The most common non-cancerous tumours in women . The most common indication for hysterectomy. Apparent in up to 25% of women. More common in a higher body mass index women. 3 times more common in black American women than white women. Asian women have a lower incidence . Symptoms appear at age of 30s or 40s . The incidence increases with age up to the menopause. Women over the age of 30 are commonly affected by fibroid uterine. 50% of all women are affected by fibroid uterine. Most common solid pelvic tumors. Develop in 20～25% of women during reproductive years.

1. DONE BY :
MUSTAFA KHALIL IBRAHIM
TBILISI STATE MEDICAL UNIVERSITY
4th year, 2nd semester, 1st group

2.  Epidemiology
 Anatomy
 Introduction
 Pathology
 Pathophysiology
 Risk factors
 Etiology
 Signs and symptoms
 Complications
 Diagnosis
 Treatments
 Prevention
 References

3.  The most common non-cancerous tumours in women .
 The most common indication for hysterectomy.
 Apparent in up to 25% of women.
 More common in a higher body mass index women.
 3 times more common in black American women than white
women.
 Asian women have a lower incidence .
 Symptoms appear at age of 30s or 40s .
 The incidence increases with age up to the menopause.
 Women over the age of 30 are commonly affected by fibroid
uterine.
 50% of all women are affected by fibroid uterine.
 Most common solid pelvic tumors.
 Develop in 20～25% of women during reproductive years.

5.  Uterine fibroids are noncancerous growths of the
uterus that often appear during childbearing years.
 A benign tumors of the smooth muscle cells of the
uterus
 Uterine fibroid is a leiomyoma (benign (non-
cancerous) tumor from smooth muscle tissue) that
originates from the smooth muscle layer (myometrium) of
the uterus
 They can grow as a single tumor or as a cluster.

9. Composition：smooth muscle
connective tissue
The nonstriated muscle fibers are arranged in bundles
of various sizes that run in multiple directions.

11. According to position
 70 % Intramural
(in uterine wall)
 20% Subserosal
(beneath serosa)
 10 % Submucosal
( beneath endometrium )
pedunculated submucosal or
pedunculated vaginal
According to growth location：
 Myomas on the body of uterus（90%）
 Myomas on the cervix of uterus（10%）

12. (composed of densely cellular fascicles of smooth
muscle with little intervening collagene).
(containing atypical cells, clustered or
distributed through the lesion).
(composed of round or poligonal cells rather
than spindle-shaped. This subtype includes leiomyoblastoma, clear cell
leiomyoma, plexyform leiomyoma).
(containing abundant amorphous myxoid
substance between the smooth muscle cells).
(containing dense proliferations of large, caliber,
thick-walled vessels).
(consisting of a mixture of mature adipocytes and
smooth muscle cells).
(containing tubular structures).
(occurrence of multiple
smooth-muscle nodules, most often located in the lung after previous
hysterectomy).

13. Degenerative changes
 Hyaline degeneration:
 Cystic degeneration:
 Calcification:
 Fatty degeneration:
 Red degeneration: with fever, pain
and vomiting
 Septic degeneration:
 Infection
 Atropy
 Necrosis
 Vascular changes
 Sarcomatous changes

14.  Heredity.
 Race.
 Pregnancy and childbirth.
 Nulliparity Obesity
 Oral contraceptives.

15.  unknown.
 Family history
 Genetic alterations.
 Hormones.
 Other growth factors:
such as insulin-like growth factor, may affect
fibroid growth.

18.  Recurrent miscarriage
 Fetal malpresentation
 Red degeneration: presents with
fever, pain and vomiting
 Intrauterine growth retardation
 Premature labour
 Postpartum haemorrhage
 A c-section may be needed

20.  Menorrhagia.
 Abdominal pains
 Infertility
 Leiomyosarcoma
 Twisting of the fibroid
 Anemia
 Urinary tract infections

21.  Heart rate .
 Blood pressure.
 Breathing.
 Temperature.
 BMI.
 O2 saturation
• Abdominal examination

23.  Blood test (CBC) .
-Rbc, Iron, Erthropoietin, Hematocrit,Wbc …. etc
 Hormonal test
-Estrogen
 Pregnancy test may be indicated:
-Gonadotropin chorionic

25. Hysterosalpingography

29.  Myomectomy
 Hysterectomy
Beware of side effects including amenorrhoea,
menopausal symptoms and osteoporosis in long
term use.

30.  Hysterectomy
 healthy lifestyle
 Exercise regularly.
 Manage your weight.
 Drink green tea or use green tea extract.
 Consider changing your diet.
 Understand that pregnancy and childbirth may
have protective effects against developing uterine
fibroids.

31. BOOKS :
 Current Diagnosis And Treatments In Obstetrics,
Gynecology 10Th Ed.
 Williams Gynecology, Third Edition 3rd Edition 2016 .
INTERNET :
 Mayo clinic .
 Medscape .
 Center of disease and control .
 World health organization .
 http://atlasgeneticsoncology.org/Tumors/leiomyomID
5031.html

33. MADLOBA