Medical Biospecificity of ginger

1. Medicinal Biospecificity of Ginger and
its Efficacious Bioactive Compounds in
the Context of Its Biological Activities Against
Predominant Health Issues: Current Study and
New Avenues
PRESENTED BY: GROUP 5
PRESENTED TO: MAM HASEEBA SHAHZAD

2. Group 5
• M Nouman-ul-Hassan(10)
• Sheraz Ahmad(06)
• Muhammad Arslan(43)
• Tanvir Ahmad(52)
• Muhammad Umair(46)
• Asma Riaz(15)
• Aimen Khizar(38)
• Farah Naz(13)

3. Outline
 Abstract
 Introduction
 Actions
 Limitations
 Conclusion

4. Abstract

5. Abstract
 Ginger, a perennial plant of the Zingiberaceae family with several
authentic nutritional and medicinal values
 The present study includes the medicinal effects of almost 44
most influential ginger compounds like phenolics, terpenoids,
flavonoids, and vinyllyl ketonic compounds etc.
 Ginger act as Immuno-stimulatory, Anti-inflammatory, Anti-
viral, Anti-bacterial, Anti-oxidant and Anti-cancer.
 The ginger essential oil has proven to be very effective both for
antiviral and antibacterial activity.

6. Introduction

7. Introduction
 Herbal medicine
 400 compounds
 Curative activities
 Gingerols and Shogaols
 Ginger essential oil

8. Actions

9. Anti-Inflammatory
 Inflammation
o Chemicals from WBCs
o Increased blood supply
o Leakage of fluids
 Ginger as Anti-Inflammatory
o Vinyllyl ketonic compounds
o 6-paradols
o 6-Shogaols
o 1-Dehydro-6-Gigerols

10. Anti-Inflammatory
 Inflammatory Enzymes:
o Lepoxygenases
o Cyclooxygenases
o Prostaglandins
o Thromboxane
o Arachidonic Acid
 Arthritis
o Ginger essential oil
o Ginger extract

11. Immuno-Stimulant
 Immunity
 Ginger role
 Increase WBCs
 Increase phagocytic activity
 Comparison of plasma proteins

12. Anti-Viral
 Ginger activity
 Fresh ginger
 Dried ginger
 Food borne disease
 Therapeutic effects
 COVID patients

13. Anti-Bacterial
 Bacterial infection
 Antimicrobial resistance (AMR)
o Gram-Positive
o Gram-Negative
 Ginger oil extract action
o E.coli
o Vibrio cholera
o salmonela spp

14. Anti-Bacterial
 Infection caused by V.harveyi
 Increase anti-protease activity
 Suppress attacking ability of bacteria
 Ginger essential oils

15. Anti-Oxidant
 Oxidative stress
 Preventive measures
 Antioxidative properties
 Chemotherapeutic patients
 Antioxidative enzymes in rats
 Antioxin

16. Anti-Cancer
 Cancer
 Second leading death cause
 Types of cancer:
o Brian cancer
o Liver cancer
o Gastric cancer
o Pancreatic cancer
o Prostate cancer

17. Anti-Cancer
 Ginger as an anti-cancer
o Suppress proliferation
o Induce apoptosis of cancer cells
 Components of ginger
o 10-Gingerol
o 6-Gingerol
o 6-Shogaol
o Ginger extract
o Ginger extract with alginate beads

18. Gastric Cancer
 5th most prevalent type of cancer
 6-Gingerol
o Suppress inhibitors of anti-cancer
compounds
 6-Shogaol
o Disturb tubulin
o Mitotic arrest
o Apoptosis of cancerous cells

19. Pancreatic Cancer
 Malignant tumors in pancreas
 6-Gingerol and 6-Shogaol
o Apoptosis of tumor cells
o Proliferative activity of tumor cells
o Hinder cell cycle at G1 phase
 Reactive oxygen species
o Autoptic cell death

20. Prostate Cancer
 15% of male cancer
 2nd major death cause
 Ginger decrease the level of:
o Cyclin D1
o Cyclin E
o Cdk4

21. Limitations
 Bleeding disease patients (Hemophilia)
 More bleeding during surgery
 Skin rashes, Mouth irritation, Heart burn etc
 Harmful for pregnant women

22. Conclusion

23. Thank You