Objective: To determine whether distoangular malposition of the unerupted mandibular second
premolar (MnP2) is more frequent in children with unilateral clefts of the lip and palate.
Materials and Methods: This retrospective study examined panoramic radiographs from 45 patients
with unilateral clefts of the lip and/or palate who had no previous orthodontics. A control
sample consisted of age- and sex-matched patients. The distal angle formed between the long
axis of MnP2 and the tangent to the inferior border was measured. The mean, standard deviation,
and range were calculated for the angles measured in the cleft and the control groups. The
significance of the differences between the means was evaluated by the paired t-test. The angles
of the cleft and noncleft sides were also measured and compared.
Results: The mean inclination of the MnP2 on the cleft side was 73.6°, compared with 84.6° in
the control group. This difference was highly significant statistically (P < .0001). The difference
in angles from the cleft and noncleft sides was 0.7°, not statistically significant. A significant association
was found between clefting and distoangular malposition of the developing MnP2, suggesting
a shared genetic etiology. This association is independent of the clefting side, ruling out
possible local mechanical effects.
Conclusion: Clinicians should be aware of the potential for anomalous development of MnP2 in
children with clefts.
Craniofacial growth in untreated skeletal class i subjects with low, average,...EdwardHAngle
The dental measurements showed few changes with growth in all groups. In terms of skeletal measurements from ages 9 to 18, similar growth changes were found between the sexes in most angular measurements, but males had larger values in linear measurements than females.
Angular changes and their rates in concurrence to developmental stages of the...EdwardHAngle
In the early developmental stage of the mandibular second premolar (MnP2), it is not unusual to find the tooth extremely angulated to the lower border of the mandible, as seen in the panoramic roentgenogram. On eruption, the tooth, in most cases, is close to being upright. However, impaction or other types of malocclusions due to its ectopic eruption are not rare.
Subjective classification and objective analysis of the mandibular dental arc...EdwardHAngle
Our objective was to evaluate the relationship between subjective classification of dental-arch shape, objective analyses via arch-width measurements, and the fitting with the fourth-order polynomial equation.
Transverse growth of the maxilla and mandible in untreated girls with low, av...EdwardHAngle
The purpose of this study was to investigate maxillary and mandibular transverse growth in
untreated female subjects with low, average, and high mandibular plane angles longitudinally from ages 6 to 18.
Effects of rapid palatal expansion on the sagittal and vertical dimensions of...EdwardHAngle
The purpose of this study was to use cone-beam computed tomography imaging to examine the skeletal and dental changes in the sagittal and vertical dimensions after rapid palatal expansion.
Craniofacial growth in untreated skeletal class i subjects with low, average,...EdwardHAngle
The dental measurements showed few changes with growth in all groups. In terms of skeletal measurements from ages 9 to 18, similar growth changes were found between the sexes in most angular measurements, but males had larger values in linear measurements than females.
Angular changes and their rates in concurrence to developmental stages of the...EdwardHAngle
In the early developmental stage of the mandibular second premolar (MnP2), it is not unusual to find the tooth extremely angulated to the lower border of the mandible, as seen in the panoramic roentgenogram. On eruption, the tooth, in most cases, is close to being upright. However, impaction or other types of malocclusions due to its ectopic eruption are not rare.
Subjective classification and objective analysis of the mandibular dental arc...EdwardHAngle
Our objective was to evaluate the relationship between subjective classification of dental-arch shape, objective analyses via arch-width measurements, and the fitting with the fourth-order polynomial equation.
Transverse growth of the maxilla and mandible in untreated girls with low, av...EdwardHAngle
The purpose of this study was to investigate maxillary and mandibular transverse growth in
untreated female subjects with low, average, and high mandibular plane angles longitudinally from ages 6 to 18.
Effects of rapid palatal expansion on the sagittal and vertical dimensions of...EdwardHAngle
The purpose of this study was to use cone-beam computed tomography imaging to examine the skeletal and dental changes in the sagittal and vertical dimensions after rapid palatal expansion.
Gingival recession—can orthodontics be a cure? evidence from a case presentationEdwardHAngle
Does orthodontic treatment help or hinder a patient’s periodontal status? What factors affect the
periodontium? Can those factors be managed in a way that remedies existing periodontal issues?
A 35-year-old woman presented with severe gingival recession and a unilateral Class II
malocclusion. The treatment plan was to correct the malocclusion in a way that torques the roots
more onto bone and to change her dental hygiene methods. With an extensive review of the
literature, this case review attempts to make sense of the enigma of gingival recession and
demonstrates an excellent treatment solution to concomitant orthodontic and periodontal
problems.
Role of polycystin 1 in bone remodeling- orthodontic tooth movement study in ...EdwardHAngle
Objective: To test the hypothesis that polycystin-1 (PC1) is involved in orthodontic tooth movement as a mechanical sensor.
Materials and Methods: The response to force application was compared between three mutant and four wild-type 7-week-old mice. The mutant mice were PC1/Wnt1-cre, lacking PC1 in the craniofacial region. An orthodontic closed coil spring was bonded between the incisor and the left first molar, applying 20 g of force for 4 days. Micro–computed tomography, hematoxylin and eosin staining, and tartrate-resistent acid phosphatase (TRAP) staining were used to study the differences in tooth movement among the groups.
Results: In the wild-type mice the bonded molar moved mesially, and the periodontal ligament (PDL) was compressed in the compression side. The compression side showed a hyalinized zone, and osteoclasts were identified there using TRAP staining. In the mutant mice, the molar did not move, the incisor tipped palatally, and there was slight widening of the PDL in the tension area. Osteoclasts were not seen on the bone surface or on the compression side. Osteoclasts were only observed on the other side of the bone—in the bone marrow.
