This study found that 22% of healthy adult Chinese participants exhibited a pattern of low-latency reflexive eye movements, known as "express saccades", in a task designed to inhibit such responses. This proportion is much higher than the expected 1-5% found in other populations. The study then tested these "express saccade makers" in an antisaccade task requiring voluntary eye movements instead of reflexive ones. They found that express saccade makers performed worse on this task, making more errors and errors with shorter latencies, suggesting reduced ability to inhibit reflexive responses. This has implications for studies attributing differences in eye movements between Chinese and other groups to culture, as it identifies an unexpected oculomotor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
April 2019 . Cataracts secondary to intraocular diseases are complicated cata...Vinitkumar MJ
DEMOGRAPHIC PROFILES AND AETIOLOGY OF COMPLICATED CATARACTS: A HOSPITAL BASED STUDY.
Aim: To study demographic profiles and aetiology of complicated cataracts in patients presenting to the Out-Patient Department of B. P. Koirala Lions Centre for Ophthalmic Studies (BPKLCOS).
This study examined the correlation between central corneal thickness (CCT) and results from Frequency Doubling Technology Perimetry (FDT) in 180 patients aged 40 or older with high intraocular pressure (IOP) but normal optic discs. The average CCT across both eyes was 531 microns. Abnormal FDT results were found in 18 subjects, who had thinner average CCT of 519 microns, compared to 532 microns in 162 subjects with normal FDT results. The study concludes that among patients with high IOP but normal discs, thicker corneas are associated with a lower risk of early glaucomatous damage detected by FDT, compared to patients with thinner corneas.
Objective: To evaluate the clinical effectiveness of Zero-Profile spacer versus traditional cage and plate in anterior cervical
discectomy and fusion.
Methods: An electronic search was conducted in the databases of PubMed, the Cochrane Library, Embase, Web of Science,
Science Direct, Chinese Science and Technology Periodical Database, the China National Knowledge Infrastructure, and Wanfang. A meta-analysis was performed using review manager 5.3.
APPLY MACHINE LEARNING METHODS TO PREDICT FAILURE OF GLAUCOMA DRAINAGEIJDKP
This study used machine learning methods to predict the failure of glaucoma drainage devices (GDDs) based on patient data. Five classifiers (logistic regression, artificial neural network, random forest, decision tree, and support vector machine) were compared using 165 patient records. Logistic regression and random forest performed best on the small and large datasets respectively. Key predictors of failure identified were race (Black), use of beta-blockers, and glaucoma type (open-angle). Random forest and logistic regression showed potential to predict GDD outcomes based on minimal patient information and could help understand differences between device types.
To investigate an outcome of dynamic and log mar visual acuity on cataract pa...KrishnaKumarGupta26
This document discusses a study investigating the outcomes of dynamic and logMAR visual acuity testing on cataract patients. The study aims to measure logMAR visual acuity and dynamic visual acuity using a DYOP chart on cataract patients. A literature review is presented covering previous research demonstrating differences between static and dynamic visual acuity and the impact of factors like neck muscle fatigue and vestibular dysfunction on dynamic visual acuity. The need for the study is that static acuity tests do not accurately measure visual acuity in dynamic real-world conditions, whereas the DYOP chart provides a faster dynamic assessment.
Prospective Evaluation of Intra operative Nucleus 22-channel cochlear implant...IJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
International Journal of Modern Engineering Research (IJMER) covers all the fields of engineering and science: Electrical Engineering, Mechanical Engineering, Civil Engineering, Chemical Engineering, Computer Engineering, Agricultural Engineering, Aerospace Engineering, Thermodynamics, Structural Engineering, Control Engineering, Robotics, Mechatronics, Fluid Mechanics, Nanotechnology, Simulators, Web-based Learning, Remote Laboratories, Engineering Design Methods, Education Research, Students' Satisfaction and Motivation, Global Projects, and Assessment…. And many more.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
April 2019 . Cataracts secondary to intraocular diseases are complicated cata...Vinitkumar MJ
DEMOGRAPHIC PROFILES AND AETIOLOGY OF COMPLICATED CATARACTS: A HOSPITAL BASED STUDY.
Aim: To study demographic profiles and aetiology of complicated cataracts in patients presenting to the Out-Patient Department of B. P. Koirala Lions Centre for Ophthalmic Studies (BPKLCOS).
This study examined the correlation between central corneal thickness (CCT) and results from Frequency Doubling Technology Perimetry (FDT) in 180 patients aged 40 or older with high intraocular pressure (IOP) but normal optic discs. The average CCT across both eyes was 531 microns. Abnormal FDT results were found in 18 subjects, who had thinner average CCT of 519 microns, compared to 532 microns in 162 subjects with normal FDT results. The study concludes that among patients with high IOP but normal discs, thicker corneas are associated with a lower risk of early glaucomatous damage detected by FDT, compared to patients with thinner corneas.
Objective: To evaluate the clinical effectiveness of Zero-Profile spacer versus traditional cage and plate in anterior cervical
discectomy and fusion.
Methods: An electronic search was conducted in the databases of PubMed, the Cochrane Library, Embase, Web of Science,
Science Direct, Chinese Science and Technology Periodical Database, the China National Knowledge Infrastructure, and Wanfang. A meta-analysis was performed using review manager 5.3.
APPLY MACHINE LEARNING METHODS TO PREDICT FAILURE OF GLAUCOMA DRAINAGEIJDKP
This study used machine learning methods to predict the failure of glaucoma drainage devices (GDDs) based on patient data. Five classifiers (logistic regression, artificial neural network, random forest, decision tree, and support vector machine) were compared using 165 patient records. Logistic regression and random forest performed best on the small and large datasets respectively. Key predictors of failure identified were race (Black), use of beta-blockers, and glaucoma type (open-angle). Random forest and logistic regression showed potential to predict GDD outcomes based on minimal patient information and could help understand differences between device types.
To investigate an outcome of dynamic and log mar visual acuity on cataract pa...KrishnaKumarGupta26
This document discusses a study investigating the outcomes of dynamic and logMAR visual acuity testing on cataract patients. The study aims to measure logMAR visual acuity and dynamic visual acuity using a DYOP chart on cataract patients. A literature review is presented covering previous research demonstrating differences between static and dynamic visual acuity and the impact of factors like neck muscle fatigue and vestibular dysfunction on dynamic visual acuity. The need for the study is that static acuity tests do not accurately measure visual acuity in dynamic real-world conditions, whereas the DYOP chart provides a faster dynamic assessment.
Prospective Evaluation of Intra operative Nucleus 22-channel cochlear implant...IJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
International Journal of Modern Engineering Research (IJMER) covers all the fields of engineering and science: Electrical Engineering, Mechanical Engineering, Civil Engineering, Chemical Engineering, Computer Engineering, Agricultural Engineering, Aerospace Engineering, Thermodynamics, Structural Engineering, Control Engineering, Robotics, Mechatronics, Fluid Mechanics, Nanotechnology, Simulators, Web-based Learning, Remote Laboratories, Engineering Design Methods, Education Research, Students' Satisfaction and Motivation, Global Projects, and Assessment…. And many more.
Poster: Audit of Appropriateness for Brain Scan Use for Paediatric Headache a...Lyndon Woytuck
The purpose is to evaluate practice variation at the emergency department in comparison with best practice for brain imaging in children presenting with headache. The results of the study might be used to inform a clinical prediction rule in order to better stratify risk according to the American College of Radiology Appropriateness Criteria.
I created a poster for presentation and am currently working on a paper for publication in a scholarly journal.
This study tested whether monkeys with lesions to Area 12 of the orbitofrontal cortex, which has been linked to safety signal learning and flexible decision making, would show impairments in object discrimination reversal learning. Four monkeys received lesions to Area 12 while four control monkeys received sham operations. On an object discrimination reversal task, monkeys with Area 12 lesions learned the initial discrimination as quickly as controls but made fewer reversal errors, though this difference was not significant. The study suggests that additional control monkeys may be needed to fully assess the effects of Area 12 lesions on reversal learning abilities.
Glasziou taking healthcare interventions from trial to practiceMarilyn Mann
The document discusses improving the reporting of healthcare interventions in clinical trials to facilitate moving findings from trials into practice. It notes that currently many trial reports do not adequately describe interventions, making it difficult or impossible for clinicians to replicate them. The document proposes that trial protocols and publications should provide detailed descriptions of intervention contents, delivery personnel, locations, doses, schedules, and the degree of flexibility allowed. This would help reduce waste from unusable findings and better support evidence synthesis, clinical practice, and health policy decisions.
