This document provides guidance on completing continuing review forms for research studies requiring ongoing institutional review board approval. It discusses the timing of continuing review, the review process, and steps for completing the form successfully. Investigators are advised to get off to a good start by being consistent, accurate, thorough, and ensuring the protocol and forms are current. Tables provide guidance on what materials to include or exclude when submitting continuing review forms for studies with different statuses, such as ongoing and actively recruiting versus closed to enrollment.