MST-188 is a drug being developed by Mast Therapeutics to treat microcirculatory insufficiency. It is currently in phase 3 clinical trials for sickle cell disease and phase 2 trials are planned for acute limb ischemia. If successful, the company hopes to expand MST-188 to larger markets such as heart failure and trauma resuscitation. Preclinical studies show MST-188 improves blood flow and survival in animal models of various diseases.
This corporate presentation summarizes clinical data from YM BioSciences' Phase I/II study of CYT387, a JAK1/JAK2 inhibitor being developed for the treatment of myelofibrosis. Key findings from the updated data presented at ASH 2011 include:
1) Over half of previously transfusion-dependent patients became transfusion-independent within 12 weeks at doses of 150-300mg QD.
2) Spleen responses occurred in approximately 30% of patients across doses based on IWG-MRT criteria.
3) Constitutional symptoms such as night sweats, pruritis and bone pain showed complete resolution or marked improvement in the majority of patients.
Caladrius Corporate Presentation - October 2018Steve Sizer
This corporate presentation by Caladrius Biosciences provides an overview of the company and its pipeline. Key points include:
- Caladrius has two technology platforms using CD34+ cells for ischemic repair and T regulatory cells for immune modulation.
- They have a late-stage development pipeline including programs in critical limb ischemia (CLBS12), coronary microvascular dysfunction (CLBS14-CMD), and refractory angina (CLBS14-RfA).
- The presentation highlights clinical data from prior studies of CD34+ cell therapy and outlines ongoing and planned trials across the pipeline.
La tabla muestra el número de hombres y mujeres en diferentes grupos de edad en una población, con entre 30 y 65 la cantidad más alta, y entre 0 y 6 y 65 o más la más baja. El gráfico representa esta información de forma visual.
This presentation by a mining company provides an overview of its operations and growth prospects. It discusses its producing Summit Gold-Silver Mine, potential acquisition of the Mogollon Gold-Silver Project which could double its resources, and Ortiz Gold Project which has over 1.7 million ounces of historical gold resources. The presentation highlights the company's transition to producer status, increasing cash flow outlook from its assets, low cost of production, and pursuit of strategic acquisitions and a senior stock exchange listing to further create shareholder value.
Castle Peak Mining holds a strategic land package in Ghana's Ashanti gold belt near producing mines. Drilling at its Nkwanta project returned high grade intercepts including 6m of 80 g/t gold. Exploration is ongoing across the 225km2 land package to define and prioritize targets, with a focus on the Apankrah shoot where the structure remains open. The company is well funded to advance its projects in the mining friendly jurisdiction of Ghana.
- Tom Shockley was appointed CEO of El Paso Electric Company in the second quarter of 2012.
- The PUCT approved a settlement in El Paso's 2012 Texas rate case that includes an annual base rate reduction of $15 million and lower annual depreciation expense.
- El Paso filed for approval to build two new natural gas power stations in Montana and revised its 2012 earnings guidance upwards due to lower depreciation expenses and capitalization assumptions, though losses on decommissioning funds offset some of the increase.
This corporate presentation summarizes clinical data from YM BioSciences' Phase I/II study of CYT387, a JAK1/JAK2 inhibitor being developed for the treatment of myelofibrosis. Key findings from the updated data presented at ASH 2011 include:
1) Over half of previously transfusion-dependent patients became transfusion-independent within 12 weeks at doses of 150-300mg QD.
2) Spleen responses occurred in approximately 30% of patients across doses based on IWG-MRT criteria.
3) Constitutional symptoms such as night sweats, pruritis and bone pain showed complete resolution or marked improvement in the majority of patients.
Caladrius Corporate Presentation - October 2018Steve Sizer
This corporate presentation by Caladrius Biosciences provides an overview of the company and its pipeline. Key points include:
- Caladrius has two technology platforms using CD34+ cells for ischemic repair and T regulatory cells for immune modulation.
- They have a late-stage development pipeline including programs in critical limb ischemia (CLBS12), coronary microvascular dysfunction (CLBS14-CMD), and refractory angina (CLBS14-RfA).
- The presentation highlights clinical data from prior studies of CD34+ cell therapy and outlines ongoing and planned trials across the pipeline.
La tabla muestra el número de hombres y mujeres en diferentes grupos de edad en una población, con entre 30 y 65 la cantidad más alta, y entre 0 y 6 y 65 o más la más baja. El gráfico representa esta información de forma visual.
This presentation by a mining company provides an overview of its operations and growth prospects. It discusses its producing Summit Gold-Silver Mine, potential acquisition of the Mogollon Gold-Silver Project which could double its resources, and Ortiz Gold Project which has over 1.7 million ounces of historical gold resources. The presentation highlights the company's transition to producer status, increasing cash flow outlook from its assets, low cost of production, and pursuit of strategic acquisitions and a senior stock exchange listing to further create shareholder value.
Castle Peak Mining holds a strategic land package in Ghana's Ashanti gold belt near producing mines. Drilling at its Nkwanta project returned high grade intercepts including 6m of 80 g/t gold. Exploration is ongoing across the 225km2 land package to define and prioritize targets, with a focus on the Apankrah shoot where the structure remains open. The company is well funded to advance its projects in the mining friendly jurisdiction of Ghana.
- Tom Shockley was appointed CEO of El Paso Electric Company in the second quarter of 2012.
- The PUCT approved a settlement in El Paso's 2012 Texas rate case that includes an annual base rate reduction of $15 million and lower annual depreciation expense.
- El Paso filed for approval to build two new natural gas power stations in Montana and revised its 2012 earnings guidance upwards due to lower depreciation expenses and capitalization assumptions, though losses on decommissioning funds offset some of the increase.
Canadian Zinc Corporation owns the high-grade Prairie Creek Mine in the Northwest Territories of Canada. The mine contains significant existing infrastructure valued at over $200 million. Canadian Zinc is in the final permitting phase for the mine and expects to receive a draft permit by the end of 2012. Recent studies show the mine has an 11-year mine life with positive economics. However, Canadian Zinc does not currently hold a permit to operate the mine. The document provides details on the mine's resources and reserves, infrastructure, permitting process, economics, and development timeline.
