Cuando se escribió el Libro de Kells hace más de 1000 años, Irlanda tenía una población de menos de medio millón de habitantes que vivían en poblados fortificados a lo largo de la costa y en las vías fluviales del interior.
En general, la iglesia irlandesa estaba organizada monásticamente. Los monjes vivían en comunidades dedicadas al estudio de la palabra de Dios, al ayuno, y al trabajo manual. El mensaje de la vida de Cristo se extendía principalmente por medio de los evangelios, y los escribas y artistas que los producían disfrutaban de una posición privilegiada en la sociedad irlandesa.
El Libro de Kells contiene un texto en latín de los cuatro evangelios que se ornamentaron espléndidamente.
Desde hace tiempo, el Libro de Kells se ha asociado a San Colum Cille (521-597 d. de C.) quien, alrededor del año 561, fundó el principal monasterio en la isla de lona, cerca de la costa oeste de Escocia.
Probablemente, el Libro de Kells fue creado por los monjes de lona a principios del siglo nueve y fue producido en su totalidad o parcialmente en la misma lona o en Kells (Condado de Meath) donde se trasladaron después del año 806 d. de C., cuando lona fue saqueada por los Vikingos en un ataque en que, sesenta y ocho monjes perdieron la vida.
Alrededor de 1653, por razones de seguridad durante la época de Cromwell, se envió el Libro de Kells a Dublín. Llegó a Trinity College por mediación de Henry Jones, después de que éste fuese nombrado obispo de Meath en 1661.
Silabus tematik ini membahas tentang tema pengalaman yang mencakup standar kompetensi pendidikan kewarganegaraan, IPS, bahasa Indonesia, matematika, IPA, dan seni budaya. Materi akan meliputi makna sumpah pemuda, kerja sama di lingkungan, mendengarkan penjelasan lisan, operasi hitungan bilangan, ciri-ciri mahluk hidup, dan mengidentifikasi unsur lukisan. Kegiatan pembelajaran berupa tes tertulis, diskusi kel
Where Can I Get Help Signing Up in the ACA MarketplaceSteve Levine
Deck 2 of "Hey Doc" campaign: Where Can I Get Help Signing Up in the Marketplace and What Can I Do Now to Get Ready?
Physicians are Americans’ most trusted source for information on the Affordable Care Act (ACA), according to a new national poll; but people are not turning to their doctors to learn about it. The Texas Medical Association is about to change all of that.
TMA’s “Hey, Doc” education campaign will provide objective and nonpartisan answers to the most frequently asked questions about the new ACA health insurance marketplace. We want to make sure all Texans understand what the marketplace does and what steps they need to take.
Soil is divided into 5 main horizons:
1. The O horizon contains plant litter on top of the soil.
2. The A horizon, or topsoil, is the darkest layer and contains the most nutrients for plant growth.
3. The B horizon, or subsoil, is lighter in color and contains fewer nutrients.
4. The C horizon is the lightest gray layer consisting of weathered rock and sediment.
5. The R horizon is solid bedrock below the soil layers.
The document discusses the phases of the Moon and how they occur as the Moon orbits the Earth. It explains that half of the Moon is always lit by the Sun and as the Moon orbits we see different portions of the lit side. It describes the key phases as New Moon, First Quarter Moon, Third Quarter Moon, and Full Moon and how the positioning of the Sun, Earth, and Moon causes these appearances. It also mentions some less common phases like Waxing Crescent, Waxing Gibbous, Waning Gibbous, and Waning Crescent Moons.
Cuando se escribió el Libro de Kells hace más de 1000 años, Irlanda tenía una población de menos de medio millón de habitantes que vivían en poblados fortificados a lo largo de la costa y en las vías fluviales del interior.
En general, la iglesia irlandesa estaba organizada monásticamente. Los monjes vivían en comunidades dedicadas al estudio de la palabra de Dios, al ayuno, y al trabajo manual. El mensaje de la vida de Cristo se extendía principalmente por medio de los evangelios, y los escribas y artistas que los producían disfrutaban de una posición privilegiada en la sociedad irlandesa.
El Libro de Kells contiene un texto en latín de los cuatro evangelios que se ornamentaron espléndidamente.
