Insulin pumps are small, computerized devices that help manage blood sugar levels in people with diabetes by continuously delivering rapid-acting insulin. They consist of a pump unit that holds insulin, a disposable infusion set that delivers insulin under the skin, and a control unit to program insulin delivery. Insulin pumps can deliver basal insulin throughout the day and bolus doses around meals. They provide flexibility but must be constantly worn. New hybrid closed-loop systems like the Medtronic 670G combine continuous glucose monitoring with automatic insulin delivery based on glucose levels.
Various insulin pumps used to deliver insulin to the human body and its application along with its advantages and disadvantages are outlined in this presentation.
The document summarizes information about insulin pumps. Insulin pumps are external devices that mimic the pancreas by continuously measuring blood sugar levels and injecting insulin to maintain normal levels. Traditional pumps include the pump unit to control insulin delivery, a disposable insulin reservoir, and a disposable infusion set including a cannula and tubing. Insulin pumps offer benefits over multiple daily injections such as increased flexibility and more precise insulin delivery to reduce complications. However, disadvantages include risks of infection and malfunction leading to ketoacidosis as well as the high cost of pumps.
The document summarizes different types of insulin, including human insulin and newer insulin analogues. It describes the structure and production of human insulin and discusses problems with conventional insulins like regular insulin. It then provides details on various short-acting and long-acting insulin analogues like insulin lispro, insulin glargine, insulin detemir, and insulin degludec, including their structures, mechanisms of action, advantages over human insulin, dosing, and pregnancy categories. The document also briefly mentions other newer insulins under development or approval like inhaled insulin and insulin fusion proteins.
The document discusses insulin pumps as an alternative treatment for diabetes compared to traditional multiple daily injections. Insulin pumps provide continuous insulin delivery through an infusion set and are programmed to deliver basal and bolus doses. While insulin pumps are more expensive initially than injections, they provide benefits like better blood glucose control and more flexibility with meals and activities. The technology has advanced significantly since the first prototype pump in 1964 and continues to improve, but some disadvantages remain like potential weight gain and the need to remove the pump for certain activities.
2018 Update in Diabetes Technology: Closed Loop, CGM, and MoreAaron Neinstein
A 2018 update in diabetes technology, including closed loop insulin delivery, continuous glucose monitoring, and more. Presented by Dr. Aaron Neinstein, faculty in Endocrinology at UCSF, at the UCSF Diabetes CME course in San Francisco, in April 2018.
This document provides information about basic insulin pumping. It describes what an insulin pump is, potential benefits, and challenges. It discusses calculating basal rates, bolus doses, and correction factors. It provides guidance on pump maintenance like changing sites and settings. It addresses common questions around pump use, troubleshooting, and ensuring settings are optimized. The overall message is that pumps require diligent self-care and monitoring to achieve good blood sugar control.
This document provides information on insulin therapy. It discusses what insulin is, how it is secreted normally, and its actions in the body. Insulin deficiency results in hyperglycemia and other metabolic defects. The discovery of insulin by Banting and Best in 1921 revolutionized the treatment of diabetes. Insulin comes in various forms including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed varieties. Common insulin regimens include split-mixed, basal, basal-plus, and basal-bolus. Early initiation of insulin in type 2 diabetes has clinical benefits beyond glycemic control. Barriers to insulin therapy include fear of hypoglycemia and the inconvenience of injection schedules. Pro
Insulin pumps are small, computerized devices that help manage blood sugar levels in people with diabetes by continuously delivering rapid-acting insulin. They consist of a pump unit that holds insulin, a disposable infusion set that delivers insulin under the skin, and a control unit to program insulin delivery. Insulin pumps can deliver basal insulin throughout the day and bolus doses around meals. They provide flexibility but must be constantly worn. New hybrid closed-loop systems like the Medtronic 670G combine continuous glucose monitoring with automatic insulin delivery based on glucose levels.
Various insulin pumps used to deliver insulin to the human body and its application along with its advantages and disadvantages are outlined in this presentation.
The document summarizes information about insulin pumps. Insulin pumps are external devices that mimic the pancreas by continuously measuring blood sugar levels and injecting insulin to maintain normal levels. Traditional pumps include the pump unit to control insulin delivery, a disposable insulin reservoir, and a disposable infusion set including a cannula and tubing. Insulin pumps offer benefits over multiple daily injections such as increased flexibility and more precise insulin delivery to reduce complications. However, disadvantages include risks of infection and malfunction leading to ketoacidosis as well as the high cost of pumps.
The document summarizes different types of insulin, including human insulin and newer insulin analogues. It describes the structure and production of human insulin and discusses problems with conventional insulins like regular insulin. It then provides details on various short-acting and long-acting insulin analogues like insulin lispro, insulin glargine, insulin detemir, and insulin degludec, including their structures, mechanisms of action, advantages over human insulin, dosing, and pregnancy categories. The document also briefly mentions other newer insulins under development or approval like inhaled insulin and insulin fusion proteins.