The Lancet - Human embryonic stem cell-derived retinal pigment epithelium in...John Redaelli
This summarizes the results of two clinical trials evaluating the safety and efficacy of transplanting human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) in patients with Stargardt's macular dystrophy or dry age-related macular degeneration. A total of 18 patients received subretinal injections of hESC-RPE in one eye. Over a median follow-up of 22 months, there were no safety issues identified and 72% of patients showed signs of graft survival. Visual acuity improved in some patients and quality of life measures increased, suggesting possible biological activity. The results provide initial evidence that hESC-derived cells can be safely transplanted and have potential for treating retinal diseases
Part 2 Of 2 Comment/Reply on ACT/Ocata Lancet Report (Oct. 2014)
Reply by, *Steven D Schwartz, Eddy Anglade, Robert Lanza, on behalf of the Ocata
Macular Disease Investigator Group
schwartz@jsei.ucla.edu
Jules Stein Eye Institute Retina Division, and David
Geffen School of Medicine, University of California,
Los Angeles, CA 90095, USA (SDS); and Ocata
Therapeutics Inc, Marlborough, MA, USA (EA, RL)
Source Material: http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)61203-X.pdf
This document is a curriculum vitae for Kiran Aman, who has 9 years of experience in biomedical research and ophthalmologic sciences. They have a Master's degree in investigative ophthalmology and vision sciences from the University of Manchester and have worked as an investigative oculist and diagnostic optometrist in Lahore, Pakistan since 2015. Kiran Aman has experience utilizing various diagnostic tools such as optical coherence tomography, fundus fluorescein angiography, and ophthalmic ultrasonography.
quantative critique (yasmeen msn 1 st semester fall 2020)yasmeenzulfiqar
This article summarizes a quantitative study that examined factors affecting successful employment for transition-age youth with visual impairments. The study analyzed variables like work experience, self-determination, academic competence, self-esteem, locus of control, involvement with vocational rehabilitation counselors, and use of assistive technology. The study found that employment history, academic skills, sense of control, self-advocacy, and assistive technologies were significantly correlated with finding work. However, the small sample size and multiple statistical tests limited the reliability of the results. Overall, the study provided insight into supports that may help youth with visual impairments obtain jobs.
Faro An Interactive Interface For Remote Administration Of Clinical Tests Bas...Kalle
A challenging goal today is the use of computer networking and advanced
monitoring technologies to extend human intellectual capabilities in medical decision making. Modern commercial eye trackers
are used in many of research fields, but the improvement of eye tracking technology, in terms of precision on the eye movements capture, has led to consider the eye tracker as a tool for vision analysis, so that its application in medical research, e.g. in ophthalmology, cognitive psychology and in neuroscience has grown considerably. The improvements of the human eye tracker interface become more and more important to allow medical doctors to increase their diagnosis capacity, especially if the interface allows them to remotely administer the clinical tests more appropriate for the problem at hand. In this paper, we propose a client/server eye tracking system that provides an interactive system for monitoring patients eye movements depending on the clinical test administered by the medical doctors. The system supports the retrieval of the gaze information and provides statistics to both medical research and disease diagnosis.
This study compared the use of external condom catheters and Foley's catheters in bedridden male patients with head injuries. The study found that patients using external catheters had lower rates of urinary tract infections and fewer cases of penile ulceration and edema compared to those using Foley's catheters. The conclusion was that external catheters are preferable for these patients as they do not increase the risk of UTIs or urethral injuries, though care needs to be taken in application to avoid issues with the penis.
Terrando et al-2015-anesthesia_&_analgesiasamirsharshar
This article summarizes discussions from a workshop on perioperative neurotoxicity in the elderly. The workshop included presentations on:
1) Preclinical evidence that surgery and anesthesia can cause neuroinflammation and cognitive impairment in rodent models, especially in vulnerable populations like the elderly.
2) Emerging human biomarkers like CSF tau levels that show potential to objectively measure postoperative neuronal injury and predict cognitive outcomes.
3) Preliminary clinical studies finding associations between postoperative cytokines, blood-brain barrier disruption, and delirium; however, interventions like glucocorticoids have not proven effective yet.
4) The need for standardized nomenclature and consideration of preexisting patient vulnerabilities in clinical studies to help resolve
This document discusses knowledge engineering in oncology and developing decision support systems from patient data. It notes that current medical decisions are limited by the large volume of data and evidence. Rapid learning from patient data can help guide individualized treatment decisions. The document outlines MAASTRO's approach to knowledge engineering, which involves collecting data from multiple centers while keeping the data within each institution. Ontologies and semantic interoperability are used to integrate the data and develop prediction models using machine learning. The models are validated on independent data to evaluate their ability to classify outcomes and estimate survival probabilities. The goal is to develop validated models that can provide clinical decision support and help personalize cancer treatment.
An assignment for DH Theory 1 was to create an annotated bibliography for a research topic of our choice. This project was designed to challenge our critical thinking and decision making skills. I chose to research dental lasers and their effectiveness in the removal of oral lesions. It was interesting to compare different literature on this subject, and I had a lot of fun determining what articles were valid based on the evidence provided.
Dokumen tersebut memberikan panduan langkah-langkah konfigurasi web server menggunakan Windows Server 2003 dan menambahkan sertifikat HTTPS untuk mengamankan situs web. Langkah-langkahnya meliputi instalasi IIS, membuat situs web baru, menambahkan dokumen, dan mengkonfigurasi sertifikat HTTPS melalui Certificate Services.
Dokumen ini memberikan instruksi lengkap untuk mengkonfigurasi server web IIS (Internet Information Services) di Windows, mulai dari menginstal IIS, membuat situs web baru, mengatur direktori dan izin, menambahkan host DNS, dan mengubah gambar tampilan awal IIS.
Windows Server 2008 adalah sistem operasi untuk server dari Microsoft yang merupakan pengembangan dari Windows Server 2003. Sistem ini memiliki fitur-fitur seperti Windows Server Backup untuk backup sistem, Server Core untuk meminimalisasi GUI, serta Hyper-V untuk virtualisasi perangkat dan aplikasi.
Poster: Audit of Appropriateness for Brain Scan Use for Paediatric Headache a...Lyndon Woytuck
The purpose is to evaluate practice variation at the emergency department in comparison with best practice for brain imaging in children presenting with headache. The results of the study might be used to inform a clinical prediction rule in order to better stratify risk according to the American College of Radiology Appropriateness Criteria.
I created a poster for presentation and am currently working on a paper for publication in a scholarly journal.
This study tested whether monkeys with lesions to Area 12 of the orbitofrontal cortex, which has been linked to safety signal learning and flexible decision making, would show impairments in object discrimination reversal learning. Four monkeys received lesions to Area 12 while four control monkeys received sham operations. On an object discrimination reversal task, monkeys with Area 12 lesions learned the initial discrimination as quickly as controls but made fewer reversal errors, though this difference was not significant. The study suggests that additional control monkeys may be needed to fully assess the effects of Area 12 lesions on reversal learning abilities.
Glasziou taking healthcare interventions from trial to practiceMarilyn Mann
The document discusses improving the reporting of healthcare interventions in clinical trials to facilitate moving findings from trials into practice. It notes that currently many trial reports do not adequately describe interventions, making it difficult or impossible for clinicians to replicate them. The document proposes that trial protocols and publications should provide detailed descriptions of intervention contents, delivery personnel, locations, doses, schedules, and the degree of flexibility allowed. This would help reduce waste from unusable findings and better support evidence synthesis, clinical practice, and health policy decisions.
The Lancet - Human embryonic stem cell-derived retinal pigment epithelium in...John Redaelli
This summarizes the results of two clinical trials evaluating the safety and efficacy of transplanting human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) in patients with Stargardt's macular dystrophy or dry age-related macular degeneration. A total of 18 patients received subretinal injections of hESC-RPE in one eye. Over a median follow-up of 22 months, there were no safety issues identified and 72% of patients showed signs of graft survival. Visual acuity improved in some patients and quality of life measures increased, suggesting possible biological activity. The results provide initial evidence that hESC-derived cells can be safely transplanted and have potential for treating retinal diseases
Part 2 Of 2 Comment/Reply on ACT/Ocata Lancet Report (Oct. 2014)
Reply by, *Steven D Schwartz, Eddy Anglade, Robert Lanza, on behalf of the Ocata
Macular Disease Investigator Group
schwartz@jsei.ucla.edu
Jules Stein Eye Institute Retina Division, and David
Geffen School of Medicine, University of California,
Los Angeles, CA 90095, USA (SDS); and Ocata
Therapeutics Inc, Marlborough, MA, USA (EA, RL)
Source Material: http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)61203-X.pdf
This document is a curriculum vitae for Kiran Aman, who has 9 years of experience in biomedical research and ophthalmologic sciences. They have a Master's degree in investigative ophthalmology and vision sciences from the University of Manchester and have worked as an investigative oculist and diagnostic optometrist in Lahore, Pakistan since 2015. Kiran Aman has experience utilizing various diagnostic tools such as optical coherence tomography, fundus fluorescein angiography, and ophthalmic ultrasonography.
quantative critique (yasmeen msn 1 st semester fall 2020)yasmeenzulfiqar
This article summarizes a quantitative study that examined factors affecting successful employment for transition-age youth with visual impairments. The study analyzed variables like work experience, self-determination, academic competence, self-esteem, locus of control, involvement with vocational rehabilitation counselors, and use of assistive technology. The study found that employment history, academic skills, sense of control, self-advocacy, and assistive technologies were significantly correlated with finding work. However, the small sample size and multiple statistical tests limited the reliability of the results. Overall, the study provided insight into supports that may help youth with visual impairments obtain jobs.
