıdır. Yatırım hacmi, aile nitelikleri, daimi ikamet, asgari kalma süresi, vatandaşlık ve pasaportlar ile ilgili önemli farklılıklar vardır.
De Micco & Friend, müşteri için en iyi programı bulmak amacıyla analizler ve bireysel tavsiyeler sunar.
Как это работает
Несколько европейских стран предлагают «Золотые визы» на основании инвестиций в недвижимость, государственные облигации или предприятия. Наиболее известны такие программы, действующие в Испании, Португалии, на Мальте, в Греции и на Кипре.
Болгария и Венгрия предлагают резидентство и гражданство на основании инвестиций в государственные облигации.
Как следствие расширения и распространения визовых программ для инвесторов, в последние годы в распоряжении клиентов нашего глобального семейного офиса имеется несколько вариантов приобретения статуса резидента и гражданства в Европе и других странах.
Кроме того, ряд стран Карибского бассейна, а именно Сент-Китс, Антигуа, Гренада и Доминика предлагают гражданство на основании инвестиций и второй паспорт, обеспечивающий возможность въезда во многие безвизовые страны.
Программы стартуют начиная с размера инвестиций 200 000 $ плюс накладные расходы.
Все программы отличаются. Существуют значительные различия относительно размера инвестиций, квалифика-ции семьи, постоянного проживания, минимального срока пребывания, гражданства и паспортов.
De Micco & Friends предлагает анализ и индивиду-альные консультации для определения наилучшей программы для своих клиентов.
خدمات الهجرة بجميع أنحاء العالم
تساعد كبار العملاء و العائلات و المستثمرين De Micco & Friends
ليصبحوا "سكان العالم"، ويساعدهم على وصول خططهم الحية إلى واقع ملموس من خلال حلول وخدمات شخصية للغاية.
الاستثمار في العقارات والسندات الحكومية أو الشركات يفتح المجال أمام الشخصيات كبار العملاء ليحصلوا على ألإقامة العالمية
مهدت الطريق بأعلا درجات المرونة عبر السنوات الخمسة عشر السابقة أمام المئات من ألأفراد De Micco & Friends
لمئات الأفراد والأسر باعتبارها شركة المحاماة الدولية.
نحن تنفهم أهمية الاستراتيجية الكامنة وراء فلسفة الإقامة العالمية ونحن نوفر المفاهيم والمعارف وشبكتنا الدولية تمكين الأفراد من ذوي الملاءة المالية للحصول على هذه الفرصة.
كيفية تحقيق ذلك
هناك عدد من الدول الأوروبية تقدم تأشيرات الذهبية من خلال الاستثمار في العقارات والسندات الحكومية أو الشركات. برنامج الفيزا الذهبيية و أكثرهم شهرة أسبانيا والبرتغال ومالطا واليونان وقبرص .
بلغاريا والمجر توفر الإقامة والمواطنة من خلال الاستثمارات في السندات الحكومية.
كنتيجة لنمو وانتشار برامج تأشيرة المستثمر، في السنوات الأخيرة أصبح لدي عملاء مكتب العائلة العالمي حاليا عدة خيارات للحصول على الإقامة والمواطنة في أوروبا وغيرها من البلدان.
وبالإضافة إلى ذلك هناك عدد من بلدان البحر الكاريبي، وهي سانت كيتس، أنتيجوا وجرينادا ودومينيكا تقدم المواطنة من خلال الاستثمار وتقدم جواز سفر ثان يتيح السفر إلى العديد من الدول بدون تأشيرة.
بينما فيما يتعلق بالمستشارين الماليين التقليدي وما يطلق عليه مكاتب ألعائلة المتعددة نحتاج إلى الاعتماد على مستشارين خارجيين للشئون للقانونية والضريبية والمسائل المالية .
و بذلك تتحصل أنت كعميل لشركة
على جميع De Micco & Friends Global Family Office
الخدمات مباشرة من خلال جهة واحدة و عبر أنحاء جميع العالم .