The document discusses insulin pumps as an alternative treatment for diabetes compared to traditional multiple daily injections. Insulin pumps provide continuous insulin delivery through an infusion set and are programmed to deliver basal and bolus doses. While insulin pumps are more expensive initially than injections, they provide benefits like better blood glucose control and more flexibility with meals and activities. The technology has advanced significantly since the first prototype pump in 1964 and continues to improve, but some disadvantages remain like potential weight gain and the need to remove the pump for certain activities.
2018 Update in Diabetes Technology: Closed Loop, CGM, and MoreAaron Neinstein
A 2018 update in diabetes technology, including closed loop insulin delivery, continuous glucose monitoring, and more. Presented by Dr. Aaron Neinstein, faculty in Endocrinology at UCSF, at the UCSF Diabetes CME course in San Francisco, in April 2018.
This document provides information about basic insulin pumping. It describes what an insulin pump is, potential benefits, and challenges. It discusses calculating basal rates, bolus doses, and correction factors. It provides guidance on pump maintenance like changing sites and settings. It addresses common questions around pump use, troubleshooting, and ensuring settings are optimized. The overall message is that pumps require diligent self-care and monitoring to achieve good blood sugar control.
This document provides information on insulin therapy. It discusses what insulin is, how it is secreted normally, and its actions in the body. Insulin deficiency results in hyperglycemia and other metabolic defects. The discovery of insulin by Banting and Best in 1921 revolutionized the treatment of diabetes. Insulin comes in various forms including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed varieties. Common insulin regimens include split-mixed, basal, basal-plus, and basal-bolus. Early initiation of insulin in type 2 diabetes has clinical benefits beyond glycemic control. Barriers to insulin therapy include fear of hypoglycemia and the inconvenience of injection schedules. Pro
The document discusses different types of insulin available to manage diabetes, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. It reviews insulin protocols and addresses patient selection for different regimens. The document also discusses designing and adjusting insulin regimens, including using a basal-bolus approach to better mimic normal physiology.
This document discusses basics of insulin therapy including:
- The discovery of insulin in the 1920s and types of insulin including basal, mealtime, premixed, and newer combinations.
- Insulin action profiles, indications for insulin use, administration techniques using vials, syringes and pens, and common insulin regimens for type 2 diabetes including once or twice daily basal insulin +/- mealtime insulin or premixed insulin.
- Proper storage, mixing, and injection of insulin as well as recommended sites for injection are also reviewed.
This document discusses insulin therapy, including its pharmacodynamics, mechanisms of action, types of insulin, insulin regimens, administration techniques, side effects, and patient education. Insulin is secreted by the pancreas and lowers blood glucose levels by facilitating glucose uptake into cells. It acts on the liver, muscle, adipose tissue, and other organs. Types include rapid, short, intermediate and long-acting insulins. Patient education focuses on proper administration, storage, monitoring, hypoglycemia treatment, and lifestyle factors.
This document provides information about insulin therapy. It defines insulin as a polypeptide hormone secreted by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic defects. The discovery of insulin in the 1920s by Banting and Best was a major medical milestone. Insulin is now manufactured recombinantly and comes in various rapid, short, intermediate, and long-acting forms to match physiological insulin secretion. Basal bolus regimens using basal and pre-meal bolus insulin are commonly used. New delivery methods like insulin pumps provide more flexibility but also challenges. Proper insulin storage and administration technique are important for effectiveness and safety.
It includes information about Hybrid closed loop insulin delivery system-Artificial Pancreas.Its details and how insulin pump develops with the time.It also includes the information about companies which manufacturing pumps.Also includes info about diabetes mellitus.
Insulin therapy in Diabetes Mellitus discusses various types of insulin, newer insulin analogs, and insulin regimens for managing type 1 diabetes mellitus. Rapid-acting insulin analogs have advantages over regular insulin such as quicker onset of action and less risk of hypoglycemia. Long-acting insulin analogs like glargine have advantages over NPH insulin such as a more consistent time action profile. The document discusses split-mix and basal-bolus insulin regimens and factors to consider when choosing a regimen. It also covers complications of insulin therapy, monitoring of blood glucose and HbA1c levels, and sick day management for patients with type 1 diabetes.
Insulin is a polypeptide hormone produced by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic issues. There are various types of insulin that are classified by their onset and duration of action, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. Common insulin regimens include split-mixed, multiple injection, basal-bolus, and continuous subcutaneous insulin infusion. Insulin is administered via syringes, pens, or pumps and is injected into approved sites in the body. Potential side effects of insulin therapy include hypoglycemia, weight gain, and local injection
INSULIN MANAGEMENT OF TYPE 1 DIABETES DR. NEVA JAY
This document discusses insulin management for type 1 diabetes mellitus. It provides information on diabetic ketoacidosis, goals of treatment, criteria for diabetes diagnosis, the treatment team, intensive insulin therapy including different insulin preparations and regimens, goals for blood sugar and HbA1c levels, and home blood glucose monitoring. The standard treatment involves multiple daily insulin injections or insulin pump therapy to closely mimic normal insulin secretion and intensive education to allow patients to lead normal lives.
This document provides information for diabetes educators on self-monitoring of blood glucose (SMBG). It explains that SMBG, as part of diabetes self-management education and support, can help patients understand the importance of monitoring, interpreting results, and maintaining a logbook to improve diabetes care. The document then answers frequently asked questions about how to properly use a glucometer, when to test blood glucose levels, normal ranges, and what to do if levels are too high or too low. It emphasizes the importance of keeping accurate records in a logbook to share with physicians.