Faro An Interactive Interface For Remote Administration Of Clinical Tests Bas...Kalle
A challenging goal today is the use of computer networking and advanced
monitoring technologies to extend human intellectual capabilities in medical decision making. Modern commercial eye trackers
are used in many of research fields, but the improvement of eye tracking technology, in terms of precision on the eye movements capture, has led to consider the eye tracker as a tool for vision analysis, so that its application in medical research, e.g. in ophthalmology, cognitive psychology and in neuroscience has grown considerably. The improvements of the human eye tracker interface become more and more important to allow medical doctors to increase their diagnosis capacity, especially if the interface allows them to remotely administer the clinical tests more appropriate for the problem at hand. In this paper, we propose a client/server eye tracking system that provides an interactive system for monitoring patients eye movements depending on the clinical test administered by the medical doctors. The system supports the retrieval of the gaze information and provides statistics to both medical research and disease diagnosis.
This study compared the use of external condom catheters and Foley's catheters in bedridden male patients with head injuries. The study found that patients using external catheters had lower rates of urinary tract infections and fewer cases of penile ulceration and edema compared to those using Foley's catheters. The conclusion was that external catheters are preferable for these patients as they do not increase the risk of UTIs or urethral injuries, though care needs to be taken in application to avoid issues with the penis.
Terrando et al-2015-anesthesia_&_analgesiasamirsharshar
This article summarizes discussions from a workshop on perioperative neurotoxicity in the elderly. The workshop included presentations on:
1) Preclinical evidence that surgery and anesthesia can cause neuroinflammation and cognitive impairment in rodent models, especially in vulnerable populations like the elderly.
2) Emerging human biomarkers like CSF tau levels that show potential to objectively measure postoperative neuronal injury and predict cognitive outcomes.
3) Preliminary clinical studies finding associations between postoperative cytokines, blood-brain barrier disruption, and delirium; however, interventions like glucocorticoids have not proven effective yet.
4) The need for standardized nomenclature and consideration of preexisting patient vulnerabilities in clinical studies to help resolve
This document discusses knowledge engineering in oncology and developing decision support systems from patient data. It notes that current medical decisions are limited by the large volume of data and evidence. Rapid learning from patient data can help guide individualized treatment decisions. The document outlines MAASTRO's approach to knowledge engineering, which involves collecting data from multiple centers while keeping the data within each institution. Ontologies and semantic interoperability are used to integrate the data and develop prediction models using machine learning. The models are validated on independent data to evaluate their ability to classify outcomes and estimate survival probabilities. The goal is to develop validated models that can provide clinical decision support and help personalize cancer treatment.
An assignment for DH Theory 1 was to create an annotated bibliography for a research topic of our choice. This project was designed to challenge our critical thinking and decision making skills. I chose to research dental lasers and their effectiveness in the removal of oral lesions. It was interesting to compare different literature on this subject, and I had a lot of fun determining what articles were valid based on the evidence provided.
Dokumen tersebut memberikan panduan langkah-langkah konfigurasi web server menggunakan Windows Server 2003 dan menambahkan sertifikat HTTPS untuk mengamankan situs web. Langkah-langkahnya meliputi instalasi IIS, membuat situs web baru, menambahkan dokumen, dan mengkonfigurasi sertifikat HTTPS melalui Certificate Services.
Dokumen ini memberikan instruksi lengkap untuk mengkonfigurasi server web IIS (Internet Information Services) di Windows, mulai dari menginstal IIS, membuat situs web baru, mengatur direktori dan izin, menambahkan host DNS, dan mengubah gambar tampilan awal IIS.
Windows Server 2008 adalah sistem operasi untuk server dari Microsoft yang merupakan pengembangan dari Windows Server 2003. Sistem ini memiliki fitur-fitur seperti Windows Server Backup untuk backup sistem, Server Core untuk meminimalisasi GUI, serta Hyper-V untuk virtualisasi perangkat dan aplikasi.
Instalasi Windows Server 2003 melibatkan beberapa langkah seperti memulai instalasi melalui CD-ROM, memilih partisi untuk sistem C, mengisi informasi lisensi dan akun administrator, serta menunggu proses instalasi hingga selesai.
Windows Server 2008 adalah sistem operasi server terbaru dari Microsoft yang merupakan pengembangan dari Windows Server 2003. Dokumen ini menjelaskan fitur-fitur utama Windows Server 2008 seperti Windows Server Backup, Server Core, Read Only Domain Controller, Network Load Balancing, dan Hyper-V, serta spesifikasi hardware yang dibutuhkan.
Active Directory digunakan untuk mengelola akun pengguna dan kelompok secara terpusat. Dokumen ini menjelaskan cara instalasi Active Directory di Windows Server 2008 dan membuat grup dan pengguna.
Pantun adalah puisi tradisional Indonesia yang terdiri atas 4 baris dengan rima akhir a-b-a-b. Syair juga merupakan puisi tradisional yang terdiri atas 4 baris dengan rima akhir a-a-a-a. Gurindam terdiri atas 2 baris dengan rima akhir a-a yang membentuk satu kesatuan.
Dokumen tersebut membahas model OSI dan TCP/IP. Model OSI terdiri dari 7 lapisan yang menangani komunikasi data dari level aplikasi hingga fisik. TCP/IP memiliki 4 lapisan yang menangani komunikasi mulai dari aplikasi, transport, internet, hingga akses jaringan. Keduanya menggunakan pengiriman paket namun berbeda dalam jumlah dan penggabungan lapisan.
Active direc tory di windows server 2008 mIchsanvoc
Active Directory is a directory service database in Windows Server used to centrally manage domain accounts, groups, and users. It provides centralized administration of network resources across domains within a forest. The document then discusses installing Active Directory on Windows Server 2008 by running DCPROMO and guiding through the installation wizard. It also covers creating user accounts and groups within Active Directory by right-clicking folders and using the Active Directory Users and Computers tool.
High Precision And Fast Functional Mapping Of Cortical Circuitry Through A No...Taruna Ikrar
Taruna Ikrar, MD., PhD. Author at (High Precision and Fast Functional Mapping of Cortical Circuitry Through a Novel Combination of Voltage Sensitive Dye Imaging and Laser Scanning Photostimulation)
Iris Publishers - journal of ophthalmology | Demystifying Role of Ultrasound ...IrisPublishers
Objectives: The aim of this study was to compare sonoelastographic findings in the retina– choroid–sclera (RCS) complex and vitreous in glaucomatous and healthy eyes.Methods: For this cross-sectional comparative study, 20 patients with primary open-angle glaucoma (POAG) and 20 healthy volunteers were recruited. Ultrasound elastography measurements were taken with a sonographic scanner of the RCS complex, anterior vitreous (AV), posterior vitreous (PV), retrobulbar fat tissue (RFT), optic disc, and optic nerve in each eye.Results: The elasticity index of the RCS complex, RFT, optic disc, optic nerve, AV, and PV were similar in both groups (p > 0.05), though the AV/PV strain ratio in the group of patients with glaucoma was significantly higher (p = 0.04).Conclusion: Glaucoma increases the AV/PV strain ratio. In providing reproducible and consistent values, the real-time elastography technique may be helpful in elucidating the mechanisms of glaucoma in some aspects.
OM: Advanced Bio-Well Practical Hands on Training - Feb.5-6-7/2016Krishna Madappa
OM: As our global and concentrated Bio-Well community grows, so should our dedicated training.
Dr.K.Korotkov & Krishna see this as an essential educational module for creating a next generation of Bio-Well professional users.
As the software platforms continue to amplify the non-linearity and our understanding of our multi dimensional presence, we are here to ennoble a seamless interface to this evolutionary level of Human Development.
Ultimately our singular purpose is to assist all our Bio-Well users globally to be the stewards of the advanced science of Bio-Electrography and inspire a generation towards the "Sciences of Optimal Human Excellence".
