Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Comparative structure of adrenal gland in vertebrates
Marenče - Meteorološke katastrofe u slovenačkim šumama - Kako pristupiti obnovi u našim specifičnim uslovima
1. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Meteorological disasters in Slovenian forests
- How to approach the restoration in our
specific conditions
Jurij Marenče
2. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Key words:
• meteorological disaster,
• ice storm,
• restoration,
• private forest,
• small forest land,
• quality of wood,
• accidents,
• technology.
3. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
A numerous climate changes, meteorological
events.
Disturbances in forests are not something new!
The intensity, the frequency - visibly increasing.
Damaged trees and forest floor - increasing.
What to expect in the future?
A strong likelihood of an increased
number of meteorological disasters…!?
The ice storm in 2014 - affected the
highest number of Slovenian forests
so far. The largest in terms of scope,
the quantity of damaged trees.
4. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Natural disasters - structure of logging in forests?
Two periods:
• 1995-1999 period, 2 million m3 , snow and ice storm damage.
• Year 2003.
• Year 2008, heavy windthrow, 500,000 m3 of felled trees.
5. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Shares of logging - different by forest management
areas (regular logging, biotic and abiotic factors, fires).
We cannot change weather!
Stand conditions???
Natural structure of tree species,
vertical and horizontal structure of forest stands,
only reduce, not prevent .
6. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
The 2014 ice storm and restoration
• The heaviest storm ice in the history (30.1.–10.2.2014).
• Contribution of snow, heavy rain a few day before.
• The most intensive 1.–2.2.2014, glaze ice until 5.2.2014.
• In the area of Pivka - up to 8 cm.
• Up to 500 m, above 1200 m forest remained unaffected.
7. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Estimation two months after the disaster (ZGS):
• 9.3 million m3 (one third coniferous trees).
• The highest amount of damaged wood mass:
• Ljubljana (2.4 million m3),
• Postojna (2.1 million m3),
• Tolmin (1.8 million m3),
• Kranj 1.0 million m3).
It represents more than a two-year annual cut
quantity in all Slovenian forests!?
Spruce and beech trees
- the most affected trees species.
8. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Ownership structure of the
affected forests
• Affected forests:
• private forests 515,400 ha, state forests - 83,000 ha.
• 7.86 million m3 (84%) in private forests,
• 1.46 million m3 (16%) in state forests.
• Quick restoration???
• Plus:
• fragmented forest
land,
• poor equipment,
• qualification of the
majority of forest
owners to work in
forest.
9. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
The urgency of salvage logging compared to the
10-year annual cut.
Areas with a private ownership structure are mainly
overlapping with those heavily affected by this ice
storm.
10. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
From review of the current restoration progress,
October 2015.
• Refers to the February 2014 – October 2015.
• Estimation: 9.3 million m3 damaged tree.
• Almost 4.0 million m3 of wood (43%) restorated.
• The share of coniferous tree 67%, deciduous trees
31%.
• One part of damaged mass will stay in forest:
approximately 25% of such trees,
in difficult terrain with heavy
skidding conditions,
skidding costs higher than
the income,
where forest owners are not interested in or
qualified to work in so demanding conditions.
11. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Safe restoration after the disaster?
Most of the damaged wood is in the private
ownership!?
Constantly activities in the field of education on the safe
work in forest!!! Realized by Slovenian Forest Servis.
Majority of accidents occur during logging operations!
12. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Number of fatal accidents by years
From review of the restoration progress - May 2015:
• Jan-May 2015: 5 fatal accidents, private forest owners.
• These year's fatal accidents are also limited mainly to the
areas of restoration of glaze ice damages.
• 3 accidents - felling, 2- skidding operations (14???)
13. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
The data of accidents, particular during felling
operations, indicate the need and necessity to search
for technological solutions in the field of timber harvesting.
The ownership structure also forces us to find different, better
and also safer solutions.
Application of modern technologies in the
private and fragmented forest land?
Cooperation between forest owners?
Selected criteria - 54,460 ha of private forests were determined.
Data related to the whole country!
Many of them in central and west part of the country.
14. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
In 2014, Slovenia avoided large-scale damages in
forests caused by bark beetles also due to cold
and humid weather.
But this year???
15. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
The reforestation - in approximately 900 ha of forest
area, i.e. 6% of all areas that will have to be restored in
Slovenia after the ice storm.
16. 2. MEĐUNARODNO SAVETOVANJE
ŠUMSKO INŽENJERSTVO JUGOISTOČNE EVROPE - STANJE I IZAZOVI
28-30. oktobar 2015, Goč, Srbija
Hvala lepa za pozornost.
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