Milo Puhan discusses the need for individualized risk stratification to determine if a drug will provide benefit or harm for a specific patient. Currently, risks are often oversimplified by looking at single outcomes from clinical trials. Puhan advocates combining a patient's individual risk factors and characteristics, the determinants of treatment outcomes, and the patient's values and preferences using modern technology to provide a multidimensional assessment of absolute treatment effects tailored to that individual. This personalized approach would help clinicians and patients make more informed decisions about whether a treatment is likely to provide net benefit or harm.
Debate risk stratification in hcm is feasible using a clinical score (con)drucsamal
The ESC-HCM risk score for predicting sudden cardiac death (SCD) at 5 years misclassifies many patients in the study as low risk when they experienced appropriate ICD interventions or SCD. Using the ESC risk score would have left 65 patients vulnerable to SCD without ICD protection. Key risk factors like late gadolinium enhancement on cardiac MRI and left ventricular apical aneurysms are not included in the ESC model. Contemporary risk stratification guidelines are superior to relying solely on the ESC mathematical model for complex decision making around ICD implantation in hypertrophic cardiomyopathy patients.
This document discusses the conundrum of managing mitral regurgitation (MR) in patients with heart failure. It highlights the importance of using multimodality imaging to:
1) Assess the severity of MR at rest and with exercise to determine risk and need for intervention.
2) Evaluate left ventricular function, dyssynchrony, viability and ischemia to determine indications for cardiac resynchronization therapy or revascularization.
3) Assess left ventricular remodeling and mitral valve deformation to predict risk of recurrent MR after repair and determine the best repair/replacement option.
Imaging provides essential information to optimize treatment strategies for MR in heart failure.
In highly congested hospitals it may be common for patients to overstay at Intensive Care Units (ICU) due to blockages and imbalances in capacity.
Watch the webinar in full at: https://www.simul8healthcare.com/case-studies/releasing-icu-bed-capacity
Medical Decision Making associated with Clinical test interpretations. Depending on the situation one should get a second test to confirm the result of the first one; or one should move on to the treatment phase.
Dr. Megan Schnur - Field Experience with Mycoplasma hyosynoviae Lameness in G...John Blue
1) The document discusses Mycoplasma hyosynoviae (MHS), a pathogen that can cause arthritis in pigs. It was found on a farm ("Farm B") where grow-finish pigs were experiencing hind limb lameness.
2) A comprehensive control strategy was implemented on Farm B including early identification of lame pigs, controlled exposure of pigs to MHS, and targeted antibiotic treatment which significantly reduced lameness prevalence and severity.
3) Other options discussed include developing an autogenous vaccine and further research on optimal timing of antibiotic treatment to control MHS.
The document asks 6 multiple choice questions about percentages of breast cancer diagnoses at different stages and receptor statuses. It also asks about preferred hormone therapy options for adjuvant breast cancer treatment.
The document asks six multiple choice questions about percentages of breast cancer cases by stage at diagnosis, hormone receptor status, and HER2 status. It also asks two questions about treatment choices for adjuvant hormone therapy and neoadjuvant therapy for stage 2/3 HER2 positive breast cancer.
Debate risk stratification in hcm is feasible using a clinical score (con)drucsamal
The ESC-HCM risk score for predicting sudden cardiac death (SCD) at 5 years misclassifies many patients in the study as low risk when they experienced appropriate ICD interventions or SCD. Using the ESC risk score would have left 65 patients vulnerable to SCD without ICD protection. Key risk factors like late gadolinium enhancement on cardiac MRI and left ventricular apical aneurysms are not included in the ESC model. Contemporary risk stratification guidelines are superior to relying solely on the ESC mathematical model for complex decision making around ICD implantation in hypertrophic cardiomyopathy patients.
This document discusses the conundrum of managing mitral regurgitation (MR) in patients with heart failure. It highlights the importance of using multimodality imaging to:
1) Assess the severity of MR at rest and with exercise to determine risk and need for intervention.
2) Evaluate left ventricular function, dyssynchrony, viability and ischemia to determine indications for cardiac resynchronization therapy or revascularization.
3) Assess left ventricular remodeling and mitral valve deformation to predict risk of recurrent MR after repair and determine the best repair/replacement option.
Imaging provides essential information to optimize treatment strategies for MR in heart failure.
In highly congested hospitals it may be common for patients to overstay at Intensive Care Units (ICU) due to blockages and imbalances in capacity.
Watch the webinar in full at: https://www.simul8healthcare.com/case-studies/releasing-icu-bed-capacity
Medical Decision Making associated with Clinical test interpretations. Depending on the situation one should get a second test to confirm the result of the first one; or one should move on to the treatment phase.
Dr. Megan Schnur - Field Experience with Mycoplasma hyosynoviae Lameness in G...John Blue
1) The document discusses Mycoplasma hyosynoviae (MHS), a pathogen that can cause arthritis in pigs. It was found on a farm ("Farm B") where grow-finish pigs were experiencing hind limb lameness.