Conclusions: These results suggest a difference in tooth movement and osteoclast activity between PC1 mutant mice and wild-type mice in response to orthodontic force. The impaired tooth movement and the lack of osteoclasts on the bone surface in the mutant working side may be related to lack of signal from the PDL due to PC1 deficiency.
Effects of bonded rapid palatal expansion on the transverse dimensions of the...EdwardHAngle
The purpose of this study was to examine the maxillary response on the transverse dimensions to rapid palatal expansion (RPE) by using cone-beam computed tomography (CBCT).
Long term clinical and bacterial effetcx of xylitol on paitnets with fixed or...EdwardHAngle
Background: The objective of this study was to evaluate long-term clinical and bacterial effects of using 6 g of
xylitol per day for 3 months on patients with full fixed orthodontic appliances.
Methods: The study was a pilot clinical trial that included 41 subjects who were undergoing orthodontic
treatment. The subjects were randomly divided into three groups. Group A received xylitol chewing gum, group B
received xylitol dissolvable chewable tablets, and Group C served as the control group and did not receive xylitol
gums or tablets. Clinical examination and the collection of plaque and saliva samples were carried out at baseline
and 3, 6, and 12 months. All three groups were given oral hygiene instruction and were put on a 6-month cleaning
and topical fluoride schedule. Plaque scores and bacterial counts were used to evaluate the effectiveness of the
different approaches at reducing the caries risk.
Results: Xylitol groups did not experience any more reduction in plaque score, plaque MS counts, or salivary MS
counts than the control group nor did they have lower values at any of the time points. Chewing gum did not
significantly increase the incidence of debonded brackets over the other groups.
Conclusions: Xylitol does not have a clinical or bacterial benefit in patients with fixed orthodontic appliances. Oral
hygiene instructions and 6-month topical fluoride application were effective at reducing plaque scores and bacterial
counts in patients with full fixed appliances regardless of whether or not xylitol was used.
Purpose: To assess the amount of dental and skeletal expansion and stability after surgically assisted
rapid maxillary expansion (SARPE).
Patients and Methods: Data from 20 patients enrolled in this prospective study were collected before
treatment, at maximum expansion, at the removal of the expander 6 months later, before any second
surgical phase, and at the end of orthodontic treatment, using posteroanterior cephalograms and dental
casts.
Results: With SARPE, the mean maximum expansion at the first molar was 7.48 1.39 mm, and the
mean relapse during postsurgical orthodontics was 2.22 1.39 mm (30%). At maximum, a 3.49 1.37
mm skeletal expansion was obtained, and this expansion was stable, such that the average net expansion
was 67% skeletal.
Conclusion: Clinicians should anticipate a loss of about one third of the transverse dental expansion
obtained with SARPE, although the skeletal expansion is quite stable. The amount of postsurgical relapse
with SARPE appears quite similar to the changes in dental-arch dimensions after nonsurgical rapid palatal
expansion, and also quite similar to dental-arch changes after segmental maxillary osteotomy for
expansion.
Increased occurrence of dental anomalies associated with infraocclusion of de...EdwardHAngle
Objective: To test the null hypothesis that there is no relationship between infraocclusion and the
occurrence of other dental anomalies in subjects selected for clear-cut infraocclusion of one or
more deciduous molars.
Materials and Methods: The experimental sample consisted of 99 orthodontic patients (43 from
Boston, Mass, United States; 56 from Jerusalem, Israel) with at least one deciduous molar in
infraocclusion greater than 1 mm vertical discrepancy, measured from the mesial marginal ridge of
the first permanent molar. Panoramic radiographs and dental casts were used to determine the
presence of other dental anomalies, including agenesis of permanent teeth, microdontia of
maxillary lateral incisors, palatally displaced canines (PDC), and distal angulation of the mandibular
second premolars (MnP2-DA). Comparative prevalence reference values were utilized and
statistical testing was performed using the chi-square test (P< .05) and odds ratio.
Results: The studied dental anomalies showed two to seven times greater prevalence in the
infraocclusion samples, compared with reported prevalence in reference samples. In most cases,
the infraoccluded deciduous molar exfoliated eventually and the underlying premolar erupted
spontaneously. In some severe phenotypes (10%), the infraoccluded deciduous molar was
extracted and space was regained to allow uncomplicated eruption of the associated premolar.
Conclusion: Statistically significant associations were observed between the presence of
infraocclusion and the occurrence of tooth agenesis, microdontia of maxillary lateral incisors,
PDC, and MnP2-DA. These associations support a hypothesis favoring shared causal genetic
factors. Clinically, infraocclusion may be considered an early marker for the development of later
appearing dental anomalies, such as tooth agenesis and PDC.
Malposition of unerupted mandibular second premolar in children with palatall...EdwardHAngle
Objective: To test the hypotheses that (1) the distal angulation of unerupted mandibular premolar
(MnP2) is significantly greater in children with palatally displaced canines (PDC) than in those in
a control sample; and (2) delayed tooth formation is significantly more frequent in children with
both malposed MnP2 and PDC than in children with PDC only.
Materials and Methods: We examined retrospectively panoramic radiographs from 43 patients
with PDC who had no previous orthodontics. A control sample consisted of age- and sex-matched
patients. The distal angle formed between the long axis of MnP2 and the tangent to the inferior
border was measured. Dental age was evaluated using the Koch classification.
Results: A significant difference was observed between the mean inclination of the right side
MnP2 in the PDC group (75.4 degrees) and that of the control group (85.8 degrees). This difference
was highly statistically significant (P < .0001). The same evaluation was carried out for the
left side, with similar results. The average dental age was found to be delayed in patients who
showed both abnormalities (malposed MnP2 and PDC) compared with patients who showed the
PDC anomaly only.
Conclusion: Both hypotheses are retained. Statistically, PDC and MnP2 malposition are significantly
associated suggesting a common genetic etiology, despite taking place on opposite jaws.
