Dhaval Panchal discusses the importance of maintaining a healthy product backlog in agile project management, emphasizing the need for a single prioritized list to align business objectives and development efforts. He highlights challenges such as over-specification, difficulty in prioritizing, and incomplete tasks, advocating for techniques like dot voting and user story splitting to enhance backlog readiness and clarity. Key practices include ensuring acceptance criteria, involving the product owner in prioritization, and conducting regular backlog grooming sessions to remain responsive to business needs.