This document discusses how concepts from cancer biology can help predict future economic growth and transitions. It draws parallels between tumor formation and urban sprawl, noting how both systems evolve from an initial niche to expand peripherally as the environment deteriorates. It also summarizes a model showing how organizational growth is driven by depletion of non-renewable resources. The document argues that societies must transition to new energy sources to avoid economic crises, and suggests high-population urban centers are well-positioned to transition to renewable and low-power energy systems through virtualization, recycling, and localized manufacturing enabled by information and computing technologies.