This study compared visual outcomes after cataract surgery using femtosecond laser-assisted cataract surgery (FLACS) versus conventional phacoemulsification (CPS) with implantation of an extended depth of focus (EDOF) intraocular lens (IOL). The study found that FLACS produced significantly less IOL decentration and tilt, lower wavefront aberrations, better contrast sensitivity, and fewer visual disturbances reported by patients. Therefore, FLACS may provide improved visual performance compared to CPS when using an EDOF IOL by achieving a more precisely centered IOL position. The study provides evidence that lens positioning is an important factor for optimal visual outcomes with EDOF IOLs.
The document summarizes evidence from 166 studies across 64 interventions for children with cerebral palsy. It finds that 24% of interventions are proven effective, receiving a 'green light' recommendation. However, 70% have uncertain effects and require ongoing outcome measurement (yellow light). 6% are proven ineffective and should be discontinued (red light). Effective interventions reflect current knowledge in neuroscience and pharmacology, but all only address a single level of the ICF model. The review provides clinicians a comprehensive overview of the state of evidence for cerebral palsy interventions.
Rachael Pearson is a Royal Society University Research Fellow whose research focuses on developing stem cell therapy for retinal repair and regeneration. She has established proof-of-concept for restoring vision through rod photoreceptor transplantation. Her current areas of interest include defining strategies to restore cone-mediated vision, understanding photoreceptor precursor migration in development and transplantation, and determining how to break down barriers in the degenerating retina to improve transplantation outcomes. Her lab utilizes techniques such as microscopy, stem cell culture, molecular biology, and behavioral testing to advance photoreceptor replacement therapies for treating blindness.
This study examined patterns of cortical activity using four different EEG testing protocols: an extended 8-minute baseline with alternating eyes open and closed, viewing a 10-minute dyadic social interaction video, and completing a personality survey. The protocols elicited different levels of activity in the alpha band and theta/beta ratio. Specifically, all protocols differed significantly in alpha activity, and the three eyes-open conditions still differed when just compared to each other. This suggests protocol design impacts EEG results and more representative real-world designs should be explored.
This presentation provides a general introduction to neuroanatomy after cerebral hemispherectomy, a procedure where half the brain is removed to stop intractable epilepsy that originates from one side of the brain. Topics include potential of the remaining hemisphere, cortical plasticity, clinical presentation of hemiparesis due to innervation by only the ipsilateral corticospinal tract, life span impairments. Various case studies discussed.
Presented at the Combined Section Meeting of the American Physical Therapy Association
February 2014
By: Dr. Stella de Bode, Ph.D. Chief Science Officer, The Brain Recovery Project
Nisha Pagan, PT, DPT, NCS, PCS, Owner Wholehearted Pediatric Physical Therapy
This research article examines the organization of projections from the mouse dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) using retrograde tracers. The study finds that:
1) Projection columns within the dLGN that project to V1 exhibit highly variable organization in young mice that is refined in adults, displaying profiles consistent with shell and core zones.
2) Projection column organization is disrupted in adult mice that lacked correlated spontaneous activity during development.
3) Analysis across groups suggests there may be 4-6 cryptic laminae along the length of projection columns, indicating greater complexity in dLGN organization than previously thought.
This document describes a study using spectral-domain optical coherence tomography (SD-OCT) to examine long-term cerebrovascular changes in response to voluntary exercise in rats. 14 rats were assigned to either an exercise or control group. SD-OCT scanning was performed under anesthesia to image the motor cortex at high resolution before and after inducing hypoxia, allowing non-invasive longitudinal assessment. Histology will also be performed and compared to SD-OCT. The results will help explore exercise-induced cerebrovascular plasticity and validate SD-OCT for mapping vascular changes over time.
VisualSonics has introduced a revolutionary micro-ultrasound and photoacoustic imaging system that allows researchers to collect a plethora of important data over the lifespan of animals, thereby significantly reducing the number of animals needed.
Shallow introduction for Deep Learning Retinal Image AnalysisPetteriTeikariPhD
This document provides an overview of various retinal imaging techniques and applications of deep learning to retinal image analysis. It discusses fundamentals of eye anatomy and image formation, as well as common retinal diseases. Imaging modalities covered include fundus photography, optical coherence tomography (OCT), and multispectral imaging. The document also explores nonlinear optical properties of the eye and applications of techniques like third harmonic generation microscopy. Finally, it touches on topics relevant to deep learning like data sources, annotation, data augmentation, network architectures, and hardware optimization. The goal is to introduce key concepts from different disciplines to facilitate communication across fields involved in retinal image analysis.
This document is an accepted manuscript that has been peer-reviewed but not yet copyedited or formatted. It describes new research on the role of mTOR activity in sensory axon regeneration induced by a conditioning lesion. Specifically, it finds that rapamycin-resistant mTOR activity is required for the regeneration response triggered by a conditioning lesion. The research was conducted by scientists in Hong Kong and China, and was funded by several grants.
- An article describes what is the impact of refractive error on a layer of retina ( nerve fiber layer) in myopic subjects, Download its full text from Isra Medical Journal.
Objective: To evaluate myopic impact on thickness of nerve fiber layer of the retina in healthy myopic subjects.
Study Design: Prospective Observational study.
Place and Duration: Investigative Department of Ophthalmology of Al-Ibrahim Eye Hospital, Karachi from 1st May 2018 to 30th October 2018.
Methodology: In this study 80 eyes of myopic subjects (SE -0.5 to -11.0 DS) were enrolled. Each eye underwent through comprehensive ocular examination beginning with visual acuity, refraction, fundoscopy by slit lamp and ending up to optical coherence tomography of Nidek. Mean average peripapillary thickness of nerve fiber layer and thickness in superior, inferior, nasal and temporal quadrants was taken into consideration, calculated by Spectral Domain Optical Coherence Tomography (version 1.5.5.0).
Results: Forty subjects volunteered for study protocol among which 21 were male and 19 were female with a degree of refractive breakdown of 30% mild myopic, 50% moderately myopic and 20% highly myopic. The calculated average age was 25.0 ± 5.0 years (range 16-40 years). The average total nerve fiber layer thickness in myopic respondents was 90.85μm; superiorly 112.37μm; inferiorly 117.52μm; temporally 71.85μm and in nasal quadrant was 61.55μm. Retinal nerve fiber layer thickness was statistically significant in superior and temporal quadrant. In high myopes thickness was clinically significant in inferior quadrant in terms of quantity as compared to mild and moderate myopia
Conclusion: Average retinal nerve fiber layer thickness was significantly decreased in high myopia as compared to mild myopia while moderate group had slightly thicker thickness than high myopic group. Hence impact of dioptric power on nerve fiber layer thickness in myopic patients is significant.
1) A meta-analysis of 14,567 eyes from 37 studies found that femtosecond laser-assisted cataract surgery (FLACS) had similar outcomes to manual phacoemulsification cataract surgery (MCS) in terms of visual acuity and refractive error, but required less time.
2) FLACS produced capsulotomies that were closer to the intended diameter and resulted in more centered intraocular lenses. It also caused less endothelial cell loss and thinner corneas post-operatively.
3) Rates of overall complications were similar between FLACS and MCS, but MCS had a higher risk of posterior capsule tears.
A systematic review of interventions for children with cerebral palsy state ...MaradelRocioHuertaTe
This systematic review analyzed 166 studies across 64 interventions for children with cerebral palsy. The studies were rated using several evidence scales. Sixteen percent of outcomes were rated as highly effective ("green light"), 58% as probably effective with monitoring ("yellow light"), 20% as possibly ineffective ("yellow light"), and 6% as ineffective ("red light"). Effective interventions included anticonvulsants, bimanual training, botulinum toxin injections, casting, and occupational therapy after botulinum toxin. However, most evidence was lower quality and some interventions were found to be ineffective. The review provides an overview of the current evidence for cerebral palsy interventions to guide clinical decision-making.
Automatic eye fixations identification based on analysis of variance and cova...Giuseppe Fineschi
Eye movement is the simplest and repetitive movement that enables humans to interact with the environment. The common daily activities, such as reading a book or watching television, involve this natural
activity, which consists of rapidly shifting our gaze from one region to another. In clinical application, the
identification of the main components of eye movement during visual exploration, such as fixations and
saccades, is the objective of the analysis of eye movements: however, in patients affected by motor control disorder the identification of fixation is not banal. This work presents a new fixation identification
algorithm based on the analysis of variance and covariance: the main idea was to use bivariate statistical
analysis to compare variance overxandyto identify fixation. We describe the new algorithm, and we
compare it with the common fixations algorithm based on dispersion. To demonstrate the performance
of our approach, we tested the algorithm in a group of healthy subjects and patients affected by motor
control disorder
NIRS-BASED CORTICAL ACTIVATION ANALYSIS BY TEMPORAL CROSS CORRELATIONsipij
In this study we present a method of signal processing to determine dominant channels in near infrared spectroscopy (NIRS). To compare measuring channels and identify delays between them, cross correlation is computed. Furthermore, to find out possible dominant channels, a visual inspection was performed. The
outcomes demonstrated that the visual inspection exhibited evoked-related activations in the primary somatosensory cortex (S1) after stimulation which is consistent with comparable studies and the cross correlation study discovered dominant channels on both cerebral hemispheres. The analysis also showed a relationship between dominant channels and adjacent channels. For that reason, our results present a new
method to identify dominant regions in the cerebral cortex using near-infrared spectroscopy. These findings have also implications in the decrease of channels by eliminating irrelevant channels for the experiment.