لدينا مفهوم فريد من نوعه بخصوص الاستشارات والدعم . لأن مكتب العائلة العالمي يأخذ بعين الاعتبار الطلب المتزايد من عملائنا، والناتج عن العولمة في جميع أنحاء العالم فيما يتعلق بالعمليات التجارية وحالات الأصول.
على عكس ما يسمى مكاتب الأسرة ألمجانية المتعددة أو مكاتب ألعائلة فى البنوك، نحن لا نسأل عن الأصول أو حجم الاستثمار لعملائنا، ولكن ما يحتاجون إليه. كما نحسب فقط ألرسوم أو ألعمولات الأساسية فقط على الخدمات التي تم توفيرها لك بالفعل.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
New business summary of BMDSys Optical investment
1. Executive Summary
Company: BMDSys Optical GmbH
Copy: No. 1/3
Date: October, 2014
Business plan: 3 business years plan
Founder (team): Volker Schall (CEO)
Dr. rer. nat. Gertrud Lembke (CTO)
Any information in this summary is confidential! Reproduction and copy ing requires
the agreement of De Micco & Friends Group!
1 www.demicco.ch
2. DISCLAIMER
The contents of this document are strictly confidential and were obtained inter alia from
publicly available information. This document (the “Concept, Structure & Investors
Presentation”) is a marketing document and not a regulatory document.
The sole purpose of this document is to assist the recipient in deciding whether to proceed with
a further investigation of an investment in BMDSys Optical GmbH, registered in Germany,
(“the “COMPANY”) and the "Proposed Transaction". This document does not purport to be all‐inclusive
or to contain all the information that a prospective interested party may desire to
evaluate the Proposed Transaction. This document has been prepared only for informational
purposes relating to the Proposed Transaction only.
Neither COMPANY nor its affiliates or representatives assumes any responsibility for the
independent verification of any of the information set forth in this document, or of any
additional evaluation material made available in connection with any further investigation of
the Proposed Transaction. Neither COMPANY nor its affiliates or representatives make any
express or implied representation or warranty as to the accuracy or completeness of the
information contained in, or for any omissions from, this document or any additional evaluation
material made available in connection with any further investigation of the Proposed
Transaction. In addition, COMPANY (on its own behalf and on behalf of its affiliates or
representatives) expressly disclaims any and all liability which may be based on such
information, errors therein or omissions there from.
Neither the receipt of this document by any person nor any information contained herein or
supplied herewith or subsequently communicated to any person in connection with the
Proposed Transaction is or is to be taken as constituting the giving of investment advice to any
such person. It is the responsibility of the recipient, before entering into any transaction, to
make its own appraisal of the Proposed Transaction, its advantages and risks, without relying
exclusively on the information that was provided to the recipient. If it deems necessary or
useful, the recipient may consult its own legal, tax, financial, accounting and other professional
advisors.
In furnishing this document, neither COMPANY nor its affiliates or representatives undertakes
any obligation to provide the recipient with access to any additional evaluation material.
COMPANY reserves the right to negotiate with one or more parties at any time and to enter into
a definitive agreement, without prior notice to the recipient or any other party. COMPANY
reserves the right to terminate, at any time, solicitation of indications of interest in the
Proposed Transaction or in the further participation in the investigation and proposal process by
any party.
Finally, COMPANY reserves the right to modify, at any time, any procedures relating to this
process without assigning any reason therefore. The information contained herein or made
available in connection with any further investigation of the Proposed Transaction is strictly
confidential. This document may not be photocopied, reproduced or distributed to any third
party at any time without the prior written consent of COMPANY. All communications, inquiries
and requests for information relating to these materials should be addressed to COMPANY.
COMPANY is the primary contact for the Proposed Transaction. Please direct all inquiries
regarding the Proposed Transaction to the representatives of COMPANY referred to below.
Interested parties will be required to sign a Non Disclosure Agreement (NDA) and send it, by
email and by post/hand, to the address below.
