The document is a 2011 election manifesto for two candidates, McGowan and McMenamin, running for Assembly seats in West Tyrone, Northern Ireland. It summarizes that West Tyrone is one of the most deprived constituencies and argues the area deserves better. It outlines priorities if elected, including better healthcare by setting a date for progress on Omagh Hospital, increasing economic investment and jobs, improving infrastructure like the A5 corridor, and better protections for vulnerable groups and homeowners during the economic downturn.
This document is a legislative update from State Senator Andrea Stillman representing parts of eastern Connecticut. It summarizes her efforts in the recent legislative session to pass a state budget that cuts over $3 billion in spending while protecting families, seniors, small businesses, and communities. It also discusses supporting small businesses that are important to Connecticut's economy through economic assistance programs and efforts to lower healthcare costs for employers.
Tax lawyers at Tees Law are members of STEP (The Society of Estate and Trust Practitioners) with extensive experience in the field. With this fact sheet Tees Law aims to explain the tax regime so you can assess your inheritance tax.
Q4 2015 is here already! Take a look at our Key Numbers for Income, Taxation and more. Weiss & Hale works with clients to help them to Plan Well, Invest Well & Live Well! Visit us at : www.weissandhale.com!
This document appears to be the agenda for the 2018 Annual Meeting of the Lehigh Valley Economic Development Corporation (LVEDC). The summary includes:
1) The agenda included videos on topics like thriving culture, quality healthcare, quality and cost of lifestyle, recruiting from local colleges, transportation infrastructure, labor force size, and water and natural gas resources.
2) There were presentations from county executives and the LVEDC president on the continued economic renaissance of the Lehigh Valley.
3) Awards and recognition were given to outgoing and incoming board members and sponsors who supported the annual meeting.
Valley Patriot July 2016 issue - article by Forest RainForest Rain
article published in the Valley Patriot July addition about the most incredible day in Israel - the day Gilad Shalit was released from Hamas captivity and came home
Legal Aid of Marin is celebrating its 50th anniversary of providing free legal services to low-income residents of Marin County. With the support of over 200 pro bono attorneys, it is committed to continuing its mission of justice for all. While it has made progress, there is still much more work to do to meet the overwhelming legal needs in the community. It relies on community support to carry out its important work.
This document provides cost of living analyses for two individuals, Kayla Moore and Monica Sagowitz, living in Trenton, New Jersey. It details their incomes, taxes, housing costs, utilities, transportation, healthcare, food, and other expenses. For Kayla with an initial income of $40,000, expenses totaled $31,357, leaving $7,643 remaining. For Monica with an initial income of $55,000, expenses totaled $40,310.50, leaving $14,256.47 remaining. The document also includes an analysis section reflecting on the complexity of living independently and all the associated costs.
This document is a legislative update from State Senator Andrea Stillman representing parts of eastern Connecticut. It summarizes her efforts in the recent legislative session to pass a state budget that cuts over $3 billion in spending while protecting families, seniors, small businesses, and communities. It also discusses supporting small businesses that are important to Connecticut's economy through economic assistance programs and efforts to lower healthcare costs for employers.
Tax lawyers at Tees Law are members of STEP (The Society of Estate and Trust Practitioners) with extensive experience in the field. With this fact sheet Tees Law aims to explain the tax regime so you can assess your inheritance tax.
Q4 2015 is here already! Take a look at our Key Numbers for Income, Taxation and more. Weiss & Hale works with clients to help them to Plan Well, Invest Well & Live Well! Visit us at : www.weissandhale.com!
This document appears to be the agenda for the 2018 Annual Meeting of the Lehigh Valley Economic Development Corporation (LVEDC). The summary includes:
1) The agenda included videos on topics like thriving culture, quality healthcare, quality and cost of lifestyle, recruiting from local colleges, transportation infrastructure, labor force size, and water and natural gas resources.
2) There were presentations from county executives and the LVEDC president on the continued economic renaissance of the Lehigh Valley.
3) Awards and recognition were given to outgoing and incoming board members and sponsors who supported the annual meeting.
