Immunostimulants & Immunosuppressents

1. Immunomodulators
Chauhan Chandan
Dept. of Pharmacology &
Toxicology
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10. Mechanism of action of BCG Vaccines
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12. Mechanism of action of Levamisole
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14. Mechanism of action of Cytokines :
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23. Immunosuppressants:-
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24. Classification of Immunosuppressants
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25. Mechanism of action of cyclosporine
Cyclosporine (CsA) binds to cyclophylin (CpN), forming a complex that binds and blocks the function of the
enzyme calcineurin (CaN). As a result, CaN fails to dephosphorylate the cytoplasmic component of the
nuclear factor of activated T cells (NF-ATc), and the transport of NF-ATc to the nucleus and the binding of NF-
ATc to the nuclear component of the nuclear factor of activated T cells (NF-ATn). The NF-ATc–NF-ATn complex
binds to the promoter of the interleukin 2 (IL-2) gene and initiates IL-2 production. Consequently, T cells do
not produce IL-2, which is necessary for full T-cell activation.
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26. Mechanism of action of m-TOR inhibitors
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27. Mechanism of action of Antiproliferative
& IL-2 Receptor Antagonists
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29. Mechanism of action of
Glucocorticoids:-
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30. Mechanism of action of TNFα inhibitors -Infliximab
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31. References :-
Goodman & Gilman’s” 13th Edition “The
Pharmacological Basis of Therapeutics
KD Tripathi “ Essentials of Medical Pharmacology ” 8th Edition
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