De Micco & Friends Group Corporation
(advisors, lawyers, auditors)
Switzerland
and
BMDSys Optical GmbH
Germany
2 www.demicco.ch
3. Contents
Overview
1. Executive summary
2. Product
3. Founder and management team
4. Market
5. Chances and risks
6. Financial planning
7. Offer for investors
3 www.demicco.ch
5. Overview
Project data
Entrepreneurs: Volker Schall and Dr. rer. nat. Gertrud Lembke
Planning: Continuation, development and marketing of an already developed
technology
Business location: Kurfürst‐Schönborn‐Straße 25, 56070 Koblenz, Germany
Legal form: GmbH (German Limited)
Company name: BMDSys Optical GmbH
Start of operation : previous company BMDSys GmbH 2005
Funding: Own funding and private equity
Future prospects: A unique product for risk stratification of sudden cardiac death (SCD)
has been developed that now has to be introduced worldwide.
5 www.demicco.ch
7. 1. Executive Summary
Product/Business model
In the industrialized countries heart diseases are cause of death number one!
Worldwide approx. 9 mio. people die per year because of sudden cardiac
death (SCD). In Germany there are 100,000 cases per year.
In approximately 80 % of all cases high frequent heart arrhythmias are
responsible. In principle every person can be in danger.
Sudden cardiac death (SCD) is in approx. 50 % of all cases the first
manifestation of a heart disease. The affected persons did not know about
their heart problem and thus could not take any preventive action.
The BMDSys Optical GmbH offers with a unique technical innovation a
solution for this problem!
7 www.demicco.ch
8. 1. Executive Summary
Product/Business model
The diagnostic system developed by BMDSys Optical GmbH allows a
cardiologist to estimate the risk for sudden cardiac death within five
minutes based on the heart‘s magnetic signals.
The team of BMDSys Optical GmbH and the physicians accompanying
the clinical studies developed a technology that allows an individual risk
stratification, which saves many lives.
Thus, this innovation is not only a highly interesting investment, but of
high medical, clinical, sociological and economical relevance.
Investors can participate actively in the company and profit from the
future prospects.
8 www.demicco.ch
10. 2. Product
2.1 Previous model
BMDSys Optical GmbH with its team is the follow-up of BMDSys
Production GmbH, which developed, produced and sold with the
same staff the first systems for MFI diagnostics.
With its research and development activities it achieved breaking
results and international acknowledgement. For the first time a
reliable system was available that could detect an enhanced risk
for sudden cardiac death.
Approx. 8 M. EURO were invested in the industrialization of
the first version.
10 www.demicco.ch
11. 2. Product
2.1 Previous model
The systems of the first generation work perfectly and have
successfully been used in various hospitals.
However, the used technology requires liquid helium cooling, which
means an expense of approx. 700 to 900 K EURO during a mean
life cycle of 10 years. This generates high costs and reduces the
economical effectiveness of the systems in the clinical use.
This lack of economical efficiency of the previous model has
reduced the chances in sales in such a way that the former
company could not reach sustainable profit.
11 www.demicco.ch
12. 2. Product
2.2 APOLLO CXS – the new sensor generation
Test finished
Prototype ready
More efficient
Low maintenance costs
ISO certification
Ready for market
Cheaper
New technology
Quicker production
Without cooling
Use in hospitals
Direct sales
Distributors
Sports organisations
Orders are placed!
Potential health insurances
High margins (50‐60 %)
First mover Technology
International demand
Mass production
Das team of BMDSys Optical
GmbH developed, based on the
original technology, a new
system that makes the helium
cooling superfluous. In this way
the operating costs are
importantly reduced.
Thus, the new systems are
highly interesting for any
hospital worldwide that offers
heart diagnostics. The prototype
developed under the label
APOLLO CXS is already
available. All tests have been
successful.
12 www.demicco.ch
13. 2. Product
2.3 Projected development schedule
To distribute the APOLLO CXS with the new optical technology (OPM) in clinics and medical centers, a series production
has to be set up and financed. For the international market introduction a period of 1-2 years is scheduled. Already 8-12
months after project start, revenues are possible. The production time per system will be reduced in medium term to 4
weeks for being able to respond to the increasing demand. In 2 years an industrial mass production will become
necessary.
