Nephrotic Syndrome vs nephritic syndrome made easy

1. Nephrotic vs Nephritic Syndrome
Pathology

2. What’s Happening ?
Nephrotic
• Changes to glomerulus
leaking of massive proteins
Nephritic
• Inflammation of glomerulus
= leaking of RBCs and
Protein (mild)

3. Main Cause
Nephrotic
• Unknown = Change to
glomeruli.
• Minimal change disease.
• Other diseases: Lupus,
diabetes, HF etc.
Nephritic
• Post streptococcal infection
• 14 days after infection of
throat and skin.
• Immune system create
antigen-antibody complex
that inflame glomerulus.

4. Nephrotic Nephritic

5. Clinical manifestations of Nephrotic Syndrome
Triad
Hypoalbuminia
Massive
proteinuria
Generalized
edema

6. Clinical manifestations of Nephritic Syndrome
Triad
Hematuria
Generalized
edema
Hypertension

7. Disorders manifested by nephrotic syndrome

8. Disorders manifested by nephritic syndrome

10. Lets Assay

11. • Which of the following conditions most commonly
causes acute glomerulonephritis ?
a) A congenital condition leading to renal dysfunction.
b) Prior infection with group A Streptococcus within
the past 10-14 days.
c) Viral infection of the glomeruli.
d) Nephrotic syndrome.

12. • Which of the following characteristics is used to
define a nephritic syndrome?
a) Red Blood Cell casts in urine with a decreased BUN
and creatinine
b) Polyuria and hypotension
c) Fatty casts in urine
d) Protein in the urine (under 3.5 grams per day)

13. The End