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223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA.
Mobile No: 08121260004,0005
LIST OF INTRMEDIATES
S.NO CAS NO NAME OF THE PRODUCT STRUCTURE END USE
1 197892-69-6
(E)-4-(piperidin-1-yl)but-2-
enoic acid hydrochloride
Tyrosine kinase inhibitors,
for the
prevention of proliferative
diseases
including cancer,
atherosclerosis,
restenosis, endometriosis and
psoriasis
2
methyl 3-(4-hydroxy-6-methyl-
2-oxopyridin-1(2H)-yl)-4-
methylbenzoate
N
O
O
OH
O
A novel pyridinone inhibitor
to p38α with IC50 of 26 nM
3 1023298-54-5
tert-butyl 4-(3-aminopyridin-4-
yl)piperazine-1-carboxylate
N
N
N
Boc
H2N
4 39903-01-0 2-amino-5-bromopyridin-3-ol
N NH2
OH
Br
Crizotinib
5 399-72-4 5-fluoro-2-methyl-1H-indole
N
H
F
6
tert-butyl 5-fluoro-3-iodo-2-
methyl-1H-indole-1-carboxylate
N
F
I
O
O
223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA.
Mobile No: 08121260004,0005
7 849928-34-3
benzyl 2-methyl-4-
oxopiperidine-1-carboxylate
N
O
O
O
Lactams Beta-secretase
1 (BACE1)
8 143612-79-7 3-(4-chlorobutyl)-1H-indole-5-
carbonitrile N
H
NC
Cl
Vilazodone
9 1016636-76-2
6-bromo-2-chloro-8-
cyclopentyl-5-
methylpyrido[2,3-d]pyrimidin-
7(8H)-one
N
N N O
Me
Cl
Br
Palbociclib
10 292067-84-6
trifluoromethyl vinamidinium h
exafluorophosphate salt
N+
N
CF3
PF6
.
Pyrazole
11
1-(4-bromo-2,6-
dimethylphenyl)-4-
(trifluoromethyl)-1H-pyrazole
Br
N
N
CF
3
Glucagon receptor
modulators
12 423165-13-3
8-benzyl-3-(3-isopropyl-5-
methyl-4H-1,2,4-triazol-4-yl)-8-
aza-bicyclo[3.2.1]octane
BnN N
H
N
N
Triazolyl tropane,
Maraviroc
13 179337-57-6
1-(2,5-dihydrothiazol-2-
yl)azetidine-3-thiol
hydrochloride
N SH
N
S
HCl
Tebipenem
223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA.
Mobile No: 08121260004,0005
14 5807-14-7 Triazabicyclodecene

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Intermediates

  • 1. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 LIST OF INTRMEDIATES S.NO CAS NO NAME OF THE PRODUCT STRUCTURE END USE 1 197892-69-6 (E)-4-(piperidin-1-yl)but-2- enoic acid hydrochloride Tyrosine kinase inhibitors, for the prevention of proliferative diseases including cancer, atherosclerosis, restenosis, endometriosis and psoriasis 2 methyl 3-(4-hydroxy-6-methyl- 2-oxopyridin-1(2H)-yl)-4- methylbenzoate N O O OH O A novel pyridinone inhibitor to p38α with IC50 of 26 nM 3 1023298-54-5 tert-butyl 4-(3-aminopyridin-4- yl)piperazine-1-carboxylate N N N Boc H2N 4 39903-01-0 2-amino-5-bromopyridin-3-ol N NH2 OH Br Crizotinib 5 399-72-4 5-fluoro-2-methyl-1H-indole N H F 6 tert-butyl 5-fluoro-3-iodo-2- methyl-1H-indole-1-carboxylate N F I O O
  • 2. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 7 849928-34-3 benzyl 2-methyl-4- oxopiperidine-1-carboxylate N O O O Lactams Beta-secretase 1 (BACE1) 8 143612-79-7 3-(4-chlorobutyl)-1H-indole-5- carbonitrile N H NC Cl Vilazodone 9 1016636-76-2 6-bromo-2-chloro-8- cyclopentyl-5- methylpyrido[2,3-d]pyrimidin- 7(8H)-one N N N O Me Cl Br Palbociclib 10 292067-84-6 trifluoromethyl vinamidinium h exafluorophosphate salt N+ N CF3 PF6 . Pyrazole 11 1-(4-bromo-2,6- dimethylphenyl)-4- (trifluoromethyl)-1H-pyrazole Br N N CF 3 Glucagon receptor modulators 12 423165-13-3 8-benzyl-3-(3-isopropyl-5- methyl-4H-1,2,4-triazol-4-yl)-8- aza-bicyclo[3.2.1]octane BnN N H N N Triazolyl tropane, Maraviroc 13 179337-57-6 1-(2,5-dihydrothiazol-2- yl)azetidine-3-thiol hydrochloride N SH N S HCl Tebipenem
  • 3. 223A, Block-D, APIIC, Gajuwaka, Visakhapatnam – 530012, A.P. INDIA. Mobile No: 08121260004,0005 14 5807-14-7 Triazabicyclodecene