The document discusses forward-looking statements made by Natural Resource Partners L.P. during a presentation and notes that actual results may differ due to risks and uncertainties. It outlines risks including changes in business conditions, demand for coal, costs, geology, regulations, and production cuts. The document then provides an outlook on the global coal market, noting coal was the fastest growing fossil fuel in 2011 and its consumption and share of global energy continues to increase driven primarily by growth in Asia. It also summarizes trends and outlooks for the US steam coal and metallurgical coal markets.
This document provides a disclaimer and overview of Shanta Gold Limited, an AIM-listed gold exploration and development company focused in Tanzania. It notes that Shanta has a 2.6 million ounce JORC-compliant resource across its two advanced projects, New Luika and Singida, and is approaching first production. Key details about the company include its experienced Tanzania-focused management team, growth pipeline, and top shareholders. The document also contains several disclaimers regarding the information presented.
Este documento presenta información sobre dos jóvenes que viven en el mundo de Atherton. Edgar tiene unos 15-16 años y vive en el altiplano, trabajando para el señor Ratikan recogiendo higos. Aunque trabaja duro, también disfruta explorando los alrededores. Samuel es otro joven que vive en los altiplanos con su madre, quien trabaja como cocinera. Ambos chicos no están contentos con sus situaciones actuales, ya que son tratados mal por sus empleadores.
Los animales se clasifican según su hábitat de origen, con ejemplos de animales del Perú encontrados en la costa, selva y sierra, mientras que a nivel mundial existen diversas especies de animales distribuidas en diferentes regiones.
El documento habla sobre qué es un blog. Explica que un blog es una herramienta de comunicación digital donde el autor publica y recopila información sobre un tema. Los blogs permiten que los lectores comenten y se comuniquen con el autor a través de correo electrónico. También define términos clave relacionados con los blogs como blogosfera, blogroll y post. Finalmente, distingue entre soluciones gratuitas y profesionales para crear y mantener blogs.
Este documento anuncia a abertura de inscrições para um concurso público para preencher 300 vagas para o cargo de Técnico em Informações Geográficas e Estatísticas A I no IBGE. Detalha os requisitos para participar, as atribuições e remuneração do cargo, a distribuição de vagas por município/UF e as reservas para pessoas com deficiência.
El documento presenta información sobre varios temas de química incluyendo potencial iónico, tabla periódica, electronegatividad, afinidad electrónica, las octavas de Newlands, triadas de Dobereiner, número de oxidación, radio atómico y radio iónico. Explica conceptos clave como la energía requerida para ionizar un átomo, las propiedades que se usan para organizar los elementos en la tabla periódica, y las leyes y teorías iniciales sobre la clasificación de elementos propuestas por científicos como
Este documento contiene la hoja de vida de Bryan Ariel Manrique Román. Incluye sus datos personales como nombre, edad, lugar de nacimiento y estudios realizados. También incluye sus redes sociales y un índice de 10 lecciones sobre la solución de problemas divididas en 4 unidades. El documento proporciona información biográfica básica y una introducción al tema de la resolución de problemas.
Las aplicaciones Web 2.0 permiten crear y compartir información directamente en la web principalmente para compartir. Las herramientas Web 2.0 facilitan el aprendizaje electrónico pero las aplicaciones Web 1.0 siguen siendo válidas.
Los grandes pensadores frases awards 2012 2013 4to medio f presentacion de di...Renato García Espinosa
Este documento contiene varias conversaciones y fragmentos de diálogo entre diferentes personas. Algunas de las conversaciones tratan sobre temas académicos como fracciones y verbos, mientras que otras contienen bromas y chistes entre amigos. También incluye algunas letras de canciones.
CLBS Corporate Slide Presentation March 2018Steve Sizer
This corporate presentation discusses Caladrius Biosciences' business model evolution and future plans. It summarizes that Caladrius has transitioned to focus solely on clinical-stage therapeutics development using two technology platforms: autologous T-regulatory cells for immune modulation and CD34 cells for ischemic repair. Key programs outlined include an ongoing Phase 2 trial of T-regulatory cells for recent-onset type 1 diabetes and planned Phase 2 trials of CD34 cells for critical limb ischemia and coronary microvascular dysfunction. The presentation positions Caladrius for continued growth with a well-funded pipeline and strategic partnerships.
This presentation discusses the company's stem cell research programs. It provides an overview of recent events including acquiring the myoblast program for treating heart failure and commencing clinical trials. Key highlights of the myoblast program acquisition are described, including Phase I clinical trial results demonstrating improvements in symptoms. The RPE and hemangioblast programs are also summarized. The company aims to translate stem cell research into human therapies.
Opexa therapeutics corporate presentation september 2016OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their lead asset, Tcelna, is in Phase 2b development for secondary progressive multiple sclerosis and top-line data is expected in the next 1-2 months. They are also developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies. Opexa has secured an option agreement with Merck Serono for Tcelna in MS and could receive up to $25 million in milestones if Merck exercises their option after seeing Phase 2b data.
This corporate presentation by Caladrius Biosciences provides an overview of the company and its pipeline. Key points include:
- Caladrius has two technology platforms using CD34+ cells for ischemic repair and T regulatory cells for immune modulation.
- They have a late-stage development pipeline including programs in critical limb ischemia (CLBS12), coronary microvascular dysfunction (CLBS14-CMD), and refractory angina (CLBS14-RfA).
- The presentation highlights clinical data from prior studies of CD34+ cell therapy and outlines ongoing and planned trials across the pipeline.
- Caladrius has an experienced management team and a strong financial position to support advancing its programs toward value
IntelGenx is an innovative pharmaceutical company focused on oral thin film drug delivery technologies. They have developed a proprietary oral thin film technology platform called VersaFilm that can be used to improve existing drugs or develop new products. Their pipeline includes several product candidates targeting large markets like migraines, erectile dysfunction, and brain degenerative diseases. They have state-of-the-art manufacturing facilities and strategic partnerships to commercialize their products globally.