While the presence of PDC or MnP2 anomaly has been associated with a delay in tooth formation,
we find the presence of both anomalies to show a more profound delay. Our findings suggest a
delay in tooth formation as a possible common genetic mechanism for these 2 malposition anomalies.
ABSTRACT
Objective: To evaluate the role of age as a moderator of bone regeneration patterns and
symphysis remodeling after genioplasty.
Method: Fifty-four patients who underwent genioplasty at the end of their orthodontic treatment
were divided into three age groups: younger than 15 years at the time of surgery (group 1), 15 to
19 years (group 2), and 20 years or older (group 3). Twenty-three patients who did not accept
genioplasty and had a follow-up radiograph 2 years after the end of their orthodontic treatment
were used as a control group. Patients were evaluated at three time points: immediate preoperative
(T1), immediate postoperative (T2,) and 2 years postsurgery (T3).
Results: The mean genial advancement at surgery was similar for the three age groups, but the
extent of remodeling around the repositioned chin was greater in group 1, less in group 2, and still
less in group 3. Symphysis thickness increased significantly during the 2-year postsurgery interval
for the three groups, and this increase was significantly greater in group 1 than in group 3.
Remodeling above and behind the repositioned chin also was greater in the younger patients. This
was related to greater vertical growth of the dentoalveolar process in the younger patients. There
was no evidence of a deleterious effect on mandibular growth.
Conclusion: The outcomes of forward-upward genioplasty include increased symphysis
thickness, bone apposition above B point, and remodeling at the inferior border. When indications
for this type of genioplasty are recognized, early surgical correction (before age 15) produces a
better outcome in terms of bone remodeling. (Angle Orthod. 0000;00:000–000.)
Gingival recession—can orthodontics be a cure? evidence from a case presentationEdwardHAngle
Does orthodontic treatment help or hinder a patient’s periodontal status? What factors affect the
periodontium? Can those factors be managed in a way that remedies existing periodontal issues?
A 35-year-old woman presented with severe gingival recession and a unilateral Class II
malocclusion. The treatment plan was to correct the malocclusion in a way that torques the roots
more onto bone and to change her dental hygiene methods. With an extensive review of the
literature, this case review attempts to make sense of the enigma of gingival recession and
demonstrates an excellent treatment solution to concomitant orthodontic and periodontal
problems.
Role of polycystin 1 in bone remodeling- orthodontic tooth movement study in ...EdwardHAngle
Objective: To test the hypothesis that polycystin-1 (PC1) is involved in orthodontic tooth movement as a mechanical sensor.
Materials and Methods: The response to force application was compared between three mutant and four wild-type 7-week-old mice. The mutant mice were PC1/Wnt1-cre, lacking PC1 in the craniofacial region. An orthodontic closed coil spring was bonded between the incisor and the left first molar, applying 20 g of force for 4 days. Micro–computed tomography, hematoxylin and eosin staining, and tartrate-resistent acid phosphatase (TRAP) staining were used to study the differences in tooth movement among the groups.
Results: In the wild-type mice the bonded molar moved mesially, and the periodontal ligament (PDL) was compressed in the compression side. The compression side showed a hyalinized zone, and osteoclasts were identified there using TRAP staining. In the mutant mice, the molar did not move, the incisor tipped palatally, and there was slight widening of the PDL in the tension area. Osteoclasts were not seen on the bone surface or on the compression side. Osteoclasts were only observed on the other side of the bone—in the bone marrow.
Conclusions: These results suggest a difference in tooth movement and osteoclast activity between PC1 mutant mice and wild-type mice in response to orthodontic force. The impaired tooth movement and the lack of osteoclasts on the bone surface in the mutant working side may be related to lack of signal from the PDL due to PC1 deficiency.
Effects of bonded rapid palatal expansion on the transverse dimensions of the...EdwardHAngle
The purpose of this study was to examine the maxillary response on the transverse dimensions to rapid palatal expansion (RPE) by using cone-beam computed tomography (CBCT).
Long term clinical and bacterial effetcx of xylitol on paitnets with fixed or...EdwardHAngle
Background: The objective of this study was to evaluate long-term clinical and bacterial effects of using 6 g of
xylitol per day for 3 months on patients with full fixed orthodontic appliances.
Methods: The study was a pilot clinical trial that included 41 subjects who were undergoing orthodontic
treatment. The subjects were randomly divided into three groups. Group A received xylitol chewing gum, group B
received xylitol dissolvable chewable tablets, and Group C served as the control group and did not receive xylitol
gums or tablets. Clinical examination and the collection of plaque and saliva samples were carried out at baseline
and 3, 6, and 12 months. All three groups were given oral hygiene instruction and were put on a 6-month cleaning
and topical fluoride schedule. Plaque scores and bacterial counts were used to evaluate the effectiveness of the
different approaches at reducing the caries risk.
Results: Xylitol groups did not experience any more reduction in plaque score, plaque MS counts, or salivary MS
counts than the control group nor did they have lower values at any of the time points. Chewing gum did not
significantly increase the incidence of debonded brackets over the other groups.
Conclusions: Xylitol does not have a clinical or bacterial benefit in patients with fixed orthodontic appliances. Oral
hygiene instructions and 6-month topical fluoride application were effective at reducing plaque scores and bacterial
counts in patients with full fixed appliances regardless of whether or not xylitol was used.
Purpose: To assess the amount of dental and skeletal expansion and stability after surgically assisted
rapid maxillary expansion (SARPE).
Patients and Methods: Data from 20 patients enrolled in this prospective study were collected before
treatment, at maximum expansion, at the removal of the expander 6 months later, before any second
surgical phase, and at the end of orthodontic treatment, using posteroanterior cephalograms and dental
casts.
