This document provides a detailed history of tobacco use from its origins in the Americas circa 6000 BCE to modern times. It discusses the spread of tobacco use from indigenous populations to Europeans. Key events covered include Rodrigo de Jerez being the first confirmed European smoker in the 15th century and the development of tobacco plantations in the Americas in the 16th century. The document also examines the biology and pharmacology of nicotine, health effects of tobacco use, and societal impacts. It provides an overview of the World Health Organization's Framework Convention on Tobacco Control and efforts to prevent tobacco use through warnings, advertising bans, and graphic health warnings on packaging.