Canadian Zinc Corporation owns the high-grade Prairie Creek Mine in the Northwest Territories of Canada. The mine contains significant existing infrastructure valued at over $200 million. Canadian Zinc is in the final permitting phase for the mine and expects to receive a draft permit by the end of 2012. Recent studies show the mine has an 11-year mine life with positive economics. However, Canadian Zinc does not currently hold a permit to operate the mine. The document provides details on the mine's resources and reserves, infrastructure, permitting process, economics, and development timeline.
The document discusses forward-looking statements made by Natural Resource Partners L.P. during a presentation and notes that actual results may differ due to risks and uncertainties. It outlines risks including changes in business conditions, demand for coal, costs, geology, regulations, and production cuts. The document then provides an outlook on the global coal market, noting coal was the fastest growing fossil fuel in 2011 and its consumption and share of global energy continues to increase driven primarily by growth in Asia. It also summarizes trends and outlooks for the US steam coal and metallurgical coal markets.
This document provides a disclaimer and overview of Shanta Gold Limited, an AIM-listed gold exploration and development company focused in Tanzania. It notes that Shanta has a 2.6 million ounce JORC-compliant resource across its two advanced projects, New Luika and Singida, and is approaching first production. Key details about the company include its experienced Tanzania-focused management team, growth pipeline, and top shareholders. The document also contains several disclaimers regarding the information presented.
Este documento presenta información sobre dos jóvenes que viven en el mundo de Atherton. Edgar tiene unos 15-16 años y vive en el altiplano, trabajando para el señor Ratikan recogiendo higos. Aunque trabaja duro, también disfruta explorando los alrededores. Samuel es otro joven que vive en los altiplanos con su madre, quien trabaja como cocinera. Ambos chicos no están contentos con sus situaciones actuales, ya que son tratados mal por sus empleadores.
Los animales se clasifican según su hábitat de origen, con ejemplos de animales del Perú encontrados en la costa, selva y sierra, mientras que a nivel mundial existen diversas especies de animales distribuidas en diferentes regiones.
El documento habla sobre qué es un blog. Explica que un blog es una herramienta de comunicación digital donde el autor publica y recopila información sobre un tema. Los blogs permiten que los lectores comenten y se comuniquen con el autor a través de correo electrónico. También define términos clave relacionados con los blogs como blogosfera, blogroll y post. Finalmente, distingue entre soluciones gratuitas y profesionales para crear y mantener blogs.
Este documento anuncia a abertura de inscrições para um concurso público para preencher 300 vagas para o cargo de Técnico em Informações Geográficas e Estatísticas A I no IBGE. Detalha os requisitos para participar, as atribuições e remuneração do cargo, a distribuição de vagas por município/UF e as reservas para pessoas com deficiência.
El documento presenta información sobre varios temas de química incluyendo potencial iónico, tabla periódica, electronegatividad, afinidad electrónica, las octavas de Newlands, triadas de Dobereiner, número de oxidación, radio atómico y radio iónico. Explica conceptos clave como la energía requerida para ionizar un átomo, las propiedades que se usan para organizar los elementos en la tabla periódica, y las leyes y teorías iniciales sobre la clasificación de elementos propuestas por científicos como
Este documento contiene la hoja de vida de Bryan Ariel Manrique Román. Incluye sus datos personales como nombre, edad, lugar de nacimiento y estudios realizados. También incluye sus redes sociales y un índice de 10 lecciones sobre la solución de problemas divididas en 4 unidades. El documento proporciona información biográfica básica y una introducción al tema de la resolución de problemas.
Las aplicaciones Web 2.0 permiten crear y compartir información directamente en la web principalmente para compartir. Las herramientas Web 2.0 facilitan el aprendizaje electrónico pero las aplicaciones Web 1.0 siguen siendo válidas.
Los grandes pensadores frases awards 2012 2013 4to medio f presentacion de di...Renato García Espinosa
Este documento contiene varias conversaciones y fragmentos de diálogo entre diferentes personas. Algunas de las conversaciones tratan sobre temas académicos como fracciones y verbos, mientras que otras contienen bromas y chistes entre amigos. También incluye algunas letras de canciones.
CLBS Corporate Slide Presentation March 2018Steve Sizer
This corporate presentation discusses Caladrius Biosciences' business model evolution and future plans. It summarizes that Caladrius has transitioned to focus solely on clinical-stage therapeutics development using two technology platforms: autologous T-regulatory cells for immune modulation and CD34 cells for ischemic repair. Key programs outlined include an ongoing Phase 2 trial of T-regulatory cells for recent-onset type 1 diabetes and planned Phase 2 trials of CD34 cells for critical limb ischemia and coronary microvascular dysfunction. The presentation positions Caladrius for continued growth with a well-funded pipeline and strategic partnerships.
This presentation discusses the company's stem cell research programs. It provides an overview of recent events including acquiring the myoblast program for treating heart failure and commencing clinical trials. Key highlights of the myoblast program acquisition are described, including Phase I clinical trial results demonstrating improvements in symptoms. The RPE and hemangioblast programs are also summarized. The company aims to translate stem cell research into human therapies.
Opexa therapeutics corporate presentation september 2016OpexaTherapeutics
Opexa Therapeutics presented information on their precision immunotherapy platform and lead programs. Their lead asset, Tcelna, is in Phase 2b development for secondary progressive multiple sclerosis and top-line data is expected in the next 1-2 months. They are also developing OPX-212 for neuromyelitis optica, an orphan indication with no approved therapies. Opexa has secured an option agreement with Merck Serono for Tcelna in MS and could receive up to $25 million in milestones if Merck exercises their option after seeing Phase 2b data.
This corporate presentation by Caladrius Biosciences provides an overview of the company and its pipeline. Key points include:
- Caladrius has two technology platforms using CD34+ cells for ischemic repair and T regulatory cells for immune modulation.
