Martha Ariza Sáenz is a biologist with a PhD in Pharmacy who has worked for 8 years in Spanish research institutions. She has experience with analytical techniques such as HPLC, FTIR, UV-Vis, DSC, AFM and SEM, as well as cell culture, in vitro release techniques, fluorescence probe marking and peptide synthesis. Her career includes roles as a predoctoral researcher, senior technician, and QA technician. She has published research on topics including nanoparticle-based HIV treatment and the use of polyphenols for conditions like polycythemia vera.

1. Martha Ariza Sáenz
1
Personal Details
Name: Martha Ariza Sáenz
Mobile: 34 656977833
Email: martharocioariza@gmail.com
LinkedIn: https://www.linkedin.com/in/marthaarizasaenz
Summary
Highly skilled Biologist with a PhD in Pharmacy. Worked the last 8 years in the Spanish public sector across different
research institutions with an excellent scientific reputation both locally and Internationally. Hands-on experience
with analytical techniques such as, HPLC, FTIR, UV-Vis, DSC, AFM and SEM, culture cells, in vitro release techniques,
fluorescence probe marking and peptides synthesis. Additional expertise with animal experimentation and QA.
Highly creative problem solver with exceptional analytical and communication skills, teamwork oriented, very
determined with meticulous attention to detail and accuracy. Used to working with multidisciplinary teams from
different scientific backgrounds, always obtaining outstanding results.
Career History Summary
Institution Role Years
Universidad de Barcelona, Spain Predoctoral Researcher 2010 - 2017
Universidad de Barcelona, Spain Senior Technician 2011 – 2018
IQAC-CSIC, Barcelona, Spain.
Predoctoral Researcher
2012 - 2015
LACER Laboratories S.A, Barcelona,
Spain. QA Technician
Feb 2011 – Dec 2011
Hospital Clinic, Barcelona, Spain. Predoctoral Researcher 2009 – 2010
Pontificia Universidad Javeriana,
Bogotá, Colombia.
Research Technician
2004 – 2007
Hospital del Niño, Pereira, Colombia. Laboratory Technician 2000 – 2004
Experience in Research
Universitat de Barcelona 2010– 2017
Barcelona, Spain
Predoctoral Researcher
Achievements
• Successfully crated, characterized and designed a nanoparticle for HIV-1 treatment, .
• Validated and optimized the creation process of polymeric nanoparticles through the factorial design (DOE
technicques).

2. Martha Ariza Sáenz
2
• Executed histologic techniques with the objective of evaluating the formulation toxicity in the in-vivo mucosae
and successfully demonstrated the safety of the formulation at the tissue level.
• Implemented innovating permeation methods with animals such as swine, use due to the similarity to the
human vaginal tissue.
Research Duties
• Strongly involved in the conception, design and execution of the Predoctoral Research, and effectively
addressed issues when they arose.
• Executed and oversaw specialized analytical testing as well as elaboration of the research documentation.
• Pursued independent but complementary research interests and interacted with a broad spectrum of
scientists both internally and externally.
• Maintained a strong awareness of current scientific literature, particularly in the area of drug substance and
drug product characterization, and actively applied new concepts accordingly.
• Applied technical knowledge to the project and the evaluation of new technologies and processes.
• Collaborated closely with expert scientists as well as Tech teams.
• Published research results in scientific journals as well as presenting the results in seminars and congresses.
IQAC-CSIC 2012 - 2015
Barcelona, Spain
Predoctoral Researcher
Achievements
• Created and executed the research project of design, synthesis and characterisation of peptides with the aim
of them to be use as inhibitors of HIV – 1.
• Designed a formulation which working as a microbicide for the prevention and treatment of the HIV -1.
• Derivatized synthesized peptides through fluorescent probes oriented to evaluate their penetration in ex-vivo
and in-vivo mucosae.
Research Duties
• Obtained experiment results to be reviewed with the Principal Researcher.
• Designed theories which explained the experiment results for them to be discussed with the Principal
Researcher.
• Carried out multiple parallel experiments varying key reaction parameters and analysed results to develop
process improvements.
• Recorded analysis data and presented results to other senior research staff.
• Organized products and material testing.
• Kept updated with relevant scientific and technical research.
• Prepared research papers, reviews and summaries.
Hospital Clinic – Primary Haemostasis Laboratory 2009 – 2010
Barcelona, Spain
Predoctoral Researcher
Achievements
• Identified the therapeutic potential of polyphenols such as apigenin in patients suffering from Polycythaemia
vera.