Valley Patriot July 2016 issue - article by Forest RainForest Rain
article published in the Valley Patriot July addition about the most incredible day in Israel - the day Gilad Shalit was released from Hamas captivity and came home
Legal Aid of Marin is celebrating its 50th anniversary of providing free legal services to low-income residents of Marin County. With the support of over 200 pro bono attorneys, it is committed to continuing its mission of justice for all. While it has made progress, there is still much more work to do to meet the overwhelming legal needs in the community. It relies on community support to carry out its important work.
This document provides cost of living analyses for two individuals, Kayla Moore and Monica Sagowitz, living in Trenton, New Jersey. It details their incomes, taxes, housing costs, utilities, transportation, healthcare, food, and other expenses. For Kayla with an initial income of $40,000, expenses totaled $31,357, leaving $7,643 remaining. For Monica with an initial income of $55,000, expenses totaled $40,310.50, leaving $14,256.47 remaining. The document also includes an analysis section reflecting on the complexity of living independently and all the associated costs.
This document summarizes the achievements and future plans of the Financial Inclusion Project in Rotherham. Some key achievements include securing over £1 million in funding, establishing partnerships to increase access to affordable credit and advice, and delivering financial capability training to over 120 people. Moving forward, the project aims to maintain momentum, continue focusing on vulnerable groups, increase advice capacity, expand credit union services, and strengthen partnerships with organizations in housing, health, and employment. The overall goal is to sustainably improve financial inclusion in Rotherham.
Five candidates are running for the parliamentary seat in Havant:
1. Alan Mak of the Conservative Party who wants to bring his experience to support local businesses, schools, and communities.
2. Tim Dawes of the Green Party who advocates for a politics that looks to the long term and shares resources more equally.
3. Dr. Graham Giles of the Labour Party who has decades of experience in social and economic development and wants to defend the NHS and boost the local economy.
4. Steve Sollitt of the Liberal Democrats who has been a local councillor for over 20 years and promises to be a strong voice for the constituency if elected.
5. John Perry of UKIP who believes Britain
The document summarizes the work of the Commissioner for Older People for Northern Ireland from 2011 to 2015. It outlines the establishment of the Commissioner's office and organization, with the goal of being an independent champion for older people. Over the term, the Commissioner engaged with older people, provided legal assistance to individuals, advised government on key issues, and published reports on topics like crime rates against older people, adult safeguarding, and social care.
The Senate President outlines his vision for the 16th Senate Congress, which includes having younger and more diverse members that better represent the concerns of all Filipinos. He emphasizes that the Senate must craft laws that spur economic development and job creation while ensuring social protections for the poor and marginalized. Key priorities include tax reform, infrastructure development, and improving health care, education and anti-poverty programs to enable inclusive growth that benefits all citizens. He calls on Senators to work diligently to address the challenges facing the country and regain the trust of the Filipino people through effective lawmaking and oversight.
Family first Policies on Property rights, tax, water, climate change, small b...David
Family First believes that small businesses are the lifeblood of the economy and offer the greatest opportunities for employment growth. They oppose excessive taxes and support a fairer tax system that provides incentives for productivity and work. Family First also believes that Australians deserve access to clean, affordable water and that more research is needed on climate change policies before implementing major economic changes. Overall, Family First supports traditional family values, the dignity of life, disability inclusion, and property rights.
Madam Speaker
In A Tale of Two Cities, Charles Dickens opens with:
“It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity… we were all going direct to Heaven, we were all going direct the other way...”
So too is the present time. As a country, we stand at a crossroads. We can choose a path of hope; or a path of despair. We can go directly to Heaven, or as Dickens so politely puts it, we can go the other way.
Student guidance the northern ireland political partiesDB3igs
The document provides information on several political parties in Northern Ireland, including the Alliance Party, the Democratic Unionist Party (DUP), the Social Democratic and Labour Party (SDLP), Sinn Féin, and summarizes their histories, key aims, and policies on the economy, education, the environment, and immigration. Each party section outlines the party's founding, leadership, and stances on building a prosperous and united/stable Northern Ireland society.
Health@Simcoe Muskoka is an annual look at both ongoing activities and the new public health issues emerging in our changing world. This document includes the agency’s annual report.
Health@Simcoe Muskoka is an annual look at both ongoing activities and the new public health issues emerging in our changing world. This document includes the agency’s annual report.
