SlideShare a Scribd company logo
Maternal Excess Weight Stresses Oozytes
Introduction 	Substantially increased body weight can have a significant negative impact on female fertility. 	But how exactly can excess body weight affect reproductive function in women? 	A possible explanation comes from a study by Natalia Igosheva and colleagues from King’s College London, London, UK, just published in PLoS. Notes: http://www.ncbi.nlm.nih.gov/pubmed/20404917
Study 	Using an established mouse model of maternal diet-induced obesity and live cell dynamic fluorescence imaging techniques, the researchers demonstrated that maternal obesity prior to conception is associated with altered mitochondria in mouse oocytes (eggs) and zygotes.
Fat vs Lean 	Specifically, maternal diet-induced obesity in mice led to an increase in mitochondrial potential, mitochondrial DNA content and biogenesis. Generation of reactive oxygen species (ROS) was raised while glutathione was depleted and the redox state became more oxidised, suggestive of oxidative stress. (for my non-technical readers, it suffices to say that none of this is good for the egg or the zygote). 	These altered mitochondrial properties were associated with significant developmental impairment as shown by the increased number of obese mothers who failed to support blastocyst formation compared to lean dams.
Strategy – Weight Loss 	These studies show that compromised oocyte and early embryo mitochondrial metabolism, resulting from excessive nutrient exposure prior to and during conception, may underlie poor reproductive outcomes frequently reported in obese women. While the leap from mice to women may seem a bit of a stretch, there is no doubt that in many overweight and obese women trying to become pregnant, weight loss is clearly one of the most effective strategies. Now all we need are more effective strategies to help manage excess weight.
About Dr. Arya M. Sharma 	Dr. Arya M. Sharma, MD/PhD, FRCPC is Professor of Medicine & Chair for Obesity Research and Management at the University of Alberta, Edmonton, Canada. He is also the Medical Director of the Edmonton Capital Health Region’s interdisciplinary Weight Wise Program. 	Dr. Sharma is also the Scientific Director of the Canadian Obesity Network funded through the federal  "Networks of Centres"ofExcellence program. Dr. Sharma has authored and co-authored more than 250 scientific articles and has lectured widely on the etiology and management of obesity and related cardiovascular disorders. He sends his informative messages through his blog Dr. Sharma’s Obesity Notes. 	For more information on Obesity visit; Website: http://www.drsharma.ca/ Facebook: http://www.facebook.com/pages/Dr-Arya-Sharma/115328778486319  

More Related Content

Similar to Maternal excess weight stresses oozytes

Friedman o&p2013
Friedman o&p2013Friedman o&p2013
Friedman o&p2013_IASO_
 
Jack Oughton - Compiled Health and Fitness Articles.pdf
Jack Oughton - Compiled Health and Fitness Articles.pdfJack Oughton - Compiled Health and Fitness Articles.pdf
Jack Oughton - Compiled Health and Fitness Articles.pdfJack Oughton
 
The obese woman
The obese womanThe obese woman
The obese woman
janewilcock
 
Obesity and infertility ajami 2021
Obesity and infertility ajami 2021Obesity and infertility ajami 2021
Obesity and infertility ajami 2021
’Mohamed Alajami
 
EuropePMC 2014
EuropePMC  2014EuropePMC  2014
EuropePMC 2014luchan81
 
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. indiaObesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
alka mukherjee
 
Pregnancy and aesthetics
Pregnancy and aestheticsPregnancy and aesthetics
Pregnancy and aesthetics
Dr. Patrick J. Treacy
 
White Lies
White LiesWhite Lies
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...Lifecare Centre
 
Diet-Induced Metabolic Syndrome models.pdf
Diet-Induced Metabolic Syndrome models.pdfDiet-Induced Metabolic Syndrome models.pdf
Diet-Induced Metabolic Syndrome models.pdf
Agustin Carmona Castro
 
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
Prof Dr Bashir Ahmed Dar
 
One In Nine
One In NineOne In Nine
The association between gut microbiota and body weight
The association between gut microbiota and body weightThe association between gut microbiota and body weight
The association between gut microbiota and body weightAshwath Venkatasubramanian
 
Maternal nutrion 5
Maternal nutrion 5Maternal nutrion 5
Maternal nutrion 5
sushin isvaran
 
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
SoM
 
Genetic influence on obesity
Genetic influence on obesityGenetic influence on obesity
Genetic influence on obesityNeha Dronamraju
 
OBESITY
OBESITYOBESITY
Tackling Obesity in Infertility
Tackling Obesity in InfertilityTackling Obesity in Infertility
Tackling Obesity in Infertility
Sujoy Dasgupta
 
Dr jaideep malhotra Adhbhut Matrutva
Dr jaideep malhotra   Adhbhut MatrutvaDr jaideep malhotra   Adhbhut Matrutva
Dr jaideep malhotra Adhbhut Matrutva
NARENDRA MALHOTRA
 