Development processes Phase 1 Phase 2 Phase 3 Phase 4 Phase 5 Phase 6
Development of the first system (helium)
Tests in hospitals and universities
First marketing national
Development APOLLO CXS (OPM)
Test APOLLO CXS
Start series production and marketing
Mass production, worldwide sales
Sales , marketing Development phases
International marketing
today mass production
13 www.demicco.ch
14. 2. Product
2.3 Projected development schedule
Parallel to the development of the series production, direct and indirect sales channels will
be set up to acquire new customers and advanced bookings.
For systems based on the new technology, orders from the Chinese distributor are already
included in the distribution contract with the previous company BMDSys Production GmbH.
The marketing for the new technology has not been started yet.
14 www.demicco.ch
15. 2. Product
2.3 Projected development schedule
APOLLO CXS delivers information about the actual electrophysiological status of the heart
based on the record of the heart‘s magnetic signals.
The new system can become a standard diagnostic tool and can be easily combined with
other diagnostics.
APOLLO CXS provides in the handling of heart patients in the clinical routine a new
parameter that surely in the future will be considered for inclusion in the guidelines of
cardiology.
APOLLO CXS leads to a paradigm change in cardiac diagnostics!
15 www.demicco.ch
16. 2. Product
2.3 Projected development schedule
ADVANTAGES:
Quick and easy: An MFI examination takes maximum 5 minutes including data analysis.
No patient preparation is necessary, not even undressing.
Non-invasive: The sensor system is positioned over the patient‘s chest, it does not touch
the patient!
Side-effect-free: The data acquisition is pure passive, no contrast agents are necessary
and no ionizing radiation is used.
Cost efficient: No helium cooling, room temperature leads to minimum operational costs.
Repeatable: The examination can be repeated as often as required as there are no side
effects. The diagnosis is applicable for all patient groups.
16 www.demicco.ch
17. 2. Product
2.4 Production/production costs, sales prices
Current production costs per system based on the new technology:
348,000 EURO
Production costs considering a rationalized series production (from 2nd
year)
290,000 EURO
Sales prices:
Price per system for direct sales
650,000 EURO
Price per system for sales via distributors:
500,000 EURO
17 www.demicco.ch
18. 2. Product
2.5 Technology
The technology have two key fields:
The management of the environmental noise, obtained
with a intelligent distribution of the load to the
different system component (Shielding, sensor, real‐time
signal processing, software noise compensation)
The Analysis algorithm to extract the clinical relevant
information from the magnetic data.
More information will be given by Dr. Erné
18 www.demicco.ch
20. 3. Management team
3.1 Volker Schall, CEO
Volker Schall is a skilled banker and was able to successfully apply
his knowledge in several production and sales companies in the
sports industry.
Because of his expertise in the sports industry he knows the
demands and problems in this field and thus can take advantage of
the enormous potential of this market.
With his great experience as sales manager he is ideal for the
scopes of marketing and sales of the optical diagnosis systems.
Volker offers the whole necessary commercial and sales-related
know-how for being able to lead BMDSys Optical GmbH towards a
successful future.
20 www.demicco.ch
21. 3. Management team
3.2 Dr. rer. nat. Gertrud Lembke, CTO
Since finishing her studies in physics and her doctorate in 2007, Dr.
rer. nat. Gertrud Lembke (Ms.) was involved in the development of
the optical magnetometers as a scientific employee at the
University Hospital Jena.
Here, she extended her experience in the construction of a
multichannel optical magnetic field sensor system as well as in
simulation and construction of complex coil systems for well
defined magnetic fields.
For her work on this system she received in 2010 the price „Young
Investigator Award“ in the field „instrumentation“ at the
international conference for biomagnetism BIOMAG 2010. She has
the necessary physical know-how for optimizing the system for the
use in clinical routine.
Gertrud is the technical developer from the start of the
company.
21 www.demicco.ch
22. 3. Management team
3.3 Further executive personnel and employees
Heike Kroker-Häge
Heike Kroker-Häge (Ms.) was responsible for
the quality management of the
superconducting MFI systems for a long time
and knows the necessary steps for the
registration of a medical product.