- They have a late-stage development pipeline including programs in critical limb ischemia (CLBS12), coronary microvascular dysfunction (CLBS14-CMD), and refractory angina (CLBS14-RfA).
- The presentation highlights clinical data from prior studies of CD34+ cell therapy and outlines ongoing and planned trials across the pipeline.
- Caladrius has an experienced management team and a strong financial position to support advancing its programs toward value
IntelGenx is an innovative pharmaceutical company focused on oral thin film drug delivery technologies. They have developed a proprietary oral thin film technology platform called VersaFilm that can be used to improve existing drugs or develop new products. Their pipeline includes several product candidates targeting large markets like migraines, erectile dysfunction, and brain degenerative diseases. They have state-of-the-art manufacturing facilities and strategic partnerships to commercialize their products globally.
This corporate presentation provides an overview of Caladrius Biosciences and its pipeline. It discusses the company's two technology platforms focusing on CD34+ cells for ischemic repair and T regulatory cells for immune modulation. Key programs discussed include CLBS12 in critical limb ischemia, CLBS14-CMD in coronary microvascular dysfunction, CLBS14-RfA in refractory angina, and CLBS03 in type 1 diabetes. It highlights positive clinical data from previous studies and outlines upcoming milestones and clinical trials. The presentation positions Caladrius as financially stable with multiple value creating events expected in the next 18 months across its late-stage cell therapy programs.
Caladrius Corporate Presentation - August 2018Steve Sizer
This corporate presentation by Caladrius Biosciences outlines their late-stage therapeutics development focusing on two technology platforms: CD34+ cells for ischemic repair and T regulatory cells for immune modulation. They have three CD34+ cell therapy candidates in development for critical limb ischemia, coronary microvascular dysfunction, and refractory angina. The presentation provides details on the clinical development programs and positive results to date for these candidates. It also introduces the experienced executive team leading the company and their financial position with $50 million in cash.
Caladrius Biosciences Corporate Presentation, January 2019Steve Sizer
This corporate presentation from Caladrius Biosciences outlines their pipeline of late-stage development programs focused on cell and immunotherapies. They have four active programs targeting ischemic repair using CD34+ cells and immune modulation using T regulatory cells. Their lead programs include CLBS12 for critical limb ischemia in Japan, which has received a breakthrough designation, and CLBS14-CMD for coronary microvascular dysfunction in the US. The presentation highlights the large market opportunities and compelling clinical data from prior studies supporting further development of these programs. Caladrius has an experienced management team and a strong cash position to advance multiple value-creating milestones over the next 18 months.
Ctxr presentation mid-size_02.22.2019_spring.finalScott Martin
This 3-page corporate presentation by Citius Pharmaceuticals provides an overview of their investment opportunity and pipeline. Their lead product Mino-Lok is in Phase 3 trials for treating central line-associated bloodstream infections (CLABSI) and has the potential to salvage infected central venous catheters rather than requiring removal. They have a Phase 2 product for hemorrhoids and a pre-clinical product for preventing breast implant infections. The presentation highlights the large market opportunities and management team's experience advancing 505(b)(2) products.
This corporate presentation from Caladrius Biosciences provides an overview of the company and its pipeline. Key points include:
- Caladrius is a late-stage therapeutics development company focused on four development programs using CD34+ cells for ischemic repair and T regulatory cells for immune modulation.
- The company has a strong balance sheet with $50 million in cash as of June 2018 and low operating costs, positioning it for near-term success.
- Multiple value-creating events are expected in the next 18 months, including regulatory and clinical trial milestones across the pipeline.
Opexa therapeutics corporate presentation march 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy, for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin reactive T-cell clones that are believed to trigger an immune response targeting pathogenic myelin reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa Therapeutics Corporate Presentation - May 2013OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a personalized immunotherapy for the treatment of multiple sclerosis (MS). Tcelna aims to specifically target myelin-reactive T-cells (MRTCs) that cause damage to the myelin sheath in MS patients. Clinical trials have shown Tcelna reduces MRTCs and relapses in both relapsing-remitting and secondary progressive MS patients. Opexa has an agreement with Merck for the development of Tcelna in MS that could provide up to $220 million in milestones for Opexa.
Opexa Therapeutics Corporate Presentation July 2014OpexaTherapeutics
Opexa Therapeutics is developing precision immunotherapy treatments, with its lead candidate Tcelna in Phase IIb clinical trials for secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are believed to trigger an immune response targeting pathogenic T-cells that destroy myelin. The Phase IIb trial in SPMS has fully enrolled 180 patients and top-line data is expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa therapeutics corporate presentation june 2014OpexaTherapeutics
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTCs) that cause damage in MS. Opexa has completed enrollment in its Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) patients and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and commercial milestones are achieved.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of multiple sclerosis (MS). Tcelna consists of attenuated antigen-specific T-cell clones that are designed to program the immune system to target pathogenic myelin reactive T-cells (MRTC) that cause damage in MS. Opexa has completed enrollment in a Phase IIb clinical trial of Tcelna in secondary progressive MS (SPMS) and expects top-line data in mid-2016. The company has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments if certain development and sales milestones are achieved.
Cytori Therapeutics is developing adipose-derived regenerative cell therapies using a point-of-care device platform. The platform allows for autologous cell therapies to be prepared at the bedside from a patient's own fat tissue. Clinical trials show the cells are safe and may provide benefits in cardiac and soft tissue applications. Near-term value drivers include government contract milestones and cardiovascular trial data. The business model involves selling single-use consumables for each procedure at price points around $2,000-$12,000, depending on the indication.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are designed to program the immune system to target pathogenic myelin-reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
Opexa Therapeutics is developing Tcelna, a precision immunotherapy for the treatment of secondary progressive multiple sclerosis (SPMS). Tcelna consists of attenuated myelin-reactive T-cell clones that are designed to program the immune system to target pathogenic myelin-reactive T-cells. Opexa has an ongoing Phase IIb clinical trial of Tcelna in SPMS and expects to complete enrollment in mid-2014, with top-line data expected in mid-2016. Opexa has an option agreement with Merck for the development and commercialization of Tcelna in MS that could provide up to $220 million in payments.