Unsgsa address at unilevers post 2015 a new global partnership dinnerDr Lendy Spires
This document summarizes a speech given by Queen Maxima of the Netherlands at an event hosted by Unilever on public-private partnerships for development. The key points made in the speech are:
1) Public-private partnerships are needed to achieve both the MDGs and an ambitious post-2015 development agenda.
2) Financial inclusion cuts across many development issues by enabling things like government payments, loans, insurance and savings.
3) True development requires scaling up efforts beyond small programs to reach universality, which requires both the public and private sectors working together.
4) Analyzing issues of supply and demand is important for partnerships, such as ensuring stable infrastructure, regulations, affordable costs and products people
John Shimmin is running for re-election in Douglas West. In his manifesto, he highlights his 15 years of experience in government, serving as Minister in four departments. He argues this experience will be valuable in guiding the Isle of Man through challenging economic times ahead. Shimmin outlines key issues for voters like the economy, housing, and cost of living. He summarizes investments made during good financial years and says the focus must now be rebuilding the economy while reducing the size and cost of government.
The document discusses the community and economic impact of healthcare in Clayton County, Georgia. It states that healthcare and social assistance is the fifth largest economic sector in Clayton County, employing over 7,200 people with a payroll of $314 million. It also highlights several major healthcare facilities in the county, including Southern Regional Medical Center, which is the third largest employer with 1,700 employees and a payroll of over $110 million. The healthcare industry helps drive other sectors of the local economy and ensures residents have access to quality healthcare.
This document provides information about an investment forum called "Invest Sierra Leone 2016" that will take place in London. The forum aims to encourage investment in Sierra Leone and will include presentations and discussions with Sierra Leone government ministers and business leaders. Some of the key topics to be discussed are the investment climate in Sierra Leone, challenges and opportunities in sectors like agriculture, and the country's economic recovery since the Ebola outbreak. The agenda outlines the schedule of speakers and presentations.
The document provides an overview of Western Australia's business environment and its preparedness to host the 2011 Commonwealth Heads of Government Meeting (CHOGM) and Commonwealth Business Forum. It notes that Western Australia, and Perth specifically, are well positioned to capitalize on the shifting global economy due to key trading relationships and proximity to fast growing Asian and African markets. It also highlights the economic opportunities within the Commonwealth for trade, investment and partnerships between developed and developing member countries.
The document is the final report from the Partnership Council on Employment Opportunities for People with Disabilities presented to the Ontario Minister of Economic Development, Employment and Infrastructure. Some key points:
- The report recommends appointing a senior Minister and Deputy Minister with accountability for developing an employment strategy for people with disabilities in Ontario to help engage more in the workforce.
- It urges the government to take strong action to eliminate barriers that prevent employers from hiring people with disabilities and to assist people with disabilities in seeking fulfilling work.
- The report argues that investing in eliminating employment barriers will result in a more prosperous economy and society by creating a more diverse and inclusive workforce.
100 Answers to 20 Questions – Havant Parliamentary CandidatesHayling Island
This document contains 20 questions posed to parliamentary candidates in the Havant constituency and 100 word answers from 5 candidates: Alan Mak (Conservative), Tim Dawes (Green), Dr Graham Giles (Labour), Steve Sollitt (Liberal Democratic), and John Perry (UK Independence Party).
The questions cover a range of national issues like defence spending, the economy, environmental regulations, the NHS, education, taxation, the EU, and constitutional reform in the UK. The candidates provide their perspectives on these issues and how they would address them if elected. Local issues discussed include priorities for Havant and Hayling like jobs, schools, and community development.
The Wealth Management Association responded positively to announcements in the UK budget aimed at encouraging investment and saving for future generations. The budget proposed a new "Lifetime ISA" for under 40s, allowing savings of up to £4000 annually with government contributions of £1 for every £4 saved. It also increased the annual ISA limit to £20,000 and cut capital gains tax, measures intended to help long-term retail investors benefit from asset growth. The WMA chief executive welcomed these initiatives as important for establishing a stronger culture of investment in the UK.
Governor Aminu Waziri Tambuwal fielded questions from journalists in Sokoto on wide range of issues affecting his state and the country. He gave his frank assessment of the measures needed to take Nigeria out of recession.
