Giid

1. PATHOLOGY ASSOCIATED WITH
ENVIRONMENTAL FACTORS
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Department of pathology, basic and
clinical pharmacology

2. DEFINITION
GEOGRAPHICAL PATHOLOGY - area of ​​medicine and
biology, which studies the characteristics of various
diseases associated with local natural and applied to
human beings - and social factors. It is not the same as
the geography of disease, since the object of pathology,
including geographical, are not only well-defined disease,
but any deviation from the norm, often found in healthy
people. Subject geographical pathology - a set of
diseases, pathological processes and conditions, the
occurrence of which is associated with the geographical
(natural, socio-economic and environmental hygiene)
factors.
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3. BRANCHES OF GEOGRAPHIC MEDICINE
 Mountain medicine
 Polar medicine
 Pathology arid zone
 Tropical diseases
 Private forms of regional pathology (pathology
geochemical provinces, natural focal
zooantroponozy, extreme loci and others.)
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4. MOUNTAIN PATHOLOGY
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1.Original nosological
forms of diseases:
 Alpine acute pulmonary
edema
Alpine acute cerebral
edema
Chronic mountain
sickness (Monge's
disease).
2. Modification of the
course of infectious and
noninfectious diseases.
right ventricular
hypertrophy
«pulmonary heart»

5. SANOGENIC EFFECT
OF MOUNTAIN CLIMATE
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 Highland
climatotherapy on the
pass Tuya-Ashu - 3200
meters above sea level
 Mid-sea
climatotherapy in the
resorts of Issyk-Kul -
1600 meters above sea
level
 Highland
speleotherapy -
speleological clinics
Chon-Tuz

6. HEALTH
Genetic factors
Ecology, environment 20-25%
Work actıvıty
Medıcıne
15-20%
Lıfestyle
Factors of human health problems

7. INFLUENCE OF ENVIRONMENTAL FACTORS ON
THE ANNUAL MORTALITY (A) AND CANCER
INCIDENCE (B) (ACCORDING TO WHO)
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environmental factors
other factors

8. ECOLOGICAL FACTORS
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9. FACTORS PLAY AN IMPORTANT ROLE IN THE
DEVELOPMENT OF ENVIRONMENTAL DISEASE
Heredity. There are defects of the immune system and the ability to detoxify toxic
compounds. It is established that about 50% of people have certain defects in
mechanisms acetylation different compounds - one of the means of neutralization of
foreign compounds. • Nutritional status. This may include depleted or enriched for
certain substances diet, imperfect digestion, absorption disorders, and others
• Features of the toxic effects. It can occur at home (the action of natural gas
combustion products) in the street (the action of lead from vehicle exhaust gases)
and at work (eg, the impact of microorganisms in cooling systems, air conditioning,
and chemicals). • The action of allergens. One of the main causes of environmental
diseases (for example, due to house dust mite waste products).
• The free radical stress. Caused by physical factors, as well as being in humans
organic compounds, heavy metals (Pb, Cr, C (1, A1, Fe, etc.). Thus initiated free
radical-forming reaction, resulting in damage to biopolymers processes peroxidation
lipids. this is due to DNA damage, the occurrence of mutations and other genetic
effects.
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10. DISEASES THAT CAN BE ASSOCIATED WITH
EXPOSURE TO ENVIRONMENTAL FACTORS:
 Seasonal affective disorder (winter depression);
 Multiple chemical sensitivities;
 Some gastrointestinal disease (ulcerative colitis,
Crohn's disease, etc.);
 Chronic allergic disease;
 Bronchial asthma;
 A series of autoimmune diseases; eczema;
 A number of chronic neurologic diseases; multiple
sclerosis;
 Alzheimer's disease (senile dementia);
 Chronic fatigue syndrome;
 A number of diseases of the musculoskeletal system
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11. ANTHROPOGENIC POLLUTION
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12. CATEGORIES OF PERSONS EXPOSED TO THE
NEGATIVE IMPACT OF THE INDUSTRY ON HUMAN
HEALTH
Employees of the company
(occupational diseases)
The population of closely spaced
areas
 Systemic effects on the biosphere
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13. Хром (YI)
Бензол
Бутадиен, 1,3-
Никель
Тетрахлорметан
Мышьяк
Формальдегид
Трихлорэтилен
Азот диоксид
Сера диоксид
Ванадий
Марганец
Цинк
Медь
Взвешенные вещества
Водород сульфид
Carcinogens NON carcinogens
Emission components that occupy the first
10 places ranked by hazard
The first place on ecotoxicity - chemical compounds of oil
and gas industry emissions (30-40% of air pollution)

14. CANCER OF LIPS, TONGUE, ORAL MUCOSA IN SMOKING,
DRINKING AND OTHER NASVAY CHEWING NARCOTIC
MIXTURES
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15. NORMAL LUNGS AND LUNGS OF
SMOKER
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16. LUNG CANCER AS A CONSIQUENCE OF
CHRONIC BRONCHITIS IN SMOKING
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17. STEATOSIS AND LIVER CIRRHOSIS IN ALCOHOLISM
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18. ULTRASTRUSTURAL CHANGES OF BRONCHIAL
MUCOSA IN CHRONIC BRONCHITIS
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19. CHANGES IN THE LUNGS IN AIR POLLUTION
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20. ATROPHIC AND INFLAMMATORY CHANGES IN THE
GASTROINTESTINAL MUCOSA IN CHILDREN IN THE AREA
OF ENVIRONMENTAL PRESSURES
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21. ATROPHIC AND INFLAMMATORY CHANGES IN
RENAL EPITHELIUM IN CHILDREN IN THE AREA
OF ENVIRONMENTAL PRESSURES
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22. CHROMOSOMAL ABERRATIONS IN LYMPHOCYTES
OF CHILDREN IN THE AREA OF ENVIRONMENTAL
PRESING
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23. SILICOSIS
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24. SILICOSIS AND COAL MINERS DISEASE
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25. The distribution of dust particles in different parts
of the respiratory tract
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Fibers:
-asbestos,
- other natural mineral
fibers,
- man-made mineral fibers
-synthetic fibers,
-organic fibers,
and many others ...

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28. ASBESTOSIS
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29. Differences in the delay fibrous and nonfibrous particles in the pleura
Donaldson K., Murphy F. A, Duffin R., and Poland C. A Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role
of long fibre retention in the parietal pleura, inflammation and mesothelioma Part Fibre Toxicol. 2010; 7: 5. Published online 2010 March 22.
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30. STILL FROM THE FILM "THE WIZARD OF OZ" - SNOW FROM
ASBESTOS
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31. MINING OF ASBESTOS IN CANADA
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32. WATER QUALITY
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
Kyrgyzstan has a
countless inventory of
ecologically clean
drinking water and
mineral water.

33. GLACIERS
Glaciers and eternal snow are the adornment of the landscape and one of the
riches of the country. The area of ​​glaciers is 6578 km2

34. WITH INCREASED MELTING OF GLACIERS CAUSED BY CLIMATE CHANGE MAY
INCREASE THE FLOOD EVENTS, DEBRIS FLOWS, LANDSLIDES, WHICH CAUSE
DAMAGE TO THE TAILINGS OF URANIUM, GOLD, ANTIMONY AND MERCURY
PRODUCTION AND RELEASE INTO THE ENVIRONMENT OF RADIOACTIVE AND
TOXIC SUBSTANCES

35. THANK YOU FOR YOUR PATIENCE !
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