Leadership Session: Accelerating Transformation in the Life Sciences (LFS201-iL) - AWS re:Invent 2018

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In this session, learn our vision for continued innovation in the life sciences industry and how AWS services can help. Gain insight into the key cloud computing trends for biotechnology, pharmaceutical, and medical device companies. Hear how you can use the AWS cloud to accelerate research, modernize clinical trials, build smarter manufacturing processes, and create deeper partnerships with healthcare providers and payers through real world evidence and digital therapeutics.

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Leadership Session:
Accelerating Transformation
in the Life Sciences
Lita Sands
WW Head Life Sciences Business Development
AWS
L F S 2 0 1 - L i

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Jumping the curve

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A selection of our global life sciences and genomics customers

Modernizing the value chain
Early phase research Clinical trials Manufacturing Commercialization
© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

A selection of AWS life sciences partners driving change
Early phase research Clinical trials Manufacturing Commercialization
© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Accelerating transformation
Clinical trials Manufacturing Commercialization
Shortened search across tens
of billions of molecules, using
thousands of models, from
years to days
200 scientists across five global
institutions studying genetic
variation to prevent and treat
stroke and heart disease
Building pre-clinical
consortiums, open APIs, and
enterprise-ready platforms
to speed drug research
Early phase research
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© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
What’s next?
Labs of the future
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© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Accelerating transformation
New ways to measure health in
everyday life
Enabling synthetic control arms
to support improved decision-
making and accelerated approvals
Comprehensive guidelines
for the use of mobile
technologies
in clinical trials
Manufacturing CommercializationEarly phase research Clinical trials
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Driving intelligent clinical trial planning
Greater accuracy shortens timeline =
$325K per month saved
Manufacturing CommercializationEarly phase research Clinical trials
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What’s next?
Virtual trials from home
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© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Accelerating transformation
CommercializationEarly phase research Clinical trials Manufacturing
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© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
15

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Increased focus on optimization
For example, reduction of the main waste drivers:
Overtime cost
Unplanned downtime
Inventory
adjustment cost
Batch change over
cost
NCs discovered
In process scrap

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17

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18

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
What’s next?
Smaller, smarter, cleaner factories

Early phase research Clinical trials Manufacturing
Accelerating transformation
Commercialization
© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

Accelerating transformation
Commercialization
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Digital medicines and therapeutics
Early phase research Clinical trials Manufacturing Commercialization
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Making a difference
in patients’ lives today

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Roche is positioned to deliver “digital diagnostics”
Decision support software with 120 years of medical innovation rooted in science
• Leading provider of cancer treatments worldwide
• 137 million patients treated with Roche medicines
• Focused on major medical indications and disease
areas
• #1 in biotechnology and in vitro diagnostics
• 19 billion+ diagnostic tests performed
• Advanced scientific knowledge and
technology
NAVIFY®
Decision Support Portfolio
Workflow + Data + Analytics
Diagnostics Pharmaceuticals

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
NAVIFY® Clinical Decision Support portfolio
An integrated portfolio of
scalable, secure workflow
solutions and apps
designed to support care
teams with analytics and
insights.

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What’s next for you?

© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
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Thank you!
© 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.
Lita Sands
lssands@amazon.com

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Many enterprises who are embarking on a journey to the cloud view this effort as an opportunity to transform their operations and development practices. DevOps, agile software development, and design thinking are the popular methodologies that are being used to create a more customer-centric mindset and speed up the delivery of new products & features. This session breaks down the essential components of each methodology and provides best practices on navigating the challenges that are commonly encountered when adopting these methods during a cloud migration.

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Il Forecasting è un processo importante per tantissime aziende e viene utilizzato in vari ambiti per cercare di prevedere in modo accurato la crescita e distribuzione di un prodotto, l’utilizzo delle risorse necessarie nelle linee produttive, presentazioni finanziarie e tanto altro. Amazon utilizza delle tecniche avanzate di forecasting, in parte questi servizi sono stati messi a disposizione di tutti i clienti AWS. In questa sessione illustreremo come pre-processare i dati che contengono una componente temporale e successivamente utilizzare un algoritmo che a partire dal tipo di dato analizzato produce un forecasting accurato.

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La varietà e la quantità di dati che si crea ogni giorno accelera sempre più velocemente e rappresenta una opportunità irripetibile per innovare e creare nuove startup. Tuttavia gestire grandi quantità di dati può apparire complesso: creare cluster Big Data su larga scala sembra essere un investimento accessibile solo ad aziende consolidate. Ma l’elasticità del Cloud e, in particolare, i servizi Serverless ci permettono di rompere questi limiti. Vediamo quindi come è possibile sviluppare applicazioni Big Data rapidamente, senza preoccuparci dell’infrastruttura, ma dedicando tutte le risorse allo sviluppo delle nostre le nostre idee per creare prodotti innovativi.