This document provides a summary of the Opposition Spokesman on Finance and Planning's response to the Jamaican government's 2015-2016 budget. The summary criticizes the poor state of the nation under the ruling PNP government, noting deteriorating social services, high costs of living, and increasing poverty. It also argues that the government is not creating enough jobs or economic growth and is instead focused on passing IMF fiscal tests. Overall, the summary paints a dire picture of Jamaica's economy and citizens' welfare after several years under PNP leadership.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
This document summarizes the achievements and future plans of the Financial Inclusion Project in Rotherham. Some key achievements include securing over £1 million in funding, establishing partnerships to increase access to affordable credit and advice, and delivering financial capability training to over 120 people. Moving forward, the project aims to maintain momentum, continue focusing on vulnerable groups, increase advice capacity, expand credit union services, and strengthen partnerships with organizations in housing, health, and employment. The overall goal is to sustainably improve financial inclusion in Rotherham.
Five candidates are running for the parliamentary seat in Havant:
1. Alan Mak of the Conservative Party who wants to bring his experience to support local businesses, schools, and communities.
2. Tim Dawes of the Green Party who advocates for a politics that looks to the long term and shares resources more equally.
3. Dr. Graham Giles of the Labour Party who has decades of experience in social and economic development and wants to defend the NHS and boost the local economy.
4. Steve Sollitt of the Liberal Democrats who has been a local councillor for over 20 years and promises to be a strong voice for the constituency if elected.
5. John Perry of UKIP who believes Britain
The document summarizes the work of the Commissioner for Older People for Northern Ireland from 2011 to 2015. It outlines the establishment of the Commissioner's office and organization, with the goal of being an independent champion for older people. Over the term, the Commissioner engaged with older people, provided legal assistance to individuals, advised government on key issues, and published reports on topics like crime rates against older people, adult safeguarding, and social care.
The Senate President outlines his vision for the 16th Senate Congress, which includes having younger and more diverse members that better represent the concerns of all Filipinos. He emphasizes that the Senate must craft laws that spur economic development and job creation while ensuring social protections for the poor and marginalized. Key priorities include tax reform, infrastructure development, and improving health care, education and anti-poverty programs to enable inclusive growth that benefits all citizens. He calls on Senators to work diligently to address the challenges facing the country and regain the trust of the Filipino people through effective lawmaking and oversight.
Family first Policies on Property rights, tax, water, climate change, small b...David
Family First believes that small businesses are the lifeblood of the economy and offer the greatest opportunities for employment growth. They oppose excessive taxes and support a fairer tax system that provides incentives for productivity and work. Family First also believes that Australians deserve access to clean, affordable water and that more research is needed on climate change policies before implementing major economic changes. Overall, Family First supports traditional family values, the dignity of life, disability inclusion, and property rights.
Madam Speaker
In A Tale of Two Cities, Charles Dickens opens with:
“It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity… we were all going direct to Heaven, we were all going direct the other way...”
So too is the present time. As a country, we stand at a crossroads. We can choose a path of hope; or a path of despair. We can go directly to Heaven, or as Dickens so politely puts it, we can go the other way.
Student guidance the northern ireland political partiesDB3igs
The document provides information on several political parties in Northern Ireland, including the Alliance Party, the Democratic Unionist Party (DUP), the Social Democratic and Labour Party (SDLP), Sinn Féin, and summarizes their histories, key aims, and policies on the economy, education, the environment, and immigration. Each party section outlines the party's founding, leadership, and stances on building a prosperous and united/stable Northern Ireland society.
Health@Simcoe Muskoka is an annual look at both ongoing activities and the new public health issues emerging in our changing world. This document includes the agency’s annual report.
Health@Simcoe Muskoka is an annual look at both ongoing activities and the new public health issues emerging in our changing world. This document includes the agency’s annual report.
Unsgsa address at unilevers post 2015 a new global partnership dinnerDr Lendy Spires
This document summarizes a speech given by Queen Maxima of the Netherlands at an event hosted by Unilever on public-private partnerships for development. The key points made in the speech are:
1) Public-private partnerships are needed to achieve both the MDGs and an ambitious post-2015 development agenda.