Furthermore, she has great experience as an
executive assistant, in the scope of
administration, national and international
sales, export, import and purchase.
Dr. rer. nat. Reinhard Kürsten
Reinhard Kürsten studied physics in
Hamburg and obtained his doctorate in 2002.
Subsequently, he was employed at the
‚Physikalisch-Technischen Bundesanstalt‘ in
Berlin in the field of biomagnetic diagnostic.
He was responsible for the final assembly
and testing of the present MFI systems as
well as for their installation.
His extensive knowledge regarding the
behavior and treatment of highly permeable
metal plates is of great importance for the
future development.
22 www.demicco.ch
23. 3. Management team
3.3 Further executive personnel and employees
MsC. Yingbin Wu
Yingbin Wu works on the programming of the
data acquisition and analysis software of the
present MFI systems.
His knowledge and experience are of great
importance for the adaption of the present
programming to the optical magnetometers.
Furthermore, Yingbin Wu is responsible for
the contact to a Chinese distributor who
currently sells the helium cooled systems in
China.
Dipl.-Ing. Klaus Brandt
As experienced development engineer in the
field of medical engineering Mr. Brandt was
involved in the whole production process of
the helium cooled MFI systems since 2010.
In addition, as development and construction
engineer, Klaus Brandt is responsible for the
mechanical parts necessary for the operation
of the system.
23 www.demicco.ch
24. 3. Management team
3.4 Advisory board
Professor Dr. Sergio Nicola Erné
Has been involved since 1976 in research
and development in all aspects of the
technology of high sensitive magnetic
measurement for biological and medical
applications.
He was active at the PTB in Berlin, the
University of Ulm,(GE), the University of
Chieti (IT) and the University of Jena (GE).
He had cooperating with Siemens, General
Electric and Atb.
He joined all industrial efforts of BMDSys.
(For more information please see the CV)
Dr. Luigi Carlo De Micco
Luigi joined the company as consultant and
investor in the beginning of 2014. He is an
experienced entrepreneur and investment
banker with a strong background in the
growth development of IT and technology
companies. He did and managed several
IPO’s in European stock exchanges and at
NASDAQ. Today Luigi is the CEO &
president of the De Micco & Friends group
which is represented with more than 200
lawyers, auditors and investment bankers in
Europe.
(For more information please see the CV)
24 www.demicco.ch
26. 4. Market overview
4.1 Target groups
The largest sales potential is in hospitals
and large medical centers that offer heart
diagnostics on the latest state of
technology. APOLLO CXS offers
acquisition, display and analysis of the
magnetic signals of the human heart.
Thus, several large diagnostic sectors in
cardiology can be covered at the same
time, e.g. risk stratification of future life-threatening
arrhythmias and detection of
acute and stress induced ischemia.
The alternative diagnostic methods do
not provide the precision, comfort,
efficiency or a combination of the
mentioned criteria. Some of the
alternatives are invasive and/or put high
side effects to the patient .
Special hospitals,
universities
Large medical
centers
Medical
prevention
Sports centers
Cardiological
hospitals
Cardiologists
Prevention
Sports centers
Sports
organisations
Modern
practices
Direct sales Sales via distributors Admission of health
insurances
Sports Prevention facilities
Medical
26 www.demicco.ch
27. 4. Market overview
4.2 Competitors
AtB, Pescara (Italy) (A)
AtB was founded in 1990 and had co-operations with
the universities of Ulm and Jena for some years. It
carried out orders of the universities and delivered a
system named „Argos 200“ for magnetic heart
measurement to the university of Jena. This
company is not significantly active any more since
2006 and never established an industrial production
of MFI systems. AtB does not offer an optical
technology!
CardioMag Imaging (USA) (B)
Cardiomag sold in the past a 9-channel system for
the measurement of the heart‘s magnetic field with
which acute ischemia in the human heart can be
detected. However, the recording bandwidth was so
small and the noise so high that the system could not
be used for risk stratification based on the QRS
fragmentation. No optical technology available.
