Intermediates
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This document lists 13 intermediates along with their CAS numbers, chemical structures, and potential end uses. The intermediates are used in a variety of therapeutic areas including cancer, atherosclerosis, restenosis, endometriosis, and psoriasis. They include compounds used in tyrosine kinase inhibitors, BACE1 inhibitors, crizotinib, palbociclib, maraviroc, and tebipenem among others. The contact information provided is for a company located in Visakhapatnam, India that synthesizes and supplies these pharmaceutical intermediates.
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![223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA.
Mobile No: 08121260004,0005
7 849928-34-3
benzyl 2-methyl-4-
oxopiperidine-1-carboxylate
N
O
O
O
Lactams Beta-secretase
1 (BACE1)
8 143612-79-7 3-(4-chlorobutyl)-1H-indole-5-
carbonitrile N
H
NC
Cl
Vilazodone
9 1016636-76-2
6-bromo-2-chloro-8-
cyclopentyl-5-
methylpyrido[2,3-d]pyrimidin-
7(8H)-one
N
N N O
Me
Cl
Br
Palbociclib
10 292067-84-6
trifluoromethyl vinamidinium h
exafluorophosphate salt
N+
N
CF3
PF6
.
Pyrazole
11
1-(4-bromo-2,6-
dimethylphenyl)-4-
(trifluoromethyl)-1H-pyrazole
Br
N
N
CF
3
Glucagon receptor
modulators
12 423165-13-3
8-benzyl-3-(3-isopropyl-5-
methyl-4H-1,2,4-triazol-4-yl)-8-
aza-bicyclo[3.2.1]octane
BnN N
H
N
N
Triazolyl tropane,
Maraviroc
13 179337-57-6
1-(2,5-dihydrothiazol-2-
yl)azetidine-3-thiol
hydrochloride
N SH
N
S
HCl
Tebipenem](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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Intermediates Chemicals CAS NO
CAS No INTERMEDIATE NAME USED IN MANUFACTURE OF Images
10310-21-1 2-Amino-6-Chloro Purine(6-Chloro Guanine) Abacavir 10310-21-1.JPG
136522-35-5 (1S.Cis)-4-Amino-2-Cyclopenten-1-Methanol Abacavir 136522-35-5.JPG
171887-03-9 N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Abacavir 171887-03-9.JPG
172015-79-1 (IS,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-Cyclopentene-1-methanol hydrochloride Abacavir 172015-79-1.JPG
229177-46-2 ((1S,4R)-4-aminocyclopent-2-enyl)methanol D(+) Tartarate Abacavir 229177-46-2.JPG
2743-38-6 Dibenzoyl-L-Tartaric Acid Abacavir 2743-38-6.JPG
49805-30-3 2-Azabicyclo[2.2.1]hept-5-en-3-one Abacavir 49805-30-3.JPG
56-05-3 2-Amino-4,6-Dichloro Pyrimidine Abacavir 56-05-3.JPG
56-06-4 2,4-Diamino-6-Hydroxy Pyrimidine Abacavir 56-06-4.JPG
56830-58-1 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride Abacavir 56830-58-1.JPG
765-30-0 Cyclopropylamine Abacavir 765-30-0.JPG
114611-53-9 (3beta)-17-iodo-Androsta-5,16-dien-3-ol 3-acetate Abiraterone 114611-53-9.JPG
32138-69-5 17-Iodoandrosta-5,16-dien-3beta-ol Abiraterone 32138-69-5.JPG
626-55-1 3-Pyridyl bromide Abiraterone 626-55-1.JPG
89878-14-8 Diethyl(3-pyridyl)borane Abiraterone 89878-14-8.JPG
40188-45-2 2-Acetyl-4-Butyramido Phenol Acebutolol 40188-45-2.JPG
28197-66-2 N-(3-Acetyl-4-(2,3-Epoxypropoxy)Phenyl)Butyramide Acebutololum 28197-66-2.JPG
1076-38-6 4-Hydroxy coumarin Acenocoumarol 1076-38-6.JPG
32873-56-6 2-Acetylamino-5-mercapto-1,3,4-thiadiazole Acetazolamide 32873-56-6.JPG
54344-92-2 4-Methoxy-2,3,6-trimethyl-benzaldehyde Acitretin 54344-92-2.JPG
62924-31-6 (3E)-4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)BUT-3-EN-2-ONE Acitretin 62924-31-6.JPG
3056-33-5 2,9-Diacetyl Guanine Acyclovir 3056-33-5.JPG
73-40-5 Guanine Acyclovir 73-40-5.JPG
281-23-2 Adamantane Adamantadine 281-23-2.JPG
768-90-1 1-Bromoadamantane Adamantadine 768-90-1.JPG
768-94-5 Adamantylamine Adamantadine 768-94-5.JPG
768-95-6 1-Adamantanol Adamantane 768-95-6.JPG
880-52-4 N-(1-Adamantyl) Acetamide Adamantane 880-52-4.JPG
