Adrenal medulla

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Adrenal medulla

  1. 1. Adrenal Medulla Dr. Sadaf Mumtaz 10/03/11
  2. 2. Autonomic nerve pathway
  3. 3. ANS
  4. 4. Comparison of the release and binding to receptors of epinephrine and norepinephrine <ul><li>β 1 bind equally with both epinephrine and nor-epinephrine </li></ul><ul><li>β 2 bind primarily with epinephrine </li></ul><ul><li>α (of both subtypes) have greater affinity for norepinephrine than for epinephrine </li></ul>
  5. 5. All adrenergic receptors are coupled to G-protein <ul><li>β 1 & β 2 ---------- cAMP </li></ul><ul><li>α 1 ------------ Ca 2+ second messenger </li></ul><ul><li>α 2 ----------- blocks cAMP </li></ul>
  6. 6. Effects of epinephrine <ul><li>Organ systems </li></ul><ul><li>Metabolic effects </li></ul><ul><li>CNS </li></ul><ul><li>Sweat glands </li></ul><ul><li>Eyes </li></ul>
  7. 7. Integrated stress response
  8. 8. <ul><li>Which of the following hormone does not exert a direct metabolic effect? </li></ul><ul><li>Epinephrine </li></ul><ul><li>GH </li></ul><ul><li>Aldosterone </li></ul><ul><li>Cortisol </li></ul><ul><li>Thyroid hormone </li></ul>
  9. 9. Thanks

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