Elekta, Stockholm (Sweden) (C)
In a subsidiary of Elekta a system for
electroencephalography (helmet shaped) is
produced and sold. It is not possible to measure
heart signals with this system and thus this product
is no competition to our system. No optical
technology available.
BMP Hamburg (Germany) (D)
In August 2010 the magnetocardiography (MCG)
technology of KRISS was transferred to Biomagnetik
Park GmbH. In January 2012 an MCG system of the
company Biomagnetik Park GmbH was certified as a
new medical device for the diagnose of coronary
heart diseases according to the European Medical
Directive 93/42/EEC. There is no compatible
software for a risk stratification of sudden cardiac
death. No optical technology available.
27 www.demicco.ch
28. 4. Market overview
4.2 Competitors
All systems of competitors are
based on superconductive sensors,
i.e. they require helium cooling for
operation.
Thus, those suppliers are no real
competition for the optical system
of BMDSys Optical GmbH.
The operation without helium is a
unique selling proposition that is
not offered by any competitor and
saves approx. 900 K EURO of
operation costs during 10 years (life
cycle of a SQUID based MFI
system).
Thus, the optical MFI system
APOLLO CXS is unique in the
whole world.
Competitor
A
Competitor
B
Competitor
C
Competitor
D
APOLLO CXS
Price ↑ ↓ ↔ ↑ ↓
Performance ↑ ↓ ↙ ↔ ↑
Regional market
share ↓ ↓ ↓ ↓ ↓
National market
share ↓ ↓ ↓ ↓ ↓
Regional
acceptance ↔ ↔ ↔ ↔ ↑
National
acceptance ↔ ↔ ↔ ↔ ↑
Product range ↔ ↓ ↔ ↗ ↓
Marketing ↔ ↙ → ↔ ↔
Innovation ↔ ↔ ↙ ↔ ↑
Company size ↓ ↑ ↓ ↔ ↔
On the market
since 1990 2005 2000 ‐ 2005 2010 2008
Legend: ↑ very high; ↗ high; ↔ moderate; ↙ low; ↓ very low
28 www.demicco.ch
29. 4. Market overview
4.3 Market potential
The market potential is enormous!
Considering the fact that no
comparable product for heart
diagnostics is available until now,
BMDSys Optical GmbH has the
potential for being a „global
player“ in this segment.
It can be supposed that BMDSys
Optical GmbH first will have a
monopoly position on the global
market with its product.
The developmental edge of
approx. 5 years can hardly be
caught up with even by larger
companies that want to set up a
competition.
600.0 bn
60.0 bn
2.0 bn
75 %
Market capacity global
Market potential
Market volume
Scheduled
market share until 2018
29 www.demicco.ch
31. 5. Chances and risks
Optimum initial situation for investors
BMDSys Optical GmbH is in a classic „next‐ level‐position“.
The management and development team
is well attuned, the main product is ready for market.
The newly founded company is completely free from
encumbrances and can now start with an
appropriate funding.
Contrary to comparable technology companies
where the main part of financial resources had to be
invested in research and development BMDSys
Optical GmbH provides a nearly finished and
market‐ready product.
Chances
Best product on the market
Competitive edge can be secured in case of preferably
soonest market entry
Potential for global player and market leader
Worldwide high demand
Existing orders
Risks
Supply bottleneck at suppliers of applicable material
Handling of the expected growth
Copying of the technology by competitors (very difficult)
31 www.demicco.ch
33. 6. Financial planning
6.1 Sales figures
Sales planning P1 P2 P3
Price/system
China & US (Transfer of distribution contract) 500,000,00 € 2 7 16
Channel direct sales 650,000,00 € 0 2 5
Channel distribution 600,000,00 € 0 14 11
Mobile system option 380,000,00 € 2 2 0
Revenues from sales 1,760,000,00 € 14,590,000,00 € 18,170,000,00 €
Maintenance 20,000,00 € 0 80,000,00 € 500,000,00 €
Capital inflow from investors 3,000,000,00 €
Revenues in total 1,760,000,00 € 14,670,000,00 € 18,670,000,00 €
The sales figures of BMDSys Optical GmbH especially depend on the production capacities to be
managed. In case of conservative planning, from 2nd. Year on 25 units, i.e. approximately two
system per month, will be produced if the expected funding will be available. This means a turn over
of already 14,6 mio. EURO. Up from 3th. year the production will be increased to at least 32 units
which means an average turn over of 18,6 mio. EURO.