This document discusses various methods for delivering insulin, including current and future technologies. It begins by covering traditional insulin delivery methods like vials and syringes as well as insulin pens. It then discusses continuous subcutaneous insulin infusion (CSII) using insulin pumps in more detail, including how they work, advantages over multiple daily injections, and types of pumps. Finally, it briefly introduces sensor augmented pump therapy, which combines insulin pumps with continuous glucose monitors to help adjust insulin delivery.
This document discusses childhood diabetes mellitus. It defines diabetes as a metabolic disorder characterized by chronic hyperglycemia. Type 1 diabetes accounts for over 90% of childhood cases and is an autoimmune disease triggered by environmental factors in genetically susceptible individuals. Proper treatment involves education, insulin therapy tailored to the individual, diet and exercise, and regular monitoring to prevent complications and achieve metabolic control goals. Advances allow more precise glucose monitoring and individualized insulin regimens.
This document provides an outline and overview of diabetes mellitus, including its classification, clinical presentation, investigations, management, and complications. It discusses the main types of diabetes (type 1, type 2, gestational, and MODY), risk factors, pathophysiology, diagnostic criteria. Key tests for diagnosis and monitoring such as HbA1c, oral glucose tolerance test, and criteria for prediabetes are summarized. The document outlines the epidemiology, presentations, assessments including history and examinations, general treatment objectives and management approaches for diabetes.
Controlling blood sugar (glucose) levels is the major goal of diabetes treatment, in order to prevent complications of the disease.
Type 1 diabetes is managed with insulin as well as dietary changes and exercise.
Type 2 diabetes may be managed with non-insulin medications, insulin, weight reduction, or dietary changes.
Medications for type 2 diabetes are designed to
increase insulin output by the pancreas,
decrease the amount of glucose released from the liver,
increase the sensitivity (response) of cells to insulin,
decrease the absorption of carbohydrates from the intestine, and
slow emptying of the stomach, thereby delaying nutrient digestion and absorption in the small intestine.
The document discusses diabetes, including:
- Diabetes is a group of metabolic disorders characterized by hyperglycemia due to defects in insulin secretion or action.
- India currently has 63 million people with diabetes, the second highest number after China.
- There are two main types of diabetes - type 1 caused by beta cell destruction leading to insulin deficiency, and type 2 caused by insulin resistance and relative insulin deficiency.
- Treatment involves diet, exercise, oral medications like metformin and sulfonylureas, and sometimes insulin therapy. The goal is to control blood sugar levels and prevent complications like damage to eyes, kidneys, nerves, and blood vessels.
The document summarizes insulin therapy for diabetes mellitus. It describes the cells in the pancreas that secrete insulin and other hormones. It details the discovery and purification of insulin in the 1920s which revolutionized treatment of diabetes. The document discusses different insulin formulations including short-acting and long-acting types. It explains factors that affect insulin absorption and common dosing regimens for insulin therapy.
This is a presentation describing the management principles of a newly diagnosed diabetic patient, including, diet therapy, medical treatment and exercise
This document discusses various types of diabetes in young people. It begins by defining diabetes mellitus and describing the worldwide rise in prevalence. It then covers the main etiological types including Type 1, Type 2, other genetic defects, and diabetes resulting from diseases of the exocrine pancreas. Risk factors for Type 2 diabetes in children and adolescents are outlined. Maturity-onset diabetes of the young (MODY) is explained in detail, including the genetic defects involved and treatments. Diagnosis and management of diabetes in youth are also addressed.
SIGNIFICANCE
OVERVIEW
WHAT IS DIABETES?
DEFINITION
MECHANISM
PREVELANCE
EPIDEMIOLOGY
CLASSIFICATION
GESTATIONAL DIABETES
RISK FACTORS
DIAGNOSIS
COMPLICATIONS
MEDICAL TEST
MEDICAL NUTRITIONAL THERAPY
HERBS FOR DIABETES
MYTHS AND FACTS
REFERENCES
JS, a 12-year old girl with type 1 diabetes, has been experiencing episodes of fatigue, weakness, and weight loss. During a soccer game, she felt sick and her blood glucose level was found to be low. She was treated for heat exhaustion. The doctor thinks she may be experiencing diabetic ketoacidosis. Proper management of type 1 diabetes requires lifelong insulin administration, monitoring of blood glucose and ketone levels, and maintenance of a healthy diet and activity levels to prevent dangerous fluctuations.
1) The document discusses the history and progression of insulin delivery methods, from early insulins derived from animals to current innovations like insulin pens, pumps, and closed-loop systems.
2) It describes various routes of insulin administration that have been developed or investigated, including inhaled, oral, colonic, nasal, buccal, transdermal, intraperitoneal, and others. Each route has advantages and disadvantages.