2) A comprehensive control strategy was implemented on Farm B including early identification of lame pigs, controlled exposure of pigs to MHS, and targeted antibiotic treatment which significantly reduced lameness prevalence and severity.
3) Other options discussed include developing an autogenous vaccine and further research on optimal timing of antibiotic treatment to control MHS.
The document asks 6 multiple choice questions about percentages of breast cancer diagnoses at different stages and receptor statuses. It also asks about preferred hormone therapy options for adjuvant breast cancer treatment.
The document asks six multiple choice questions about percentages of breast cancer cases by stage at diagnosis, hormone receptor status, and HER2 status. It also asks two questions about treatment choices for adjuvant hormone therapy and neoadjuvant therapy for stage 2/3 HER2 positive breast cancer.
Men's Health & Primary Care: Improving Access and OutcomesMen's Health Forum
Presentation made to the EMHF Primary Care Roundtable about men's health and primary care access - including usage of the internet for health purposes - England - July 2, 2014
The document discusses vitamin D, what it does, and how much we need. It begins by defining nutrient deficiency and adequacy. It then examines different models for how nutrition is viewed, such as prevention and maintenance for physiologists versus risk avoidance for regulators. The rest of the document reviews evidence that vitamin D deficiency is widespread and has consequences like increased risk of fractures, falls, heart disease, infections, and some cancers. It presents several studies showing benefits of vitamin D for bone health, blood pressure, neuromuscular function, and influenza prevention. The overall message is that vitamin D status is important for overall health and most people have inadequate levels.
This document summarizes key findings from the EUPROMS study on the impact of prostate cancer treatments on patient-reported outcomes. Some highlights include:
- Radical prostatectomy (RP) and radiation therapy (RT) both significantly reduced sexual function scores compared to active surveillance (AS), with about 1/3 of AS scores. RP also significantly reduced urinary continence scores compared to healthy controls.
- About 30-40% of RP patients and 15-20% of RT patients reported urinary incontinence issues like pad usage. RP also saw greater issues with urinary, bowel and sexual dysfunction compared to RT.
- Shared decision making scores were generally in the moderate range (median 33-
The document provides an overview of epithelial ovarian tumours, which make up 90% of ovarian tumours. They most commonly originate from the coelomic epithelium. The four main histological types are serous, mucinous, endometrioid, and clear cell. Risk factors include increased age, family history, and lack of pregnancy. Screening and tumor markers like CA125 are used for early detection but have limitations. Surgery is the main treatment and chemotherapy is used for advanced stages. Prognosis depends on stage, with 5-year survival rates ranging from 76-93% for stage 1 to 11% for stage 4.
Prostate cancer detection, UroLifts, HaematuriaMarc Laniado
This document discusses innovations in prostate disease management, including focal therapy options for prostate cancer and the UroLift procedure for treating benign prostatic hyperplasia (BPH). It summarizes guidelines for investigating hematuria and evaluating prostate cancer risk. It also compares treatment options for localized prostate cancer and BPH, noting UroLift offers symptom relief while preserving sexual function unlike other BPH treatments. Clinical data shows UroLift improves urinary symptoms and quality of life compared to TURP, with faster recovery and no effect on ejaculation.
This advisory board meeting discussed the diagnosis and treatment of patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) by consultant urologists. Key discussion points included the typical patient profile and journey, diagnostic process, choice of medical versus surgical treatment options and the reasoning behind them. Presentation of complications and the use of various drug therapies such as alpha blockers and 5-alpha reductase inhibitors were also covered. Surgical treatment modalities like transurethral resection of the prostate (TURP) and various laser procedures were mentioned.
The document discusses prostate cancer, including that it is the most common malignancy of the male urogenital tract, with about 10,000 cases per year in the UK. It is rare before age 50 and found in 80% of men older than 80 upon autopsy. Prostate cancer arises in the prostate gland and can spread through the capsule, lymph nodes, bones, and other sites. Risk factors include family history and diet. Screening includes digital rectal exam and PSA testing, while diagnosis involves biopsy. Staging uses the TNM system and Gleason grading provides a prognosis. Treatment depends on stage and includes surgery, radiation, hormone therapy, and active surveillance.
Blood pressure market research study - November 2020Valencell, Inc
In November 2020, Valencell conducted a research study on people with hypertension to understand the personal impact of managing the disease every day and the potential for digital health solutions to improve hypertension management.
The document presents findings from a study on factors associated with anemia in pregnant patients. The study found that older age, diet low in meat/green vegetables, and non-compliance with iron supplements were associated with increased risk of anemia. Younger women were more likely to forget taking their iron tablets. The study recommends educating patients on diet, avoiding iron absorption reducers when taking supplements, and having a routine to improve compliance.
