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Abstract
Spatial navigation ability is indispensable for our daily life. We rely on the
spatial representations to guide us from place to place. The cognitive processes
involved in spatial navigation are very complex. The spatial navigation includes
encoding, storing, and retrieving spatial information. Although the ability to identify
the direction and encode the spatial layout of an unfamiliar environment is important
to us, there are big considerable differences between people. Here we investigated the
relationship between hippocampo-thalamic anatomy and spatial learning by training
participants in an unfamiliar environment. Participants were asked to remember the
spatial layout of the campus. The familiarization with the campus took place in three
sessions on one day. After each session participants’ spatial knowledge of the medical
campus was tested by spatial navigational tests, including detecting the facing
direction, examination of the direction and distance between the distinct locations.
Volumetric analyses of structural MRI data revealed that the size of the anterior
hippocampus related to the learning speed of the relative position of landmarks, and
the volume of the anterior thalamus predicts the ability of remembering the directional
information. These results suggested that the individual difference in navigation
ability in large-scale environment can be explained by anatomical differences of
individual brains.

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MSc of Integrative Neuroscience Ab

  • 1. Abstract Spatial navigation ability is indispensable for our daily life. We rely on the spatial representations to guide us from place to place. The cognitive processes involved in spatial navigation are very complex. The spatial navigation includes encoding, storing, and retrieving spatial information. Although the ability to identify the direction and encode the spatial layout of an unfamiliar environment is important to us, there are big considerable differences between people. Here we investigated the relationship between hippocampo-thalamic anatomy and spatial learning by training participants in an unfamiliar environment. Participants were asked to remember the spatial layout of the campus. The familiarization with the campus took place in three sessions on one day. After each session participants’ spatial knowledge of the medical campus was tested by spatial navigational tests, including detecting the facing direction, examination of the direction and distance between the distinct locations. Volumetric analyses of structural MRI data revealed that the size of the anterior hippocampus related to the learning speed of the relative position of landmarks, and the volume of the anterior thalamus predicts the ability of remembering the directional information. These results suggested that the individual difference in navigation ability in large-scale environment can be explained by anatomical differences of individual brains.