This poster summarizes results presented at the 2010 American Society of Blood and Marrow Transplantation meeting comparing outcomes of two stem cell transplantation trials for acute myeloid leukemia patients. The trials utilized either T-cell depleted grafts (TCD) after CD34+ selection or unmodified grafts. While disease-free survival, overall survival, and transplant-related mortality were similar between the groups, the TCD group had significantly lower rates of acute graft-versus-host disease (20% vs 38%) and chronic GVHD (19% vs 47%) without increased relapse risk. The results support T-cell depletion in matched transplantation and suggest its extension to matched unrelated transplantation.
Presentation Clayton Valley, NevadaFrom Drilling to PEA in under 2 YearsCompany Spotlight
The document summarizes Cypress Development Corp's Clayton Valley lithium project in Nevada. Key points include:
- A Preliminary Economic Assessment shows promising economics including a 32.7% IRR and $1.45 billion NPV.
- Measured and indicated resources total 8.9 million tonnes LCE with additional inferred resources.
- The project has the potential for low-cost production due to favorable geology and metallurgy.
- Upcoming catalysts in 2019 include a metallurgical study and prefeasibility study to further de-risk the project.
Aben Resources has made a new high-grade gold discovery at its flagship Forrest Kerr project in BC's Golden Triangle region. The region is known for major gold deposits and saw $100 million in exploration spending in 2017. Recent improvements have made the Forrest Kerr project more accessible via new roads. Aben's technical team has reinterpreted historical data and identified additional exploration targets. The project covers over 23,000 hectares of prospective geology along the Forrest Kerr fault zone that is similar to other major deposits in the Golden Triangle.
Aben Resources has discovered high-grade gold zones at its Forrest Kerr project in British Columbia's Golden Triangle. The first hole of the 2018 drill program intersected four separate high-grade gold zones within 190 metres, including 331.0 g/t Au over 1.0 metre. Aben plans to expand drilling at the Boundary North Zone and test other gold anomalies identified through soil sampling. The company also holds the Justin project in Yukon and Chico project in Saskatchewan near recent discoveries.
Cypress Development Corp. owns lithium claims in Clayton Valley, Nevada near Albemarle's Silver Peak lithium mine. A preliminary economic assessment found the project could have a 32.7% IRR and $1.45 billion NPV. The project would extract lithium from claystone using leaching and have average annual production of 24,042 tonnes of lithium carbonate over 40 years. Capital costs are estimated at $482 million to build a 15,000 tonne per day operation.
The document discusses Aben Resources Ltd., a gold exploration company with projects in British Columbia's Golden Triangle region and other areas of Western Canada. It provides an overview of Aben's management team and directors, flagship Forrest Kerr project, recent drilling results showing new high-grade gold discoveries, and its strategy to advance exploration through 2018. The document also briefly outlines Aben's other projects including the Chico gold project in Saskatchewan and Justin gold project in Yukon.
Cypress Development Corp. owns the Clayton Valley lithium project in Nevada. Drilling in 2017 intersected lithium-bearing claystone averaging 921 ppm Li over 77 meters thick. A maiden resource estimate calculated 3.287 million tonnes of lithium carbonate equivalent in the indicated category and 2.916 million tonnes LCE in inferred. Metallurgical tests show the claystone is acid leachable and able to recover over 80% of the lithium. Cypress plans additional drilling, engineering studies, and permitting to advance the project towards production.
- Aben Resources has three highly prospective gold projects in Western Canada including its flagship Forrest Kerr Project in BC's Golden Triangle region, which had recent drilling success expanding the Boundary North Zone.
- Management has over 100 years of combined experience in Western Canada and a proven track record of success.
- The projects have significant historic work identifying high-grade gold and robust discovery potential remains.
Cypress Development Corp. owns the Clayton Valley lithium project in Nevada. Drilling in 2017 intersected lithium-bearing claystone averaging 921 ppm Li over 77 meters. A maiden resource estimate classified over 1.3 million tonnes of lithium carbonate equivalent as indicated and inferred. Metallurgical testing shows the claystone is leachable with over 80% lithium recovery. Cypress aims to advance the project with engineering studies and further drilling to define resources with the goal of becoming a domestic lithium producer for the growing battery market.
The document provides forward-looking statements and discusses risks associated with such statements. It notes that some statements may be deemed forward-looking and lists factors that could cause actual results to differ from forward-looking statements. The document also identifies the qualified person for the technical information as Cornell McDowell and provides Aben's trading symbols and recent share information.
The document provides an overview of Aben Resources Ltd., a mineral exploration company with gold projects in Western Canada. It summarizes Aben's three key projects - Forrest Kerr in BC's Golden Triangle region with recent drill results discovering the Boundary Zone, Chico in Saskatchewan near producing mines, and Justin in Yukon's White Gold district. It outlines the management team's expertise and provides company details like shares outstanding and trading symbols.
- Cypress Development Corp owns the Clayton Valley lithium project in Nevada located near Albemarle's Silver Peak lithium brine operation.
- Drilling in 2017 encountered lithium mineralization averaging 921 ppm Li over 77 meters in 14 holes drilled.
- Metallurgical tests show the claystone is acid leachable with over 80% lithium extraction possible.
- Cypress aims to define a resource estimate in 2018 and advance the project with feasibility studies to develop a lithium operation.
The document discusses forward-looking statements and provides disclaimers about them. It introduces the qualified person for the technical information presented. It also lists Aben's trading symbols and recent share information including price and market capitalization.
1) Cypress Development Corp owns the Clayton Valley lithium project located next to Albemarle's Silver Peak mine in Nevada. Drilling in 2017 intersected lithium-bearing claystone averaging over 900 ppm Li to a depth of over 100 meters.