Dr Ho Siew Hong delivered a public lecture on differentiating prostate cancer from non cancer enlargement of the prostate during the Prostate Awareness Month 2008
As part of the IFPRI Egypt Seminar in partnership with the National Nutrition Committee: "the 100 million healthy lives initiative: Food availability, access and consumption patterns in Egypt"
Gastric tumors can be benign or malignant. The most common malignant tumors are adenocarcinoma, lymphoma, and gastrointestinal stromal tumor (GIST). Risk factors for gastric cancer include H. pylori infection, diet, genetics, and conditions causing gastric atrophy. Early detection of gastric cancer improves survival rates. Treatment depends on the stage but may involve surgery, chemotherapy, and radiation therapy. Gastric lymphoma is usually non-Hodgkin's lymphoma and has a better prognosis than adenocarcinoma. GIST tumors originate in the stomach wall and can be benign or malignant depending on size and other characteristics.
1. Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE affects about 1 in 1000 people yearly and PE causes 50,000 deaths in the US yearly.
2. Risk factors for DVT include venous stasis, trauma, surgery, increasing age, and cancers. Inherited thrombophilias like factor V Leiden and protein C/S deficiencies increase risk of recurrent VTE.
3. Prevention includes anticoagulation and other antithrombotics. Without prophylaxis, the risk of DVT is 20-30% for some surgeries, reduced to 5-10% with prophylaxis.
The document summarizes outcomes data from the Atlantic City Pilot Practice. Some key findings include:
1) After the first two weeks of operation over 600 patients enrolled, with 25 patients seen per day.
2) Patient experience improved over prior care across all domains of a nationally validated survey.
3) Control of hypertension, diabetes, and other conditions improved significantly. For example, the percentage of patients with diabetes in poor control of HbA1c dropped from 26.1% to 15.8%.
4) Smoking cessation rates improved dramatically across various patient groups, such as from 29.6% to 11.1% for those with COPD.
5) Patients self-
Flipping the clinic: in home health monitoring using mobile phonesEric Larson
This document discusses the potential for mobile phones to be used for remote health monitoring and disease management. It describes several ongoing research projects using phones to measure lung function, detect jaundice in newborns, and potentially monitor other vital signs. For lung function, algorithms are being developed to estimate measurements like FEV1 and FVC using only a phone's microphone. Early studies show results correlate well with clinical spirometers. For jaundice, a camera-based method estimates bilirubin levels in newborns with 85% accuracy compared to blood tests. Future work aims to expand monitoring to conditions like cervical cancer screening and measuring blood pressure. Overall, the document outlines the promise of mobile health technologies to improve access
5th Annual Early Age Onset Colorectal Cancer Summit - Session III: Earliest Possible Diagnosis and Treatment Through Timely Recognition of Symptoms and Signs of Young Adult CRC
Scoring systems used to grade patients in liver disease , their impact on outcomes in liver transplant and perioperative setting. We describe the history of scoring systems in liver disease, their relevance to liver transplatation, critical care management and operating theater decisions.
Screening, Surveillance And Diagnosis Of Colorectal Cancerensteve
Screening and surveillance for colorectal cancer involves assessing risk based on family history and personal medical history to determine appropriate screening methods and schedules. The National Bowel Cancer Screening Program in Australia uses fecal immunochemical testing every 2 years for average risk individuals aged 50-74, with colonoscopy for positive tests. Participation rates are around 40-50% and cancer detection rates are around 5% for those undergoing colonoscopy. Ongoing evaluation aims to improve participation and outcomes.
This document provides an overview of abdominal trauma. It begins by discussing epidemiology, noting that abdominal trauma is a leading cause of death, especially in those aged 15-30 from motor vehicle accidents and falls. It then covers types of abdominal trauma including blunt and penetrating. Specific injuries like liver, spleen, and hollow viscus injuries are discussed. Diagnostic tools like FAST, CT, and laparoscopy are summarized. Management of unstable versus stable patients is outlined. Finally, it notes that pediatric abdominal trauma is usually blunt and has a high success rate with non-operative management.
In the final ELC West of England series, we look back at the data we've collected over the past two years to show us how we, as a collaborative, have progressed.
Revolutionizing Heathcare and Wellness Management through Systems P4 Medicinebrnbarcelona
Revolutionizing healthcare and wellness management through systems medicine approaches like predictive, preventive, personalized and participatory (P4) medicine. The document discusses establishing networks and consortiums across Europe to advance systems medicine through data and knowledge sharing, standardized methods, and integrating multi-omics data with clinical information. The goal is to transition to more proactive, cost-efficient healthcare by better understanding disease at the systems level.
Implications for the Health Care Systembrnbarcelona
This document discusses implications for the health care system from personalized and population-based approaches. It contains 3 key points:
1) Balancing population and individual interventions can maximize health benefits, minimize harm, and avoid unnecessary costs. This requires considering predictive, preventive, personalized and participatory (P4) perspectives as well as population perspectives (P5).