3) The goal has been to identify minimally invasive, effective, safe, convenient and affordable insulin delivery to improve treatment of diabetes. Current innovations like pumps and sensors aim to more closely mimic the body's natural insulin secretion, but noninvasive routes may revolutionize diabetes care if successful
Flexulin is developing a lightweight, wireless patch that administers both insulin and glucose to maintain blood glucose levels, allowing active diabetics to exercise without concerns about hypoglycemia or needing to adjust their insulin manually. It seeks $4 million in funding to develop a prototype and launch the product, which will initially be sold for $5,500 including the device and 10 patches. Flexulin has negotiated an agreement with Medtronic, the largest insulin pump manufacturer, for Medtronic to purchase and distribute Flexulin devices. The investment is expected to be recouped by 2017 and profitable in 2016.
The document discusses different types of insulin available to manage diabetes, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. It reviews insulin protocols and addresses patient selection for different regimens. The document also discusses designing and adjusting insulin regimens, including using a basal-bolus approach to better mimic normal physiology.
This document discusses basics of insulin therapy including:
- The discovery of insulin in the 1920s and types of insulin including basal, mealtime, premixed, and newer combinations.
- Insulin action profiles, indications for insulin use, administration techniques using vials, syringes and pens, and common insulin regimens for type 2 diabetes including once or twice daily basal insulin +/- mealtime insulin or premixed insulin.
- Proper storage, mixing, and injection of insulin as well as recommended sites for injection are also reviewed.
This document discusses insulin therapy, including its pharmacodynamics, mechanisms of action, types of insulin, insulin regimens, administration techniques, side effects, and patient education. Insulin is secreted by the pancreas and lowers blood glucose levels by facilitating glucose uptake into cells. It acts on the liver, muscle, adipose tissue, and other organs. Types include rapid, short, intermediate and long-acting insulins. Patient education focuses on proper administration, storage, monitoring, hypoglycemia treatment, and lifestyle factors.
This document provides information about insulin therapy. It defines insulin as a polypeptide hormone secreted by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic defects. The discovery of insulin in the 1920s by Banting and Best was a major medical milestone. Insulin is now manufactured recombinantly and comes in various rapid, short, intermediate, and long-acting forms to match physiological insulin secretion. Basal bolus regimens using basal and pre-meal bolus insulin are commonly used. New delivery methods like insulin pumps provide more flexibility but also challenges. Proper insulin storage and administration technique are important for effectiveness and safety.
It includes information about Hybrid closed loop insulin delivery system-Artificial Pancreas.Its details and how insulin pump develops with the time.It also includes the information about companies which manufacturing pumps.Also includes info about diabetes mellitus.
Insulin therapy in Diabetes Mellitus discusses various types of insulin, newer insulin analogs, and insulin regimens for managing type 1 diabetes mellitus. Rapid-acting insulin analogs have advantages over regular insulin such as quicker onset of action and less risk of hypoglycemia. Long-acting insulin analogs like glargine have advantages over NPH insulin such as a more consistent time action profile. The document discusses split-mix and basal-bolus insulin regimens and factors to consider when choosing a regimen. It also covers complications of insulin therapy, monitoring of blood glucose and HbA1c levels, and sick day management for patients with type 1 diabetes.
Insulin is a polypeptide hormone produced by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic issues. There are various types of insulin that are classified by their onset and duration of action, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. Common insulin regimens include split-mixed, multiple injection, basal-bolus, and continuous subcutaneous insulin infusion. Insulin is administered via syringes, pens, or pumps and is injected into approved sites in the body. Potential side effects of insulin therapy include hypoglycemia, weight gain, and local injection
INSULIN MANAGEMENT OF TYPE 1 DIABETES DR. NEVA JAY
This document discusses insulin management for type 1 diabetes mellitus. It provides information on diabetic ketoacidosis, goals of treatment, criteria for diabetes diagnosis, the treatment team, intensive insulin therapy including different insulin preparations and regimens, goals for blood sugar and HbA1c levels, and home blood glucose monitoring. The standard treatment involves multiple daily insulin injections or insulin pump therapy to closely mimic normal insulin secretion and intensive education to allow patients to lead normal lives.
This document provides information for diabetes educators on self-monitoring of blood glucose (SMBG). It explains that SMBG, as part of diabetes self-management education and support, can help patients understand the importance of monitoring, interpreting results, and maintaining a logbook to improve diabetes care. The document then answers frequently asked questions about how to properly use a glucometer, when to test blood glucose levels, normal ranges, and what to do if levels are too high or too low. It emphasizes the importance of keeping accurate records in a logbook to share with physicians.
This document discusses various methods for delivering insulin, including current and future technologies. It begins by covering traditional insulin delivery methods like vials and syringes as well as insulin pens. It then discusses continuous subcutaneous insulin infusion (CSII) using insulin pumps in more detail, including how they work, advantages over multiple daily injections, and types of pumps. Finally, it briefly introduces sensor augmented pump therapy, which combines insulin pumps with continuous glucose monitors to help adjust insulin delivery.
This document discusses childhood diabetes mellitus. It defines diabetes as a metabolic disorder characterized by chronic hyperglycemia. Type 1 diabetes accounts for over 90% of childhood cases and is an autoimmune disease triggered by environmental factors in genetically susceptible individuals. Proper treatment involves education, insulin therapy tailored to the individual, diet and exercise, and regular monitoring to prevent complications and achieve metabolic control goals. Advances allow more precise glucose monitoring and individualized insulin regimens.