33 www.demicco.ch
34. 6. Financial planning
6.2 Cost of materials
Cost of materials P1 P2 P3
Shelter 75,000,00 € 1,650,000,00 € 1,200,000,00 € 1,500,000,00 €
Mu‐Metall 75,000,00 € 1,650,000,00 € 1,200,000,00 € 1,500,000,00 €
Master console and workstation 12,000,00 € 264,000,00 € 192,000,00 € 240,000,00 €
Elektronic hardware 40,000,00 € 880,000,00 € 640,000,00 € 800,000,00 €
Laser 12,000,00 € 264,000,00 € 192,000,00 € 240,000,00 €
Optical sensor 100,000,00 € 2,200,000,00 € 1,600,000,00 € 2,000,000,00 €
Cosmetics und electrical infrastructur 12,000,00 € 264,000,00 € 192,000,00 € 240,000,00 €
Other materials 12,000,00 € 264,000,00 € 192,000,00 € 240,000,00 €
Installation 10,000,00 € 220,000,00 € 160,000,00 € 200,000,00 €
Cost of material / mashine 348,000,00 €
Cost of material in total 7,656,000,00 € 5,568,000,00 € 6,960,000,00 €
The costs of material are calculated proportionally to the sold units. Based on the long delivery time
of up to 3 months for single components, purchasing and financing has to be scheduled accordingly.
34 www.demicco.ch
35. 6. Financial planning
6.3 Cost of personnel
Cost of personnel P1 P2 P3
Number of employees 18 18 18
CEO 11,000,00 € 132,000,00 € 138,600,00 € 145,200,00 €
CTO 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
Backoffice 5,000,00 € 55,000,00 € 63,000,00 € 66,000,00 €
Software/Analysis 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
Software/ data base 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
QM 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
RealTime Software 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
Medical technics 5,900,00 € 53,100,00 € 74,340,00 € 77,880,00 €
Elektronic 5,900,00 € 53,100,00 € 74,340,00 € 77,880,00 €
Production eng. 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
Produkcion eng. 5,900,00 € 29,500,00 € 74,340,00 € 77,880,00 €
Production assistance 4,200,00 € 37,800,00 € 52,920,00 € 55,440,00 €
Production assistance 2 4,200,00 € 37,800,00 € 52,920,00 € 55,440,00 €
Production assistance3 / Customer ralation 4,200,00 € 50,400,00 € 52,920,00 € 55,440,00 €
Production assistance 4 4,200,00 € 8,400,00 € 52,920,00 € 55,440,00 €
Production assistance 5 4,200,00 € 8,400,00 € 52,920,00 € 55,440,00 €
Sales‐Rep 1 5,900,00 € 70,800,00 € 74,340,00 € 77,880,00 €
Sales‐Rep 2 5,900,00 € 64,900,00 € 74,340,00 € 77,880,00 €
Costs of personel 1,026,000,00 € 1,283,940,00 € 1,345,080,00 €
The costs for personnel increase with increasing production. For the two founders (CEO and CTO) an
additional performance‐related bonus system should be developed.