Results: With SARPE, the mean maximum expansion at the first molar was 7.48 1.39 mm, and the
mean relapse during postsurgical orthodontics was 2.22 1.39 mm (30%). At maximum, a 3.49 1.37
mm skeletal expansion was obtained, and this expansion was stable, such that the average net expansion
was 67% skeletal.
Conclusion: Clinicians should anticipate a loss of about one third of the transverse dental expansion
obtained with SARPE, although the skeletal expansion is quite stable. The amount of postsurgical relapse
with SARPE appears quite similar to the changes in dental-arch dimensions after nonsurgical rapid palatal
expansion, and also quite similar to dental-arch changes after segmental maxillary osteotomy for
expansion.
Increased occurrence of dental anomalies associated with infraocclusion of de...EdwardHAngle
Objective: To test the null hypothesis that there is no relationship between infraocclusion and the
occurrence of other dental anomalies in subjects selected for clear-cut infraocclusion of one or
more deciduous molars.
Materials and Methods: The experimental sample consisted of 99 orthodontic patients (43 from
Boston, Mass, United States; 56 from Jerusalem, Israel) with at least one deciduous molar in
infraocclusion greater than 1 mm vertical discrepancy, measured from the mesial marginal ridge of
the first permanent molar. Panoramic radiographs and dental casts were used to determine the
presence of other dental anomalies, including agenesis of permanent teeth, microdontia of
maxillary lateral incisors, palatally displaced canines (PDC), and distal angulation of the mandibular
second premolars (MnP2-DA). Comparative prevalence reference values were utilized and
statistical testing was performed using the chi-square test (P< .05) and odds ratio.
Results: The studied dental anomalies showed two to seven times greater prevalence in the
infraocclusion samples, compared with reported prevalence in reference samples. In most cases,
the infraoccluded deciduous molar exfoliated eventually and the underlying premolar erupted
spontaneously. In some severe phenotypes (10%), the infraoccluded deciduous molar was
extracted and space was regained to allow uncomplicated eruption of the associated premolar.
Conclusion: Statistically significant associations were observed between the presence of
infraocclusion and the occurrence of tooth agenesis, microdontia of maxillary lateral incisors,
PDC, and MnP2-DA. These associations support a hypothesis favoring shared causal genetic
factors. Clinically, infraocclusion may be considered an early marker for the development of later
appearing dental anomalies, such as tooth agenesis and PDC.
Malposition of unerupted mandibular second premolar in children with palatall...EdwardHAngle
Objective: To test the hypotheses that (1) the distal angulation of unerupted mandibular premolar
(MnP2) is significantly greater in children with palatally displaced canines (PDC) than in those in
a control sample; and (2) delayed tooth formation is significantly more frequent in children with
both malposed MnP2 and PDC than in children with PDC only.
Materials and Methods: We examined retrospectively panoramic radiographs from 43 patients
with PDC who had no previous orthodontics. A control sample consisted of age- and sex-matched
patients. The distal angle formed between the long axis of MnP2 and the tangent to the inferior
border was measured. Dental age was evaluated using the Koch classification.
Results: A significant difference was observed between the mean inclination of the right side
MnP2 in the PDC group (75.4 degrees) and that of the control group (85.8 degrees). This difference
was highly statistically significant (P < .0001). The same evaluation was carried out for the
left side, with similar results. The average dental age was found to be delayed in patients who
showed both abnormalities (malposed MnP2 and PDC) compared with patients who showed the
PDC anomaly only.
Conclusion: Both hypotheses are retained. Statistically, PDC and MnP2 malposition are significantly
associated suggesting a common genetic etiology, despite taking place on opposite jaws.
While the presence of PDC or MnP2 anomaly has been associated with a delay in tooth formation,
we find the presence of both anomalies to show a more profound delay. Our findings suggest a
delay in tooth formation as a possible common genetic mechanism for these 2 malposition anomalies.
ABSTRACT
Objective: To evaluate the role of age as a moderator of bone regeneration patterns and
symphysis remodeling after genioplasty.
Method: Fifty-four patients who underwent genioplasty at the end of their orthodontic treatment
were divided into three age groups: younger than 15 years at the time of surgery (group 1), 15 to
19 years (group 2), and 20 years or older (group 3). Twenty-three patients who did not accept
genioplasty and had a follow-up radiograph 2 years after the end of their orthodontic treatment
were used as a control group. Patients were evaluated at three time points: immediate preoperative
(T1), immediate postoperative (T2,) and 2 years postsurgery (T3).
Results: The mean genial advancement at surgery was similar for the three age groups, but the
extent of remodeling around the repositioned chin was greater in group 1, less in group 2, and still
less in group 3. Symphysis thickness increased significantly during the 2-year postsurgery interval
for the three groups, and this increase was significantly greater in group 1 than in group 3.
Remodeling above and behind the repositioned chin also was greater in the younger patients. This
was related to greater vertical growth of the dentoalveolar process in the younger patients. There
was no evidence of a deleterious effect on mandibular growth.
Conclusion: The outcomes of forward-upward genioplasty include increased symphysis
thickness, bone apposition above B point, and remodeling at the inferior border. When indications
for this type of genioplasty are recognized, early surgical correction (before age 15) produces a
better outcome in terms of bone remodeling. (Angle Orthod. 0000;00:000–000.)
Mandibular arch form the relationship between dental and basal anatomyEdwardHAngle
We investigated mandibular dental arch form at the levels of both the clinically relevant application points of the orthodontic bracket and the underlying anatomic structure of the apical base. The correlation of both forms was evaluated and examined to determine whether the basal arch could be used to derive a standardized clinical arch form.