This document provides an outline and overview of diabetes mellitus, including its classification, clinical presentation, investigations, management, and complications. It discusses the main types of diabetes (type 1, type 2, gestational, and MODY), risk factors, pathophysiology, diagnostic criteria. Key tests for diagnosis and monitoring such as HbA1c, oral glucose tolerance test, and criteria for prediabetes are summarized. The document outlines the epidemiology, presentations, assessments including history and examinations, general treatment objectives and management approaches for diabetes.
Controlling blood sugar (glucose) levels is the major goal of diabetes treatment, in order to prevent complications of the disease.
Type 1 diabetes is managed with insulin as well as dietary changes and exercise.
Type 2 diabetes may be managed with non-insulin medications, insulin, weight reduction, or dietary changes.
Medications for type 2 diabetes are designed to
increase insulin output by the pancreas,
decrease the amount of glucose released from the liver,
increase the sensitivity (response) of cells to insulin,
decrease the absorption of carbohydrates from the intestine, and
slow emptying of the stomach, thereby delaying nutrient digestion and absorption in the small intestine.
The document discusses diabetes, including:
- Diabetes is a group of metabolic disorders characterized by hyperglycemia due to defects in insulin secretion or action.
- India currently has 63 million people with diabetes, the second highest number after China.
- There are two main types of diabetes - type 1 caused by beta cell destruction leading to insulin deficiency, and type 2 caused by insulin resistance and relative insulin deficiency.
- Treatment involves diet, exercise, oral medications like metformin and sulfonylureas, and sometimes insulin therapy. The goal is to control blood sugar levels and prevent complications like damage to eyes, kidneys, nerves, and blood vessels.
The document summarizes insulin therapy for diabetes mellitus. It describes the cells in the pancreas that secrete insulin and other hormones. It details the discovery and purification of insulin in the 1920s which revolutionized treatment of diabetes. The document discusses different insulin formulations including short-acting and long-acting types. It explains factors that affect insulin absorption and common dosing regimens for insulin therapy.
This is a presentation describing the management principles of a newly diagnosed diabetic patient, including, diet therapy, medical treatment and exercise
This document discusses various types of diabetes in young people. It begins by defining diabetes mellitus and describing the worldwide rise in prevalence. It then covers the main etiological types including Type 1, Type 2, other genetic defects, and diabetes resulting from diseases of the exocrine pancreas. Risk factors for Type 2 diabetes in children and adolescents are outlined. Maturity-onset diabetes of the young (MODY) is explained in detail, including the genetic defects involved and treatments. Diagnosis and management of diabetes in youth are also addressed.
SIGNIFICANCE
OVERVIEW
WHAT IS DIABETES?
DEFINITION
MECHANISM
PREVELANCE
EPIDEMIOLOGY
CLASSIFICATION
GESTATIONAL DIABETES
RISK FACTORS
DIAGNOSIS
COMPLICATIONS
MEDICAL TEST
MEDICAL NUTRITIONAL THERAPY
HERBS FOR DIABETES
MYTHS AND FACTS
REFERENCES
JS, a 12-year old girl with type 1 diabetes, has been experiencing episodes of fatigue, weakness, and weight loss. During a soccer game, she felt sick and her blood glucose level was found to be low. She was treated for heat exhaustion. The doctor thinks she may be experiencing diabetic ketoacidosis. Proper management of type 1 diabetes requires lifelong insulin administration, monitoring of blood glucose and ketone levels, and maintenance of a healthy diet and activity levels to prevent dangerous fluctuations.
1) The document discusses the history and progression of insulin delivery methods, from early insulins derived from animals to current innovations like insulin pens, pumps, and closed-loop systems.
2) It describes various routes of insulin administration that have been developed or investigated, including inhaled, oral, colonic, nasal, buccal, transdermal, intraperitoneal, and others. Each route has advantages and disadvantages.
3) The goal has been to identify minimally invasive, effective, safe, convenient and affordable insulin delivery to improve treatment of diabetes. Current innovations like pumps and sensors aim to more closely mimic the body's natural insulin secretion, but noninvasive routes may revolutionize diabetes care if successful
Flexulin is developing a lightweight, wireless patch that administers both insulin and glucose to maintain blood glucose levels, allowing active diabetics to exercise without concerns about hypoglycemia or needing to adjust their insulin manually. It seeks $4 million in funding to develop a prototype and launch the product, which will initially be sold for $5,500 including the device and 10 patches. Flexulin has negotiated an agreement with Medtronic, the largest insulin pump manufacturer, for Medtronic to purchase and distribute Flexulin devices. The investment is expected to be recouped by 2017 and profitable in 2016.
Insulin pumps are small, computerized devices that mimic the pancreas's function by continuously delivering rapid-acting insulin through a cannula inserted under the skin. Pumps allow users to program both a continuous basal insulin rate and bolus doses around meals. Popular pump brands include Medtronic, Tandem, Animas, and Insulet Omnipod. Pumps provide improved blood sugar control and flexibility over multiple daily injections but require diligent care and monitoring. New hybrid closed-loop systems like the Medtronic 670G can automatically adjust insulin based on continuous glucose monitor readings.