2) A maiden resource estimate classified over 1.5 million tonnes of lithium carbonate equivalent as indicated and inferred. Metallurgical testing shows the claystone is acid leachable to extract over 80% of the lithium.
3) The project is located in a strategic location to supply the growing lithium-ion battery market in the US, with lithium demand accelerating due to the increased production of electric vehicles globally.
TerraX Minerals is a Canadian mineral exploration company focused on exploring and developing its 100% owned 772 square km Yellowknife City Gold project located adjacent to the city of Yellowknife, Northwest Territories. The project covers high-grade Archean gold districts and has had multiple high-grade gold discoveries. TerraX has a strong management team with experience discovering and developing gold deposits and low exploration costs due to the project's excellent infrastructure and year-round access near Yellowknife.
This document discusses forward-looking statements and provides information about Aben Resources Ltd., including its stock symbols, shares outstanding, recent share price, market capitalization, and three gold exploration projects in Western Canada. It summarizes the management team's experience and the company's investment highlights. Specifically, it owns the Forrest Kerr gold project in British Columbia's Golden Triangle region, which saw successful drilling results in 2017 that led to a new discovery called the North Boundary zone.
Cypress Development Corp owns lithium claystone deposits in Clayton Valley, Nevada near Albemarle's Silver Peak lithium mine. Drilling in 2017 encountered lithium mineralization averaging 921 ppm Li over 77 meters in 14 holes. Metallurgical tests show the claystone is acid leachable with up to 80% lithium extraction. Cypress plans additional drilling, process engineering, and a preliminary economic assessment in 2018 to advance the project. The company sees potential for the project given growing lithium demand from electric vehicles and batteries.
TerraX Minerals is a Canadian mineral exploration company focused on exploring its 100% owned 772 square km Yellowknife City Gold project located near Yellowknife, Northwest Territories. The project covers high-grade Archean gold districts with known deposits and past producers. TerraX has made multiple high-grade gold discoveries on the property and identified several high-priority targets for further exploration and drilling. The company has a strong management team with experience discovering and developing deposits in the region.
Cypress Development Corp owns lithium claystone deposits in Clayton Valley, Nevada that have the potential to be a significant lithium resource. Drilling in 2017 encountered mineralization averaging 921 ppm lithium over 77 meters thick in 14 drill holes. Metallurgical testing shows the claystone is acid leachable with up to 80% lithium extraction. Cypress plans additional drilling, metallurgical testing, and a preliminary economic assessment in 2018 to further define the resource potential.
Cypress Development Corp owns lithium claystone deposits in Clayton Valley, Nevada near Albemarle's Silver Peak lithium mine. Drilling in 2017 encountered mineralization averaging 921 ppm lithium over 77 meters thick in 14 drill holes. Metallurgical tests show the claystone is acid leachable with up to 80% lithium extraction. Cypress plans additional drilling, metallurgical testing, and a preliminary economic assessment in 2018 to evaluate the project's potential.
Cypress Development Corp is exploring for lithium resources in Clayton Valley, Nevada. Recent drilling has encountered lithium-bearing claystone up to 112 meters below surface, with grades averaging over 800 ppm lithium. Metallurgical testing indicates 80% of the lithium can be extracted using a weak sulfuric acid solution. Cypress plans additional drilling in 2018 and expects to publish a initial lithium resource estimate in Q1 2018 to advance the project towards a preliminary economic assessment. The project is located near existing lithium production and infrastructure to be a potential new supply of lithium for the growing battery market.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
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Mast apr13pres
1. NYSE MKT: MSTX
NYSE MKT: MSTX
Corporate Overview
April 3, 2013
Brian M. Culley, CEO
2. NYSE MKT: MSTX
Forward-Looking Statements
2
This presentation includes forward-looking statements about our business prospects, financial position, and
development of MST-188 for therapeutic use in humans. Any statement that is not a statement of historical
fact should be considered a forward-looking statement. Because forward-looking statements relate to the
future, they are subject to inherent risks, uncertainties and changes in circumstances that are difficult to
predict. Actual events or performance may differ materially from our expectations indicated by these forward-
looking statements due to a number of factors, including, but not limited to, results of our pending and future
clinical studies, the timeline for clinical and manufacturing activities and regulatory approval; our
dependency on third parties to conduct our clinical studies and manufacture our clinical trial material; our
ability to raise additional capital, as needed; our ability to establish and protect proprietary rights related to
MST-188; and other risks and uncertainties more fully described in our press releases and our filings with the
SEC, including our annual report on Form 10-K for the period ended December 31, 2012.
We caution you not to place undue reliance on any of these forward-looking statements, which speak only as
of the date of this presentation. We do not intend to update any forward-looking statement included in this
presentation to reflect events or circumstances arising after the date of the presentation, except as may be
required by law.
3. NYSE MKT: MSTX
2009
2010
2011
2012
2013
Corporate Restart
“From the brink of liquidation in 2009
to the most clinically-advanced
new drug in SCD in 2013.”
