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Acute complications of Diabetes :
Diabetic keto -acidosis
Hyperosmolar Coma (HHS)
Hypoglycemia
DKA and hyperglycemic hyperosmolar
state[HHS]are acute, severe disorders directly
related to diabetes.
DKA was formerly considered a hallmark of type 1
DM, but also occurs in individuals with type 2
HHS is primarily seen in individuals with type 2 DM.
Both disorders are associated with absolute or
relative insulin deficiency, with or without excess
counter regulatory hormones (glucagon and
cortisol) , volume depletion, and acid-base
abnormalities.
Manifestations of Diabetic Keto acidosis
Pathophysiology
• Polyuria
• Polydipsia
• Nausea and vomiting
• Abdominal Pain
• Breathing difficulty
Symptoms
Signs
Dehydration
Hyperventilation ( Kussmal Breathing)
Ketotic breath
Tachycardia and hypotension
Disturbed conscious state and shock
Alteration of consciousness correlate better
with elevated serum osmolality (>320
mOsm/L) than with severity of metabolic
acidosis
DKA/HHS
Management
HYPERGLYCEMIC HYPEROSMOLAR STATE
Typical patient with HHS is an elderly
individual with type 2 DM, with a
several-week history of polyuria, weight
loss, and diminished oral intake that
culminates in mental confusion, lethargy,
or coma.
How is it different from DKA
 Relative insulin deficiency and inadequate
fluid intake are the underlying causes of HHS.
 The absence of ketosis in HHS is presumably
due to the insulin deficiency being only
relative and less severe than in DKA.
 Lower levels of counterregulatory hormones
and free fatty acids
 It is also possible that the liver is less capable
of ketone body synthesis or that the
insulin/glucagon ratio does not favour
ketogenesis.
Fluid replacement should initially stabilize the
hemodynamic status of the patient (1–3 L of
0.9% normal saline over the first 2–3 h). Even
upto 9 litres may be needed.
If the serum sodium is >150 mmol/L (150
meq/L), 0.45% saline should be used
Even hypotonic solutions like D5% with water
is used in case with severe hyperosmolarity
which prevents use of normal saline or even
half normal saline.
Management

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Integrated Dr Pagawat.pptx

  • 1. Let us learn: Acute complications of Diabetes : Diabetic keto -acidosis Hyperosmolar Coma (HHS) Hypoglycemia
  • 2. DKA and hyperglycemic hyperosmolar state[HHS]are acute, severe disorders directly related to diabetes. DKA was formerly considered a hallmark of type 1 DM, but also occurs in individuals with type 2 HHS is primarily seen in individuals with type 2 DM. Both disorders are associated with absolute or relative insulin deficiency, with or without excess counter regulatory hormones (glucagon and cortisol) , volume depletion, and acid-base abnormalities.
  • 5. • Polyuria • Polydipsia • Nausea and vomiting • Abdominal Pain • Breathing difficulty Symptoms
  • 6. Signs Dehydration Hyperventilation ( Kussmal Breathing) Ketotic breath Tachycardia and hypotension Disturbed conscious state and shock Alteration of consciousness correlate better with elevated serum osmolality (>320 mOsm/L) than with severity of metabolic acidosis
  • 9.
  • 10. HYPERGLYCEMIC HYPEROSMOLAR STATE Typical patient with HHS is an elderly individual with type 2 DM, with a several-week history of polyuria, weight loss, and diminished oral intake that culminates in mental confusion, lethargy, or coma.
  • 11. How is it different from DKA  Relative insulin deficiency and inadequate fluid intake are the underlying causes of HHS.  The absence of ketosis in HHS is presumably due to the insulin deficiency being only relative and less severe than in DKA.  Lower levels of counterregulatory hormones and free fatty acids  It is also possible that the liver is less capable of ketone body synthesis or that the insulin/glucagon ratio does not favour ketogenesis.
  • 12.
  • 13. Fluid replacement should initially stabilize the hemodynamic status of the patient (1–3 L of 0.9% normal saline over the first 2–3 h). Even upto 9 litres may be needed. If the serum sodium is >150 mmol/L (150 meq/L), 0.45% saline should be used Even hypotonic solutions like D5% with water is used in case with severe hyperosmolarity which prevents use of normal saline or even half normal saline. Management