2) There is significant variability in clinical practice and resource use across regions, indicating uncertainty around effectiveness. Standardizing rates can help address inequalities.
3) Personalization requires considering individual variability, balancing individual needs with population responsibilities, and rethinking business models to focus on coordinated long-term care through facilitated networks rather than one-size-fits-all
Men's Health & Primary Care: Improving Access and OutcomesMen's Health Forum
Presentation made to the EMHF Primary Care Roundtable about men's health and primary care access - including usage of the internet for health purposes - England - July 2, 2014
The document discusses vitamin D, what it does, and how much we need. It begins by defining nutrient deficiency and adequacy. It then examines different models for how nutrition is viewed, such as prevention and maintenance for physiologists versus risk avoidance for regulators. The rest of the document reviews evidence that vitamin D deficiency is widespread and has consequences like increased risk of fractures, falls, heart disease, infections, and some cancers. It presents several studies showing benefits of vitamin D for bone health, blood pressure, neuromuscular function, and influenza prevention. The overall message is that vitamin D status is important for overall health and most people have inadequate levels.
This document summarizes key findings from the EUPROMS study on the impact of prostate cancer treatments on patient-reported outcomes. Some highlights include:
- Radical prostatectomy (RP) and radiation therapy (RT) both significantly reduced sexual function scores compared to active surveillance (AS), with about 1/3 of AS scores. RP also significantly reduced urinary continence scores compared to healthy controls.
- About 30-40% of RP patients and 15-20% of RT patients reported urinary incontinence issues like pad usage. RP also saw greater issues with urinary, bowel and sexual dysfunction compared to RT.
- Shared decision making scores were generally in the moderate range (median 33-
The document provides an overview of epithelial ovarian tumours, which make up 90% of ovarian tumours. They most commonly originate from the coelomic epithelium. The four main histological types are serous, mucinous, endometrioid, and clear cell. Risk factors include increased age, family history, and lack of pregnancy. Screening and tumor markers like CA125 are used for early detection but have limitations. Surgery is the main treatment and chemotherapy is used for advanced stages. Prognosis depends on stage, with 5-year survival rates ranging from 76-93% for stage 1 to 11% for stage 4.
Prostate cancer detection, UroLifts, HaematuriaMarc Laniado
This document discusses innovations in prostate disease management, including focal therapy options for prostate cancer and the UroLift procedure for treating benign prostatic hyperplasia (BPH). It summarizes guidelines for investigating hematuria and evaluating prostate cancer risk. It also compares treatment options for localized prostate cancer and BPH, noting UroLift offers symptom relief while preserving sexual function unlike other BPH treatments. Clinical data shows UroLift improves urinary symptoms and quality of life compared to TURP, with faster recovery and no effect on ejaculation.
This advisory board meeting discussed the diagnosis and treatment of patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) by consultant urologists. Key discussion points included the typical patient profile and journey, diagnostic process, choice of medical versus surgical treatment options and the reasoning behind them. Presentation of complications and the use of various drug therapies such as alpha blockers and 5-alpha reductase inhibitors were also covered. Surgical treatment modalities like transurethral resection of the prostate (TURP) and various laser procedures were mentioned.
The document discusses prostate cancer, including that it is the most common malignancy of the male urogenital tract, with about 10,000 cases per year in the UK. It is rare before age 50 and found in 80% of men older than 80 upon autopsy. Prostate cancer arises in the prostate gland and can spread through the capsule, lymph nodes, bones, and other sites. Risk factors include family history and diet. Screening includes digital rectal exam and PSA testing, while diagnosis involves biopsy. Staging uses the TNM system and Gleason grading provides a prognosis. Treatment depends on stage and includes surgery, radiation, hormone therapy, and active surveillance.
Blood pressure market research study - November 2020Valencell, Inc
In November 2020, Valencell conducted a research study on people with hypertension to understand the personal impact of managing the disease every day and the potential for digital health solutions to improve hypertension management.
The document presents findings from a study on factors associated with anemia in pregnant patients. The study found that older age, diet low in meat/green vegetables, and non-compliance with iron supplements were associated with increased risk of anemia. Younger women were more likely to forget taking their iron tablets. The study recommends educating patients on diet, avoiding iron absorption reducers when taking supplements, and having a routine to improve compliance.
Dr Ho Siew Hong delivered a public lecture on differentiating prostate cancer from non cancer enlargement of the prostate during the Prostate Awareness Month 2008
As part of the IFPRI Egypt Seminar in partnership with the National Nutrition Committee: "the 100 million healthy lives initiative: Food availability, access and consumption patterns in Egypt"
Gastric tumors can be benign or malignant. The most common malignant tumors are adenocarcinoma, lymphoma, and gastrointestinal stromal tumor (GIST). Risk factors for gastric cancer include H. pylori infection, diet, genetics, and conditions causing gastric atrophy. Early detection of gastric cancer improves survival rates. Treatment depends on the stage but may involve surgery, chemotherapy, and radiation therapy. Gastric lymphoma is usually non-Hodgkin's lymphoma and has a better prognosis than adenocarcinoma. GIST tumors originate in the stomach wall and can be benign or malignant depending on size and other characteristics.
1. Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE affects about 1 in 1000 people yearly and PE causes 50,000 deaths in the US yearly.
2. Risk factors for DVT include venous stasis, trauma, surgery, increasing age, and cancers. Inherited thrombophilias like factor V Leiden and protein C/S deficiencies increase risk of recurrent VTE.
3. Prevention includes anticoagulation and other antithrombotics. Without prophylaxis, the risk of DVT is 20-30% for some surgeries, reduced to 5-10% with prophylaxis.
The document summarizes outcomes data from the Atlantic City Pilot Practice. Some key findings include:
1) After the first two weeks of operation over 600 patients enrolled, with 25 patients seen per day.
2) Patient experience improved over prior care across all domains of a nationally validated survey.
3) Control of hypertension, diabetes, and other conditions improved significantly. For example, the percentage of patients with diabetes in poor control of HbA1c dropped from 26.1% to 15.8%.
4) Smoking cessation rates improved dramatically across various patient groups, such as from 29.6% to 11.1% for those with COPD.
5) Patients self-
Flipping the clinic: in home health monitoring using mobile phonesEric Larson
This document discusses the potential for mobile phones to be used for remote health monitoring and disease management. It describes several ongoing research projects using phones to measure lung function, detect jaundice in newborns, and potentially monitor other vital signs. For lung function, algorithms are being developed to estimate measurements like FEV1 and FVC using only a phone's microphone. Early studies show results correlate well with clinical spirometers. For jaundice, a camera-based method estimates bilirubin levels in newborns with 85% accuracy compared to blood tests. Future work aims to expand monitoring to conditions like cervical cancer screening and measuring blood pressure. Overall, the document outlines the promise of mobile health technologies to improve access
5th Annual Early Age Onset Colorectal Cancer Summit - Session III: Earliest Possible Diagnosis and Treatment Through Timely Recognition of Symptoms and Signs of Young Adult CRC
Scoring systems used to grade patients in liver disease , their impact on outcomes in liver transplant and perioperative setting. We describe the history of scoring systems in liver disease, their relevance to liver transplatation, critical care management and operating theater decisions.
Screening, Surveillance And Diagnosis Of Colorectal Cancerensteve
Screening and surveillance for colorectal cancer involves assessing risk based on family history and personal medical history to determine appropriate screening methods and schedules. The National Bowel Cancer Screening Program in Australia uses fecal immunochemical testing every 2 years for average risk individuals aged 50-74, with colonoscopy for positive tests. Participation rates are around 40-50% and cancer detection rates are around 5% for those undergoing colonoscopy. Ongoing evaluation aims to improve participation and outcomes.
This document provides an overview of abdominal trauma. It begins by discussing epidemiology, noting that abdominal trauma is a leading cause of death, especially in those aged 15-30 from motor vehicle accidents and falls. It then covers types of abdominal trauma including blunt and penetrating. Specific injuries like liver, spleen, and hollow viscus injuries are discussed. Diagnostic tools like FAST, CT, and laparoscopy are summarized. Management of unstable versus stable patients is outlined. Finally, it notes that pediatric abdominal trauma is usually blunt and has a high success rate with non-operative management.
In the final ELC West of England series, we look back at the data we've collected over the past two years to show us how we, as a collaborative, have progressed.
Revolutionizing Heathcare and Wellness Management through Systems P4 Medicinebrnbarcelona
Revolutionizing healthcare and wellness management through systems medicine approaches like predictive, preventive, personalized and participatory (P4) medicine. The document discusses establishing networks and consortiums across Europe to advance systems medicine through data and knowledge sharing, standardized methods, and integrating multi-omics data with clinical information. The goal is to transition to more proactive, cost-efficient healthcare by better understanding disease at the systems level.
Implications for the Health Care Systembrnbarcelona
This document discusses implications for the health care system from personalized and population-based approaches. It contains 3 key points:
1) Balancing population and individual interventions can maximize health benefits, minimize harm, and avoid unnecessary costs. This requires considering predictive, preventive, personalized and participatory (P4) perspectives as well as population perspectives (P5).
2) There is significant variability in clinical practice and resource use across regions, indicating uncertainty around effectiveness. Standardizing rates can help address inequalities.
3) Personalization requires considering individual variability, balancing individual needs with population responsibilities, and rethinking business models to focus on coordinated long-term care through facilitated networks rather than one-size-fits-all
Personalized medicine: an industry viewbrnbarcelona
Dr. Bertil Lindmark discusses personalized medicine from an industry perspective. He argues that while personalized medicine aims to provide the right prevention and treatment for each patient, applying it to all situations may lead to overly expensive therapies for small patient groups and neglect of broader patient needs. For pharmaceutical companies, the "sweet spot" of personalized medicine is small, requiring a balance between development costs, therapeutic effects, and market size. Effective collaboration is needed between industry and academia to focus efforts on both specific disease areas with high costs and predictability, as well as broader indications where incremental innovation can still be profitable.