Influence of common fixed retainers on the diagnostic quality of cranial magn...EdwardHAngle
Introduction: Orthodontists are often asked to remove fixed retainers before magnetic resonance imaging
(MRI). This study was undertaken to assess the effects of 2 commonly used fixed retainers on MRI distortion
and whether they should be removed. Methods: MRI scans were performed on a dry skull with Twistflex (Dentaurum,
Ispringen, Germany) and Ortho Flex Tech (Reliance Orthodontic Products, Itasca, Ill) retainers. Two
neuroradiologists independently ranked the distortions. The influence of the fixed retainers' alloys, their distance
to the area of diagnosis, location, strength of the magnetic field, and the spin-echo sequence were examined.
Statistical analysis included kappa and Pearson chi-square tests. Results: Ortho Flex Tech retainers caused
no distortion. Twistflex retainers caused distortion in 46% of the tests in areas close to the retainer (tongue
and jaws). Maxillary fixed retainers and the combination of maxillary and mandibular fixed retainers further
increased the distortion. Greater distortion was observed with 3-T magnetic fields and T1-weighted spin-echo
sequences. Conclusions: Removal of the Ortho Flex Tech retainer is unnecessary before MRI. Removal of
the Twistflex should be considered if the MRI scans are performed to diagnose areas close to the fixed retainers,
when 3-T magnetic fields and T1-weighted sequences are used, and when both maxillary and mandibular fixed
retainers are present.
Short term and long-term stability of surgically assisted rapid palatal expan...Dr Sylvain Chamberland
Introduction: The purpose of this article is to present further longitudinal data for short-term and long-term
stability, following up our previous article in the surgery literature with a larger sample and 2 years of stability
data. Methods: Data from 38 patients enrolled in this prospective study were collected before treatment, at maximum
expansion, at removal of the expander 6 months later, before any second surgical phase, at the end of
orthodontic treatment, and at the 2-year follow-up, by using posteroanterior cephalograms and dental casts.
Results: With surgically assisted rapid palatal expansion (SARPE), the mean maximum expansion at the first
molar was 7.60 6 1.57 mm, and the mean relapse was 1.83 6 1.83 mm (24%). Modest relapse after completion
of treatment was not statistically significant for all teeth except for the maxillary first molar (0.99 6 1.1 mm). A
significant relationship (P-.0001) was observed between the amount of relapse after SARPE and the posttreatment
observation. At maximum, a skeletal expansion of 3.58 6 1.63 mm was obtained, and this was stable.
Conclusions: Skeletal changes with SARPE were modest but stable. Relapse in dental expansion was almost
totally attributed to lingual movement of the posterior teeth; 64% of the patients had more than 2 mm of dental
changes. Phase 2 surgery did not affect dental relapse.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Dental Patterns in Peruvians: A Panoramic Radiography StudyIván E Pérez
The dental pattern is defined as the combination of distinct codes assigned to describe specific tooth conditions including virgin, missing, and restored teeth that comprise the complete dentition or from discrete groups of teeth. This pattern can be then compared to the dentition of individual/s in an attempt to determine positive identification. The aims of the present investigation were to study and determine the diversity of dental patterns in Peruvian citizens based on a sample of panoramic radiographs. Digital panoramic radiographs of 900 adult Peruvian patients (450 female and 450 male) were evaluated to determine the dental patterns. The most frequent dental patterns found in the complete dentition, maxillae, upper-anterior and lower-anterior sextants were all-virgin-teeth (0.3%), all-extracted teeth (1.9%), all-virgin teeth (1%) and all-virgin-teeth (34.2% and 72.3%) respectively. The diversity was calculated by the use of the Simpson´s diversity index, the resulting values for the full-dentition, maxilla and mandible were over the 99.8% value and were similar to those previously reported in the scientific literature. This study demonstrates the positive benefit of dental patterns in the process of identification. Additionally a combination of codes is proposed that could prove useful in cases where a better radiographic description is required.
Congenitally Missing Lateral Incisors; Orthodontic, Restorative, and Implant ...Abu-Hussein Muhamad
This article discusses factors in determining
whether to close an open space or to open enough space for a prosthetic treatment for congenitally missing maxillary lateral
incisors. Further, the importance of a total treatment approach using an interdisciplinary dental specialty team to maximize
function, aesthetics, and oral health is discussed.
Clinical study of impacted maxillary canine in the Arab population in IsraelAbu-Hussein Muhamad
The objective of the present study was to determine the prevalence of impacted maxillary canine in patients in Arabs Community in Israel (ARAB48,Israel) visiting our Center For Dentistry,Research & Aesthetics,Jatt,Almothalath,Israel, 4250 patients . This study comprises data from patients who attended the O.P.D.2200 patients between Jun. 2006 to Dec 2013. Patients were examined in order to detect the impacted maxillary canines by intraoral examination, palpation, dental records and followed by radiographs. It was found that the prevalence of canine impaction was 0,8 % (N=4250), 1,6 (N=2200), 43,9 (N-82) in males and 1,1% (N=4250), 2,1 (N=2200), 56,1 (N-82) in females suggesting that prevalence of impacted maxillary canines is more in females than males and it is statistically significant. The overall prevalence for maxillary impacted canines was found to be 3,7 % (N=2200) which suggested that it is much higher than previous studies. The results of this study were slightly different than other studies, while the dissimilarities may be attributed to the sample selection, method of the study and area of patient selection, which suggest racial and genetic differences.
Similar to Malposition of unerupted mandibular second premolar in children with cleft lip and palate (20)
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
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Malposition of unerupted mandibular second premolar in children with cleft lip and palate
1. 1062Angle Orthodontist, Vol 77, No 6, 2007 DOI: 10.2319/052106-207
Original Article
Malposition of Unerupted Mandibular Second Premolar in
Children with Cleft Lip and Palate
Miri Shalisha
; Leslie A. Willb
; Stephen Shustermannc
ABSTRACT
Objective: To determine whether distoangular malposition of the unerupted mandibular second
premolar (MnP2) is more frequent in children with unilateral clefts of the lip and palate.