In this paper we present the use of a signal processing technique to find dominant channels in
near infrared spectroscopy (NIRS). Cross correlation is computed to compare measuring
channels and identify delays among the channels. In addition, visual inspection was used to
detect potential dominant channels. The results showed that the visual analysis exposed painrelated
activations in the primary somatosensory cortex (S1) after stimulation which is
consistent with similar studies and the cross correlation analysis found dominant channels on
both cerebral hemispheres. The analysis also showed a relationship between dominant channels
and neighbouring channels. Therefore, our results present a new method to detect dominant
regions in the cerebral cortex using near-infrared spectroscopy. These results have also
implications in the reduction of number of channels by eliminating irrelevant channels for the
experiment.
CROSS CORRELATION ANALYSIS OF MULTI-CHANNEL NEAR INFRARED SPECTROSCOPYcscpconf
In this paper we present the use of a signal processing technique to find dominant channels in near infrared spectroscopy (NIRS). Cross correlation is computed to compare measuring channels and identify delays among the channels. In addition, visual inspection was used to detect potential dominant channels. The results showed that the visual analysis exposed painrelated activations in the primary somatosensory cortex (S1) after stimulation which is consistent with similar studies and the cross correlation analysis found dominant channels on both cerebral hemispheres. The analysis also showed a relationship between dominant channels
and neighbouring channels. Therefore, our results present a new method to detect dominant regions in the cerebral cortex using near-infrared spectroscopy. These results have also implications in the reduction of number of channels by eliminating irrelevant channels for the experiment.
2. Performance Deficits in a Voluntary Saccade Task in
Chinese ‘‘Express Saccade Makers’’
Paul C. Knox1
*, Nabin Amatya2
, Xiaoyu Jiang2
, Qyong Gong2
1 Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom, 2 Department of Radiology, Centre for Medical
Imaging, Huaxi MR Research Centre, West China Hospital, Sichuan University, Chengdu, China
Abstract
Differences in behaviour and cognition have been observed in different human populations. It has been reported that in
various types of complex visual task, eye movement patterns differ systematically between Chinese and non-Chinese
participants, an observation that has been related to differences in culture between groups. However, we confirm here that,
in healthy, naı¨ve adult Chinese participants, a far higher proportion (22%) than expected (1–5%) exhibit a pattern of
reflexive eye movement behaviour (high numbers of low latency express saccades) in circumstances designed to inhibit
such responses (prosaccade overlap tasks). These participants are defined as ‘‘express saccade makers’’ (ESMs). We then
show using the antisaccade paradigm, which requires the inhibition of reflexive responses and the programming and
execution of voluntary saccades, that the performance of ESMs is compromised; they have higher antisaccade directional
error rates, and the latency distributions of their error saccades again exhibit a higher proportion of low latency express
saccade errors consistent with a reduced ability to inhibit reflexive responses. These results are difficult to reconcile with
a cultural explanation as they relate to important and specific performance differences within a particular population. They
suggest a potential unexpected confound relevant to those studies of Chinese versus other groups which have investigated
group differences using oculomotor measures, and explained them in terms of culture. The confirmation of higher numbers
of ESMs among Chinese participants provides new opportunities for examining oculomotor control.
Citation: Knox PC, Amatya N, Jiang X, Gong Q (2012) Performance Deficits in a Voluntary Saccade Task in Chinese ‘‘Express Saccade Makers’’. PLoS ONE 7(10):
e47688. doi:10.1371/journal.pone.0047688
Editor: Markus Lappe, University of Muenster, Germany
Received May 28, 2012; Accepted September 17, 2012; Published October 16, 2012
Copyright: ß 2012 Knox et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by the National Natural Science Foundation of China (Grant No. ) and a UK Royal Society International Joint Project
grant (Grant No. 30711130226). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
* E-mail: pcknox@liv.ac.uk
Introduction
Over the last decade, cognitive and behavioural differences
between human populations have been reported in a wide range of
studies [1,2,3,4,5,6]. It has recently also been argued that most of
what is currently known about human cognition is based on data
from a strikingly unrepresentative sample of the global human
population [7]. So on the one hand the literature is dominated by
data generated from this narrow participant base, while on the
other when different populations are examined it appears that
brain and behaviour vary systematically for reasons that remain
a matter of debate [8,9].
A useful contrast might be drawn between differences in
cognition (eg in processes such as memory and attention) and
differences in reflexive behaviours. We recently demonstrated
a difference between groups of Chinese and (white) UK
participants in a reflexive saccade task [10]. Express saccades
(ES) are low latency visually-guided saccades that have a distinct
neurophysiological origin [11,12,13]. Although saccade latency is
modified by many factors, and is dependent on task design,
saccades with latency in the range of 80 ms to 130 ms can
reasonably be considered to be ES [10,14]. In circumstances
which greatly decrease the occurrence of express saccades –
prosaccade overlap tasks in which a central fixation target remains
present when the saccade target appears - we found that 29% of
Chinese participants persisted in producing high numbers of ES
compared to only 3% of the UK group. This phenomenon has
been reported previously [15,16], giving rise to the concept of the
‘‘express saccade maker’’ (ESM), a naı¨ve participant who in the
absence of any pathology exhibits a high proportion (.30%) of ES
in overlap conditions. A previous informal estimate suggested that
ESMs are encountered rarely (comprising 1% to 5% of the adult
population [15]); this is consistent with a number of relatively large
saccade studies that did not observe any ESMs [17,18].
Confirmation of high numbers of ESMs among Chinese
participants would provide a new avenue for the investigation of
population differences as well as a means of investigating ESMs in
greater numbers than previously possible. It would also imply
a possible confound in experiments which have found differences
in eye movement patterns between Chinese and non-Chinese
groups and attributed them to culture [19,20]. Where dependant
variables such as fixation time or saccade number have been the
focus of analysis, altered low-level oculomotor performance in the
Chinese group might explain part or all of the group differences in
performance. What we do not yet know is whether the saccade
performance differences in Chinese participants generalise to tasks
beyond the simple reflexive tasks that we used previously.
The links between saccade behavioural measurements and their
underlying neurophysiology are well understood. Therefore,
saccades provide a behavioural means of investigating specific
neural circuits [21]. If in ESMs there is an important general
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81030027
3. alteration in oculomotor processing, then their performance
should be distinguishable from non-ESM participants across
testing paradigms. And their performance in other task types
should provide important additional information allowing stronger
inferences to be made about which specific aspects of the saccade
system (in both functional and anatomical terms) are altered in
ESMs. Finally, if ESMs, defined on the basis of their performance
on reflexive saccade tasks, do perform differently from non-ESM
participants in other task types, this would add validity to their
classification as a distinct group.
We therefore tested a large group of naı¨ve Chinese participants
in order to identify ESMs, and to confirm whether ESMs occurred
in larger numbers than expected. We then used the antisaccade
task [22,23], which requires the participant to inhibit a reflexive
saccade towards a target, and compute and execute a voluntary
saccade to the mirror image of the target position, to explore their
oculomotor control further. Directional errors, composed of error
prosaccades (saccades towards the target), reflect problems
inhibiting reflexive responses. Correct antisaccade latency is
considerably greater than the latency of error prosaccades,
because of both the processing required to inhibit the reflexive
response and to compute the appropriate voluntary saccade.
Antisaccade task performance is critically dependent on a number
of cortical areas, particularly the frontal eye fields (FEF) and
dorsolateral prefrontal cortex (dlPFC) [23].
Materials and Methods
Ethics Statement
Experiments were specifically approved by the West China
Hospital of the University of Sichuan Ethics Committee. All
participants provided their written informed consent and experi-
ments were performed in accordance with the ethical standards
laid down in the Declaration of Helsinki (as modified 2004).
Participants
A total of 77 healthy, naı¨ve, adult participants with normal or
corrected to normal visual acuity were recruited from staff and
students of, and tested in, the West China Hospital, Chengdu,
China. The median age of the group was 24 y (range 19 y–45 y),
and 39 (50%) were male. All were Han Chinese.
