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Ganesh Bagler
Center for Computational Biology, IIIT-Delhi
http://faculty.iiitd.ac.in/~bagler
bagler@iiitd.ac.in
Image Credits: Chloe Cushman
Image Credits: Chloe Cushman
Genes
Friends
Physical activity
Diet
Why do we eat what we eat?
Why do we combine ingredients in
our recipes the way we do?
Cuisines: Traditional Recipes
A data and hypothesis oriented approach to food
The Molecular Essence
The quintessential molecular character
Exploiting patterns for health
Data-driven personalized food recommendation
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
:: Data ::
well tested
&
well tasted
2543 Traditional Indian Recipes (TarlaDalal)
Regional cuisines: Bengali, Gujarati, Jain, Maharashtrian,
Mughlai, Punjabi, Rajasthani, South Indian.
Why do we combine ingredients in our recipes
the way we do?
Cuisines: Traditional Recipes
A data and hypothesis oriented approach to food
The Molecular Essence
The quintessential molecular character
Exploiting patterns for health
Data-driven personalized food recommendation
Food Pairing Hypothesis
Ingredients sharing flavor compounds are more likely to taste well
together than ingredients that do not.
𝑁𝑠 = 𝐹𝑖 ∩ 𝐹𝑗
𝐹𝑖
𝐹𝑗
Ahn et. al, “Flavor network and the principles of food pairing”, 1, 196, Scientific Reports (2011).
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
fla•vor = aroma + taste
olfactory
gustatory
194 ingredients
1170 flavor molecules
Ahn et. al, Sci.Rep., 1, 196 (2011).
𝑁𝑠
𝑅𝑎𝑛𝑑
𝑁𝑠
𝐶𝑢𝑖𝑠𝑖𝑛𝑒
𝑁𝑠
𝐶𝑢𝑖𝑠𝑖𝑛𝑒
∆𝑁𝑠
∆𝑁𝑠
Western Cuisines
Ahn et. al, Sci.Rep. (2011)
Indian Cuisine
Jain et. al, PLoS ONE (2015)
Uniform Food Pairing
Contrasting Food Pairing
Unique pairing in Indian cuisine
Indian cuisine is
characterized with
contrasting food pairing.
more the extent of flavor sharing between any two
ingredients, lesser their co-occurrence
Contrasting Food Pairing
—at the level of ingredient pairs—
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
Contrasting Food Pairing
—at the level of cuisine—
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
Contrasting Food Pairing
—at the level of sub-cuisines—
Indian cuisine is
characterized with
contrasting food pairing.
more the extent of flavor sharing between any two
ingredients, lesser their co-occurrence
A Jain, NK Rakhi & G Bagler,* “Analysis of Food Pairing in Regional Cuisines of India”, PLoS ONE, 10(10): e0139539(2015).
Culinary Fingerprinting of Regional Cuisines of India
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
Spices are key to the food pairing in Indian cuisine
Positive (Uniform)Negative (Contrasting)
A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
Role of ingredients in biasing the food pairing
Spice
The Taste of India
Discovery of the molecular essence of Indian cuisine & applications
Highlighted as an
Emerging Technology in
A Jain, NK Rakhi and G Bagler*, arXiv (2015); A Jain, NK Rakhi and G Bagler*, PLoS ONE (2015).
Best of 2015
MIT Technology Review
Cuisines: Traditional Recipes
A data and hypothesis oriented approach to food
The Molecular Essence
The quintessential molecular character
Exploiting patterns for health
Data-driven personalized food recommendation
Molecular
Essence
Novel Recipe
Generation
Food
Formulations
Food-
Beverage
pairing
Hypothesis
Generation
& Testing
Nutri-
Genomics
Food-
Disease
Association
Can we find scientific ways for altering diet
to improve health?
Personalized food recommendation
Levels of glucose in the blood are measured in terms of
“Postprandial Glycemic Response (PPGR)”.
Image Credits: HealthClinic
Machine learning applied to multidimensional data
for personalized dietary recommendation
ED Sonnenburg and JL Sonnenburg, Nature, 528, 484 (Dec 2015).
Zeevi et al., “Personalized Nutrition by Prediction of Glycemic Responses”, Cell, 163, 1079-1094 (Nov 2015);
The discovery of a new dish confers
more happiness on humanity, than the
discovery of a new star.
Jean Anthelme Brillat-Savarin
“
”
as seen in IUCAA canteen circa 1998
Image Credits: Wikipedia, Google Images (wherever applicable)

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Leveraging food for better health through data-driven approaches

  • 1. Ganesh Bagler Center for Computational Biology, IIIT-Delhi http://faculty.iiitd.ac.in/~bagler bagler@iiitd.ac.in
  • 3. Image Credits: Chloe Cushman Genes Friends Physical activity Diet
  • 4.