2) Financial inclusion cuts across many development issues by enabling things like government payments, loans, insurance and savings.
3) True development requires scaling up efforts beyond small programs to reach universality, which requires both the public and private sectors working together.
4) Analyzing issues of supply and demand is important for partnerships, such as ensuring stable infrastructure, regulations, affordable costs and products people
John Shimmin is running for re-election in Douglas West. In his manifesto, he highlights his 15 years of experience in government, serving as Minister in four departments. He argues this experience will be valuable in guiding the Isle of Man through challenging economic times ahead. Shimmin outlines key issues for voters like the economy, housing, and cost of living. He summarizes investments made during good financial years and says the focus must now be rebuilding the economy while reducing the size and cost of government.
The document discusses the community and economic impact of healthcare in Clayton County, Georgia. It states that healthcare and social assistance is the fifth largest economic sector in Clayton County, employing over 7,200 people with a payroll of $314 million. It also highlights several major healthcare facilities in the county, including Southern Regional Medical Center, which is the third largest employer with 1,700 employees and a payroll of over $110 million. The healthcare industry helps drive other sectors of the local economy and ensures residents have access to quality healthcare.
This document provides information about an investment forum called "Invest Sierra Leone 2016" that will take place in London. The forum aims to encourage investment in Sierra Leone and will include presentations and discussions with Sierra Leone government ministers and business leaders. Some of the key topics to be discussed are the investment climate in Sierra Leone, challenges and opportunities in sectors like agriculture, and the country's economic recovery since the Ebola outbreak. The agenda outlines the schedule of speakers and presentations.
The document provides an overview of Western Australia's business environment and its preparedness to host the 2011 Commonwealth Heads of Government Meeting (CHOGM) and Commonwealth Business Forum. It notes that Western Australia, and Perth specifically, are well positioned to capitalize on the shifting global economy due to key trading relationships and proximity to fast growing Asian and African markets. It also highlights the economic opportunities within the Commonwealth for trade, investment and partnerships between developed and developing member countries.
The document is the final report from the Partnership Council on Employment Opportunities for People with Disabilities presented to the Ontario Minister of Economic Development, Employment and Infrastructure. Some key points:
- The report recommends appointing a senior Minister and Deputy Minister with accountability for developing an employment strategy for people with disabilities in Ontario to help engage more in the workforce.
- It urges the government to take strong action to eliminate barriers that prevent employers from hiring people with disabilities and to assist people with disabilities in seeking fulfilling work.
- The report argues that investing in eliminating employment barriers will result in a more prosperous economy and society by creating a more diverse and inclusive workforce.
100 Answers to 20 Questions – Havant Parliamentary CandidatesHayling Island
This document contains 20 questions posed to parliamentary candidates in the Havant constituency and 100 word answers from 5 candidates: Alan Mak (Conservative), Tim Dawes (Green), Dr Graham Giles (Labour), Steve Sollitt (Liberal Democratic), and John Perry (UK Independence Party).
The questions cover a range of national issues like defence spending, the economy, environmental regulations, the NHS, education, taxation, the EU, and constitutional reform in the UK. The candidates provide their perspectives on these issues and how they would address them if elected. Local issues discussed include priorities for Havant and Hayling like jobs, schools, and community development.
The Wealth Management Association responded positively to announcements in the UK budget aimed at encouraging investment and saving for future generations. The budget proposed a new "Lifetime ISA" for under 40s, allowing savings of up to £4000 annually with government contributions of £1 for every £4 saved. It also increased the annual ISA limit to £20,000 and cut capital gains tax, measures intended to help long-term retail investors benefit from asset growth. The WMA chief executive welcomed these initiatives as important for establishing a stronger culture of investment in the UK.
Governor Aminu Waziri Tambuwal fielded questions from journalists in Sokoto on wide range of issues affecting his state and the country. He gave his frank assessment of the measures needed to take Nigeria out of recession.