Apparatus and Stimuli
Horizontal eye movements were recorded binocularly with the
same miniaturized head-mounted infrared saccadometer (Ad-
vanced Clinical Instrumentation, Cambridge, UK) used in our
previous experiment [10]. This samples infrared reflectance signals
at 1 KHz, and low-pass filters them at 250 Hz with 12-bit
resolution. The device incorporates three low-power red lasers
projecting 13 cd/m2
target spots subtending approximately 0.1u,
in a horizontal line, centrally and at 10u to left and right of centre.
As the stimuli move with the head, participants were not head-
fixed; they sat in a comfortable position approximately 1.5 m in
front of a near-white surface.
We exposed participants to two blocks of trials of two types:
prosaccade overlap and synchronous antisaccade trials. Each block
consisted of two runs of 200 trials (thus we had a potential
maximum of 400 trials of each type). In prosaccade trials after
a randomised fixation time of 1 s–2 s, a saccade target appeared
randomly 10u to the right or left of the central fixation target while
the fixation target remained illuminated. Participants were
instructed to saccade to the eccentric target as soon as they
detected it. These tasks were identical to the prosaccade overlap
tasks that we used previously [10]. In antisaccade trials a synchro-
nous task was used in which after the same variable fixation time
the fixation target was extinguished and a saccade target appeared
randomly 10u to the right or left. Participants were instructed not
to look at the target, but to saccade to its mirror image position ie
10u from the central fixation target, in the opposite direction to the
target. At the beginning of each run we stepped through the task
while giving verbal instructions. We asked participants to respond
as quickly and accurately as they were able, and during the
antisaccade runs provided verbal reminders to ‘‘look in the
opposite direction from the target, but the same distance from
fixation’’. The order of the two prosaccade and antisaccade blocks
was counterbalanced across participants.
Analysis
Data were stored on the Saccadometer handset, and down-
loaded for offline analysis using the supplied software (Latency
Meter 4.0). The latency and amplitude of each prosaccade from
the overlap blocks were collated and saccade latency distributions
calculated for each individual participant. We excluded from the
analysis saccades with a latency of less than 50 ms or more than
500 ms. Median latency and mean saccade amplitude were
calculated for each participant. We also calculated the percentage
of express saccades, that is those saccades with latency in the range
80 ms to 130 ms [14,24]. We defined participants who had greater
than 30% of their saccades in this range as ‘‘express saccade
makers’’ (ESMs [10,15]). For each participant we calculated
antisaccade directional error rate (ie the number of saccades
towards the target in antisaccade tasks, as a percentage of the
total), median prosaccade error latency, and median antisaccade
latency (for all saccades with latency between 50 ms and 700 ms).
For each participant the distribution of these latencies was also
calculated. We also calculated mean saccade amplitude for
prosaccade errors and correct antisaccades.
Results
Prosaccade Tasks
Prosaccade overlap data were obtained for all 77 participants.
The intersubject mean median saccade latency across all 77 was
184632 ms. However, we observed a high number of individual
frequency distributions histograms (Figure 1A,B) in which there
was a clear early latency peak, centred close to 100 ms (Figure 1B;
all the individual frequency distributions histograms are shown in
Supporting Information as Figures S1 and S2). In 17 of the 77
participants (22%), the proportion of saccades with latency in the
range 80 ms to 130 ms (express saccades, ES) exceeded 30%
(Figure 2). We defined these 17 participants as ‘‘express saccade
makers’’ (ESMs) and the remaining participants as ‘‘normal’’.
Mean median latency and percentage of ES for the ESMs were
150622 ms and 43610% compared to 193628 ms and 1267%
for the 60 normals respectively. Both latency (t = 5.67; p,0.0001)
and percentage of express saccades (t = 13.37; p,0.0001) were
statistically significantly different between these two groups.
For each group, the individual percentage distribution histo-
grams for each participant were used to calculate the mean (695%
CI) percentage for each 10 ms histogram bin in order to construct
a mean distribution histogram (Figure 1C,D). This analysis
confirmed a group difference in latency distributions, with the
most noticeable feature being the early peak in the ESM
distribution centred at around 100 ms. However, this analysis
also suggested that this early peak in the ESM distribution was
complemented by later peaks at 160 ms and 210 ms where the
percentages were greater in the normal compared to the ESM
distribution. We compared the mean bin values across the ranges
ESM Antisaccade Performance
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4. 80 ms to 130 ms (the express saccade range; Figure 1C, range 1),
150 ms to 180 ms (range 2), and 200 ms to 230 ms (range 3)
between the two groups. For each range the data were analysed
with a repeated measures ANOVA, treating ‘‘latency bin’’ as
a within subjects factor and group (normal vs ESM) as a between
subjects factor. For all three ranges the effect of group was
statistically significant (F1,74 = 577, 153 and 233 respectively, all
p,0.001).
Antisaccade Tasks
Of the 17 ESM participants, antisaccade data were obtained for
16. Subsequent analysis is based on this group of 16 ESMs
(median age 24 y, 7 males) compared to a group of 60 normal
participants (median age 23.5 y, 30 males). ESM antisaccade
directional error rate (41624%; Figure 3A) was statistically
significantly higher (t = 2.5, p = 0.01) compared to the normal
participants (28616%). Error pro-saccade latency (ie saccades
directed at the target in the antisaccade task, ErrPS) and correct
antisaccade latency (CorAS) were analysed. For all bar one of the
normal participants, and all of the ESMs, median ErrPS latency
was less than that of CorAS latency. However, the intersubject
mean difference between the medians (CorAS-ErrPS) was
97654 ms and 127645 ms for the normal and ESM groups
respectively; this difference was statistically significant (t = 2.01,
p,0.05). The reason for this greater difference in the EMSs was
that while CorAS latency was identical between the groups
(Figure 3C; Norm: 290661 ms vs ESM:290637 ms), the ErrPS
latency was lower in the ESMs (Figure 3B; Norm:193631 ms vs
ESM: 164635 ms). When investigated with a repeated measures
ANOVA with saccade type (ErrPS vs CorAS) as a within subjects
factor, and group (Norm vs ESM) as a between subjects factor,
saccade type was significant (F1,74 = 233.9, p,0.001) while group
was not (F1,74 = 1.9, p = 0.187). The interaction between type and
group was statistically significant (F1,74 = 4.1, p = 0.045).
We examined the influence of target direction on the generation
of errors by calculating the directional error rate separately for
each participant in each direction (Figure 4). Note that by target
direction we are referring to the side on which the visual target was
presented, not the required direction of a correct antisaccade. For
normal participants there was very little difference in the rightward
(29619%) and leftward (20620%) error rates, with 29/60
participants (48%) having a larger absolute error rate for
rightward targets. For the ESMs there was more evidence of an
asymmetry with the rightward mean error rate (42620%) slightly
higher than the leftward (38626%); 11/16 (69%) exhibited higher
error rates when targets were presented on the right.
We examined the distribution of CorAS and ErrPS latencies in
the two groups by plotting mean (695% CI) distribution
Figure 1. Percentage frequency distribution histograms of
saccade latency in the prosaccade overlap task. A. Example from
an individual ‘‘normal’’ subject; B. individual ESM. In A. and B. the
median saccade latency, and the percentage of express saccades is
shown. C. Mean695%CI distribution for 60 ‘‘normal’’ subjects. D.
Mean695%CI distribution for 16 ESMs. In C. and D. the intersubject
mean (6SD) of the individual median latencies and the intersubject
mean (6SD) percentage of express saccades is shown. The vertical grey
region shows the range of express saccade latency (80 ms to 130 ms)
and the dotted vertical line is at 100 ms. The three horizontal grey bars
in C. show the three latency ranges (1 to 3) over which latency was
compared between ESMs and normal subjects.
doi:10.1371/journal.pone.0047688.g001
Figure 2. Data from prosaccade task. A. Plot of the percentage of express saccades against median prosaccade latency. B. Distribution of
percentage of express saccades in the prosaccade task. Vertical dashed line shows the criterion used to define an ESM (30% ES in the prosaccade
task). Columns to the right of this line show counts of ESMs.
doi:10.1371/journal.pone.0047688.g002
ESM Antisaccade Performance
PLOS ONE | www.plosone.org 3 October 2012 | Volume 7 | Issue 10 | e47688
5. histograms for each saccade type in each of the groups (Figure 5).
While the distribution of CorrAS latency was identical, the lower
mean latency for ESM ErrPS latency was explained by
a prominent early peak in the distribution, which (as in overlap
tasks) occurred in the express saccade range. The mean proportion
of ErrPS with latencies in the express range was 36626%. This
contrasted with the normal group in whom there were fewer errors
with latency in the express range (11611%). The difference
between these percentages was statistically significant (t = 5.69,
p,0.0001).