Unbiased BIOmarkers for the PREDiction of respiratory disease outcomebrnbarcelona
The document summarizes the U-BIOPRED study, which aims to use an integrative systems medicine approach to analyze molecular, physiological, and clinical biomarker profiles from over 1,000 asthma patients. The goal is to identify distinct "handprints" or signatures that can predict clinical outcomes, therapeutic responses, and identify novel treatment targets for severe asthma. The study involves collecting multi-dimensional omics data, including genomics, transcriptomics, proteomics, metabolomics, from various sample types like sputum, biopsies, and breath. It is hypothesized that integrating these complex datasets will enable the definition of clinical and biological phenotypes that can improve asthma management.
MeDALL (Mechanisms of the Development of ALLergy): an integrated approach fro...brnbarcelona
This document summarizes research from the MeDALL project investigating the mechanisms of allergy development. It discusses:
1) Analyzing data from 12 birth cohorts involving over 16,000 children to identify classical and novel phenotypes of asthma, rhinitis, and eczema, finding high levels of comorbidity between the conditions.
2) Developing a new microarray to improve detection of allergen sensitization across Europe.
3) Conducting the first epigenome-wide analysis of asthma and allergy combining multiple countries and time points, identifying several genome-wide significant hits.
4) Using targeted proteomics to identify protein biomarkers associated with asthma/allergy and integrating these findings with genetic
This document provides an introduction to network medicine and discusses its application to chronic obstructive pulmonary disease (COPD). It defines network medicine as studying cellular, disease, and social networks to quantify factors contributing to individual diseases. For COPD, network approaches are being used to build disease networks, define molecular pathways, identify optimal disease phenotypes, develop new classifications, and integrate multi-omics data. Genome-wide association studies have identified risk loci for COPD, which are now being functionally validated in cellular and animal models. Network medicine aims to take a holistic rather than reductionist approach to complex diseases like COPD.
From Systems Biology to Personalized Medicine: an epidemiological viewbrnbarcelona
This document summarizes a presentation on the contributions of epidemiology to systems biology and medicine. It discusses how epidemiology takes a population-based approach to health and disease, and how post-genome epidemiology examines genes, gene-environment interactions, and new insights into disease mechanisms. It also reviews several ongoing research initiatives that aim to understand the complexity of conditions like asthma and COPD using a systems approach. Finally, it outlines how epidemiology can integrate different levels of complexity, study diverse patient samples, apply bioinformatics tools, lead multidisciplinary efforts, and provide a public health framework for systems medicine.
(1) The document discusses integrating heterogeneous biomedical data such as clinical data, 'omics data, biomedical literature, and drugs to gain a more complete understanding of diseases and therapeutics. (2) It describes how the GRIB group mines, integrates, filters, annotates, analyzes, and visualizes different data types to enable integrative bioinformatics. (3) As an example, it discusses how the group analyzed gene-disease networks from the DisGeNET database to reveal functional modules underlying different disease types and identify disease comorbidities.
James Sharpe is the coordinator of the EMBL-CRG Systems Biology Unit in Barcelona. He discusses how systems biology goes beyond correlations to model biological complexity and dynamics through iterative cycles of generating and testing predictions with computational models and experimental perturbations in accessible model systems. While patient data can be used for statistical analyses, mechanistic systems models require extensive experimentation to develop and validate, which cannot be done in human patients.
Historical and ethical aspects of personalized medicinebrnbarcelona
This document discusses the shift from traditional medicine to personalized/precision medicine. It outlines several key eras: from the period of incidental discoveries up to the 1960s where specific germs were discovered to cause diseases; the era of high throughput screening from the 1970s-2000s which yielded treatments like statins and Velcade; and now the era of personalized/precision "iMedicine" which aims to be predictive, preventive, participatory and personalized. The document provides examples of advances and challenges that have contributed to this shift.
This document summarizes a presentation on applying systems biology approaches to epidemiology and personalized medicine. It discusses how epidemiology has evolved from studying single risk factors to investigating complex interactions between genes, environments and diseases. Systems approaches integrate multiple levels of data to gain insights into disease mechanisms. Large consortia now apply these methods to conditions like asthma and COPD to understand their complexity. Epidemiology contributes a population perspective and helps develop evidence-based systems medicine frameworks.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
1. Milo Puhan, MD, PhD
Professor of Epidemiology & Public Health
University of Zurich, Switzerland
Johns Hopkins University, USA
Individual Risk Stratification
BRN – AJRCCM Workshop
Personalized Respiratory Medicine
Barcelona, June 13, 2014
2. Will this drug be beneficial for a specific individual?
-20% COPD exacerbations
Insomnia + 300%
Anxiety + 200%
Depression + 180%
Diarrhea + 300%
Nausea + 300%
Weight loss + 400%
Headache + 200%
Dizziness + 300%
Excess of
3. How to apply these results to individual patients?
-20% COPD exacerbations
Acute pancreatitis + 500% ?
