This short talk covers some of the things we learned about TB outbreaks in street-involved population as a a result of a genomic investigation we carried out in BC over several years.
Declaring a TB outbreak over with genomicsJennifer Gardy
1) A tuberculosis outbreak that began in 2008 in Central Okanagan, BC and resulted in 52 cases by 2014 was declared over in late 2014.
2) Genome sequencing of TB bacteria from outbreak cases identified transmission ended around 2012, with no evidence of ongoing transmission by 2014.
3) Declaring the outbreak over will allow health authorities to transition from outbreak response to preventing future outbreaks through addressing social determinants of health.
This document provides tips for designing effective posters. It discusses determining the audience and purpose of the poster, using a clear storytelling structure, and visualizing data through tools like Canva and Piktochart. Effective design techniques are outlined such as using space, varying font sizes and styles, choosing readable colors, and labeling figures. Open-source images and minimizing logos are also recommended. Overall the document gives guidance on developing the content, structure, and visual design of a poster presentation.
Satya Nadella has been certified as a Microsoft Certified Professional with certification number F349-6411 achieved on June 14, 2015. The certification is for Part No. X18-83700 and recognizes that Satya Nadella has successfully completed the requirements.
The document announces the 2016-2017 participants of the Nurse Faculty Leadership Academy (NFLA), a 20-month mentoring program administered by Sigma Theta Tau International (STTI) with funding from The Elsevier Foundation. The NFLA pairs early career nurse faculty ("scholars") with experienced faculty mentors to develop leadership skills and promote nurse faculty retention. The announcement lists the 16 scholar participants, 15 leadership mentors, and faculty advisors for the 2016-2017 cohort. The NFLA aims to foster academic success, leadership development, and supportive work environments for nurse educators.
Declaring a TB outbreak over with genomicsJennifer Gardy
1) A tuberculosis outbreak that began in 2008 in Central Okanagan, BC and resulted in 52 cases by 2014 was declared over in late 2014.
2) Genome sequencing of TB bacteria from outbreak cases identified transmission ended around 2012, with no evidence of ongoing transmission by 2014.
3) Declaring the outbreak over will allow health authorities to transition from outbreak response to preventing future outbreaks through addressing social determinants of health.
This document provides tips for designing effective posters. It discusses determining the audience and purpose of the poster, using a clear storytelling structure, and visualizing data through tools like Canva and Piktochart. Effective design techniques are outlined such as using space, varying font sizes and styles, choosing readable colors, and labeling figures. Open-source images and minimizing logos are also recommended. Overall the document gives guidance on developing the content, structure, and visual design of a poster presentation.
Satya Nadella has been certified as a Microsoft Certified Professional with certification number F349-6411 achieved on June 14, 2015. The certification is for Part No. X18-83700 and recognizes that Satya Nadella has successfully completed the requirements.
The document announces the 2016-2017 participants of the Nurse Faculty Leadership Academy (NFLA), a 20-month mentoring program administered by Sigma Theta Tau International (STTI) with funding from The Elsevier Foundation. The NFLA pairs early career nurse faculty ("scholars") with experienced faculty mentors to develop leadership skills and promote nurse faculty retention. The announcement lists the 16 scholar participants, 15 leadership mentors, and faculty advisors for the 2016-2017 cohort. The NFLA aims to foster academic success, leadership development, and supportive work environments for nurse educators.
El documento presenta al Ingeniero Celso Carreiro Barco y recomienda sus cualidades. Explica que entre 2012 y 2014, Carreiro lideró el equipo de desarrollo de herramientas de software para el análisis genómico del maíz y trigo como parte de un proyecto. También destaca su implementación exitosa de una nueva estrategia de sistemas de información para garantizar soluciones flexibles e integradas. Finalmente, el autor recomienda ampliamente a Carreiro debido a sus cualidades humanas, preparación ac
The poem "The Laburnum Top" describes a goldfinch settling onto the top of a Laburnum tree in the late afternoon sunlight. The goldfinch enters the tree's branches abruptly, like a lizard, stirring the branches and thrilling the whole tree. It stokes the tree by shaking up its branches, then flits to the end of a branch, revealing its barred face before launching away with a delicate whistle, causing the laburnum tree to subside once more into stillness.