Relationship between Overlap and Antisaccade
Performance
The two groups, defined on the basis of their performance on
the prosaccade task, exhibited different patterns of performance in
the antisaccade task. What then of the relationship between
performance in the two different tasks? Performance in the
prosaccade task was summarised using median saccade latency for
each participant and the percentage of express saccades. We
investigated the relationship between these parameters and
antisaccade directional error rate (expressed as a percentage)
and median ErrPS latency (Figure 6). Antisaccade directional
error rate was correlated both with the median latency in the
prosaccade task (Figure 6A; r = 20.33, p = 0.003) and with the
percentage of express saccades (6B; r = 0.36, p = 0.002). Correla-
tion coefficients were slightly higher between the median
prosaccade latency and antisaccade error prosaccade latencies
(6C; r = 20.55, p,0.0001) and percentage of express saccades in
prosaccade tasks and antisaccade prosaccade error latency (6D;
r = 0.43, p,0.0001). The highest correlation coefficient was
observed for the relationship between the percentage of express
saccades in prosaccade tasks, and the percentage of ErrPS that
were express saccades (Figure 6E; r = 0.63, p,0.0001). We also
examined whether a general difference in the speed of prosaccade
and antisaccade systems might have a strong influence on
directional error rate. For each participant we calculated the
difference between the median correct antisaccade latency and the
median prosaccade latency, and plotted this against the anti-
saccade directional error rate (Figure 6f). While there was a positive
correlation, it was modest (r = 0.32, p = 0.004).
Discussion
Our first objective was to establish the proportion of express
saccade maker participants (ESMs) in a large group of healthy,
adult, naı¨ve Chinese participants using a prosaccade overlap task,
identical to that used in our previous study [10]. In such tasks, the
central fixation target remains illuminated when the eccentric
saccade target appears. Compared to prosaccade gap tasks, the
continued presence of the fixation target provides no visual
warning signal of the imminent appearance of the saccade target
caused by early fixation offset, and makes fixation disengagement
more difficult. This usually results in an increase in saccade latency
and a reduction in express saccades [24,25].
Previous estimates [15] and studies in which relatively large
numbers of participants had been tested [17], suggest that ESMs
comprise no more than 5% of healthy adults. In our earlier
experiment [10] 29% of a naı¨ve Chinese group were ESMs
compared to 3% in a UK group. In the current study 17/77 (22%)
were ESMs. Thus ESMs were again encountered much more
frequently than expected.
We have used the criterion employed previously [10] as
developed in the original reports on ESMs [15,16] to divide the
Chinese participants into two groups (ESMs and ‘‘Norms’’). While
consistent with the previous literature, it might be argued that we
have dichotomised what is continuous, producing groups where
there is in fact a continuum. However, as plotted in Figure 2, the
data suggest that the 30% ES criterion does capture something
that other parameters (eg median prosaccade latency) do not. We
reported previously that the distribution of %ES in Caucasian and
Chinese groups is different (Figure 5 in [10]), with no occurrence
in the Caucasian data of the bulge that appears to the right of the
criterion line in Figure 2B. The data do not appear to be consistent
with the hypothesis that the distribution of this parameter is simply
shifted to the right in the Chinese group as a whole. There
continue to be many Chinese participants who in overlap
conditions execute few ES, who are indistinguishable from their
Caucasian counterparts. The difference between the two popula-
tions is the occurrence of the high number of participants in the
Chinese population who execute many ES in prosaccade overlap
conditions, defined here as ESMs.
While the 30% criterion is to some extent arbitrary, it is not
equivalent to other procedures such as performing a median split
on a continuous variable. In fact the median proportion of ES for
our dataset of 76 participants is 15%. The higher 30% criterion
was originally adopted because it identified a particular type of
naı¨ve participant [15]. Our main aim in the current experiment
was to investigate how participants meeting this criterion behave
in a voluntary saccade task (the antisaccade task).
The difference between the ESMs, defined as discussed above,
and other participants was not a simple speeding of saccade
reaction times. There was considerable overlap between the
Figure 3. Data from antisaccade tasks. Comparison of
mean695%CI between 60 normal (non-ESM) subjects and 16 ESMs.
A. Antisaccade directional error rate. B. Mean error pro-saccade latency.
C. Mean correct antisaccade latency. Note different y-axis scales in B and
C.
doi:10.1371/journal.pone.0047688.g003
Figure 4. Influence of target direction (Left vs Right) on the
antisaccade directional error rate (%) for A. Normal participants; B
ESMs. Solid line is the line of equality (x = y).
doi:10.1371/journal.pone.0047688.g004
ESM Antisaccade Performance
PLOS ONE | www.plosone.org 4 October 2012 | Volume 7 | Issue 10 | e47688
6. groups in terms of their median saccade latencies (Figure 2A).
However, average frequency distribution histograms (Figure 1)
demonstrated an alteration of the relative proportions of saccades
within latency ranges falling close to those suggested previously for
express, fast and slow regular saccades [24]. The ESMs exhibited
both a selective overproduction of express saccades, and a compli-
mentary underproduction of saccades of longer latency. The
distributions also confirmed that a latency range of 80 ms to
130 ms captured the ‘‘express peak’’ previously encountered
infrequently in healthy naı¨ve participants in prosaccade overlap
tasks [24,26]. In addition, the non-overlapping 95% confidence
intervals suggest that the criterion we have used produces a clear
separation of the two groups. The normal group exhibited saccade
distributions essentially indistinguishable from those reported in
many other studies.
Our second objective was to compare ESM and normal
participants, defined on the basis of their performance in the
prosaccade task, using the antisaccade task [23,27]. Antisaccades
require the inhibition of responses towards a suddenly appearing
target (an error prosaccade), the transformation of the stimulus
position into a voluntary motor command, and the execution of
a voluntary saccade (the correct antisaccade) to the mirror image
position of the stimulus. Antisaccade directional error rate was
higher in the ESMs (41624%) compared to the normal subjects
(28616%). While the distribution of correct antisaccade latency
for ESM and normal groups was identical, a large express peak
persisted in the ESM error prosaccade latency distribution. We
also observed, that in the ESMs there was a slight asymmetry in
the directional error rate; the rate tended to be higher when the
target appeared to the right of fixation. This may be related to the
production of ES, for which there is also a slight asymmetry, with
more ES generated with targets on the right.
Directional error rates vary between studies, and are affected by
diverse methodological issues such as prior participant experience,
task instructions, target eccentricity and number [27,28]. We used
consistent methods and instructions across all participants and
counterbalanced the order of overlap and antisaccade runs. We
were explicit about instructing participants not simply to look in
the opposite direction to the target, but to look to the mirror image
position of the target. A synchronous antisaccade task was used
(the saccade target appeared when the fixation target was
extinguished) as opposed to a gap antisaccade task which
encourages both the production of lower latency responses and
express saccade errors [29]. An error rate of 23617% for
a synchronous task (albeit with targets appearing at a range of
eccentricities from 2u to 10u) for a large sample of over 2000 young
men aged between 18 y and 24 y has been reported previously
[30]. This compares reasonably well with the error rate in our
normal participants (28616%). Given the variability in directional
error rate in this and in many other studies, how should we
interpret the difference we observed? A complementary approach
is to calculate the difference as an ‘‘effect size’’. Often this is the
effect size of an intervention (eg the comparison of some
measurement in a treated group versus the same measurement
in an untreated group). Here we compared the directional error
rate in the ESM and normal groups using Cohen’s d [31,32]. The
computed ‘‘effect size’’ (ie the standardised magnitude of the
difference in error rate) was 0.69; this is considered to be a medium
to large effect size [31,32].
Evdokimidis et al [30] plotted pooled latency distributions for
both correct antisaccades and error prosaccades for their large
sample. For correct antisaccades they showed a broad unimodal
distribution with a mean (6SD) of 270639 ms, similar to what we
observed in both ESM (290637 ms ) and normal groups
(290661 ms; Figure 5A,C). Their distribution of error prosaccades
was also unimodal (mean 208638 ms) with no responses at
a latency of less than 120 ms. This is broadly similar to what we
observed in normal participants (with regard to both the mean and
variability; Figure 5B), but very different to the ESMs, where we
observed both a large peak in the express range and a reduction in
the proportion of saccades with longer latencies (Figure 5D). The
second peak in the ESM distribution is at 160 ms, precisely where
the main peak is in the distribution for the normal participants.
While in the normal participant distribution there were some
errors in the express range (11611%), the proportion was much
smaller than in the ESMs (36626%). It is the generation of this
population of express saccades that produces the overall statisti-
cally significant reduction in error prosaccade latency in the
ESMs, not a generalised shift of a unimodal distribution to the left.
Thus, in circumstances where participants would be expected to
inhibit reflexive responses, and in which they are aided by the use
of a synchronous task rather than a gap task, ESMs continue to
exhibit high proportions of express saccades.