Materials and Methods: This retrospective study examined panoramic radiographs from 45 pa-
tients with unilateral clefts of the lip and/or palate who had no previous orthodontics. A control
sample consisted of age- and sex-matched patients. The distal angle formed between the long
axis of MnP2 and the tangent to the inferior border was measured. The mean, standard deviation,
and range were calculated for the angles measured in the cleft and the control groups. The
significance of the differences between the means was evaluated by the paired t-test. The angles
of the cleft and noncleft sides were also measured and compared.
Results: The mean inclination of the MnP2 on the cleft side was 73.6Њ, compared with 84.6Њ in
the control group. This difference was highly significant statistically (P Ͻ .0001). The difference
in angles from the cleft and noncleft sides was 0.7Њ, not statistically significant. A significant as-
sociation was found between clefting and distoangular malposition of the developing MnP2, sug-
gesting a shared genetic etiology. This association is independent of the clefting side, ruling out
possible local mechanical effects.
Conclusion: Clinicians should be aware of the potential for anomalous development of MnP2 in
children with clefts.
KEY WORDS: Malposition; Dental anomalies; Cleft; Mandibular second premolar; MSX1; Genetic
etiology
INTRODUCTION
Exaggerated distoangular malposition of the un-
erupted mandibular second premolar (MnP2) has
been found to be associated with agenesis of its an-
timere.1
This finding relates the MnP2 malposition to a
group of tooth developmental abnormalities of possible
common genetic origin, including agenesis (hypodon-
tia), peg-shaped maxillary lateral incisors, palatally dis-
a
Assistant Professor, Harvard School of Dental Medicine, De-
velopmental Biology (Orthodontics), Boston, Mass.
b
Associate Professor, Harvard School of Dental Medicine,
Developmental Biology (Orthodontics), Boston, Mass.
c
Associate Professor, Harvard School of Dental Medicine,
Developmental Biology (Pediatric Dentistry), Boston, Mass.
Corresponding author: Dr Miri Shalish, Harvard School of
Dental Medicine, Developmental Biology (Orthodontics), 188
Longwood Avenue, Boston, MA 02115
(e-mail: mshalish@hsdm.harvard.edu)
Accepted: August 2006. Submitted: May 2006.
ᮊ 2006 by The EH Angle Education and Research Foundation,
Inc.
placed canines, and transpositions of various
teeth.2–10
Accumulated evidence on associations among this
group go well beyond coincidence, suggesting them
as part of a broader genetically related pattern of den-
tal anomalies. Several of these anomalies have been
found more frequently in patients with clefting.11–13
Re-
cent studies have linked both familial posterior tooth
agenesis and orofacial clefting to mutations of the ho-
meobox gene, MSX1.14,15
If both the MnP2 anomaly
and clefting are indeed related to tooth agenesis, as
part of a broader biological relation, they should also
exhibit a direct association. Figure 1 places this hy-
pothesis in a diagram among previously established
associations.
Although a genetic basis of clefting is considered
likely in many cases,16
it may also constitute a me-
chanical growth disturbance. For example, the lateral
incisor in the region of the alveolar cleft is known to
be sensitive to developmental disorders.17
However,
when the clefting is unilateral the range of its mechan-
ical effect is usually limited to that side. Nonetheless,
2. 1063MALPOSITION OF MANDIBULAR SECOND PREMOLAR IN CLEFT
Angle Orthodontist, Vol 77, No 6, 2007
Figure 1. Diagrammatic representation of syllogistic relations be-
tween the hypothesis of this study and published biological associ-
ations.
Figure 2. The distal angle () between the long axis of the mandib-
ular second premolar and the tangent to the lower border of the
mandible defined on a typical drawing of the relevant part of an
orthopantomogram.
teeth outside the cleft area are known to be affected
as well with dental growth anomalies. For example,
Shapira et al12
observed high prevalence (18%) of
missing premolars in cleft lip and cleft palate children.
This study was undertaken to test the hypothesis
that MnP2 would show a significantly greater distal an-
gulation in cleft lip and palate children than those in
an age- and sex-matched control sample.
MATERIALS AND METHODS
Two samples, a cleft group and a noncleft control
group, were selected retrospectively from pretreat-
ment records of patients in Children’s Hospital, Bos-
ton, Mass. The cleft sample consisted of 45 patients
(21 girls and 24 boys). The criteria for inclusion in this
sample were (1) unilateral cleft lip and/or palate; (2)
no previous orthodontic treatment; and (3) develop-
ment of MnP2 tooth bud in stages D to G of tooth
formation, according to the classification of Koch et
al.18
Unerupted stage D is defined as crown formation
completed down to the cementoenamel junction, un-
erupted stage E is with root length smaller than crown
length, unerupted stage F is with root length equal to
or larger than crown length, and unerupted stage G is
with the walls of the root canal parallel and the root
apex still partially open.
The mandibular deciduous second molars were
present for all participants. Among the 21 girls, 14
showed left-side clefting and all showed clefting of
both lip and palate; among the 24 boys, 18 showed
left-side clefting, 22 had clefting of both lip and palate,
and two had clefting of lip only. A control sample was
collected consisting of age- (rounded to a half year)
and sex-matched patients from the same orthodontic
patient pool.
In both samples, panoramic radiographs were used
to trace each MnP2 along with the neighboring man-
dibular first molar, the deciduous first molar, and a tan-
gent to the inferior border of the mandibular body on
the side of the second premolar. The long axis of the
MnP2 was determined as the line connecting the up-
permost point of the pulp with the point bisecting the
distance between the mesial and the distal points of
the apex. A protractor was then used to measure the
distal angle formed between the long axis of the MnP2
and the line drawn tangent to the inferior border of the
mandible. Figure 2 shows a typical drawing with the
assigned lines and the resulting angle. All tracings
were made independently by one examiner with
0.003-inch frosted-acetate paper and a 0.5-mm pencil.