SMBE Satellite Meeting on Pathogen Evolution and TransmissionJennifer Gardy
This document discusses the use of genomics in public health tuberculosis (TB) research and outlines key studies and findings over time. It begins with early work in 2008-2010 sequencing 36 genomes from a Port Alberni outbreak to understand transmission. From 2011-2013, 40-52 genomes were analyzed from a Kelowna outbreak to infer transmission patterns and evaluate outbreak control strategies. A later study sequenced over 276 genomes from Vancouver from 2005-2014 to analyze TB epidemiology and trends in British Columbia. Ongoing work aims to use genomics to rapidly detect drug resistance for improved diagnosis and outbreak detection, including analyzing suspected lab contamination events. The field continues advancing with new techniques to study rare variants with the goal of sequencing over 750 TB
SNP Calling & Outbreak Reconstruction in a Monomorphic PathogenJennifer Gardy
This document contains variant call format (VCF) data from whole genome sequencing of Mycobacterium tuberculosis isolates. The VCF contains single nucleotide polymorphisms (SNPs) identified by comparing isolate genomes to a reference genome. Key information provided for each variant includes position, reference and alternate alleles, quality metrics, and genotype information for an isolate sample. The data can be used for outbreak investigation and phylogenetic analysis to study transmission of the pathogen.
2014 BERHAMPORE LIPIKA MEMORIAL GIRLS HIGH SCHOOL GOLDEN JUBILEE QUIZ (ROUND-1)Saswata Chakraborty
BERHAMPORE LIPIKA MEMORIAL GIRLS HIGH SCHOOL GOLDEN JUBILEE QUIZ (ROUND-1)
DATE: SEPTEMBER 06, 2014
PLACE: LIPIKA MEMORIAL AUDITORIUM
PARTICIPANTS: SECONDARY LEVEL SCHOOL STUDENTS (SCHOOLS AROUND THE AREA)
This document discusses how genomics is revolutionizing public health microbiology. It provides three examples:
1) Rapid WGS-based diagnosis identified Leptospira bacteria in a patient's cerebrospinal fluid, allowing targeted penicillin treatment that resolved his illness within two weeks.
2) WGS-based drug sensitivity testing allows personalized therapy by predicting resistance from a pathogen's genome within 1 day, compared to weeks for conventional methods.
3) Genomic epidemiology tracks person-to-person disease spread by comparing whole genomes from outbreak isolates. This approach helped determine the key locations and time period fueling a TB outbreak in BC, and later demonstrated transmission had ended.
This document provides instructions and questions for rounds of a quiz competition between multiple teams. It outlines the scoring system and rules, including points awarded for correct answers within the time limit and penalties for incorrect or out-of-turn responses. The quiz covers topics like geography, history, mythology, sports, logos and books. Each round is focused on a different subject area and includes 10-12 multiple choice or short answer questions to test the teams' knowledge.
Whole genome sequencing as a starting point to understanding antimicrobial re...Jennifer Gardy
Slides from my Sunday, June 19 symposium talk on using genomics as a tool for understanding antimicrobial resistance at the ASM Microbe 2016 conference.
Interpreting genomic variation and phylogenetic trees to understand disease t...Jennifer Gardy
The document discusses using genomic sequencing data and phylogenetic trees to understand disease transmission. It provides an example of using whole genome sequencing to determine that multiple tuberculosis isolates showing identical molecular typing patterns were the result of laboratory contamination rather than transmission. The importance of high quality sequencing data and appropriate bioinformatics analysis is emphasized. Methods for manually inferring transmission by examining mutation patterns in isolates in the context of epidemiological data are described. Mathematical approaches that use phylogenetic trees to probabilistically infer transmission are also discussed.
