jurnal kulit

1. Oral Candidiasis in Patients with Psoriasis: Correlation of Oral
Examination and Cytopathological Evaluation with Psoriasis Disease
Severity andTreatment
(Journal of the American Academy of Dermatology 2013, 986-991)

2. Infections are known to trigger and
exacerbate psoriasis.Although oral
candidiasis is often clinically
diagnosed, it is not always confirmed
by laboratory test such as oral
cytopathology.. Psoriasis is a common
multifactorial inflammatory
skin disease, affecting 1% to
3% of the population.
Pathogenesis combines
genetic and external factors,
such as infections with
activatedT cells.2 Recent
preclinical and clinical findings
have suggested a role for
interleukin 17 in the
pathogenesis of psoriasis.
These toxidermia are polymorphic
ranging from mild forms to serious forms
that can threaten the life of the patients

3. Stevens-Johnson syndrome (SJS) and toxic
epidermal necrolysis (TEN) are severe forms
and are marked by extensive epidermal
detchment and erosions of the mucous
membrane.
Incidence is higher in people living with
HIS/AIDS.With the event of
antiretroviral drugs, these patients have
faced an additional risk.
In sub-saharan Afrika,
many studies on
SJS/Ten have been
conducted and results
vary according to the
context, country, and
periode of study.

4. • This is a retrospective study
• cases of SJS/TEN treated in the dermatology departments and/or intensice
care units on burn victims at teaching hospital from 2000 to 2010.
• It was conducted in four countries in Sub-saharanAfrica (Benin, Burkina
Faso, CentralAfrican Republic, andTogo).
• The variables collected and analyzed were dermographic (age and sex),
clinical (type of toxidermia, surface epidermal detachment, duration of
hospitalization), etiological { drug(s) involved, other non-drug causes}, and
outcomes (death and sequelae)

5. The HIV serology was not systematically performed
in all patients.
SJS when the epidermal detachment covers less than 10% of the
skon surface,TEN when it covers over 30% and overlapping
SJS/TEN when it is between 10 and 30%.
Accountability criteria to find the implicated drug are form that
French pharmacovigilance. We selected drug(s) that potentially had a
high-risk of inducting SJS/TEN according ti data from the literature.
All cases of SJS/TEN selected in this study met the international
classification criteria. Erythema multiforme majus and Rittel-Lyell syndrome
were excluded

6. 129
37
11
0
177 cases
SJS
TEN
Overlapping

7. 113 cases inTogo (93 with SJS,
11TEN, and 9 overlapping
SJS/TEN)
28 cases in Burkina Faso (18
with SJS, 9TEN, 1 overlapping
SJS/TEN)
24 cases in Benin (11 SJS, 12
TEN, 1 overlapping SJS/TEN)
12 cases in Central African
Republic (7 SJS, 5TEN).
Distribution of
cases per country

8. Average surface of epidermal
detachment was 5.9 ± 5.8 % for
SJS, 15.3 ± 1.7% for the overlapping
SJS/TEN, and 36.9 ± 18.2 % forTEN.
The average age of patients
was 32.3 ± 15.4 years, and sex
ratio (M/F) was 0,6. 131 (74%) of
177 patients were aged
between 20 and 49 years.
Serological testing for HIV was carried
out on 126 patients and was positive in
69 (54.8%), including 51 patients wwith
SJS, 13 withTEN, adn 5 overlapping
SJS/TEN.

9. Psoriasis
Psoriasis merupakan penyakit kulit inflamasi kronik yang
berkaitan erat dengan genetik. Sebelumnya psoriasis dianggap
sebagai suatu penyakit primer akibat gangguan keratinosit,
namun saat ini psoriasis dikenal sebagai suatu penyakit yang
diperantarai oleh sistem imun.
Candidiasis Mulut
Kandidiasis mulut adalah infeksi jamur yang paling umum dari
rongga mulut dan disebabkan oleh pertumbuhan berlebih dari C.
albicans yang biasanya hadir dalam rongga mulut dalam bentuk
non patogen pada orang yang sehat.
Fitzpatrik’s Dermatology In General Medicine (2012),
National Clinical Guideline Centre. Psoriasis : Assesmnet and Management of Psoriasis (2012).