104224-68-2 4-Bromo-2-Adamantyl phenol Adapalene 104224-68-2.JPG
106685-41-0 Methyl-6-[3-(1-Adamantyl)-4-Methoxy Phenyl]-2-Naphthoate Adapalene 106685-41-0.JPG
33626-98-1 Methyl 6-Bromo-2-Naphthoate Adapalene 33626-98-1.JPG
106941-25-7 [2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methylphosphonic Acid Adefovil Dipivoxil 106941-25-7.JPG
116384-53-3 [2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl] Phosphonic Acid Diethyl Ester Adefovil Dipivoxil 116384-53-3.JPG
142340-99-6 Phosphonyl Methoxy Ethyl Adenine Adefovil Dipivoxil 142340-99-6.JPG
31618-90-3 Diethyl-Tosyloxy Methyl Phosphonate Adefovil Dipivoxil 31618-90-3.JPG
138113-08-3 7-Methoxy-1-naphthylacetonitrile Agomelatine 138113-08-3.JPG
138113-09-4 2-(7-Methoxynaphthalen-1-yl)ethanamine(N-1) Agomelatine 138113-09-4.JPG
139525-77-2 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride Agomelatine 139525-77-2.JPG
6836-19-7 7-Methoxy-1-tetralone Agomelatine 6836-19-7.JPG
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Intermediates Chemicals CAS NO
CAS No INTERMEDIATE NAME USED IN MANUFACTURE OF Images
10310-21-1 2-Amino-6-Chloro Purine(6-Chloro Guanine) Abacavir 10310-21-1.JPG
136522-35-5 (1S.Cis)-4-Amino-2-Cyclopenten-1-Methanol Abacavir 136522-35-5.JPG
171887-03-9 N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Abacavir 171887-03-9.JPG
172015-79-1 (IS,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-Cyclopentene-1-methanol hydrochloride Abacavir 172015-79-1.JPG
229177-46-2 ((1S,4R)-4-aminocyclopent-2-enyl)methanol D(+) Tartarate Abacavir 229177-46-2.JPG
2743-38-6 Dibenzoyl-L-Tartaric Acid Abacavir 2743-38-6.JPG
49805-30-3 2-Azabicyclo[2.2.1]hept-5-en-3-one Abacavir 49805-30-3.JPG
56-05-3 2-Amino-4,6-Dichloro Pyrimidine Abacavir 56-05-3.JPG
56-06-4 2,4-Diamino-6-Hydroxy Pyrimidine Abacavir 56-06-4.JPG
56830-58-1 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride Abacavir 56830-58-1.JPG
765-30-0 Cyclopropylamine Abacavir 765-30-0.JPG
114611-53-9 (3beta)-17-iodo-Androsta-5,16-dien-3-ol 3-acetate Abiraterone 114611-53-9.JPG
32138-69-5 17-Iodoandrosta-5,16-dien-3beta-ol Abiraterone 32138-69-5.JPG
626-55-1 3-Pyridyl bromide Abiraterone 626-55-1.JPG
89878-14-8 Diethyl(3-pyridyl)borane Abiraterone 89878-14-8.JPG
40188-45-2 2-Acetyl-4-Butyramido Phenol Acebutolol 40188-45-2.JPG
28197-66-2 N-(3-Acetyl-4-(2,3-Epoxypropoxy)Phenyl)Butyramide Acebutololum 28197-66-2.JPG
1076-38-6 4-Hydroxy coumarin Acenocoumarol 1076-38-6.JPG
32873-56-6 2-Acetylamino-5-mercapto-1,3,4-thiadiazole Acetazolamide 32873-56-6.JPG
54344-92-2 4-Methoxy-2,3,6-trimethyl-benzaldehyde Acitretin 54344-92-2.JPG
62924-31-6 (3E)-4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)BUT-3-EN-2-ONE Acitretin 62924-31-6.JPG
3056-33-5 2,9-Diacetyl Guanine Acyclovir 3056-33-5.JPG
73-40-5 Guanine Acyclovir 73-40-5.JPG
281-23-2 Adamantane Adamantadine 281-23-2.JPG
768-90-1 1-Bromoadamantane Adamantadine 768-90-1.JPG
768-94-5 Adamantylamine Adamantadine 768-94-5.JPG
768-95-6 1-Adamantanol Adamantane 768-95-6.JPG
880-52-4 N-(1-Adamantyl) Acetamide Adamantane 880-52-4.JPG
104224-68-2 4-Bromo-2-Adamantyl phenol Adapalene 104224-68-2.JPG
106685-41-0 Methyl-6-[3-(1-Adamantyl)-4-Methoxy Phenyl]-2-Naphthoate Adapalene 106685-41-0.JPG
33626-98-1 Methyl 6-Bromo-2-Naphthoate Adapalene 33626-98-1.JPG
106941-25-7 [2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methylphosphonic Acid Adefovil Dipivoxil 106941-25-7.JPG
116384-53-3 [2-(6-Amino-9H-Purin-9-Yl)Ethoxy]Methyl] Phosphonic Acid Diethyl Ester Adefovil Dipivoxil 116384-53-3.JPG
142340-99-6 Phosphonyl Methoxy Ethyl Adenine Adefovil Dipivoxil 142340-99-6.JPG