The document provides a summary of the short story "The Last Lesson" by Alphonse Daudet. It describes how in 1870 Prussian forces captured the French regions of Alsace and Lorraine. The new Prussian rulers then discontinued the teaching of French in schools in those regions and asked French teachers to leave. The story focuses on the last day of school for a French teacher named M. Hamel, as he is transferred out after many years of teaching. It depicts the sadness felt by both teacher and students at losing their French language and teacher.
HBaseCon 2013: A Developer’s Guide to CoprocessorsCloudera, Inc.
This document discusses coprocessors in HBase, which allow arbitrary code to run on each region server. It provides examples of using coprocessors for observers that react to events and endpoints that clients can explicitly call. The examples include expanding single-row JSON data into multiple columns, collecting real-time analytics, and optimizing searches through endpoints.
Scopeo Valladolid. La Web 2.0 a tu alcance: herramientas y sistemas audiovisu...Gorka J Palacio Arko
Web 2.0 a tu alcance se llama la jornada de TIC y Educación organizada por Scopeo en la Facultad de Educación de la Universidad de Valladolid (calle Paseo de Belén 1; campus Miguel Delibes). Es el primero de los eventos educativos que se van a organizar en Castilla y León con el fin de formar a profesores e investigadores de las universidades castellano-leonesas. Esta es mi presentación sobre la educación colaborativa, las herramientas y actitudes Web 2.0 y las aplicaciones audiovisuales y virtuales que nos hacen las acciones formativas más efectivas (casi siempre).
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
El documento presenta al Ingeniero Celso Carreiro Barco y recomienda sus cualidades. Explica que entre 2012 y 2014, Carreiro lideró el equipo de desarrollo de herramientas de software para el análisis genómico del maíz y trigo como parte de un proyecto. También destaca su implementación exitosa de una nueva estrategia de sistemas de información para garantizar soluciones flexibles e integradas. Finalmente, el autor recomienda ampliamente a Carreiro debido a sus cualidades humanas, preparación ac
The poem "The Laburnum Top" describes a goldfinch settling onto the top of a Laburnum tree in the late afternoon sunlight. The goldfinch enters the tree's branches abruptly, like a lizard, stirring the branches and thrilling the whole tree. It stokes the tree by shaking up its branches, then flits to the end of a branch, revealing its barred face before launching away with a delicate whistle, causing the laburnum tree to subside once more into stillness.
SMBE Satellite Meeting on Pathogen Evolution and TransmissionJennifer Gardy
This document discusses the use of genomics in public health tuberculosis (TB) research and outlines key studies and findings over time. It begins with early work in 2008-2010 sequencing 36 genomes from a Port Alberni outbreak to understand transmission. From 2011-2013, 40-52 genomes were analyzed from a Kelowna outbreak to infer transmission patterns and evaluate outbreak control strategies. A later study sequenced over 276 genomes from Vancouver from 2005-2014 to analyze TB epidemiology and trends in British Columbia. Ongoing work aims to use genomics to rapidly detect drug resistance for improved diagnosis and outbreak detection, including analyzing suspected lab contamination events. The field continues advancing with new techniques to study rare variants with the goal of sequencing over 750 TB
SNP Calling & Outbreak Reconstruction in a Monomorphic PathogenJennifer Gardy
This document contains variant call format (VCF) data from whole genome sequencing of Mycobacterium tuberculosis isolates. The VCF contains single nucleotide polymorphisms (SNPs) identified by comparing isolate genomes to a reference genome. Key information provided for each variant includes position, reference and alternate alleles, quality metrics, and genotype information for an isolate sample. The data can be used for outbreak investigation and phylogenetic analysis to study transmission of the pathogen.
