Tobacco is a plant within the Nicotiana genus of the Solanaceae family. The most common commercial crop is Nicotiana tabacum, which contains the stimulant alkaloid nicotine. Tobacco use is a risk factor for many diseases, especially those affecting the heart, lungs and liver, and several cancers. It has a long history of use among indigenous peoples in the Americas prior to European colonization. While it was initially popularized and its production fostered economies, it is now recognized as a cause of preventable death and its use is regulated in many places.