Desde hace tiempo, el Libro de Kells se ha asociado a San Colum Cille (521-597 d. de C.) quien, alrededor del año 561, fundó el principal monasterio en la isla de lona, cerca de la costa oeste de Escocia.
Probablemente, el Libro de Kells fue creado por los monjes de lona a principios del siglo nueve y fue producido en su totalidad o parcialmente en la misma lona o en Kells (Condado de Meath) donde se trasladaron después del año 806 d. de C., cuando lona fue saqueada por los Vikingos en un ataque en que, sesenta y ocho monjes perdieron la vida.
Alrededor de 1653, por razones de seguridad durante la época de Cromwell, se envió el Libro de Kells a Dublín. Llegó a Trinity College por mediación de Henry Jones, después de que éste fuese nombrado obispo de Meath en 1661.
Silabus tematik ini membahas tentang tema pengalaman yang mencakup standar kompetensi pendidikan kewarganegaraan, IPS, bahasa Indonesia, matematika, IPA, dan seni budaya. Materi akan meliputi makna sumpah pemuda, kerja sama di lingkungan, mendengarkan penjelasan lisan, operasi hitungan bilangan, ciri-ciri mahluk hidup, dan mengidentifikasi unsur lukisan. Kegiatan pembelajaran berupa tes tertulis, diskusi kel
Where Can I Get Help Signing Up in the ACA MarketplaceSteve Levine
Deck 2 of "Hey Doc" campaign: Where Can I Get Help Signing Up in the Marketplace and What Can I Do Now to Get Ready?
Physicians are Americans’ most trusted source for information on the Affordable Care Act (ACA), according to a new national poll; but people are not turning to their doctors to learn about it. The Texas Medical Association is about to change all of that.
TMA’s “Hey, Doc” education campaign will provide objective and nonpartisan answers to the most frequently asked questions about the new ACA health insurance marketplace. We want to make sure all Texans understand what the marketplace does and what steps they need to take.
Soil is divided into 5 main horizons:
1. The O horizon contains plant litter on top of the soil.
2. The A horizon, or topsoil, is the darkest layer and contains the most nutrients for plant growth.
3. The B horizon, or subsoil, is lighter in color and contains fewer nutrients.
4. The C horizon is the lightest gray layer consisting of weathered rock and sediment.
5. The R horizon is solid bedrock below the soil layers.
The document discusses the phases of the Moon and how they occur as the Moon orbits the Earth. It explains that half of the Moon is always lit by the Sun and as the Moon orbits we see different portions of the lit side. It describes the key phases as New Moon, First Quarter Moon, Third Quarter Moon, and Full Moon and how the positioning of the Sun, Earth, and Moon causes these appearances. It also mentions some less common phases like Waxing Crescent, Waxing Gibbous, Waning Gibbous, and Waning Crescent Moons.
The Moon is Earth's only natural satellite, located about 384,000 km away. It was formed 4-5 billion years ago from debris after a collision between Earth and a Mars-sized object. The Moon has no atmosphere and extreme temperature variations, and its features include mountains, rills, large impact craters, and dark basaltic plains called maria. It always keeps the same face towards Earth due to synchronous rotation as it revolves around our planet every 27 days.
The document provides information about the Moon. It discusses that the Moon is Earth's only natural satellite, located about 384,000 km away. The Moon has no atmosphere or liquid water and experiences extreme temperatures. It has various features like mountains, trenches, craters formed by impacts, and dark maria areas filled with ancient lava. The Moon orbits Earth every 27 days while rotating on its axis at the same rate, so the same side always faces Earth. Lunar phases and eclipses are explained by the relative positions of the Moon, Earth and Sun. Tides on Earth are caused by the gravitational pull of the Moon.
This document discusses the difference between observations and inferences in scientific investigations. It defines observations as any information gathered through the senses that can be quantitative, like measurements, or qualitative, like descriptions. Inferences are conclusions or deductions made based on observations. The document provides examples of making observations about animal tracks or footprints and then making an inference about what animal could have made them. It encourages practicing distinguishing observations from inferences.