  • 5. Why do we eat what we eat? Why do we combine ingredients in our recipes the way we do?
  • 6. Cuisines: Traditional Recipes A data and hypothesis oriented approach to food The Molecular Essence The quintessential molecular character Exploiting patterns for health Data-driven personalized food recommendation
  • 7. 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0 1 0
  • 8. :: Data :: well tested & well tasted
  • 9. 2543 Traditional Indian Recipes (TarlaDalal) Regional cuisines: Bengali, Gujarati, Jain, Maharashtrian, Mughlai, Punjabi, Rajasthani, South Indian.
  • 10. Why do we combine ingredients in our recipes the way we do?
  • 11. Cuisines: Traditional Recipes A data and hypothesis oriented approach to food The Molecular Essence The quintessential molecular character Exploiting patterns for health Data-driven personalized food recommendation
  • 12. Food Pairing Hypothesis Ingredients sharing flavor compounds are more likely to taste well together than ingredients that do not. 𝑁𝑠 = 𝐹𝑖 ∩ 𝐹𝑗 𝐹𝑖 𝐹𝑗 Ahn et. al, “Flavor network and the principles of food pairing”, 1, 196, Scientific Reports (2011). A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
  • 13. fla•vor = aroma + taste olfactory gustatory
  • 14. 194 ingredients 1170 flavor molecules Ahn et. al, Sci.Rep., 1, 196 (2011).
  • 15.
  • 16. 𝑁𝑠 𝑅𝑎𝑛𝑑 𝑁𝑠 𝐶𝑢𝑖𝑠𝑖𝑛𝑒 𝑁𝑠 𝐶𝑢𝑖𝑠𝑖𝑛𝑒 ∆𝑁𝑠 ∆𝑁𝑠 Western Cuisines Ahn et. al, Sci.Rep. (2011) Indian Cuisine Jain et. al, PLoS ONE (2015) Uniform Food Pairing Contrasting Food Pairing Unique pairing in Indian cuisine
  • 17. Indian cuisine is characterized with contrasting food pairing. more the extent of flavor sharing between any two ingredients, lesser their co-occurrence
  • 18. Contrasting Food Pairing —at the level of ingredient pairs— A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015).
  • 19. A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015). Contrasting Food Pairing —at the level of cuisine—
  • 20. A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015). Contrasting Food Pairing —at the level of sub-cuisines—
  • 21. Indian cuisine is characterized with contrasting food pairing. more the extent of flavor sharing between any two ingredients, lesser their co-occurrence
  • 22. A Jain, NK Rakhi & G Bagler,* “Analysis of Food Pairing in Regional Cuisines of India”, PLoS ONE, 10(10): e0139539(2015). Culinary Fingerprinting of Regional Cuisines of India
  • 23. A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015). Spices are key to the food pairing in Indian cuisine
  • 24. Positive (Uniform)Negative (Contrasting) A Jain, NK Rakhi, G Bagler*, “Spices form the basis of food pairing in Indian cuisine”, arXiv:1502.03815 (2015). Role of ingredients in biasing the food pairing
  • 25.
  • 27. Discovery of the molecular essence of Indian cuisine & applications Highlighted as an Emerging Technology in A Jain, NK Rakhi and G Bagler*, arXiv (2015); A Jain, NK Rakhi and G Bagler*, PLoS ONE (2015). Best of 2015 MIT Technology Review
  • 28.
  • 29.
  • 30. Cuisines: Traditional Recipes A data and hypothesis oriented approach to food The Molecular Essence The quintessential molecular character Exploiting patterns for health Data-driven personalized food recommendation
  • 32.
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  • 34. Can we find scientific ways for altering diet to improve health? Personalized food recommendation
  • 35. Levels of glucose in the blood are measured in terms of “Postprandial Glycemic Response (PPGR)”. Image Credits: HealthClinic
  • 36.
  • 37. Machine learning applied to multidimensional data for personalized dietary recommendation ED Sonnenburg and JL Sonnenburg, Nature, 528, 484 (Dec 2015). Zeevi et al., “Personalized Nutrition by Prediction of Glycemic Responses”, Cell, 163, 1079-1094 (Nov 2015);
  • 38. The discovery of a new dish confers more happiness on humanity, than the discovery of a new star. Jean Anthelme Brillat-Savarin “ ” as seen in IUCAA canteen circa 1998
  • 39.
  • 40. Image Credits: Wikipedia, Google Images (wherever applicable)