2014 BERHAMPORE LIPIKA MEMORIAL GIRLS HIGH SCHOOL GOLDEN JUBILEE QUIZ (ROUND-1)Saswata Chakraborty
BERHAMPORE LIPIKA MEMORIAL GIRLS HIGH SCHOOL GOLDEN JUBILEE QUIZ (ROUND-1)
DATE: SEPTEMBER 06, 2014
PLACE: LIPIKA MEMORIAL AUDITORIUM
PARTICIPANTS: SECONDARY LEVEL SCHOOL STUDENTS (SCHOOLS AROUND THE AREA)
This document discusses how genomics is revolutionizing public health microbiology. It provides three examples:
1) Rapid WGS-based diagnosis identified Leptospira bacteria in a patient's cerebrospinal fluid, allowing targeted penicillin treatment that resolved his illness within two weeks.
2) WGS-based drug sensitivity testing allows personalized therapy by predicting resistance from a pathogen's genome within 1 day, compared to weeks for conventional methods.
3) Genomic epidemiology tracks person-to-person disease spread by comparing whole genomes from outbreak isolates. This approach helped determine the key locations and time period fueling a TB outbreak in BC, and later demonstrated transmission had ended.
This document provides instructions and questions for rounds of a quiz competition between multiple teams. It outlines the scoring system and rules, including points awarded for correct answers within the time limit and penalties for incorrect or out-of-turn responses. The quiz covers topics like geography, history, mythology, sports, logos and books. Each round is focused on a different subject area and includes 10-12 multiple choice or short answer questions to test the teams' knowledge.
Whole genome sequencing as a starting point to understanding antimicrobial re...Jennifer Gardy
Slides from my Sunday, June 19 symposium talk on using genomics as a tool for understanding antimicrobial resistance at the ASM Microbe 2016 conference.
Interpreting genomic variation and phylogenetic trees to understand disease t...Jennifer Gardy
The document discusses using genomic sequencing data and phylogenetic trees to understand disease transmission. It provides an example of using whole genome sequencing to determine that multiple tuberculosis isolates showing identical molecular typing patterns were the result of laboratory contamination rather than transmission. The importance of high quality sequencing data and appropriate bioinformatics analysis is emphasized. Methods for manually inferring transmission by examining mutation patterns in isolates in the context of epidemiological data are described. Mathematical approaches that use phylogenetic trees to probabilistically infer transmission are also discussed.
The document provides a summary of the short story "The Last Lesson" by Alphonse Daudet. It describes how in 1870 Prussian forces captured the French regions of Alsace and Lorraine. The new Prussian rulers then discontinued the teaching of French in schools in those regions and asked French teachers to leave. The story focuses on the last day of school for a French teacher named M. Hamel, as he is transferred out after many years of teaching. It depicts the sadness felt by both teacher and students at losing their French language and teacher.
HBaseCon 2013: A Developer’s Guide to CoprocessorsCloudera, Inc.
This document discusses coprocessors in HBase, which allow arbitrary code to run on each region server. It provides examples of using coprocessors for observers that react to events and endpoints that clients can explicitly call. The examples include expanding single-row JSON data into multiple columns, collecting real-time analytics, and optimizing searches through endpoints.
Scopeo Valladolid. La Web 2.0 a tu alcance: herramientas y sistemas audiovisu...Gorka J Palacio Arko
Web 2.0 a tu alcance se llama la jornada de TIC y Educación organizada por Scopeo en la Facultad de Educación de la Universidad de Valladolid (calle Paseo de Belén 1; campus Miguel Delibes). Es el primero de los eventos educativos que se van a organizar en Castilla y León con el fin de formar a profesores e investigadores de las universidades castellano-leonesas. Esta es mi presentación sobre la educación colaborativa, las herramientas y actitudes Web 2.0 y las aplicaciones audiovisuales y virtuales que nos hacen las acciones formativas más efectivas (casi siempre).
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
The debris of the ‘last major merger’ is dynamically youngSérgio Sacani
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
BREEDING METHODS FOR DISEASE RESISTANCE.pptxRASHMI M G
Plant breeding for disease resistance is a strategy to reduce crop losses caused by disease. Plants have an innate immune system that allows them to recognize pathogens and provide resistance. However, breeding for long-lasting resistance often involves combining multiple resistance genes