There were a number of relationships between parameters in
the prosaccade and antisaccade tasks. Participants with lower
median prosaccade saccade latency tended to be those with higher
antisaccade directional error rates (Figure 6A) and lower
antisaccade error prosaccade latency (Figure 6C). However, as
discussed above, the ESMs exhibit a selective overproduction of
saccades within a particular latency range, not a general reduction
in saccade latency. Therefore median latency in the prosaccade
task poorly captures the difference between groups, with consider-
able overlap between normal and ESM participants. Not
surprisingly when the data are plotted using the percentage of
express saccades in prosaccade tasks, a clearer pattern emerges
(Figure 6B,D). In common with other studies in which these
Figure 5. Mean695%CI distributions for 60 normal subjects
(A,B) and 16 ESMs (C,D) for correct antisaccades (A,C) and
error prosaccades (B,D). The grey region shows the express saccade
latency range (80 ms to 130 ms). The intersubject mean of the
individual subject median latencies (6SD), and the intersubject
percentage of express saccades is also shown.
doi:10.1371/journal.pone.0047688.g005
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7. various relationships have been examined, the correlations, while
statistically significant, were relatively weak [33,34]. The highest
correlation coefficient was for the relationship between the
percentage of express saccades in prosaccade tasks and pro-
saccade errors in the antisaccade task. This is consistent with the
hypothesis that pro-saccade errors in the antisaccade task are
uninhibited reflexive responses to the target. ESMs were relatively
unsuccessful at inhibiting reflexive responses (hence the higher
directional error rate), but as will be discussed below this could be
a consequence of the low latency nature of their reflexive
responses.
A number of models have been developed which seek to explain
patterns of saccade latency. Accumulator models describe saccade
triggering in terms of a decision signal rising from a baseline to
a threshold; when the threshold is crossed, a saccade is initiated
[35]. Saccade latency modulations are related to changes in the
baseline level of activity, the rate of rise of the decision signal or the
level of the threshold [36]. For antisaccades, competitive race
accumulator models [37] assume that a prosaccade decision signal
(initiated by the appearance of the target, and therefore
exogenously triggered) and an antisaccade decision signal (gener-
ated internally and therefore usually considered to be endogenous)
‘‘race’’ each other towards threshold. If the prosaccade signal
‘‘wins’’, a prosaccade error is the result; if the antisaccade signal
‘‘wins’’, a correct antisaccade is the result. On this account it is the
inability of ESMs to successfully inhibit low latency prosaccades
(many in the express latency range) that explains their perfor-
mance in antisaccade tasks (higher error rates, lower prosaccade
Figure 6. Relationship between prosaccade (PS) and antisaccade (AS) performance. A. Median prosaccade latency and AS directional error
rate. B. Percentage of express saccades in the PS task and AS directional error rate. C. Median PS latency and median AS prosaccade error latency. D.
Percentage of express saccades in the PS task and median AS error prosaccade latency (AS). E. Percentage of express saccades in the PS task and
percentage of ES in AS prosaccade errors. F. The difference between correct AS latency and PS latency calculated for each subject, and AS directional
error rate. On each plot the solid black line is the least-squares linear regression line calculated for the whole dataset. Data from ESMs: grey symbols;
data from normal subjects: black symbols.
doi:10.1371/journal.pone.0047688.g006
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8. error latencies), the close similarity between the average distribu-
tions for the prosaccade task (eg Figure 1D) and the antisaccade
prosacccade error distributions (Figure 5D), and the correlation
between the percentage of express saccades in prosaccade and
antisaccade tasks. The dissimilarity in the ESM distributions
(higher express peak, and lower subsequent peaks in prosaccade
compared to prosaccade error distributions) could be explained by
our using a synchronous rather than overlap antisaccade task.
One appealing aspect of accumulator models in general, and
race models in particular, is that various model elements appear to
map to specific saccade-related neurophysiological structures and
processes in a relatively straightforward manner [23,38]. Indeed
the underlying neurophysiology, particularly with respect to the
superior colliculus is a key component of some models [39,40].
The rate of rise of activity in saccade related neurons in both
frontal eye fields (FEF) [41] and the superior colliculus (SC)
[13,42] is related to saccade latency. There is some evidence that
the trigger threshold is relatively fixed [41,43], while pretarget
activity levels vary systematically in both FEF [44]and SC [13].
Compared to pretarget activity levels in both the FEF and SC
when a normal latency saccade is executed, pretarget activity is
increased prior to an express saccade, leading to the visual
response in the SC being sufficient to trigger a saccade [12,13].
Pretarget activity levels in both the SC and FEF are also relatively
higher in prosaccade errors relative to correct antisaccades
[44,45]. In both cases, the behavioural result (an express saccade
or prosaccade error) is explained in terms of increased pretarget
activity in the SC; the decision signal rises from a higher baseline,
and assuming a constant rate of rise and threshold, crosses
threshold triggering a saccade earlier than would otherwise be the
case. However, note that in the antisaccade task, a general increase
in pretarget activity in the SC in ESMs, would imply higher
antisaccade directional error rates and decreased prosaccade error
latencies (which we observed) and decreased antisaccade latencies
(which we did not observe). A change in trigger threshold at the
level of the SC would also imply linked alteration in both error
prosaccades and correct antisaccades. Rather, our results suggest
that in ESMs there is a specific alteration in the timing and
variability of reflexive prosaccades, perhaps related to descending
inhibitory control, which compromises their performance in the
antisaccade task.
Descending inhibitory control in the oculomotor system
involves a number of cortical areas (FEF; dlPFC; supplementary
eye fields; parietal eye fields). Frontal lesions in humans have been
shown to increase antisaccade directional error rates [46], with
most recent attention directed at dlPFC [47,48]. However, effects
on saccade, prossacade error and antisaccade latency were either
not reported in these studies, or the results were unclear. Increased
directional error rates have been produced in healthy humans
using TMS of the dlPFC [49], and deactivation of dlPFC in
monkeys using cooling [50]. However, microstimulation of dlPFC
has also been shown to increase error rates, and increase saccade
latency [51]. Given this background, it would be unwise to claim
that a specific alteration in dlPFC can explain the pattern of results
observed in the ESMs [52]. However, a specific and circumscribed
alteration of frontal function in the ESMs, affecting inhibition of
reflexive responses, leading to poorer performance in the
antisaccade task, might explain our observations.
Given that in ESMs a high proportion of express saccades
persists even in a testing paradigm which requires high levels of
inhibition, it seems likely that they may also persist in other task
contexts [53]. Thus in comparing Chinese and other participant
groups (in which ESMs remain rare) using a range of oculomotor
based measures, a low level effect (high numbers of express
saccades in a large proportion of Chinese participants) not related
to task context might bias dependant measures and be mistakenly
assumed to be driven by cultural differences between groups. For
example, Chinese groups have been observed to make more
fixations and have shorter fixation times in scene processing tasks,
compared to non-Chinese participants [19,20]. But suppose that
a large proportion of the Chinese participants executed the
equivalent of express saccades while scanning scenes (presumably
sequences of saccades with short fixation durations), this might
increase the average number of saccades and reduce average
fixation duration compared to a group that did not contain a high
proportion of ESMs.
The cultural neuroscience literature assumes that environment
(broadly constructed to include everything from the physical
environment to the general cultural milieu) acts on a basically
similar neurophysiological substrate to produce observed differ-
ences between population groups (ie distinct cultural groups). Our
results demonstrate a difference in reflexive oculomotor control
within a particular cultural group. While that there were
undoubtedly many ways in which the habits and environments
of our individual participants differed, it is difficult to see how
these might produce the specific alteration in saccade function we
have observed. Our results could imply a difference in neuro-
physiological substrate, at least as far as eye movement control is
concerned, not primarily related to culture.
It has recently been demonstrated that for certain relevant
functions such as attentional processing [8] and eye movement
strategies during face processing [9] ethnicity (or at least continent
of origin) rather than culture is a key determinant of performance.
For the difference between Chinese and non-Chinese groups we
have observed, it remains to be established whether the high
proportion of ESMs persist in Chinese groups whose main cultural
exposure is non-Chinese.
Supporting Information
Figure S1 Individual frequency distribution histograms
of latency for the 16 ESMs. In each plot the median
prosaccade latency, and the percentage of express saccades is
shown. Plots are ordered by %ES, from highest (top left) to lowest
(bottom right).
(TIF)
Figure S2 Individual frequency distribution histograms
for 60 normal participants. Conventions as for Figure S1.
(TIF)
Author Contributions
Conceived and designed the experiments: PCK QG. Performed the
experiments: PCK NA XJ. Analyzed the data: PCK. Contributed
reagents/materials/analysis tools: PCK QG. Wrote the paper: PCK.
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