The document discusses key facts about the moon, including that it orbits Earth and reflects sunlight from its surface. It also explains the phases of the moon, which are caused by the moon orbiting Earth as the sun lights different parts of its surface over the course of about 29 days. The moon's gravitational pull causes ocean tides on Earth. Diagrams show each moon phase as the portion of the lit surface visible from Earth changes from new to full to new again in a repeating cycle.
The document discusses time zones, seasons, and the Earth's relationship to the sun. It explains that as the Earth rotates and revolves around the sun, different parts of the planet receive sunlight at different times, resulting in time zones. It also notes that the Earth is tilted on its axis and takes 365.25 days to orbit the sun, leading to seasons in the Northern and Southern Hemispheres. Key dates and phenomena like equinoxes and solstices are also outlined.
The document defines the three states of matter as solids, liquids, and gases. Solids have a definite shape and volume, with particles packed closely together in a fixed position. Liquids have a definite volume but no defined shape, with particles packed closely but able to move freely past one another. Gases have no definite shape or volume, with particles moving freely and filling available space. Changes between states are caused by increasing or decreasing thermal energy. Melting and boiling points are the specific temperatures at which a substance changes from solid to liquid and liquid to gas, respectively. Solubility refers to the maximum amount of a substance that can dissolve in a liquid at a given temperature, with the dissolving substance as the solute
This document provides 10 tips for students starting middle school. It advises students to stay organized with lockers and agendas, focus on grades by completing all assignments, follow the dress code, and plan ahead for major projects. Students are also told to embrace team seating in the cafeteria and collaborative work in classes, which are important parts of middle school.
The Moon orbits Earth and is illuminated by sunlight reflected off its surface. It takes approximately 29 days for the Moon to orbit Earth and undergo all its phases from New Moon to Full Moon and back again. The gravitational pull of the Moon causes ocean tides on Earth.
R.L. Stine is a famous author known for horror novel series like Goosebumps and Fear Street. He discovered his love of writing from finding an old typewriter in his attic as a way to escape bullying in school. His experiences as a substitute teacher during desegregation inspired some of his book characters. As one of the first children's authors to attract both boys and girls to reading, he made horror accessible and enjoyable for young readers, influencing the genre.
Jules Verne (1828-1905) was a French author best known for his science fiction novels. As a child he dreamed of adventure but lacked support from his parents. He wrote about his adventurous dreams which led to two books published within 10 years of the American Civil War. Verne's reputation suffered due to poor translations misrepresenting facts in his books. He continued writing until his death from diabetes in 1905, with his brother overseeing publication of his later works. Verne is considered the father of science fiction for creating stories featuring technologies that later became real.
The document describes different types of rocks and how they are formed. Intrusive igneous rocks like granite cool slowly underground, while extrusive rocks like basalt cool quickly above ground. Sedimentary rocks like limestone and sandstone are formed from the compaction of particles over time. Metamorphic rocks like slate and quartzite are formed from the alteration of older rocks by heat and pressure in the earth's interior. Shale, limestone, and sandstone are common sedimentary rocks that are distinguished by their composition of mud, seashells, or sand respectively.
The document provides instructions for completing a tri-fold DBQ layout. Students should include sample photos, typed text in a readable font size, and images from class resources. The middle section should use the template shown and include a map. Both the before and after sections require 3 pieces of evidence - one text, one image, and one of the student's choice, along with explanations for each. Neatness and adhering to the bullet point format are priorities, and the project is due on December 20th.
This document provides guidance on writing an effective introductory paragraph for an essay. The introductory paragraph should include a hook sentence to grab the reader's attention and a thesis statement that presents the position or main argument. It should also contain a transitional sentence at the end to connect to the first body paragraph. Effective hooks can be in the form of a question to intrigue the reader or a relevant quote from a famous person to lend authority. The goal is to motivate the reader to continue and learn more within the essay.
The document provides instructions for an activity where students will analyze a video clip on moon phases and discuss pictures and diagrams related to the moon's effect on tides and eclipses using scientific vocabulary. Students are asked questions about how the moon affects ocean tides and how scientists discovered this relationship between the moon and Earth's tides. The activity involves drawing diagrams, discussing with a partner, and reviewing information on an upcoming assessment.