This document provides a summary of the Opposition Spokesman on Finance and Planning's response to the Jamaican government's 2015-2016 budget. The summary criticizes the poor state of the nation under the ruling PNP government, noting deteriorating social services, high costs of living, and increasing poverty. It also argues that the government is not creating enough jobs or economic growth and is instead focused on passing IMF fiscal tests. Overall, the summary paints a dire picture of Jamaica's economy and citizens' welfare after several years under PNP leadership.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
4. We Want a Better West Tyrone! West Tyrone is currently ranked as one of the most deprived constituencies in Northern Ireland. This constituency needs better leadership to fight for every constituent. The centralised party machines have neglected this area for years. Put plain and simple, we feel the people of West Tyrone have got a raw deal. As experienced, elected representatives in West Tyrone, over the years we have become completely disillusioned with centralised party leadership and the trickle down effect of budget allocations for our hospital, roads, infrastructure, jobs – the list goes on... The shocking statistics on the next page prove it. The days of sitting at the back of the bus are gone. This area has always been at the end of the line when it comes to funding. Ministers and the big party machines like to look good in the big cities. West Tyrone is not their big area of focus. We are always at the end of the line. The people of this area deserve better.” Too many issues are not being resolved at Stormont regarding West Tyrone. It is time to put these issues to bed. We want to see a date set for progress on Omagh Hospital during the next term of this Assembly. It is no longer acceptable for West Tyrone not to have progress on this. It has already been listed as a high priority within the Health portfolio. We want to see that priority become a reality within this term of the Assembly. Simply put the people of Omagh and Strabane deserve better.
5. West Tyrone received the lowest amount of financial assistance from Invest NI during the last Assembly West Tyrone has the 5th highest death rate due to respiratory disease, the 8th highest death rate due to circulatory disease and the 4th highest death rate due to suicide and undetermined intent. The most deprived areas in West Tyrone are ranked in the 10% most deprived areas in Northern Ireland. No area in West Tyrone is ranked in the 10% least deprived areas in Northern Ireland. West Tyrone has the 3rd lowest number of employee jobs. West Tyrone is ranked 3rd highest in terms of the proportion of people in receipt of disability-related benefits. West Tyrone has the 4th highest proportion of benefit claimants. West Tyrone has the 5th highest proportion of unemployment-related benefit claimants A higher proportion of West Tyrone jobs are in construction and a lower proportion are in services compared to all Northern Ireland employee jobs. How West Tyrone compares to the other Constituencies
6.
7. Fighting for better enhanced Health Services in Western Region We want to see a date set for progress on Omagh Hospital during the next term of this Assembly. It is no longer acceptable for West Tyrone not to have progress on this. It has already been listed as a high priority within the Health portfolio. We want to see that priority become a reality within this term of the Assembly. We also want answers regarding the recent decision made by the Health Minister regarding the Cancer Radiotherapy unit at Altnagelvin. This decision needs to be reversed in the forthcoming Assembly. We believe in North South co operation aimed at providing the best and most efficient levels of Healthcare to West Tyrone We demand that the Health portfolio is managed efficiently and effectively and that the allocated budget is used in an efficient, non wasteful manner. West Tyrone is the only constituency without adequate healthcare facilities. We already know this is not good enough. What reasons are there for the Health department to argue that health in West Tyrone is worth less than in any other constituency?
8. Getting better economic investment and increasing employment When you consider that Peter Robinson’s Constituency of East Belfast was funded by Invest NI to the tune of £30 million plus compared to West Tyrone’s miserable £2 million, it begs the question - Why have our elected representative’s not taken Invest NI over the coals??? We need tax incentives to attract business to our region; Banks need to get real in lending & supporting Small Medium Enterprise, Business Parks are vital in attracting new business to our region. Special emphasis on areas of high unemployment a program for reform. Pilot schemes designed to employ local labour and incentives for future investors. Research & Development in our colleges. West Tyrone has been blighted with unemployment since stats began. This has never, ever been addressed....why???
9. Getting better infrastructure One of the keys issues to providing better investment into West Tyrone is to have better infrastructure. To attract investment into West Tyrone we must improve our transportation systems. The A5 Corridor will help realise the economic and investment opportunities in this region through balanced regional infrastructure. The new dual carriageway will significantly improve safety and journey times for motorists. We fully support the A5 Corridor and will be pressing for progress to be made on having the scheme fully implemented. We also wish to see the A5 development take into consideration those who are impacted by the developments and to have them compensated in a fair and sufficient manner.