• Appoint new CEO and COO
• Raise ~$60 million
• Acquire SynthRx (MST-188)
• Appoint new SVP, Development
• Appoint new CMO
• Engage CROs and manufacturers
• Initiate phase 3 EPIC study
• Rename as “Mast Therapeutics”
• Minimal business operations
• 2 employees, $1.5M working capital
3
4. NYSE MKT: MSTX
Developing MST-188 for “microcirculatory insufficiency”
Initially focused on rare/orphan diseases
Sickle Cell Disease
Acute Limb Ischemia
Planned expansion into larger markets
Resuscitation Following Major Hemorrhage
Acute Decompensated Heart Failure
Transfusion (Storage Lesion)
Acute Ischemic Cerebrovascular Infarction (Stroke)
Recruiting subjects in pivotal phase 3 study in SCD
Most clinically-advanced new molecular entity in development
Corporate Overview
4
5. NYSE MKT: MSTX
API Structure:
Drug Product: Formulated as a clear, citrate-buffered solution
CMC:
Large polymeric molecule (8,500 Daltons)
manufactured by chemical synthesis and
proprietary purification process
Administration:
24-48 hour IV infusion in acute-care settings
(hospital, ICU, specialized out-patient)
MST-188 Overview
5
6. NYSE MKT: MSTX
MST-188 Mechanism of Action
No Affinity for Healthy Cell Membranes
Adheres to Damaged Cell Membranes
Hydrophobic core binds to hydrophobic domains in circulation
(e.g., damaged cell membranes, acute phase reactant proteins)
6
7. NYSE MKT: MSTX
MST-188 Pharmacodynamics
MST-188
Cytoprotective
Restores membranes;
allows cells time to heal
Hemorheologic
Inhibits cell aggregation;
improves blood flow
Anti-Thrombotic/
Pro-Fibrinolytic
Reduces thrombosis;
improves vessel patency
Anti-Inflammatory
Arrests inflammatory
cascade at the outset
7
Single mechanism with four pharmacodynamic effects
addresses multiple pathophysiologic processes
8. NYSE MKT: MSTX
The MST-188 Pipeline
Preclinical Phase 1 Phase 2 Phase 3
2013
Sickle Cell Disease
(orphan)
Acute Limb Ischemia
(orphan)
Resuscitation following
Major Trauma*
Acute Decompensated
Heart Failure
Transfusion
(storage lesion)
2014
Stroke
* Development contingent on U.S. government funding/other collaborator
8
10. NYSE MKT: MSTX
Overview
An inherited genetic disorder and orphan disease
Characterized by “sickling” of erythrocytes (red blood cells, RBCs)
Hallmark is recurring episodes of extreme pain (“crisis”)
Typically last 4 to 5 days, but may last a week or longer
Patients “suffer at home” until pain requires IV analgesia (hospital visit)
Significant unmet need
Average age of death ~40 years
No approved agents to shorten duration or severity of crisis
Substantial interest from Big Pharma
Pfizer: $395 million* for phase 2 investigational drug (Oct 2011)
Novartis: $650 million* for phase 2 investigational drug (Sep 2012)
10
* Reported deal value
11. NYSE MKT: MSTX
Pathophysiology: impaired blood flow
11
Vaso-occlusion: RBCs cannot traverse occlusion to
deliver oxygen to tissues (ischemia/infarction)
MST-188: rheologic activity reduces RBC aggregation,
lowers viscosity, improves deformability
Early stages: adhesion of circulating blood
products to endothelial cells
MST-188: anti-inflammatory activity reduces
adhesion of molecules to endothelium
12. NYSE MKT: MSTX
MST-188: improves blood flow
Red cell velocity (mm/s)
measured by video
microscopy in nine
sickle cell patients with
vaso-occlusive crisis.
MST-188
Placebo
Before Infusion
(Crisis Baseline)
Velocity(mm/sec)
0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
1.8
2.0
2-Hours
After Loading
Infusion
7-Hours
After Loading
Infusion
Source: J. Investig. Med. 2004;52(6):402-6
(P = 0.00003)
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Improvement in microvascular blood flow in SCD patients in
crisis following treatment with MST-188
13. NYSE MKT: MSTX
Completed Phase 2 Study in SCD
Source: Blood, September 1, 1997 – Vol 90, No. 5
* 1st generation (non-purified) formulation
13
Subjects who received ≥ 24h infusion
(n=45)
MST-188* Placebo Improvement
Duration of Crisis 60 hours 88 hours 32% shorter
Duration of Hospitalization 5 days 7 days 2 days shorter
Total Analgesic Use 49mg 169mg 71% less
Parenteral Analgesic Use 40mg 150mg 73% less
Improvement in various endpoints in SCD patients in crisis
following treatment with MST-188*
14. NYSE MKT: MSTX
Completed Phase 2 Study in SCD
12.8
7.2
6.3
9.9
7.9
4.1
0
2
4
6
8
10
12
14
Duration of Hospitalization (days)
MST-188
Hi Dose (100-
120mg/kg/hr)
(n=7)
MST-188
Lo Dose (40-
80mg/kg/hr)
(n=20)
NEJM 2000
Standard of
care
(n=409)
MST-188
Hi Dose (100-
120 mg/kg/hr)
(n=4)
MST-188
Lo Dose (40-
80 mg/kg/hr)
(n=10)
NEJM 2000
Standard of
care
(n=128)
Children
(<20y)
Adults
(>20y)
14
Reduction in duration of hospitalization in SCD patients (n=41)
with acute chest syndrome following treatment with MST-188
Source: Data on file
15. NYSE MKT: MSTX
Group MST-188 Placebo P Value
All treated patients (n=249) 132 hours 140 hours 0.07
Patients <16 years old (n=73) 127 hours 149 hours 0.01
Source: JAMA, November 17, 2001 – Vol 286, No. 17
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Completed Phase 3 Study in SCD
(Primary and Post-Hoc Analyses)
Improvement in duration of crisis in SCD patients in crisis
following treatment with MST-188
16. NYSE MKT: MSTX
Group MST-188 Placebo P Value
All treated patients (n=249) 132 hours 140 hours 0.07
Patients <16 years old (n=73) 127 hours 149 hours 0.01
Original trial statistical plan required 350 patients. Reduced
by almost 30% by prior sponsor (capital constraints).
Source: JAMA, November 17, 2001 – Vol 286, No. 17
16
Completed Phase 3 Study in SCD
(Primary and Post-Hoc Analyses)
Improvement in duration of crisis in SCD patients in crisis
following treatment with MST-188
17. NYSE MKT: MSTX
Hours After Randomization
DistributionFunction
Source: JAMA, November 17, 2001 – Vol 286, No. 17
P = 0.007
17
Proportion of Patients <16 Years Remaining in Crisis Over Time
(n=73)
Completed Phase 3 Study in SCD
(Post-Hoc Analysis)
Observation was stopped at
168 hours. Many patients
had not reached endpoint.