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Ora puoi utilizzare Amazon Elastic Kubernetes Service (EKS) per eseguire pod Kubernetes su AWS Fargate, il motore di elaborazione serverless creato per container su AWS. Questo rende più semplice che mai costruire ed eseguire le tue applicazioni Kubernetes nel cloud AWS.In questa sessione presenteremo le caratteristiche principali del servizio e come distribuire la tua applicazione in pochi passaggi

Costruire Applicazioni Moderne con AWS

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Vent'anni fa Amazon ha attraversato una trasformazione radicale con l'obiettivo di aumentare il ritmo dell'innovazione. In questo periodo abbiamo imparato come cambiare il nostro approccio allo sviluppo delle applicazioni ci ha permesso di aumentare notevolmente l'agilità, la velocità di rilascio e, in definitiva, ci ha consentito di creare applicazioni più affidabili e scalabili. In questa sessione illustreremo come definiamo le applicazioni moderne e come la creazione di app moderne influisce non solo sull'architettura dell'applicazione, ma sulla struttura organizzativa, sulle pipeline di rilascio dello sviluppo e persino sul modello operativo. Descriveremo anche approcci comuni alla modernizzazione, compreso l'approccio utilizzato dalla stessa Amazon.com.

Come spendere fino al 90% in meno con i container e le istanze spot

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L’utilizzo dei container è in continua crescita. Se correttamente disegnate, le applicazioni basate su Container sono molto spesso stateless e flessibili. I servizi AWS ECS, EKS e Kubernetes su EC2 possono sfruttare le istanze Spot, portando ad un risparmio medio del 70% rispetto alle istanze On Demand. In questa sessione scopriremo insieme quali sono le caratteristiche delle istanze Spot e come possono essere utilizzate facilmente su AWS. Impareremo inoltre come Spreaker sfrutta le istanze spot per eseguire applicazioni di diverso tipo, in produzione, ad una frazione del costo on-demand!

Open banking as a service

Amazon Web Services

In recent months, many customers have been asking us the question – how to monetise Open APIs, simplify Fintech integrations and accelerate adoption of various Open Banking business models. Therefore, AWS and FinConecta would like to invite you to Open Finance marketplace presentation on October 20th. Event Agenda : Open banking so far (short recap) • PSD2, OB UK, OB Australia, OB LATAM, OB Israel Intro to Open Finance marketplace • Scope • Features • Tech overview and Demo The role of the Cloud The Future of APIs • Complying with regulation • Monetizing data / APIs • Business models • Time to market One platform for all: a Strategic approach Q&A

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Amazon Web Services

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Leadership Session: Accelerating Transformation in the Life Sciences (LFS201-iL) - AWS re:Invent 2018

2. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Leadership Session: Accelerating Transformation in the Life Sciences Lita Sands WW Head Life Sciences Business Development AWS L F S 2 0 1 - L i

6. A selection of AWS life sciences partners driving change Early phase research Clinical trials Manufacturing Commercialization © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

7. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Accelerating transformation Clinical trials Manufacturing Commercialization Shortened search across tens of billions of molecules, using thousands of models, from years to days 200 scientists across five global institutions studying genetic variation to prevent and treat stroke and heart disease Building pre-clinical consortiums, open APIs, and enterprise-ready platforms to speed drug research Early phase research © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

9. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Accelerating transformation New ways to measure health in everyday life Enabling synthetic control arms to support improved decision- making and accelerated approvals Comprehensive guidelines for the use of mobile technologies in clinical trials Manufacturing CommercializationEarly phase research Clinical trials © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

10.

11. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Driving intelligent clinical trial planning Greater accuracy shortens timeline = $325K per month saved Manufacturing CommercializationEarly phase research Clinical trials © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

13. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Accelerating transformation CommercializationEarly phase research Clinical trials Manufacturing © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

16. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Increased focus on optimization For example, reduction of the main waste drivers: Overtime cost Unplanned downtime Inventory adjustment cost Batch change over cost NCs discovered In process scrap

22. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Digital medicines and therapeutics Early phase research Clinical trials Manufacturing Commercialization © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved.

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25. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Roche is positioned to deliver “digital diagnostics” Decision support software with 120 years of medical innovation rooted in science • Leading provider of cancer treatments worldwide • 137 million patients treated with Roche medicines • Focused on major medical indications and disease areas • #1 in biotechnology and in vitro diagnostics • 19 billion+ diagnostic tests performed • Advanced scientific knowledge and technology NAVIFY® Decision Support Portfolio Workflow + Data + Analytics Diagnostics Pharmaceuticals

26. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. NAVIFY® Clinical Decision Support portfolio An integrated portfolio of scalable, secure workflow solutions and apps designed to support care teams with analytics and insights.

28. © 2018, Amazon Web Services, Inc. or its affiliates. All rights reserved. Related sessions Wednesday, November 28- LFS 316 Architecting for GXP compliance in life sciences - ChalkTalk 4:45 – 5:45 PM | Aria West, Level 3, Ironwood 3 Tuesday, November 27- LFS 304 Building IoT devices for regulated industries - Breakout 4:45 – 5:45 PM | Venetian, Level 4, Delfino 4002 Wednesday, November 28- LFS 303 AI/ML in life sciences- Workshop 7:00 – 9:15 PM | Aria West, Level 3, Ironwood 1

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