This case report describes a 27-year-old woman who was admitted to the hospital for polytrauma injuries. During her hospital stay, a blood smear unexpectedly revealed intracellular bacteria in her blood. Blood cultures grew Acinetobacter Baumannii and Enterobacter Cloacae from her central venous catheter. Despite being asymptomatic, the central line was removed and she was treated with antibiotics, to which the bacteria were sensitive. A review of previous literature found 20 similar cases where bacteria were detected on blood smears, often associated with central lines and sepsis. This case highlights the importance of carefully examining blood smears, as intracellular bacteria can indicate active infection even in asymptomatic patients with central lines.