18. NYSE MKT: MSTX
Source: JAMA, November 17, 2001 – Vol 286, No. 17
18
Group MST-188 Placebo P Value
All treated patients (n=249) 51.6% 36.6% 0.02
Patients <16 years old (n=73) 62.2% 27.8% 0.01
Completed Phase 3 Study in SCD
(Post-Hoc Analysis)
Proportion of Patients Achieving Crisis Resolution
within 168 Hours
19. NYSE MKT: MSTX
Lessons Learned
19
Simplify endpoint to minimize protocol violations and
missing (“left-censored”) data
Follow subjects until hospital discharge to avoid truncated
(“right- censored”) data
Avoid subjective endpoints, which increase variability
Standardize pain management practices across study sites
Increase homogeneity in terms of cumulative disease
burden (chronic pain)
Control duration of crisis (“suffering at home”) prior to
randomization
Limit SCD genotypes
20. NYSE MKT: MSTX
Pivotal Phase 3 Trial (EPIC)
Evaluation of Purified 188 In Children
Study Design
Randomized, two-arm, double-blind, placebo controlled
388 patients ages 8-17 from ~40 centers in the U.S.
90% power
Primary endpoint
Duration of crisis
Time from randomization to last dose of parenteral opioid
Secondary endpoints
Re-hospitalization rate (for vaso-occlusive crisis) within 14 days
Acute chest syndrome within 120 hours of randomization
Initiated: January 2013
Expected Completion (enrollment): 2015
20
27. NYSE MKT: MSTX
MST-188 Improved Survival
in Numerous Experimental Models
MST-188* studied in 5 controlled models of hemorrhagic shock /
resuscitation by 4 different investigator groups
Consistently improved survival (reproducibility across studies)
Resuscitation (2011) (DARPA-funded) MST-188
(n=7)
Control
(n=16)
P value
Median Survival Time (min)
(95% CI)
161
(80 - 180)
55.8
(36.5 - 86)
0.0186
Shock (2009) MST-188 +
Hextend
Hextend P value
Survival time from onset of hemorrhage
(min)
(n=10/arm)
589±99 289±37 0.002
27
Sources: Resuscitation 82 (2011) 1453-1459, SHOCK, Vol 32, No. 4, pp. 442-450, 2009
*Some studies evaluated 1st generation (non-purified) formulation
28. NYSE MKT: MSTX
Planned Phase 2 Study & Funding
28
Generate Clinical Proof-of-Concept Data
Study Protocol (complete)
Design: randomized, double-blind, controlled
Population: admitted to ICU for resuscitation following major torso trauma
Arms: Standard resuscitation protocol (SRP) vs SRP + MST-188
Sample Size: ~60 subjects
Evaluate multiple doses
Enrollment: 18 - 24 months
Collaboration with University of Florida
A leader in clinical research and trauma care
U.S. Government Funding
MST-188 prior recipient of funding (DARPA)
Preparing / submitting new applications
Timeline: 9 - 12 months
29. NYSE MKT: MSTX
Market Opportunities for MST-188
Therapeutic Area
U.S. Incidence
(annual)
Ex-U.S.* Incidence
(annual)
Sickle Cell Disease
(vaso-occlusive crisis)
~100,000
hospitalizations
~70,000 hospitalizations
Peripheral Arterial
Disease
(thrombolysis)**
500,000 to 600,000 1.6 to 2.0 million
Resuscitation following
Major Trauma
1.0 million 2.9 to 3.3 million
Acute Decompensated
Heart Failure
1.0 million 3.1 to 4.1 million
Transfusion 4.5 million 20 to 22 million
Stroke 800,000 2.4 million
* Includes developed countries
**Includes all end-stage PAD (i.e. ALI, CLI, DVT and other thrombotic diseases)
29
30. NYSE MKT: MSTX
MST-188 Exclusivity
Multiple Barriers to Entry
Marketing
Exclusivity
SCD: orphan drug designation in U.S. and EU
ALI: orphan drug designation expected in U.S. and EU
Patents
Filed applications cover:
proprietary purification process
methods of using poloxamers
use of poloxamers in combination therapy
Additional applications in-process
Trade
Secrets
Macromolecules difficult to characterize (“biosimilars”)
Non-patented / non-published manufacturing steps
Proprietary specifications (in-take; in-process; release)
Evaluating proprietary analytical standards / bioassays
30
31. NYSE MKT: MSTX
Financial Overview
Cash/investments at 12/31/12: ~$36.5 million
46.3 million shares outstanding
Warrants for 16.5 million shares (10.6 million @ $1.10)
Average daily volume (3 mo): ~384,000*
No debt
Opportunities for U.S. government funding
Evaluating ex-U.S. partnerships to fund U.S. development
31
*As of April 1, 2013
32. NYSE MKT: MSTX
Initiate Phase 3 Study in SCD
Identify development plans outside SCD
Secure orphan designation for MST-188 for SCD in EU
Engage ex-U.S. partnering advisor
Initiate tQT/QTc Study
Submit Applications for U.S. government funding for Phase 2 Study in Major Trauma
Request “rare pediatric disease” designation for SCD
Request Orphan Drug Designation for MST-188 for ALI in U.S.
Initiate Nonclinical Proof-of-Concept Study in Heart Failure
Report Data from tQT/QTc Study
File New Patent Applications
Open ex-U.S. Clinical Sites (EPIC)
Initiate mBF Sub-study
Initiate Phase 2 Study in ALI
32
Recent and Upcoming Events
33. NYSE MKT: MSTX
Investment Highlights
33
*Based on closing price of $0.73 on 3/26/2013
Balanced Pipeline
Mitigates corporate-level development risk
Multiple partnering opportunities
Staged Development Strategy
Initial focus on rare diseases; planned expansion into larger markets
Late-Stage Program in Sickle Cell Disease
Only company with NME in phase 3 development
Increase in Big Pharma dealmaking activity
Non-Dilutive Financing Opportunities
U.S. government funding
Ex-U.S. partnerships to fund U.S. development
Attractive Valuation
Market capitalization: $34 million*