Insomnia + 300%
Anxiety + 200%
Depression + 180%
Suicide + 500% ?
Diarrhea + 300%
Nausea + 300%
Weight loss + 400%
Headache + 200%
Dizziness + 300%
Excess of
Patient 1
Lung function ↓
≤ 1 exacerbation/y
Chronic GI problems
Mild depression
Patient 2
Lung function ↓↓
≥2 exacerbations/y
No GI problems
Mild depression
Don‘t use drug Worth a try?
6. Current practice of estimating benefits vs. harms
Evidence on
treatment effects
Patient values &
preferences
Determinants of outcome risks &
treatment effects
Exacerbations
Favors
treatment
Favors
control
0.5 0.7 1 1.5 2
Favors
treatment
Favors
control
Nausea
0.001 0.1 1 10 1000
Favors
treatment
Favors
control
Diarrhea
0.1 0.2 0.5 1 2 5 10
RCT control
group event
rates (e.g. 20%
in 1 year)
NNT: 25
NNH: 5
May be worth a try
Much uncertainty
since oversimplified:
Single outcome risks
Few outcomes
Implicit preferences
7. Evidence on
treatment effects
Patient values &
preferences
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Determinants of outcome risks &
treatment effects
Combine 3 key ingredients and use modern technology
8. How can we get there?
Personalized through risk
stratification and preferences
Based on your individual characteristics and what
is important for you
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
The chance that you will
benefit from drug X is
very low
(nine out of ten patients
like you will experience
more harm than benefit)
Your risk for a hospital admission
because of COPD
Your risk for
experiencing
severe side
effects
Evidence on
treatment effects
Patient values &
preferences
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Determinantsof outcome risks &
treatment effects
10. Multidimensional
assessments
- A quickly
emerging field
RCTs
Registries
Observational studies
Surveys (preferences)
Observational studies
(prognosis)
Various methods
Outcome risks
Estimates of effect
Absolute effects
Benefit harm
analysis
Importance of
Outcomes
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
Guo et al. Value Health 2010, 13(5):657–666.
Puhan et al. BMC Med Res Meth 2012, 12:173
Boyd, et al. AHRQ 2012 .12(13)-EHC150-EF
FDA PDUFA V Plan (FY 2013-2017)
11. Approaches for benefit harm assessment
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
Decision making
context?
12. Simulation to consider statistical uncertainty of
effects and incidence rates
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
13. Based on your individual characteristics and what
is important for you
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
The chance that you will
benefit from drug X is
very low
(nine out of ten patients
like you will experience
more harm than benefit)
Your risk for a hospital admission
because of COPD
Your risk for
experiencing
severe side
effects
14. Age 45-54 Age 55-64 Age 65-74 Age 75-84
10-year risk of ischemic stroke: 0%-5% 10-year risk of ischemic stroke: 0%-5% 10-year risk of ischemic stroke: 0%-5% 10-year risk of ischemic stroke: 0%-5%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
10-year risk of ischemic stroke: 5%-10% 10-year risk of ischemic stroke: 5%-10% 10-year risk of ischemic stroke: 5%-10% 10-year risk of ischemic stroke: 5%-10%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
10-year risk of ischemic stroke: 10%-15% 10-year risk of ischemic stroke: 10%-15% 10-year risk of ischemic stroke: 10%-15% 10-year risk of ischemic stroke: 10%-15%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
10-year risk of ischemic stroke: 15%-20% 10-year risk of ischemic stroke: 15%-20% 10-year risk of ischemic stroke: 15%-20% 10-year risk of ischemic stroke: 15%-20%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
10-year risk of ischemic stroke: 20%-25% 10-year risk of ischemic stroke: 20%-25% 10-year risk of ischemic stroke: 20%-25% 10-year risk of ischemic stroke: 20%-25%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
10-year risk of ischemic stroke: 25%-30% 10-year risk of ischemic stroke: 25%-30% 10-year risk of ischemic stroke: 25%-30% 10-year risk of ischemic stroke: 25%-30%
10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50% 10-year risk of severe GI bleeds40%-50%
30%-40% 30%-40% 30%-40% 30%-40%
20%-30% 20%-30% 20%-30% 20%-30%
15%-20% 15%-20% 15%-20% 15%-20%
10%-15% 10%-15% 10%-15% 10%-15%
5%-10% 5%-10% 5%-10% 5%-10%
1%-5% 1%-5% 1%-5% 1%-5%
0%-1% 0%-1% 0%-1% 0%-1%
0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30% 0%-1% 1%-3% 3%-5% 5%-10% 10%-15% 15%-20% 20%-25% 25%-30%
10-year risk of MI 10-year risk of MI 10-year risk of MI 10-year risk of MI
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
15. Moderate or severe
exacerbation
Acute pancreatitis
Insomnia
Anxiety
Depression
Suicide (completed)
Diarrhea
Nausea
