The study investigates multi-granularity tooth detection and classification using YOLO-based object detection models, highlighting the challenges posed by variations in tooth appearance and geometry. A granular intra-oral image dataset of 2,790 images was developed, and the YOLO models achieved mean average precision (MAP) values of up to 94%, with performance decreasing as granularity levels increased. This research emphasizes the importance of granularity in enhancing tooth detection accuracy in dental informatics.