Similar to Maternal excess weight stresses oozytes (20)

Friedman o&p2013
Friedman o&p2013Friedman o&p2013
Friedman o&p2013
 
actual poster
actual posteractual poster
actual poster
 
Jack Oughton - Compiled Health and Fitness Articles.pdf
Jack Oughton - Compiled Health and Fitness Articles.pdfJack Oughton - Compiled Health and Fitness Articles.pdf
Jack Oughton - Compiled Health and Fitness Articles.pdf
 
The obese woman
The obese womanThe obese woman
The obese woman
 
Obesity and infertility ajami 2021
Obesity and infertility ajami 2021Obesity and infertility ajami 2021
Obesity and infertility ajami 2021
 
EuropePMC 2014
EuropePMC  2014EuropePMC  2014
EuropePMC 2014
 
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. indiaObesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
Obesity in pregnancy by dr alka mukherjee dr apurva mukherjee nagpur m.s. india
 
Pregnancy and aesthetics
Pregnancy and aestheticsPregnancy and aesthetics
Pregnancy and aesthetics
 
White Lies
White LiesWhite Lies
White Lies
 
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...
Obesity in female infertility by dr. sharda jain, Dr. jyoti Agarwal , Dr. Jyo...
 
Diet-Induced Metabolic Syndrome models.pdf
Diet-Induced Metabolic Syndrome models.pdfDiet-Induced Metabolic Syndrome models.pdf
Diet-Induced Metabolic Syndrome models.pdf
 
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
OBESITY AND WEIGHT LOSS SURGERY, HOW MUCH BENEFICIAL AND SAFE?BY DR MANZOOR A...
 
One In Nine
One In NineOne In Nine
One In Nine
 
The association between gut microbiota and body weight
The association between gut microbiota and body weightThe association between gut microbiota and body weight
The association between gut microbiota and body weight
 
Maternal nutrion 5
Maternal nutrion 5Maternal nutrion 5
Maternal nutrion 5
 
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
TĂNG HUYẾT ÁP TRONG THAI KỲ (tiền sản giật)
 
Genetic influence on obesity
Genetic influence on obesityGenetic influence on obesity
Genetic influence on obesity
 
OBESITY
OBESITYOBESITY
OBESITY
 
Tackling Obesity in Infertility
Tackling Obesity in InfertilityTackling Obesity in Infertility
Tackling Obesity in Infertility
 
Dr jaideep malhotra Adhbhut Matrutva
Dr jaideep malhotra   Adhbhut MatrutvaDr jaideep malhotra   Adhbhut Matrutva
Dr jaideep malhotra Adhbhut Matrutva
 

Recently uploaded

Lapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdfLapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdf
Jean Carlos Nunes Paixão
 
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
siemaillard
 
Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
Pavel ( NSTU)
 
CACJapan - GROUP Presentation 1- Wk 4.pdf
CACJapan - GROUP Presentation 1- Wk 4.pdfCACJapan - GROUP Presentation 1- Wk 4.pdf
CACJapan - GROUP Presentation 1- Wk 4.pdf
camakaiclarkmusic
 
Supporting (UKRI) OA monographs at Salford.pptx
Supporting (UKRI) OA monographs at Salford.pptxSupporting (UKRI) OA monographs at Salford.pptx
Supporting (UKRI) OA monographs at Salford.pptx
Jisc
 
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCECLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
BhavyaRajput3
 
How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17
Celine George
 
The basics of sentences session 5pptx.pptx
The basics of sentences session 5pptx.pptxThe basics of sentences session 5pptx.pptx
The basics of sentences session 5pptx.pptx
heathfieldcps1
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
Special education needs
 
Digital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and ResearchDigital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and Research
Vikramjit Singh
 
Additional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdfAdditional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdf
joachimlavalley1
 
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th SemesterGuidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Atul Kumar Singh
 
The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
kaushalkr1407
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
Vivekanand Anglo Vedic Academy
 
Operation Blue Star - Saka Neela Tara
Operation Blue Star   -  Saka Neela TaraOperation Blue Star   -  Saka Neela Tara
Operation Blue Star - Saka Neela Tara
Balvir Singh
 
Sha'Carri Richardson Presentation 202345
Sha'Carri Richardson Presentation 202345Sha'Carri Richardson Presentation 202345
Sha'Carri Richardson Presentation 202345
beazzy04
 
The approach at University of Liverpool.pptx
The approach at University of Liverpool.pptxThe approach at University of Liverpool.pptx
The approach at University of Liverpool.pptx
Jisc
 
Acetabularia Information For Class 9 .docx
Acetabularia Information For Class 9  .docxAcetabularia Information For Class 9  .docx
Acetabularia Information For Class 9 .docx
vaibhavrinwa19
 