Insulin pump therapy can offer you a more flexible lifestyle. The benefits and disadvantages are things to consider when making the decision to switch to an insulin pump.
Liberty Medical
Overview of Diabetes Medical Devices-8-2022.pptxakramabdalla1
The document provides an overview of diabetes medical devices including insulin pumps, blood glucose meters (BGMs), and continuous glucose monitors (CGMs). It discusses the types and classifications of diabetes, functional types of insulin, ways of insulin delivery, generations of BGM sensors, and the principles and components of insulin pumps and BGMs. Enzymatic methods for blood glucose measurement using glucose oxidase and glucose dehydrogenase are also summarized.
Diabetes technology has advanced significantly over time, starting with insulin pumps and continuous glucose monitors (CGM), and now including hybrid closed loop systems that both monitor glucose and deliver insulin. The goals of diabetes technology include improving glycemic control as measured by time in range, reducing hypoglycemia and hyperglycemia, and providing insights to help prevent complications through improved self-management. Current and emerging technologies like smart insulin pens, implantable insulin pumps, and wearable glucose meters continue pushing the field forward to better mimic a natural pancreas.
This document provides an overview of diabetes technology including glucose monitoring systems, insulin pumps, and closed loop artificial pancreas systems. It discusses current continuous glucose monitoring systems like Dexcom G6 and Freestyle Libre and flash systems. Insulin pumps discussed include Medtronic, Omnipod, and Tandem T Slim pumps. The document also covers closed loop systems like the Medtronic 670G hybrid closed loop system and upcoming artificial pancreas systems from Big Foot and Sugar Beat. Key takeaways are that sensors are allowed but not relied upon in hospitals and may need to be removed for MRIs, and that companies provide support for troubleshooting pump and sensor issues.
The Artificial Pancreas Device System is a system of devices that closely mimics the glucose regulating function of a healthy pancreas.
It sense the blood glucose level, determining the amount of insulin needed, and then delivering the appropriate amount of insulin.
Sometimes an artificial pancreas device system is referred to as a "closed-loop" system, an "automated insulin delivery" system, or an "autonomous system for glycemic control."
The first hybrid closed loop system, the Medtronic's MiniMed 670G System is the first FDA approved artificial pancreas.
The FDA approved it for treating type 1 diabetes in people age 14 and older.
Artificial pancreases hit the market in 2016.
The document discusses the benefits of prescribing the ACCU-CHEK Combo insulin pump system over competitors like Medtronic for Regence patients. It notes that the ACCU-CHEK system could save patients up to $1,500 due to lower costs through Regence coverage and has several advantages such as discreet design, customizable settings, large insulin cartridges, and 24/7 customer support from Roche. Prescribing the ACCU-CHEK system keeps costs lower for patients and helps them better manage their diabetes.
The document discusses using continuous subcutaneous insulin infusion (CSII) via insulin pumps to manage type 1 diabetes in adolescents. It summarizes the types of diabetes and outlines challenges adolescents face in managing their condition. The document evaluates three insulin pumps and recommends the OmniPod system, which is discreet, wireless and easy to use. It proposes a three stage process for adolescents to begin using the OmniPod, including education, training and continuing support.
ORIGINAL ARTICLEThe Hybrid Closed-Loop SystemEvolution .docxalfred4lewis58146
ORIGINAL ARTICLE
The Hybrid Closed-Loop System:
Evolution and Practical Applications
Kathryn W. Weaver, MD, and Irl B. Hirsch, MD
Abstract
Achievement of well-controlled blood glucose is essential for preventing complications in patients with type 1
diabetes. Since the inception of continuous subcutaneous insulin infusion, the aim has been to develop an
artificial pancreas, with the ability to use an automated algorithm to deliver one or more hormones in response
to blood glucose with the intent to keep blood sugar as close to a prespecified target as possible. Development
and rapid improvement of continuous glucose sensor technology has recently allowed swift progress toward a
fully closed-loop insulin delivery system. In 2017, Medtronic began marketing the 670G insulin pump with
Guardian 3 sensor. When in auto mode, this is a hybrid closed-loop insulin delivery system that automatically
adjusts basal insulin delivery every 5 min based on sensor glucose to maintain blood glucose levels as close to a
specific target as possible. Patients receive prandial insulin by entering carbohydrate amount into the bolus
calculator. Early studies show improvement in HbA1c in both adults and adolescents with this technology.
Initial safety trials showed no occurrence of diabetic ketoacidosis or hypoglycemia. The utility of this device is
limited by blood glucose targets of 120 and 150 mg/dL that are unacceptably high for some patients. Not-
withstanding recent advances, we are far from a system that is able to replicate islet function in the form of a
fully automated, multihormonal blood glucose control device.
Keywords: Type 1 diabetes, Hybrid closed-loop, Artificial pancreas, Continuous subcutaneous insulin infusion,
670G.
Introduction
People with type 1 diabetes mellitus face a perpetualuphill battle in achieving optimal glycemic control. The
fine line between preventing hypoglycemia and avoiding
complications from hyperglycemia is challenging to navigate.