Descriptive statistics including the mean, standard
deviation, and range were calculated for the unerupted
MnP2 angles measured in the cleft and the noncleft
groups. The significance of the differences between
the compared means was evaluated by the Student’s
t-test for paired samples. The significance level was
set at P Ͻ .05. Intrapatient correlation was evaluated
by the Pearson correlation test.
To quantify the error of the method, a second set of
data was traced and measured 1 month later by the
3. 1064 SHALISH, WILL, SHUSTERMANN
Angle Orthodontist, Vol 77, No 6, 2007
Table 1. Descriptive Statistics of Cleft Sample vs. Noncleft Control Sample—Comparison of Distoangular Malposition of the Unerupted Man-
dibular Second Premolar Between the Cleft Side in the Cleft and Noncleft Samples
Group n Range, Њ Mean, Њ
Standard
Deviation, Њ
t-test
Value P Value
Cleft sample
Cleft side 45 46.0–90.0 73.6 11.1 Ϫ5.81 Ͻ.0001
Noncleft control sample
Same side 45 63.0–98.0 84.6 6.6
Table 2. Descriptive Statistics of Two Sides within the Cleft Sample—Comparison of Distoangular Malposition of the Unerupted Mandibular
Second Premolar Between the Cleft Side and the Noncleft Side
Group n Range, Њ Mean, Њ
Standard
Deviation, Њ
t-test
Value Correlation
Cleft side
Noncleft side
P value
45
45
46.0–90.0
53.0–95.0
73.6
74.3
11.1
10.1
Ϫ0.356
.72
0.303
.043
same examiner. Standard deviations calculated for
two repeated measurements of two tracings of six dif-
ferent panoramic roentgenograms were used as in-
traexaminer error. This procedural error was found to
be 1.0Њ, which is within reasonable limits in the context
of this study.
RESULTS
Table 1 shows the descriptive statistics of cleft-side
MnP2 in the cleft group and the same side in the age-
and sex-matched paired noncleft control group. The
mean distal inclination of the MnP2 in the cleft side of
the cleft sample was 73.6Њ, compared with a mean
84.6Њ obtained for the matched control group. The
mean increase of 11.0Њ in the distoangular malposition
of the developing MnP2 in cleft patients was highly
significant statistically (P Ͻ .0001). Thus, our null hy-
pothesis that the distal angulation of a developing
MnP2 does not change significantly relative to the
presence or absence of clefting lip and palate at the
same side can be rejected.
To examine a local influence of the clefting on the
distal inclination of the MnP2, we compared the cleft-
side MnP2 in each patient of the cleft group with its
antimere, that is, the MnP2 in the noncleft side. Table
2 shows the descriptive statistics of the two sides of
the same patient in the cleft group. The mean distal
inclination of the MnP2 in the cleft side of the cleft
sample was 73.6Њ, compared with a mean 74.3Њ ob-
tained for the noncleft side. The difference, 0.7Њ, is
small and insignificant statistically (P ϭ .72). More-
over, the Pearson correlation test yielded a correlation
coefficient of 0.303, which was found statistically sig-
nificant (P ϭ .043). This result clearly supports a non-
local mechanism for MnP2 angulation in cleft patients.
In other words, the distal angulation of a developing
MnP2 in the noncleft side is not significantly different
relative to the cleft side of the clefting lip and palate.
DISCUSSION
This study was designed to test a hypothesis that
angular malposition of a developing MnP2 would be
directly associated with clefting. The data suggest a
significant connection between these two conditions.
Moreover, this association is found independent of the
clefting side, thereby ruling out possible local mechan-
ical effects.
Clefting affects the maxilla. Hence, a direct mechan-
ical effect in the mandible is unlikely and even less
likely in the nonclefting side of the mandible. Further-
more, the local surroundings of the unerupted MnP2
seemed normal for all the teeth studied. The absence
of a local mechanical disturbance suggests associa-
tion through a common genetic disorder. Van den
Boogaard et al15
have already associated clefting and
agenesis through mutations of the homeobox gene,
MSX1. The results of this work along with the results
of Shalish et al1
associate the MnP2 angulation anom-
aly with both clefting and agenesis, suggesting the
MnP2 anomaly as a variable in a genetically related
group of dental anomalies likely to be associated with
MSX1 mutations. It is likely for the MnP2 anomaly to
appear in combination with any other of these inter-
associated anomalies, such as infraocclusion, mesially
4. 1065MALPOSITION OF MANDIBULAR SECOND PREMOLAR IN CLEFT
Angle Orthodontist, Vol 77, No 6, 2007
ectopic maxillary first molar, palatally displaced ca-
nine, tooth transposition, tooth rotation, tooth-size re-
duction, and peg-shaped maxillary lateral incisor.2–10,19–23
An interesting side observation made in this study
is the actual correlation of MnP2 angulation observed
between the two sides in the cleft sample. It therefore
suggests that in clefting patients, anomalous MnP2
angulation often affects both sides rather than just the
clefting side, in further support of a systemic, nonlocal
mechanism, such as genetics. This observation adds
to the accumulated evidence showing that various
dental developmental anomalies associated with cleft-
ing are not restricted to the clefting side.12
Although the statistical associations of MnP2 angu-
lation anomaly with both agenesis of its antimere and
with clefting are clearly significant, the mechanism by
which a possible common genetic disturbance could
cause both anomalies at the same time is not evident.
However, several studies have shown that clefting is
often accompanied with a delay in tooth formation not
specific to the clefting side or the maxilla.24–26
Ranta27
has clearly shown that a delay in tooth for-
mation is associated with agenesis of second premo-
lars in children with cleft palate. Independently, Was-
serstein et al28
have recently shown in a longitudinal
study that the MnP2 angulation anomaly is associated
with a delay in the MnP2 dental age. Hence, both
agenesis and the angulation anomaly of MnP2 seem
to be associated with a delay in tooth formation, a con-
dition often observed in association with clefting.
