Emergency departments can be unsafe places for nursing staff due to patient aggression and violence. Patients presenting with intoxication, psychiatric issues, or long wait times are likely to become aggressive or violent. Over half of emergency nursing staff report verbal abuse and 1 in 10 report physical violence. To protect staff, hospitals need training in de-escalation techniques and self-defense, and should provide security with non-lethal weapons and authority to intervene. As psychiatric patient numbers in emergency rooms rise, aggression and violence toward nursing staff will likely continue without measures to ensure staff safety.