Our objective is to describe the history of continuous sub-
cutaneous insulin infusion (CSII) and continuous glucose
monitor (CGM) and how these components allowed the de-
velopment of the first commercially available ‘‘artificial pan-
creas’’ (AP), although many would prefer the nomenclature of
‘‘closed-loop insulin delivery.’’ We then go on to describe
practicalities of the initial hybrid closed-loop (HCL) insulin
delivery system released by Medtronic.
Since the first use of CSII in the late 1970s, real-time
CGM in the early 2000s, and the eventual sensor-augmented
pump and ‘‘low-glucose suspend’’ after that, the obvious
next step was further integration between the two for a
closed-loop system, which ideally would require minimal
interaction from the patient. The accuracy of the sensors has
only recently become adequate to safely move this tech-
nology forward.
Devices designed to mimic pancreatic endocrine function
have been under development since the 1970s. Initial sys-
tems
1,2
were.
Recent advances in insulin manufacturing and treatmentjinanAlmousawy
This document discusses recent advances in insulin manufacturing and treatment. It describes the different types of diabetes and insulin, including rapid-acting, short-acting, intermediate-acting, and long-acting insulin. It explains insulin pens, injection techniques, recommended injection sites, and insulin pump therapy. The advantages and disadvantages of various insulin delivery methods are presented.
This document summarizes recent advancements in healthcare devices and pharmaceutical products by Abbott Laboratories. It discusses Abbott's nutrition care products including oral rehydration drinks, diabetes care technologies like continuous glucose monitors, diagnostics tests like BinaxNOW tests for COVID-19, heart health devices, and neuromodulation systems for pain management like Proclaim DRG neurostimulation. Abbott was established in 1910 and specializes in products for cardiovascular health, diagnostics, diabetes, and pain treatment, impacting over 100,000 people globally.
Dr. Shahjada Selim organized a task force to develop insulin guidelines for Bangladesh considering local resource availability and circumstances. The guidelines cover insulin initiation and intensification, delivery methods, storage, and use in hospital and ICU settings. Insulin should be initiated at low doses and gradually increased based on blood glucose monitoring. In hospitals, insulin protocols aim for blood glucose between 7.8-10 mmol/L, using basal insulin with meals rather than sliding scales in general wards, and IV infusions in ICUs.
The document discusses insulin pumps and their use for managing diabetes. It describes how insulin pumps work by continuously monitoring blood sugar levels and automatically delivering insulin to maintain safe blood sugar ranges. The document outlines important design considerations for insulin pumps, such as safety, reliability, and testing to validate the design and software. It also discusses potential hazards and failure modes that must be addressed.
LOW-COST INSULIN PUMP WITH PREDICTIVE BASED MITIGATION OF HYPERGLYCEMIA AND H...robelegemechu1
The document presents a BSc thesis report on the design and development of a low-cost insulin pump prototype. It discusses:
1) The objectives of designing a prototype that achieves the accuracy and precision of commercial pumps at a lower cost for developing countries.
2) The literature review on insulin pump design and algorithms for predictive suspension to prevent hypoglycemia.
3) The materials and methodology used, including mathematical modeling of insulin dosing, 3D printing of parts, and software development.
4) The results of in vitro testing that show the prototype achieved accuracy and precision comparable to commercial pumps.
1) Insulin therapy is considered for type 2 diabetes patients when target HbA1c levels cannot be achieved with at least two oral hypoglycemic agents. Insulin may also be started earlier if a patient is particularly symptomatic with high blood sugar levels or after a heart attack.
2) On average, type 2 diabetes patients starting insulin therapy have an HbA1c level of 9.8%, which is too high and risks complications. Both clinicians and patients are often reluctant to start insulin due to lack of confidence, technical aspects, and association with older methods of injection.
3) Insulin is the most effective drug for controlling blood glucose levels and has been proven safe over many years. Different insulin types
Insulin pumps can help manage diabetes during pregnancy by more closely mimicking normal insulin physiology compared to multiple daily injections. Starting insulin pump settings during pregnancy typically involve dividing total daily insulin dose in half, with 50% for basal rates given continuously over 24 hours and 50% for bolus doses with meals. Basal and bolus rates often need adjustment throughout pregnancy as insulin resistance and needs increase. Close monitoring of blood sugars is important for optimizing pump settings to help prevent hyperglycemia and hypoglycemia. After delivery, insulin requirements usually decrease rapidly but may need to be adjusted based on breastfeeding and return of normal glucose levels.
This document provides contact and product information for Phray Technology Co., Ltd, a manufacturer of medical devices including insulin pumps, near-infrared therapy devices, and ECG machines. It includes the company address and contact details of an individual, as well as an overview of key products and services like original equipment manufacturing and a description of Phray's insulin pump model PH300. International cooperation opportunities and terms and conditions for product use are also mentioned.
Dr. David Greene R3 stem cell Breakthroughs: Stem Cell Therapy in CardiologyR3 Stem Cell
Dr. David Greene, founder and CEO of R3 Stem Cell, is at the forefront of groundbreaking research in the field of cardiology, focusing on the transformative potential of stem cell therapy. His latest work emphasizes innovative approaches to treating heart disease, aiming to repair damaged heart tissue and improve heart function through the use of advanced stem cell techniques. This research promises not only to enhance the quality of life for patients with chronic heart conditions but also to pave the way for new, more effective treatments. Dr. Greene's work is notable for its focus on safety, efficacy, and the potential to significantly reduce the need for invasive surgeries and long-term medication, positioning stem cell therapy as a key player in the future of cardiac care.