3. Martha Ariza Sáenz
3
• Obtained patients consent to be included in the research studies.
• Obtained satisfactory results with polyphenols that allowed the further continuity of the research.
Research duties
• Assigned serial code references to the blood samples collected through an electronic data capture system.
• Isolated and cultivated endothelial cells from umbilical cord.
• Performed immunoblots to investigate the signalling path of the P-JAK-2/ STAT-5.
Pontificia Universidad Javeriana – Neurobiochemistry 2004 – 2007
Bogotá, Colombia
Research Technician
Achievements
• Designed and synthetized lineal and cyclic peptides of platelet derived growth factor (PDGF).
• Demonstrated the inhibitor potential of synthetized peptides in culture cells (HT-1080).
Research Duties
• Synthetized peptides under the F-moc strategy.
• Cultured and maintained in viability conditions the cellular line HT–1080.
• Performed competition essays in cells with radioactive materials.
• Marked proteins with 125
I to perform radioimmunoassay.
• Developed analysis of receptor-ligand interactions.
Work Experience
Universitat de Barcelona - Scientific and Technological Center 2011– 2018
Barcelona, Spain
Senior Technician
Achievements
Effectively developed and implemented a customized Quality Assurance system for the centre, under the ISO 9001
standards, obtaining the International Certification.
Responsibilities
• Provided technical training as well as assistance to researchers for animal manipulation for experimentation
purposes.
• Applied research protocols including Good Laboratory Practices (GLP).
• Handled animal’s laboratory procedures such as, post-operative monitoring and care recovery (Pain and
distress assessments and/or administration of drug’s prescription).
• Actively participated in audits both internal and external and proactively followed up the non-conformities
and worked towards their final resolution.
Lacer Laboratories SA, Feb 2011 – Dec 2011
Barcelona, Spain

4. Martha Ariza Sáenz
4
Q.A Technician
Responsibilities
• Reviewed and updated the Standard Operating Procedures (SOP) as well as quality control policies to ensure
they were compliant with the industry standards.
• Supported the QA department in the management of QA documentation and procedures.
• Advised and contributed to the improvement of the ways of working (WoW) related to control of
documentation and management practices.
• Liaised with other company departments to ensure that the controlled documentation is reviewed in a timely
manner
Clínica del Niño – Clinic Laboratory 2000 – 2004
Bogota, Colombia
Laboratory Technician
• Collected biological samples such as blood, biological fluids and vaginal tissue samples.
• Performed immunodiagnostic techniques such as ELISA, immunoblot and western blot.
• Performed urine cultures and hemocultures
• Reported and issued the results.
Qualifications and Training
• MBA. EAE, Barcelona, Spain 2017- 2019
• Pharmaceutical PhD, Research, Development and Control of Drugs, Universidad de Barcelona/IQAC-CSIC,
Barcelona, Spain. 2012-2017.
• Master, Development and Control of Medication, Universidad de Barcelona, Barcelona, Spain, 2010-2012.
• Master, International Health and Tropical Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain,
2009-2010.
• Master, Biological Sciences, Pontificia Universidad Javeriana, Bogotá-Colombia, 2004-2007.
• Bachelor’s degree, Biology, Pontificia Universidad Javeriana, Bogotá-Colombia, 1992-1997.
Publications and Seminars
1. Martha Ariza-Sáenz, Marta Espina, Ana Calpena, Maria J Gómara, Ignacio Pérez-Pomeda, Isabel Haro and
María Luisa Garcia. Design, Characterization and biopharmaceutical Behavior of Nanoparticles Loaded
with and HIV-1 Fusion Inhibitor Peptide. Molecular Pharmaceutics, 2018,15,5005-5018.
http://10.1021/acs.molpharmaceut.8b00609.

5. Martha Ariza Sáenz
5
2. Martha Ariza, Marta Espina, Ana Cristina Calpena, Nuria Bolaños, Maria- Jose Gomara, Isabel Haro, Maria-
Luisa García. Penetration of Polymeric Nanoparticles loaded with an HIV-1 inhibitor peptide derived from GB
virus C in a vaginal mucosa. International Journal of Pharmaceutics and Biopharmaceutics.2017; 120:98 -
106. http://dx.doi.org/10.1016/j.ejpb.2017.08.008.
3. Ariza-Sáenz M, Espina M, Vega E, Gómara M.J, Egea M.A, Haro I, Garcia,M.L Optimization And
Characterization Of Poly (Lactic-Coglycolic Acid) Nanoparticles Loaded With An HIV-1 Inhibitor Synthetic
Peptide (Poster). Nano Bio&Med congress, Barcelona 2015.
4. Ariza M, Díaz-Ricart M, Molina P, Escolar G, Vicente V, Lozano M. L, Rivera J. Apigenina, a natural origin
polyphenols, inhibits the in vitro growth of erythroid manifestations. Potential effect on the signalling
pathway JAK-2/STAT-5. Hematology 2010; 95 (supl 2): 91.
5. L. Morales-Álvarez, M. Ariza. Events signalling associated with the Platelet Derived Growth Factor (PDGF)
Universitas scientiarum.2005. Vol. 10, 5-20.
Other Qualifications
• Course in experimental animal science for researches. Generalitat de Catalunya, Barcelona, Spain, 2012.
• English for academical purposes. RMIT University, Melbourne, Australia, 2008-2009
Languages
• Spanish – Native
• English – Fluent
• Catalan – B2
Additional Information
• Driving licence B
Referees
Available upon request.