The document provides information about Earth and its rotation, axis, and orbit around the sun. It discusses how Earth's tilted axis and yearly orbit cause the seasons. It explains that summer begins in the Northern Hemisphere in June when the North Pole leans toward the sun. The Fall equinox marks the beginning of autumn in the Northern Hemisphere and spring in the Southern Hemisphere, when the sun shines equally on both hemispheres. During the winter solstice, the North Pole experiences complete darkness while the Southern Hemisphere experiences summer.
The document is a formative assessment for a 6th grade science class on the topic of changing Earth. It consists of 24 multiple choice questions testing students' understanding of the layers of the Earth, plate tectonics, earthquake waves, and more. Key concepts addressed include the order of Earth's layers from outer to inner, increasing heat and pressure toward the core, properties of the inner and outer core, plate boundaries and motions, Pangaea, and earthquake terminology.
The document discusses the layers of the Earth from the inner core to the crust, including the types of crust. It then explains that tectonic plates move due to convection currents in the mantle, with hot rock rising and cool rock sinking. There are three types of plate boundaries: convergent where plates move toward each other, divergent where they move apart, and transform where they scrape past each other. Hot spots in plates are used to track their movements over time.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
The Moon is Earth's only natural satellite, located about 384,000 km away. It was formed 4-5 billion years ago from debris after a collision between Earth and a Mars-sized object. The Moon has no atmosphere and extreme temperature variations, and its features include mountains, rills, large impact craters, and dark basaltic plains called maria. It always keeps the same face towards Earth due to synchronous rotation as it revolves around our planet every 27 days.
The document provides information about the Moon. It discusses that the Moon is Earth's only natural satellite, located about 384,000 km away. The Moon has no atmosphere or liquid water and experiences extreme temperatures. It has various features like mountains, trenches, craters formed by impacts, and dark maria areas filled with ancient lava. The Moon orbits Earth every 27 days while rotating on its axis at the same rate, so the same side always faces Earth. Lunar phases and eclipses are explained by the relative positions of the Moon, Earth and Sun. Tides on Earth are caused by the gravitational pull of the Moon.
This document discusses the difference between observations and inferences in scientific investigations. It defines observations as any information gathered through the senses that can be quantitative, like measurements, or qualitative, like descriptions. Inferences are conclusions or deductions made based on observations. The document provides examples of making observations about animal tracks or footprints and then making an inference about what animal could have made them. It encourages practicing distinguishing observations from inferences.
The document discusses key facts about the moon, including that it orbits Earth and reflects sunlight from its surface. It also explains the phases of the moon, which are caused by the moon orbiting Earth as the sun lights different parts of its surface over the course of about 29 days. The moon's gravitational pull causes ocean tides on Earth. Diagrams show each moon phase as the portion of the lit surface visible from Earth changes from new to full to new again in a repeating cycle.
The document discusses time zones, seasons, and the Earth's relationship to the sun. It explains that as the Earth rotates and revolves around the sun, different parts of the planet receive sunlight at different times, resulting in time zones. It also notes that the Earth is tilted on its axis and takes 365.25 days to orbit the sun, leading to seasons in the Northern and Southern Hemispheres. Key dates and phenomena like equinoxes and solstices are also outlined.
The document defines the three states of matter as solids, liquids, and gases. Solids have a definite shape and volume, with particles packed closely together in a fixed position. Liquids have a definite volume but no defined shape, with particles packed closely but able to move freely past one another. Gases have no definite shape or volume, with particles moving freely and filling available space. Changes between states are caused by increasing or decreasing thermal energy. Melting and boiling points are the specific temperatures at which a substance changes from solid to liquid and liquid to gas, respectively. Solubility refers to the maximum amount of a substance that can dissolve in a liquid at a given temperature, with the dissolving substance as the solute
This document provides 10 tips for students starting middle school. It advises students to stay organized with lockers and agendas, focus on grades by completing all assignments, follow the dress code, and plan ahead for major projects. Students are also told to embrace team seating in the cafeteria and collaborative work in classes, which are important parts of middle school.
The Moon orbits Earth and is illuminated by sunlight reflected off its surface. It takes approximately 29 days for the Moon to orbit Earth and undergo all its phases from New Moon to Full Moon and back again. The gravitational pull of the Moon causes ocean tides on Earth.