10. Better protection in the community for our most vulnerable We encourage community partnerships to ensure that all of our communities within West Tyrone feel safe. We believe that through effective policing and community initiatives that all people can be better protected within our community. We believe in investing money in fuel poor homes across West Tyrone and support the development of a network in order to ensure that senior citizens are better protected in their homes. Community safety must include preventing, reducing and containing the social, environmental and intimidatory factors, which affect people's right to live without fear of crime and which impact upon their quality of life. We need to closely monitor preventative measures that contribute to crime reduction and tackle anti-social behaviour. A partnership approach to community safety including bringing together a wide variety of organisations, which have inherited a responsibility for community safety as part of their own work, We need to co-ordination in working together for the benefit of all our senior citizens and the vulnerable in West Tyrone.
11. Better protection for Homeowners and Business owners in the current economic downturn The real issues that we hear and see on the ground everyday in West Tyrone are: 1. Families worried about how they are going to make their next mortgage payment. 2. Good people wondering if they are going to lose their jobs in a wave of cuts. West Tyrone needs a moratorium for all mortgage owners in serious difficulties of at least 12 months. There are many couples who are in dire financial need due to the economic down turn. The Banks and Building Societies who could not lend money quick enough to every one a few years ago are now repossessing homes at an alarming rate. It has to stop. This has to be a priority in the new Assembly along with a review of rates for our struggling town centre businesses. Banks once so eager to lend have closed their vaults. We strongly believe in community banking. Ireland should never allow a small cartel to control our countries finances again. More credit Unions and community banks must be encouraged. The idea of using public funds to bail out banks and then taxing working families more to pay for this is ridiculous.
12. Better delivery for agriculture and rural communities We need stability of our rural communities in West Tyrone. We want farmers in West Tyrone to still be farmers in years to come, to stop their feeling of isolation, to make sure the current financial crisis is handled with them in mind. Supporting the continuation of sustainable farming helps maintain the countryside and contributes to rural development. ensuring continued agricultural land use and, thereby, contributing to the maintenance of a viable rural community : M aintaining the countryside M aintaining and promoting sustainable farming systems which in particular take account of environmental protection requirements. We support the improvement of funding and grant initiatives available from DARD for agri-environment, farm, fishing industry, forestry and rural schemes.
13. Better arts and leisure opportunities The strategic development of tourism within West Tyrone: Liaison with relevant agencies including the Northern Ireland Tourist Board and funding organisations to maximise opportunities for West Tyrone. The implementation of an effective marketing plan for West Tyrone The provision of an effective support service to the local tourism industry and continued consultation with tourism providers in the development of tourism strategies and the provision of visitor services through-out West Tyrone. The provision of interpretation of West Tyrone’s history, heritage and culture. The vast exodus to North America by emigrants from Ireland in general is well documented. Many went on to attain fame and prosperity, while many others lived their lives in comparative obscurity. Each however contributed in his or her own way to the development of the great American Republic, the United States of America and its neighbour Canada. Strabane & Omagh West Tyrone can claim full share in these associations through the many emigrants who left the area from as early as 1773. This is just one avenue of many that we could go down renewing our acquaintances with our American and Canadian friend’s. The American Folk Park is our Jewel in the Crown. In the North West we have Derry which has won the City of Culture in 2013. there will be thousands visiting the region so we have to be prepared to facilitate our visitors.
14. Better equality and human rights We must remember that we are still in the infancy of peace in real terms. There is much work to be done in the future. And unfortunately as we have seen recently the specter of the bad old days still looms. We believe that there is a forum for every opinion within the Peace Agreement since 1998. Those who do not wish to voice their opinion in a democratic and peaceful manner are enemies of West Tyrone and enemies of the island of Ireland. We believe that every nationality, race, colour and creed within West Tyrone and beyond deserve the right to live freely without intimidation, harassment or racist slander. We vow to those who feel pressurised in this manner to understand that we refuse to tolerate this in West Tyrone and that we are here to stand by your right to freedom of living without intimidation.
15. OMAGH DISTRICT VOTE MCGOWAN 1 MCMENAMIN 2 STRABANE DISTRICT VOTE MCMENAMIN 1 MCGOWAN 2 WEST TYRONE DESERVES better