Therefore, it seems possible that the common mech-
anism is a delay in tooth formation.
Knowledge of the timing of tooth formation and the
dental age are essential parameters in any orthodontic
treatment plan involving the mixed dentition. A delay
in the dental age, whether or not combined with other
significant tooth developmental disturbance, should
alert the clinician for the likelihood of anomalous de-
velopment of the MnP2.
CONCLUSION
• Clinicians should be aware of the potential for anom-
alous development of MnP2 in children with clefts.
REFERENCES
1. Shalish M, Peck S, Wasserstein A, Peck L. Malposition of
unerupted mandibular second premolar associated with
agenesis of its antimere. Am J Orthod Dentofacial Orthop.
2001;121:53–55.
2. Alvesalo L, Portin P. The inheritance pattern of missing,
peg-shaped and strongly mesio-distally reduced upper lat-
eral incisors. Acta Odontol Scand. 1969;27:563–573.
3. Garn SM, Lewis AB. The gradient and the pattern of crown-
size reduction in simple hypodontia. Angle Orthod. 1970;40:
51–58.
4. Peck S, Peck L, Kataja M. The palatally displaced canine
as a dental anomaly of genetic origin. Angle Orthod. 1994;
64:249–256.
5. Peck S, Peck L, Kataja M. Prevalence of tooth agenesis
and peg-shaped maxillary lateral incisor associated with
palatally displaced canine (PDC) anomaly. Am J Orthod
Dentofacial Orthop. 1996;110:441–443.
6. Peck L, Peck S, Attia Y. Maxillary canine-first premolar
transposition, associated dental anomalies and genetic ba-
sis. Angle Orthod. 1993;63:99–109.
7. Peck S, Peck L, Kataja M. Mandibular lateral incisor-canine
transposition, concomitant dental anomalies and genetic
control. Angle Orthod. 1998;68:455–466.
8. Symons AL, Stritzel F, Stamation J. Anomalies associated
with hypodontia of the permanent lateral incisor and second
premolar. J Clin Pediatr Dent. 1993;17:109–111.
9. Zilberman Y, Cohen B, Becker A. Familial trends in palatal
canines, anomalous lateral incisors, and related phenome-
na. Eur J Orthod. 1990;12:135–139.
10. Pirinen S, Arte S, Apajalahti S. Palatal displacement of ca-
nine is genetic and related to congenital absence of teeth.
J Dent Res. 1996;75:1742–1746.
11. Pirinen S. Genetic craniofacial aberrations. Acta Odontol
Scand. 1998;56:356–359.
12. Shapira Y, Lubit E, Kuftinec MM. Congenitally missing sec-
ond premolars in cleft lip and cleft palate children. Am J
Orthod Dentofacial Orthop. 1999;115:396–400.
13. Slayton RL, Williams L, Murray JC, Wheeler JJ, Lidral AC,
Nishimura CJ. Genetic association studies of cleft lip and/
or palate with hypodontia outside the cleft region. Cleft Pal-
ate Craniofac J. 2003;40:274–279.
14. Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seid-
man CE. A human MSX1 homeodomain missense mutation
causes selective tooth agenesis. Nat Genet. 1996;13:417–
421.
15. Van den Boogaard MJ, Dorland M, Beemer FA, van Amstel
HK. MSX1 mutation is associated with orofacial clefting and
tooth agenesis in humans. Nat Genet. 2000;24:342–343.
16. Cobourne MT. The complex genetics of cleft lip and plate.
Eur J Orthod. 2004;26:7–16.
17. Ribeiro LL, Das Neves TL, Costa B, Gomide RM. Dental
anomalies of the permanent lateral incisors and prevalence
of hypodontia outside the cleft area in complete unilateral
cleft lip and palate. Cleft Palate Craniofac J. 2003;40:172–
175.
18. Koch G, Modeer T, Poulsen S, Rasmussen P. Pedodontics:
A Clinical Approach. Copenhagen, Denmark: Munksgaard;
1991:60.
19. Bjerklin K, Kurol J, Valentin J. Ectopic eruption of maxillary
first permanent molars and association with other tooth and
developmental disturbances. Eur J Orthod. 1992;14:369–
375.
20. Kurol J. Infraocclusion of primary molars: an epidemiologi-
cal and familial study. Community Dent Oral Epidemiol.
1982;9:94–102.
21. Hu JR, Nakasima A, Takahama Y. Familial similarity in den-
tal arch form and tooth position. J Craniofac Genet Dev Biol.
1992;12:33–40.
22. Baccetti T. A controlled study of associated dental anoma-
lies. Angle Orthod. 1998;68:267–274.
23. Baccetti T. Tooth rotation associated with aplasia of non-
adjacent teeth. Angle Orthod. 1998;68:471–474.
24. Ranta R. A review of tooth formation in children with cleft
lip/plate. Am J Orthod Dentofacial Orthop. 1986;90:11–18.
25. Harris EF, Hullings JG. Delayed dental development in chil-
5. 1066 SHALISH, WILL, SHUSTERMANN
Angle Orthodontist, Vol 77, No 6, 2007
dren with isolated cleft lip and palate. Arch Oral Biol. 1990;
35:469–473.
26. Mitsea AG, Spyropoulos MN. Premolar development in
Greek children with cleft lip and plate. Quintessence Int.
2001;32:639–646.
27. Ranta R. Hypodontia and delayed development of the sec-
ond premolars in cleft palate children. Eur J Orthod. 1983;
5:145–148.
28. Wasserstein A, Brezniak N, Shalish M, Heller M, Rakocz M.
Angular changes and their rates in concurrence to devel-
opmental stages of the mandibular second premolar. Angle
Orthod. 2004;74:332–336.