35 www.demicco.ch
37. 6. Financial planning
6.5 Investments
Investments P1 P2 P3
IRFA 90,000,00 € 90,000,00 € 0,00 € 0,00 €
High permeable material 90,000,00 € 90,000,00 € 0,00 € 0,00 €
Coil material 10,000,00 € 10,000,00 € 0,00 € 0,00 €
New sensor head holder 25,000,00 € 25,000,00 € 0,00 € 0,00 €
New sensor head 60,000,00 € 60,000,00 € 0,00 € 0,00 €
Non‐magnetic adjustable mattress 20,000,00 € 20,000,00 € 0,00 € 0,00 €
Electronic hardware 100,000,00 € 100,000,00 € 0,00 € 0,00 €
Office equipment 75,000,00 € 60,000,00 € 15,000,00 € 0,00 €
Production equipment 150,000,00 € 75,000,00 € 75,000,00 € 0,00 €
Field testing equipment 70,000,00 € 70,000,00 € 0,00 € 0,00 €
Magnetic test equipment (2x) 40,000,00 € 80,000,00 € 0,00 € 0,00 €
Basic optical equipment 60,000,00 € 60,000,00 € 0,00 € 0,00 €
Forklifts (2x) 10,000,00 € 10,000,00 € 10,000,00 € 0,00 €
Container transport system internally (2x) 100,000,00 € 100,000,00 € 100,000,00 € 0,00 €
Power generation system for 110V / 60Hz (USA) 50,000,00 € 50,000,00 € 0,00 € 0,00 €
Investments total: 900,000,00 € 200,000,00 € 0
For the first operational year only 900K EURO are necessary, with which the whole development
and production process is covered. The previous company invested during it‘s operational time
approx. 8 M. EURO. BMDSys Optical GmbH can proceed with it‘s activities completely
unencumbered.
37 www.demicco.ch
38. 6. Financial planning
6.6 Cash Flow Overview
Cash Flow P1 P2 P3
Revenues 1,760,000,00 € 14,670,000,00 € 18,670,000,00 €
Costs of materials 7,656,000,00 € 5,568,000,00 € 6,960,000,00 €
Costs of personnel 1,026,000,00 € 1,283,940,00 € 1,345,080,00 €
Operational costs without personnel 945,870,00 € 1,666,078,00 € 2,294,101,00 €
EBITDA: ‐7,867,870,00 € 6,151,982,000,00 € 8,070,899,00 €
Cash Flow accumulated: 812,130,00 € 6,738,111,20 € 14,743,929,60 €
Cash flow: ‐87,870,00 € 5,638,111,20 € 14,543,929,60 €
When calculating conservatively, until the end of the year only a turnover of 1,7 M is achieved that
results from existing orders. But depending on the time of the financing and delivering of
components, within 9‐12 months sales profits can be achieved. The cash flow of the first year
considers already the payment of an investment sum of 10 mio. EURO.
From the second year on (see business plan) the cash flow of the company is positive.
38 www.demicco.ch
39. 6. Financial planning
6.7 Capital demand
The actual capital demand of the company is 10 mio. EURO.
The capital will be used in the following ways:
- Finishing the series-production readyness of the prototype
APOLLO CXS
- Optimizing the production
- Set up of national and international sales
- National marketing aktivities
- Continuing the health insurance license
- Prefinancing the existing and future orders
39 www.demicco.ch
41. 7. Offer for investors
7.1 Participation
Interested investors can participate directly in the BMDSys Optical
GmbH.
Considering the sales and profit and the enormous market- and
development potential the company today is rated with minimum
32 mio. EURO.
The momentary proprietors offer investors a company share of up
to 33 % for an exceptional price of 10 mio. EURO, which covers
the momentary capital need.
With an committed institutional investor on board it’s possible to get
a further finance by a German government institution (TBG) about
50% of the investors engagement on a loan basis.
41 www.demicco.ch
42. 7. Offer for investors
7.2 Exit strategies
The management teams searches investors for medium and long
term attendance.
The actual business plan was set up for 3 years. From the 4th year
on an industrial production should be established, that covers the
demand. It can be assumed that the company than faces another
developmental step.
Possible exit strategies from the momentary point of view:
- Rebuy of shares through the company owner
- IPO, Reverse Merger
- M&A transaction
42 www.demicco.ch
43. Further questions?
Please contact us:
Volker Schall
eMail: vs@bmdsysoptical.com
Phone: + 49 261 98279819
Mobile: + 49 151 432 638 01
Dr. Luigi Carlo De Micco
eMail: luigi@demicco.ch
Phone: + 34 871 944 532
Mobile: + 34 637 216 267
Web: www.demicco.ch
43 www.demicco.ch