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lymphoid lineage cell cycle WBC Cells in
- 1. Lymphoid Lineage Overview ofCells and Functions
- 2. What is theLymphoid Lineage? • The lymphoid lineage is one of the two branches of hematopoiesis, giving rise to: • - B lymphocytes (B cells) • - T lymphocytes (T cells) • - Natural Killer (NK) cells • - Innate Lymphoid Cells (ILCs) • These cells are crucial for adaptive and innate immunity.
- 3. B Lymphocytes (Bcells) • - Develop and mature in the bone marrow • - Produce antibodies (immunoglobulins) • - Differentiate into plasma cells and memory B cells • - Key players in humoral immunity
- 4. T Lymphocytes (Tcells) • - Mature in the thymus • - Subtypes: • - Helper T cells (CD4⁺): activate other immune cells • - Cytotoxic T cells (CD8⁺): kill infected/tumor cells • - Regulatory T cells (Tregs): maintain immune tolerance • - Involved in cell-mediated immunity
- 5. Natural Killer (NK)Cells • - Part of the innate immune system • - Kill virus-infected and tumor cells • - Do not require antigen sensitization • - Lack antigen-specific receptors
- 6. Innate Lymphoid Cells(ILCs) • - Recently discovered cell type • - Similar to T cells, but lack antigen receptors • - Involved in mucosal immunity and tissue repair • - Important in inflammation and homeostasis
- 7. Summary of LymphoidLineage • - Originates from Common Lymphoid Progenitor (CLP) • - Differentiation regulated by cytokines and transcription factors • - Includes B cells, T cells, NK cells, and ILCs • - Key roles in adaptive and innate immunity