A Strategic Approach: GenAI in Education
A Strategic Approach: GenAI in EducationA Strategic Approach: GenAI in Education
A Strategic Approach: GenAI in Education
Peter Windle
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
Levi Shapiro
 

Recently uploaded (20)

Lapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdfLapbook sobre os Regimes Totalitários.pdf
Lapbook sobre os Regimes Totalitários.pdf
 
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
 
Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
 
CACJapan - GROUP Presentation 1- Wk 4.pdf
CACJapan - GROUP Presentation 1- Wk 4.pdfCACJapan - GROUP Presentation 1- Wk 4.pdf
CACJapan - GROUP Presentation 1- Wk 4.pdf
 
Supporting (UKRI) OA monographs at Salford.pptx
Supporting (UKRI) OA monographs at Salford.pptxSupporting (UKRI) OA monographs at Salford.pptx
Supporting (UKRI) OA monographs at Salford.pptx
 
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCECLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
 
How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17How to Make a Field invisible in Odoo 17
How to Make a Field invisible in Odoo 17
 
The basics of sentences session 5pptx.pptx
The basics of sentences session 5pptx.pptxThe basics of sentences session 5pptx.pptx
The basics of sentences session 5pptx.pptx
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
 
Digital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and ResearchDigital Tools and AI for Teaching Learning and Research
Digital Tools and AI for Teaching Learning and Research
 
Additional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdfAdditional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdf
 
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th SemesterGuidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th Semester
 
The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
 
Operation Blue Star - Saka Neela Tara
Operation Blue Star   -  Saka Neela TaraOperation Blue Star   -  Saka Neela Tara
Operation Blue Star - Saka Neela Tara
 
Sha'Carri Richardson Presentation 202345
Sha'Carri Richardson Presentation 202345Sha'Carri Richardson Presentation 202345
Sha'Carri Richardson Presentation 202345
 
The approach at University of Liverpool.pptx
The approach at University of Liverpool.pptxThe approach at University of Liverpool.pptx
The approach at University of Liverpool.pptx
 
Acetabularia Information For Class 9 .docx
Acetabularia Information For Class 9  .docxAcetabularia Information For Class 9  .docx
Acetabularia Information For Class 9 .docx
 
A Strategic Approach: GenAI in Education
A Strategic Approach: GenAI in EducationA Strategic Approach: GenAI in Education
A Strategic Approach: GenAI in Education
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
 

Maternal excess weight stresses oozytes

  • 1. Maternal Excess Weight Stresses Oozytes
  • 2. Introduction Substantially increased body weight can have a significant negative impact on female fertility. But how exactly can excess body weight affect reproductive function in women? A possible explanation comes from a study by Natalia Igosheva and colleagues from King’s College London, London, UK, just published in PLoS. Notes: http://www.ncbi.nlm.nih.gov/pubmed/20404917
  • 3. Study Using an established mouse model of maternal diet-induced obesity and live cell dynamic fluorescence imaging techniques, the researchers demonstrated that maternal obesity prior to conception is associated with altered mitochondria in mouse oocytes (eggs) and zygotes.
  • 4. Fat vs Lean Specifically, maternal diet-induced obesity in mice led to an increase in mitochondrial potential, mitochondrial DNA content and biogenesis. Generation of reactive oxygen species (ROS) was raised while glutathione was depleted and the redox state became more oxidised, suggestive of oxidative stress. (for my non-technical readers, it suffices to say that none of this is good for the egg or the zygote). These altered mitochondrial properties were associated with significant developmental impairment as shown by the increased number of obese mothers who failed to support blastocyst formation compared to lean dams.
  • 5. Strategy – Weight Loss These studies show that compromised oocyte and early embryo mitochondrial metabolism, resulting from excessive nutrient exposure prior to and during conception, may underlie poor reproductive outcomes frequently reported in obese women. While the leap from mice to women may seem a bit of a stretch, there is no doubt that in many overweight and obese women trying to become pregnant, weight loss is clearly one of the most effective strategies. Now all we need are more effective strategies to help manage excess weight.
  • 6. About Dr. Arya M. Sharma Dr. Arya M. Sharma, MD/PhD, FRCPC is Professor of Medicine & Chair for Obesity Research and Management at the University of Alberta, Edmonton, Canada. He is also the Medical Director of the Edmonton Capital Health Region’s interdisciplinary Weight Wise Program. Dr. Sharma is also the Scientific Director of the Canadian Obesity Network funded through the federal "Networks of Centres"ofExcellence program. Dr. Sharma has authored and co-authored more than 250 scientific articles and has lectured widely on the etiology and management of obesity and related cardiovascular disorders. He sends his informative messages through his blog Dr. Sharma’s Obesity Notes. For more information on Obesity visit; Website: http://www.drsharma.ca/ Facebook: http://www.facebook.com/pages/Dr-Arya-Sharma/115328778486319