Nanotech_2010
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The document discusses various nanotechnology approaches for drug delivery to the central nervous system (CNS) and overcoming the blood-brain barrier (BBB). It outlines several short-term and long-term delivery methods including passive diffusion, prodrug approaches, brain-targeted drug delivery systems, intranasal delivery, receptor-mediated transport, and the use of nanoparticles, viral/bacterial vectors, and stem cells. The goal is to build infrastructure to support nanotechnology opportunities and drive diversity in delivery methods from molecules to medical applications.
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Nanotech_2010
- 1. Nanotechnology Time line Nanomilling, passive nano-carriers, Raised therapeutic index and reduced off-target effects Organs on a chip, Targeted delivery to the CNS, intracellular delivery of RNA’s Nanotechnology to drive diversity Drivers: Science and Economics - Molecules Define Tactics Build capability infrastructure as key enabler of opportunities EvolutionRevolution Possibilities Short term delivery & pay back / credibility External ideas, collaborations and services
- 2. “Chemical” Delivery Drug Brain Delivery Ways to cross the BBB & Delivery technologies Lipidization & Passive diffusion Prodrug & Lock-in system Brain-targeted CDS system BBB Overcome Trans-cranial drug delivery Intranasal (N2B) drug delivery Adsorptive Mediated Transcytosis Cationic Modification Carrier Mediated Transport Receptor Mediated Transport BBB disruption - Transient opening Functionalization Prodrug Trojan Horses Cell penetrating Peptides CPPs Nanoparticles Devices: pumps implant, catheters Liposome Dendrimer Polymer beads Viral – Bacterial vectors Macrophage targeting Adult Stem Cells