Hypertension and it's role of physiotherapy in it.Vishal kr Thakur
This particular slides consist of- what is hypertension,what are it's causes and it's effect on body, risk factors, symptoms,complications, diagnosis and role of physiotherapy in it.
This slide is very helpful for physiotherapy students and also for other medical and healthcare students.
Here is summary of hypertension -
Hypertension, also known as high blood pressure, is a serious medical condition that occurs when blood pressure in the body's arteries is consistently too high. Blood pressure is the force of blood pushing against the walls of blood vessels as the heart pumps it. Hypertension can increase the risk of heart disease, brain disease, kidney disease, and premature death.
Michigan HealthTech Market Map 2024. Includes 7 categories: Policy Makers, Academic Innovation Centers, Digital Health Providers, Healthcare Providers, Payers / Insurance, Device Companies, Life Science Companies, Innovation Accelerators. Developed by the Michigan-Israel Business Accelerator
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
Gemma Wean- Nutritional solution for Artemiasmuskaan0008
GEMMA Wean is a high end larval co-feeding and weaning diet aimed at Artemia optimisation and is fortified with a high level of proteins and phospholipids. GEMMA Wean provides the early weaned juveniles with dedicated fish nutrition and is an ideal follow on from GEMMA Micro or Artemia.
GEMMA Wean has an optimised nutritional balance and physical quality so that it flows more freely and spreads readily on the water surface. The balance of phospholipid classes to- gether with the production technology based on a low temperature extrusion process improve the physical aspect of the pellets while still retaining the high phospholipid content.
GEMMA Wean is available in 0.1mm, 0.2mm and 0.3mm. There is also a 0.5mm micro-pellet, GEMMA Wean Diamond, which covers the early nursery stage from post-weaning to pre-growing.
Under Pressure : Kenneth Kruk's StrategyKenneth Kruk
Kenneth Kruk's story of transforming challenges into opportunities by leading successful medical record transitions and bridging scientific knowledge gaps during COVID-19.
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
This particular slides consist of- what is hypotension,what are it's causes and it's effect on body, risk factors, symptoms,complications, diagnosis and role of physiotherapy in it.
This slide is very helpful for physiotherapy students and also for other medical and healthcare students.
Here is the summary of hypotension:
Hypotension, or low blood pressure, is when the pressure of blood circulating in the body is lower than normal or expected. It's only a problem if it negatively impacts the body and causes symptoms. Normal blood pressure is usually between 90/60 mmHg and 120/80 mmHg, but pressures below 90/60 are generally considered hypotensive.
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About this webinar: This talk will introduce what cancer rehabilitation is, where it fits into the cancer trajectory, and who can benefit from it. In addition, the current landscape of cancer rehabilitation in Canada will be discussed and the need for advocacy to increase access to this essential component of cancer care.
Stem Cell Solutions: Dr. David Greene's Path to Non-Surgical Cardiac CareDr. David Greene Arizona
Explore the groundbreaking work of Dr. David Greene, a pioneer in regenerative medicine, who is revolutionizing the field of cardiology through stem cell therapy in Arizona. This ppt delves into how Dr. Greene's innovative approach is providing non-surgical, effective treatments for heart disease, using the body's own cells to repair heart damage and improve patient outcomes. Learn about the science behind stem cell therapy, its benefits over traditional cardiac surgeries, and the promising future it holds for modern medicine. Join us as we uncover how Dr. Greene's commitment to stem cell research and therapy is setting new standards in healthcare and offering new hope to cardiac patients.
Unlocking the Secrets to Safe Patient Handling.pdfLift Ability
Furthermore, the time constraints and workload in healthcare settings can make it challenging for caregivers to prioritise safe patient handling Australia practices, leading to shortcuts and increased risks.
8. Myths Facts
You have to know a lot about technology to
use a pump
Successfully managing your glucose with
pump is often as easy as entering blood
sugar and meal information then pressing
enter.
Pump will stop patient from being active With sturdy design and ability to be tightly
secured to body, insulin pumps allow you to
participate physical activity you enjoy.
Wearing a insulin pump is uncomfortable and
painful
The pump infusion site should not cause any
pain. Most of the patients even forget they
are wearing pump until then need to deliver
a bolus dose.
Pump is a constant reminder of Diabetes According to study, pump give patients
confidence, level of control and flexibility
that no other insulin regimen can provide.
27. Pump System/Device Manufacturers
Accu-Chek Spirit Combo Roche Diagnostics
MiniMed® 530G, 630G and
MiniMed™ 670G (The world’s first
hybrid closed loop system. FDA
approved)
Medtronic diabetes
Dana Diabecare II Sooil
Tandem t:slim Insulin Pump Tandem Diabetes Care
28. With Dr. Scott W. Lee, MD & Prof. Faruque Pathan Sir, on a workshop arranged by Medtronic.