31618-90-3 Diethyl-Tosyloxy Methyl Phosphonate Adefovil Dipivoxil 31618-90-3.JPG
138113-08-3 7-Methoxy-1-naphthylacetonitrile Agomelatine 138113-08-3.JPG
138113-09-4 2-(7-Methoxynaphthalen-1-yl)ethanamine(N-1) Agomelatine 138113-09-4.JPG
139525-77-2 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride Agomelatine 139525-77-2.JPG
6836-19-7 7-Methoxy-1-tetralone Agomelatine 6836-19-7.JPG
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comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterTexas Alliance of Groundwater Districts
Presented at June 6-7 Texas Alliance of Groundwater Districts Business MeetingEquivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Shallowest Oil Discovery of Turkiye.pptx
The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
Direct Seeded Rice - Climate Smart Agriculture
Direct Seeded Rice - Climate Smart AgricultureInternational Food Policy Research Institute- South Asia Office
PPT on Direct Seeded Rice presented at the three-day 'Training and Validation Workshop on Modules of Climate Smart Agriculture (CSA) Technologies in South Asia' workshop on April 22, 2024.
20240520 Planning a Circuit Simulator in JavaScript.pptx
Evaporation step counter work. I have done a physical experiment.
(Work in progress.)
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...Abdul Wali Khan University Mardan,kP,Pakistan
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skillsRecently uploaded (20)
The cost of acquiring information by natural selection
The cost of acquiring information by natural selection
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
8.Isolation of pure cultures and preservation of cultures.pdf
8.Isolation of pure cultures and preservation of cultures.pdf
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
Basics of crystallography, crystal systems, classes and different forms
Basics of crystallography, crystal systems, classes and different forms
The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
Intermediates
- 1. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 LIST OF INTRMEDIATES S.NO CAS NO NAME OF THE PRODUCT STRUCTURE END USE 1 197892-69-6 (E)-4-(piperidin-1-yl)but-2- enoic acid hydrochloride Tyrosine kinase inhibitors, for the prevention of proliferative diseases including cancer, atherosclerosis, restenosis, endometriosis and psoriasis 2 methyl 3-(4-hydroxy-6-methyl- 2-oxopyridin-1(2H)-yl)-4- methylbenzoate N O O OH O A novel pyridinone inhibitor to p38α with IC50 of 26 nM 3 1023298-54-5 tert-butyl 4-(3-aminopyridin-4- yl)piperazine-1-carboxylate N N N Boc H2N 4 39903-01-0 2-amino-5-bromopyridin-3-ol N NH2 OH Br Crizotinib 5 399-72-4 5-fluoro-2-methyl-1H-indole N H F 6 tert-butyl 5-fluoro-3-iodo-2- methyl-1H-indole-1-carboxylate N F I O O
- 2. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 7 849928-34-3 benzyl 2-methyl-4- oxopiperidine-1-carboxylate N O O O Lactams Beta-secretase 1 (BACE1) 8 143612-79-7 3-(4-chlorobutyl)-1H-indole-5- carbonitrile N H NC Cl Vilazodone 9 1016636-76-2 6-bromo-2-chloro-8- cyclopentyl-5- methylpyrido[2,3-d]pyrimidin- 7(8H)-one N N N O Me Cl Br Palbociclib 10 292067-84-6 trifluoromethyl vinamidinium h exafluorophosphate salt N+ N CF3 PF6 . Pyrazole 11 1-(4-bromo-2,6- dimethylphenyl)-4- (trifluoromethyl)-1H-pyrazole Br N N CF 3 Glucagon receptor modulators 12 423165-13-3 8-benzyl-3-(3-isopropyl-5- methyl-4H-1,2,4-triazol-4-yl)-8- aza-bicyclo[3.2.1]octane BnN N H N N Triazolyl tropane, Maraviroc 13 179337-57-6 1-(2,5-dihydrothiazol-2- yl)azetidine-3-thiol hydrochloride N SH N S HCl Tebipenem
- 3. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 14 5807-14-7 Triazabicyclodecene