R.L. Stine is a famous author known for horror novel series like Goosebumps and Fear Street. He discovered his love of writing from finding an old typewriter in his attic as a way to escape bullying in school. His experiences as a substitute teacher during desegregation inspired some of his book characters. As one of the first children's authors to attract both boys and girls to reading, he made horror accessible and enjoyable for young readers, influencing the genre.
Jules Verne (1828-1905) was a French author best known for his science fiction novels. As a child he dreamed of adventure but lacked support from his parents. He wrote about his adventurous dreams which led to two books published within 10 years of the American Civil War. Verne's reputation suffered due to poor translations misrepresenting facts in his books. He continued writing until his death from diabetes in 1905, with his brother overseeing publication of his later works. Verne is considered the father of science fiction for creating stories featuring technologies that later became real.
The document describes different types of rocks and how they are formed. Intrusive igneous rocks like granite cool slowly underground, while extrusive rocks like basalt cool quickly above ground. Sedimentary rocks like limestone and sandstone are formed from the compaction of particles over time. Metamorphic rocks like slate and quartzite are formed from the alteration of older rocks by heat and pressure in the earth's interior. Shale, limestone, and sandstone are common sedimentary rocks that are distinguished by their composition of mud, seashells, or sand respectively.
The document provides instructions for completing a tri-fold DBQ layout. Students should include sample photos, typed text in a readable font size, and images from class resources. The middle section should use the template shown and include a map. Both the before and after sections require 3 pieces of evidence - one text, one image, and one of the student's choice, along with explanations for each. Neatness and adhering to the bullet point format are priorities, and the project is due on December 20th.
This document provides guidance on writing an effective introductory paragraph for an essay. The introductory paragraph should include a hook sentence to grab the reader's attention and a thesis statement that presents the position or main argument. It should also contain a transitional sentence at the end to connect to the first body paragraph. Effective hooks can be in the form of a question to intrigue the reader or a relevant quote from a famous person to lend authority. The goal is to motivate the reader to continue and learn more within the essay.
The document provides instructions for an activity where students will analyze a video clip on moon phases and discuss pictures and diagrams related to the moon's effect on tides and eclipses using scientific vocabulary. Students are asked questions about how the moon affects ocean tides and how scientists discovered this relationship between the moon and Earth's tides. The activity involves drawing diagrams, discussing with a partner, and reviewing information on an upcoming assessment.
The document provides information about Earth and its rotation, axis, and orbit around the sun. It discusses how Earth's tilted axis and yearly orbit cause the seasons. It explains that summer begins in the Northern Hemisphere in June when the North Pole leans toward the sun. The Fall equinox marks the beginning of autumn in the Northern Hemisphere and spring in the Southern Hemisphere, when the sun shines equally on both hemispheres. During the winter solstice, the North Pole experiences complete darkness while the Southern Hemisphere experiences summer.
The document is a formative assessment for a 6th grade science class on the topic of changing Earth. It consists of 24 multiple choice questions testing students' understanding of the layers of the Earth, plate tectonics, earthquake waves, and more. Key concepts addressed include the order of Earth's layers from outer to inner, increasing heat and pressure toward the core, properties of the inner and outer core, plate boundaries and motions, Pangaea, and earthquake terminology.
The document discusses the layers of the Earth from the inner core to the crust, including the types of crust. It then explains that tectonic plates move due to convection currents in the mantle, with hot rock rising and cool rock sinking. There are three types of plate boundaries: convergent where plates move toward each other, divergent where they move apart, and transform where they scrape past each other. Hot spots in plates are used to track their movements over time.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14...Donc Test
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7
Light waves and the eye
1. What is the Electromagnetic
Spectrum?
• How is it organized?
2.
3.
4. Three truths and 1 lie!
• The human eye can see around 7 million
colors.
• We have better eyesight at 9 months old than
our parents do as adults.
• We have only 10 light receptors to detect light
and color.
• We can see objects in space, with the naked
eye, that are 150 million trillion miles away.
5. How the Eye Works
• Pupil
• Iris
• Cornea
• Lens
• Retina
• Optic Nerve