Weight loss
Headache
Dizziness
Benefits and harms of roflumilast
Yu T, Fain K, Boyd CM, Singh S, Weiss CO, Li T, Varadhan R, Puhan MA. Thorax 2014, doi: 10.1136
FDApivotal and
safety pool
COPD observational studies
Placebo groups of RCTs
Survey (preferences)
Observationalstudies
(clustering events)
Outcome risks
Estimates of effect
Absolute effects
Benefit harm
analysis
Importance of
Outcomes
Lab research
Synthesisand
multidimensional
assessment
Epidemiological &
Clinical research
16. Net benefit-harm index* per 10,000 patients treated over 1 year by patient profiles
Type of analysis
Patients' projected 1-year risk of having ≥1 moderate or severe
COPD exacerbation
30% 60% 90%
Men Women Men Women Men Women
Age
<65 ≥65 <65 ≥65 <65 ≥65 <65 ≥65 <65 ≥65 <65 ≥65
Analysis I:
Equal weights
0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Analysis II:
Weights based on importance of
outcomes
0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Analysis III (main analysis):
Weights based on importance and
co-occurrence of harm outcomes
0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Probability that roflumilast overall beneficial
Yu T, Fain K, Boyd CM, Singh S, Weiss CO, Li T, Varadhan R, Puhan MA. Thorax 2014, doi: 10.1136
Lab research
Synthesisand
multidimensional
assessment
Epidemiological &
Clinical research
17. Probability that
roflumilast is
beneficial
Prevention of severe exacerbations (requiring admission)
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
Yu T, et al. Thorax 2013, doi: 10.1136
19. Great importance of risk prediction
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Mortality: BODE, ADO, HADO, Briggs
Exacerbations: DOSE, SAFE, Briggs
Health status: HADO, Siebeling
Harm outcomes: COPD observational
studies, RCT control groups, registries
20. Prediction models of the future?
Rigorous evaluation is critical
Mean predicted risk: 10.5%
Mean observed risk: 8.2%
HL: p<0.0001
0
10
20
30
40
Observed risk
of acute renal
failure in %
0 10 20 30 40
Predicted risk of acute
renal failure in %
0.00
0.25
0.50
0.75
1.00
Sensitivity
0.00 0.25 0.50 0.75 1.00
1 - Specificity
Area under curve
0.76 (95% CI 0.71-0.81)
<1
1-5
6-10
11-15
16-20
21-30
31-40
>40
10 year
risk for
severe GI
bleed
10 year risk for MI
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Current COPD
models
Current COPD
models
+ biomarkers
Current COPD
models
+ genetics
Only genetics
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
21. Model update with new predictors
(e.g. biomarkers) and correct re-classification
<1
1-5
6-10
11-15
16-20
21-30
31-40
>40
10 year
risk for
severe GI
bleed
10 year risk for MI
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Manolio TA. N Engl J Med 2010;363:166-176.
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
22. Thomsen et al. JAMA. 2013;309(22):2353-2361
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
High CRP,
fibrinogen and/or
leukocyte count
0: 0.9%
1: 1.8%
2: 3.2%
3: 8.1%
Only biomarkers Added value of biomarkers
From uni- to multivariate associations
24. From risk prediction to benefit harm prediction
Probability that
roflumilast is
beneficial
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
25. Testing
EBM 2.0: Focus on the individual
Exploring what is
important
Decision making
Based on your individual characteristics and what
is important for you
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
The chance that you will
benefit from drug X is
very low
(nine out of ten patients
like you will experience
more harm than benefit)
Your risk for a hospital admission
because of COPD
Your risk for
experiencing
severe side
effects
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
26. Maximizes benefit – minimizes
harms for individuals
Links individual characteristics
(from molecular to composite
level) to treatment oucomes
Individual Risk Stratification
Personalized through risk
stratification and preferences
Based on your individual characteristics and what
is important for you
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
The chance that you will
benefit from drug X is
very low
(nine out of ten patients
like you will experience
more harm than benefit)
Your risk for a hospital admission
because of COPD
Your risk for
experiencing
severe side
effects
Evidence on
treatment effects
Patient values &
preferences
<1
1-5
6-10
11-15
16-20
21-30
61-80
>80
<1 1-3 3-5 6-10 11-15 16-20 21-25 26+
Determinantsof outcome risks &
treatment effects
Well-defined translational approach to make evidence-
based personalized respiratory medicine happen
Lab research
Synthesis and
multidimensional
assessment
Epidemiological &
Clinical research
Editor's Notes
1. associations, 2. when added to other predictors; 3.